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*  The effect of bacterial flagellin on virus infection - eTheses Repository
Flagellin promotes epithelial cells to support virus entry via TLR5-dependent activation of NF-KB. To extend these observations ... Flagellin augments HIV-1 entry and promoter activity and increases the production of extracellular virus. The data presented in ... Bacteria expressing the toll-like receptor (TLR)5 agonist, flagellin, are most efficient at inducing viral uptake and studies ... using recombinant flagellin or aflagellate bacterial strains confirm that flagellin has pro-viral activity. ...
http://etheses.bham.ac.uk/7327/
*  Expressed and cryptic flagellin genes in the H44 and H55 type strains of Escherichia coli. - Semantic Scholar
In this study, the flagellin genes were cloned from these strains and their structure and expression were analyzed. It was ... Unlike E. coli K-12, they possess two flagellin genes, fliC and fllA, on their chromosomes. However, they are monophasic, ... The chromosomal locations of the fllA genes are approximately, but not exactly, identical with that of the phase-2 flagellin ... found that the fliC genes encode apparently intact flagellin subunits but possess inefficient sigma28-dependent promoters, ...
https://www.semanticscholar.org/paper/Expressed-and-cryptic-flagellin-genes-in-the-H44-a-Tominaga-Kutsukake/c8f98d983dd1f95985d91060787addad2d67fc4c
*  Flagellin - Wikipedia
The N- and C-termini of flagellin form the inner core of the flagellin protein, and is responsible for flagellin's ability to ... Flagellin perception in Arabidopsis thaliana functions via the receptor-like-kinase FLS2 (flagellin-sensitive-2)). Upon flg22 ... The propensity of the immune response to flagellin may be explained by two facts: Flagellin is an extremely abundant protein in ... Flagellin is a globular protein that arranges itself in a hollow cylinder to form the filament in a bacterial flagellum. It has ...
https://en.wikipedia.org/wiki/Flagellin
*  Flagellin lys-N-methylase C (PD035357) | InterPro | EMBL-EBI
Flagellin_lys-N-methylase_C (PD035357). Accession PD035357 Integration. Flagellin lysine-N-methylase, C-terminal (IPR020193) ...
http://www.ebi.ac.uk/interpro/ISignatureOverview?sig=PD035357&query=D
*  Nlrc4/Ipaf/CLAN/CARD12: more than a flagellin sensor. - PubMed - NCBI
Nlrc4/Ipaf/CLAN/CARD12: more than a flagellin sensor.. Abdelaziz DH1, Amr K, Amer AO. ... Nlrc4 was considered to be a devoted flagellin sensor in eukaryotic cells. However, studies using a variety of pathogens such ... Pseudomonas at high bacterial burdens revealed that Nlrc4 can mediate caspase-1 activation independent of bacterial flagellin. ...
https://www.ncbi.nlm.nih.gov/pubmed/20067841
*  Flagellin is Key in Stimulating Body's Natural Defenses, Says Research
Flagellin might play a key role in up-regulating the host innate defences against urinary tract infections (UTIs), says a new ... Flagellin is Key in Stimulating Body's Natural Defenses, Says Research. by Kathy Jones on March 18, 2013 at 1:26 AM Research ... Flagellin might play a key role in up-regulating the host innate defences against urinary tract infections (UTIs), says a new ... The scientists aimed to examine the relationship between flagellin expression and host response. ...
http://www.medindia.net/news/flagellin-is-key-in-stimulating-bodys-natural-defenses-says-research-115929-1.htm
*  Immunization with Bivalent Flagellin Protects Mice against Fatal Pseudomonas aeruginosa Pneumonia
... Bahador Behrouz,1 Farhad B. ... Bahador Behrouz, Farhad B. Hashemi, Mohammad Javad Fatemi, et al., "Immunization with Bivalent Flagellin Protects Mice against ...
https://www.hindawi.com/journals/jir/2017/5689709/cta/
*  Directed evolution of FLS2 towards novel flagellin peptide recognition (Journal Article) | DOE PAGES
In this study, we carried out in vitro evolution of the Arabidopsis thaliana flagellin receptor FLAGELLIN-SENSING 2 (FLS2) to ... recognition of an Erwinia amylovora flagellin peptide. Use of this Erwinia-based flagellin peptide to stimulate Arabidopsis ... Published Article: Directed evolution of FLS2 towards novel flagellin peptide recognition. Title: Directed evolution of FLS2 ... 59 BASIC BIOLOGICAL SCIENCES; leucine-rich repeat; bacterial elicitor flagellin; disease-resistance gene; plant immune- ...
https://www.osti.gov/pages/biblio/1346606-directed-evolution-fls2-towards-novel-flagellin-peptide-recognition
*  Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans?
