5 Xishuangbanna Aedes flavivirus Aedes flavivirus Aedes cinereus flavivirus Aedes vexans flavivirus Culex theileri flavivirus ... virus Chaoyang virus Culex flavivirus Culex theileri flavivirus Spanish Culex flavivirus Wang Thong virus Culiseta flavivirus ... crangon flavivirus Cuacua virus Donggang virus Firefly squid flavivirus Gammarus chevreuxi flavivirus Gammarus pulex flavivirus ... Flaviviridae Rfam entry for Flavivirus 3UTR stem loop IV Rfam entry for Flavivirus DB element Rfam entry for Flavivirus 3 UTR ...
The findings open new avenues for developing vaccines and antiviral compounds to target diseases caused by flaviviruses. ... providing the first detailed view of a virus from the flavivirus family. ... Scientists solve first flavivirus structure. Purdue University. Journal. Cell. Funder. National Institutes of Health. Keywords ... The flavivirus family includes a number of dangerous insect-borne diseases such as dengue, West Nile, yellow fever, tick-borne ...
... vaccines for insect-spread viruses like dengue and Zika are likely after researchers discovered models of immature flavivirus ... Flaviviruses are globally distributed and dengue virus alone infects around 400 million people annually, Dr Coulibaly said. ... Study reveals the first complete 3D molecular structure of immature flavivirus. *Download PDF Copy ... 2021) The structure of an infectious immature flavivirus redefines viral architecture and maturation. Science Advances. doi.org ...
Flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), rely heavily on the availability of endoplasmic reticulum ( ... Given that the induction of autophagy may play an important role in flavivirus replication, the antiviral role of RETREG1 ... Our study highlights the importance of the host factor BPIFB3 in regulating flavivirus replication and further confirms that ... and further contribute to our understanding of the requirements for autophagy during flavivirus infection.Flaviviruses and ...
Serological diagnosis of flavivirus infections is complicated by the antigenic similarities among the Flavivirus genus. Indeed ... most flavivirus antibodies are directed against the highly immunogenic envelope protein, which contains both flavivirus cross- ... Due to the temporal and geographical co-circulation of flaviviruses in Europe, flavivirus differentiation by diagnostic tests ... However, antibody cross-reactivity could be advantageous in efforts to control emerging flaviviruses because it ensures partial ...
NS1 is a highly conserved non-structural protein among flaviviruses, which exist in diverse forms. The intracellular dimer form ... Flaviviruses are emerging arthropod-borne viruses representing an immense global health problem. The prominent viruses of this ... secreted NS1 has been identified as a potential diagnostic marker for early detection of the infections caused by flaviviruses ...
Flaviviruses, such as dengue (DENV), West Nile (WNV), yellow fever (YFV) and Zika (ZIKV) viruses, are mosquito-borne pathogens ... Uncovering Flavivirus Host Dependency Factors through a Genome-Wide Gain-of-Function Screen. ... To identify host factors that promote flavivirus replication, we performed a genome-wide gain-of-function cDNA screen for human ... The genome-wide gain-of-function screen is thus a valid approach to advance our understanding of flavivirus replication. ...
The goal of our work has been the development of a generic flavivirus detection system and emphasis has been placed on an ... Attention has been directed at the identification and characterization of MAB with broad flavivirus group-reactive domain as ... Initial assays demonstrated the capacity of the YF-derived antibodies to capture prototype flaviviruses. ... flavivirus type-specific detector MAB directed at sites distant from the group-reactive domain have been extensively used to ...
Flavivirus replication is mediated by a complex machinery that consists of viral enzymes, nonenzymatic viral proteins, and host ... Flavivirus replication is mediated by a complex machinery that consists of viral enzymes, nonenzymatic viral proteins, and host ... Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses. Journal of VirologyJune 16, 2005 ... Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses. Journal of VirologyJune 16, 2005 ...
Flavivirus 5 UTR are untranslated regions in the genome of viruses in the genus Flavivirus. The Flavivirus positive-oriented, ... The 5 UTR of flaviviruses are highly structured, has a length of approximately 100 nucleotides and harbors two conserved RNA ... terminal regions in flavivirus RNA synthesis and viral replication". Virology. 374 (1): 170-185. doi:10.1016/j.virol.2007.12. ... "Universal RNA Secondary Structure Insight Into Mosquito-Borne Flavivirus (MBFV) cis-Acting RNA Biology". Frontiers in ...
... is a previously little-known flavivirus closely related to Japanese encephalitis, West Nile, dengue, and yellow fever viruses, ... Flavivirus methyltransferase: a novel antiviral target. Antiviral Res. 80, 1-10.PubMedPubMedCentralCrossRefGoogle Scholar ... Flaviviruses: braking the entering. Curr. Opin. Virol. 3, 3-12.PubMedPubMedCentralCrossRefGoogle Scholar ... Structures of immature flavivirus particles. EMBO J. 22, 2604-2613.PubMedPubMedCentralCrossRefGoogle Scholar ...
Flavivirus structure and membrane fusion.. Heinz FX1, Allison SL.. Author information. 1. Institute of Virology, University of ...
Envelope glycoprotein M, flavivirus (IPR000069). Short name: Env_glycoprot_M_flavivir Overlapping homologous superfamilies * ... Flaviviruses are small enveloped viruses with virions comprised of three proteins called C, M and E [PMID: 8676481, PMID: ... The interactions of the flavivirus envelope proteins: implications for virus entry and release.. Arch. Virol. Suppl. 9 339-48 ... subviral particles from tick-borne encephalitis virus are fusogenic and provide a model system for studying flavivirus envelope ...
flavivirus synonyms, flavivirus pronunciation, flavivirus translation, English dictionary definition of flavivirus. n. pl. fla· ... flavivirus. Also found in: Thesaurus, Medical, Wikipedia. fla·vi·vi·rus. (flā′vĭ-vī′rəs). n. pl. fla·vi·vi·rus·es Any of a ... Flavivirus - definition of flavivirus by The Free Dictionary https://www.thefreedictionary.com/flavivirus ... flavivirus. (ˈfleɪvɪˌvaɪrəs) n. 1. (Medicine) a type of arbovirus that causes a wide range of diseases in humans, including ...
Tick-borne flaviviruses.. Lasala PR1, Holbrook M.. Author information. 1. Department of Pathology, West Virginia University, ...
Flaviviruses encode a single polyprotein. This is cleaved into three structural and seven non-structural proteins. The NS4A ... Flavivirus genome organization, expression, and replication.. Annu. Rev. Microbiol. 44 649-88 1990 ... Positive identification of NS4A, the last of the hypothetical nonstructural proteins of flaviviruses.. Virology 170 299-301 ... protein is small and poorly conserved among the Flaviviruses. NS4A contains multiple hydrophobic potential membrane spanning ...
Mosquito-borne flaviviruses, such as yellow fever virus, dengue virus serotypes 1-4, Japanese encephalitis virus, and West Nile ... This review focuses on what is known about flavivirus-mosquito interactions and presents key data collected from the field and ... The Flavivirus genus is in the family Flaviviridae and is comprised of more than 70 viruses. These viruses have a broad ... Keywords: flavivirus; Aedes mosquito; Culex mosquito; hemorrhagic fever flavivirus; Aedes mosquito; Culex mosquito; hemorrhagic ...
The flaviviruses are a group of medically important viruses that are mainly transmitted by mosquitoes and ticks; they include ... The flaviviruses are a group of medically important viruses that are mainly transmitted by mosquitoes and ticks; they include ... Organization of the flavivirus genome and expression of proteins (genes are not drawn to scale). NCR, noncoding region; NS, ... Monath TP and Heinz FX (1996) Flaviviruses. In: Fields BN, Knipe BM, Howley PM et al. (eds) Fields Virology, 3rd edn, pp. 961- ...
Nonstructural protein 2B and 3 of the flaviviruses (NS2BNS3) form an endoplasmic reticulum (ER)... ... Flaviviruses are positive-sense RNA viruses, and many are important human pathogens. ... The Flavivirus NS3 Protein: Structure and Functions. In: Shi P Y. Eds. Molecular Virology and Control of Flaviviruses. Caister ... Molecular targets for flavivirus drug discovery. Antiviral Res, 81: 6-15.PubMedCentralPubMedGoogle Scholar ...
We searched B and T cells epitopes which were thoroughly shown to be involved in flavivirus immunological control. Such ... We found that epitopes capable of eliciting flavivirus cross-protective immunity to a wide range of human populations are ... We searched B and T cells epitopes which were thoroughly shown to be involved in flavivirus immunological control. Such ... We found that epitopes capable of eliciting flavivirus cross-protective immunity to a wide range of human populations are ...
Source Ahlers L, Trammell CE, Carrell GF et al. Insulin potentiates JAK/STAT signaling to broadly inhibit flavivirus ... Flaviviruses, including Zika, West Nile virus and dengue virus, can lead to severe illness and death. ...
Identification of two flavivirus-like genomes in the GB hepatitis agent.. J N Simons, T J Pilot-Matias, T P Leary, G J Dawson, ... Identification of two flavivirus-like genomes in the GB hepatitis agent.. J N Simons, T J Pilot-Matias, T P Leary, G J Dawson, ... Identification of two flavivirus-like genomes in the GB hepatitis agent.. J N Simons, T J Pilot-Matias, T P Leary, G J Dawson, ... Identification of two flavivirus-like genomes in the GB hepatitis agent. Message Subject (Your Name) has sent you a message ...
This page contains the laboratory case definition for alphavirus and flavivirus infections. ... Other flaviviruses. *Specific virus can be assigned if the IgM to a single flavivirus is detected in the absence of IgM to ... Unspecified flavivirus infection if the IgG cannot be shown to be specific to a single virus. *Detection of IgM to a single ... Unspecified flavivirus infection if IgM is detected against more than one virus or the full range of flavivurses has not been ...
Limited structural information of drug targets, cellular toxicity possessed by lead compounds, and large amounts of potential leads are the major issues facing the design-oriented approach of discovering new leads. In an attempt to tackle these issues, we have developed a process of virtual screening based on the observation that conformational rearrangements of the dengue virus envelope protein are essential for the mediation of viral entry into host cells via membrane fusion. Screening was based solely on the structural information of the Dengue virus envelope protein and was focused on a target site that is presumably important for the conformational rearrangements necessary for viral entry. To circumvent the issue of lead compound toxicity, we performed screening based on molecular docking using structural databases of medical compounds. To enhance the identification of hits, we further categorized and selected candidates according to ...
... Juan Santiago Salas-Benito1,2 and Mónica De Nova-Ocampo1,2 ... Juan Santiago Salas-Benito and Mónica De Nova-Ocampo, "Viral Interference and Persistence in Mosquito-Borne Flaviviruses," ...
... in vitro) ATCC ® VR-1852™ Designation: Application: ... Monoclonal Anti-Flavivirus Group Antigen, Clone D1-4G2-4-15 (produced in vitro) ATCC® VR-1852™ ... Monoclonal Anti-Flavivirus Group Antigen, Clone D1-4G2-4-15 (produced in vitro) (ATCC® VR-1852™) ... Thus, ATCC® VR-1852™ contains both MOPC21 protein and flavivirus group-specific antibody of the IgG2aκ isotype.. ATCC® VR-1852 ...
Unraveling the Zika Virus Mystery: Lessons Learned from Another Flavivirus. Feb 8, 2016 , Lauren Marsh, Sumiko Mekaru, Maia ... The Flaviviridae family contains four genuses [1]. Flaviviridae flavivirus is the largest genus and is often insect-borne. Many ... dozens of species in the flavivirus genus have been identified, including some important zoonotic diseases. West Nile Virus, ...
... flavivirus jobs in United States. Juju searches jobs from 1,000s of sites to make your virus+v OR flavivirus job search ... to investigate antibody response against Flaviviruses and differentiation of Flavivirus antibody repertoirs after infection or ... Experience in Flavivirus immunology is a plus. Experience in infectious disease models is desirable.… more ... involve generating recombinant cDNA clones for several viruses in the alpha- and flavivirus genera. In addition, work will ...
... flavivirus infection - Volume 10 - Theodore C. Pierson, Michael S. Diamond ... Meta-analysis of All Immune Epitope Data in the Flavivirus Genus: Inventory of Current Immune Epitope Data Status in the ... 81Stiasny, K., Koessl, C. and Heinz, F.X. (2003) Involvement of lipids in different steps of the flavivirus fusion mechanism. J ... 18Mukhopadhyay, S., Kuhn, R.J. and Rossmann, M.G. (2005) A structural perspective of the flavivirus life cycle. Nat Rev ...
Finally, flavivirus MIA and ELISA presented a similar sensitivity for the detection of flavivirus antibodies in JEV positive ... The flavivirus MIA provided a rapid and reliable alternative to routine methods for flavivirus serological diagnosis. As ... The use of flavivirus rEDIII proteins in ELISA as a tool to detect and differentiate flavivirus infections already proved ... a flavivirus prevalent in North America [14]. Consequently, the flavivirus surveillance programmes currently in operation in ...
... have identified wildlife species that are the most likely to host flaviviruses such as Zika, West Nile, dengue and yellow fever ... But flaviviruses can be difficult to detect, especially in wildlife.. We needed this modeling technique to help us understand ... Scientists identify wildlife species that are most likely to host flaviviruses. *Download PDF Copy ... Flaviviruses are known to cause major epidemics and widespread illness and death throughout the world. ...
Although some dengue infections are asymptomatic, severe infections of this flavivirus can cause hemorrhagic fever and dengue ... Dengue infection is caused by any of four related flaviviruses. ...
Anti-inflammatory Compound Shows Therapeutic Safety and Efficacy against Flavivirus Infection Flaviviruses comprise several ... Flaviviruses constitute an increasing source of public health concern, with growing numbers of pathogens causing disease and ... Direct Activation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by PF-06409577 Inhibits Flavivirus Infection ...
Attenuation of the Langat tick-borne flavivirus by chimerization with mosquito-borne flavivirus dengue type 4. Alexander G. ... Attenuation of the Langat tick-borne flavivirus by chimerization with mosquito-borne flavivirus dengue type 4 ... Attenuation of the Langat tick-borne flavivirus by chimerization with mosquito-borne flavivirus dengue type 4 ... Attenuation of the Langat tick-borne flavivirus by chimerization with mosquito-borne flavivirus dengue type 4 ...
... development for prevention of diseases caused by flavivirus such as Zika, Dengue, Chikungunya, West Nile, Yellow Fever, ... Flavivirus Vaccines: Zika, Dengue, Chikungunya, West Nile, Yellow Fever, Japanese Encephalitis & Tick-Borne Encephalitis Virus ... Flavivirus Vaccines: Zika, Dengue, Chikungunya, West Nile, Yellow Fever, Japanese Encephalitis & Tick-Borne Encephalitis Virus ... Competitor Analysis: Flavivirus Vaccines: Zika, Dengue, Chikungunya, West Nile, Yellow Fever, Japanese Encephalitis & Tick- ...
Basic Flavivirus Structure and Maturation. Figure 1. Flavivirus Structure. (A) Schematic representation of a flavivirus ... Flavivirus. By Alex Gonzales. Flaviviruses are small, positive sense RNA viruses that can cause yellow fever, dengue, Japanese ... left,Figure 4. Flavivirus replication complex(Muller and Young 2013) ]]. +. [[Image:Alex_Fig_4.png,thumb,. 300px. ,left,Figure ... All flavivirus NS1 genes encode a 352 amino acid polypeptide with a slight variation in glycosylation status which gives it a ...