... Daniel Y. Bargieri,1 ... Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans?," Journal of Parasitology Research, vol. 2011, ...
https://www.hindawi.com/journals/jpr/2011/965369/cta/
*  Mode of action of the vaccine adjuvant flagellin in fusion proteins has been clarified
The benefit of flagellin is that the gene sequence encoding for flagellin can be merged with gene sequences of various ... The protein flagellin is a promising adjuvant. Flagellin is a major component of spiral-shaped protein filaments on the surface ... Flagellin is recognised by the toll-like receptor 5 (TLR5). TLR5 belongs to a group of "pattern recognition receptors", which, ... This produces so-called fusion proteins, in which the antigen against which an immune response is to be induced and flagellin ...
http://www.innovations-report.com/html/reports/life-sciences/mode-of-action-of-the-vaccine-adjuvant-flagellin-in-fusion-proteins-has-been-clarified.html
*  LPS and flagellin promote osteogenic differentiation of | Open-i
LPS and flagellin promote osteogenic differentiation of USSCs. USSCs were differentiated towards the osteogenic lineage for 6 ... LPS and flagellin strongly stimulated the initial phase of osteogenic differentiation of USSCs as compared to the normal ... LPS and flagellin strongly stimulated the initial phase of osteogenic differentiation of USSCs as compared to the normal ... Bottom Line: Stimulation of USSCs with either lipopolysaccharide (LPS) or flagellin resulted in a marked increase of ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4516497_jcmm0013-3415-f7&req=4
*  New study on UTIs suggests flagellin is key in stimulating body's natural defences | Uroweb
Home › EAU News › All › New study on UTIs suggests flagellin is key in stimulating body's natural defences ... New study on UTIs suggests flagellin is key in stimulating body's natural defences. 15 March 2013 ... The scientists aimed to examine the relationship between flagellin expression and host response. ... Flagellin, a protein responsible for bacterial motility, is a key activating PAMP. ...
https://uroweb.org/new-study-on-utis-suggests-flagellin-is-key-in-stimulating-bodys-natural-defences/
*  Frontiers | The Minor Flagellin of Campylobacter jejuni (FlaB) Confers Defensive Properties against Bacteriophage Infection |...
... bacteriophages infecting a panel of Campylobacter jejuni PT14 gene knock-out mutants identified a role for the minor flagellin ... bacteriophages infecting a panel of Campylobacter jejuni PT14 gene knock-out mutants identified a role for the minor flagellin ... Figure 3. Growth profiles of C. jejuni PT14 wild type strain (A,D), flagellin B mutant (B,E) and trans-complemented flaB ... Figure 4. Determination of burst size of Campylobacter bacteriophage CP_F1 infecting C. jejuni PT14 wild type (WT), flagellin B ...
https://www.frontiersin.org/articles/10.3389/fmicb.2016.01908/full
*  Flagellin elisa and antibody
Recombinant Protein and Flagellin Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available. ... Flagellin A. Flagellin A ELISA Kit. Flagellin A Recombinant. Flagellin A Antibody. Flagellin is the subunit protein which ... Flagellin A2. Flagellin A2 ELISA Kit. Flagellin A2 Recombinant. Flagellin A2 Antibody. Flagellin is the subunit protein which ... Flagellin B. Flagellin B ELISA Kit. Flagellin B Recombinant. Flagellin B Antibody. Flagellin is the subunit protein which ...
https://www.mybiosource.com/protein_family.php?root=flagellin
*  Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice. | Sigma-Aldrich
Recombinant flagellin proteins with or without TLR5-stimulating activity were used to evaluate the role of flagellin-TLR5 ... Deletion of the N-terminal or TLR5 binding domain of flagellin inhibited flagellin-induced inflammatory responses and the ... Flagellin is a potent activator of a broad range of cell types that are involved in innate and adaptive immunity. Therefore, it ... Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice.. [Yang Xiao, Fang Liu, Jingyi Yang, ...
https://www.sigmaaldrich.com/catalog/papers/25418468
*  The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion | Science
NAIP5 (NLR family, apoptosis inhibitory protein 5) binds the bacterial protein flagellin and assembles with NLRC4 to form a ... They find that when NAIP5 binds flagellin, it changes conformation, which triggers a rotation in monomeric NLRC4, catalyzing ... Six distinct NAIP5 domains contact multiple conserved regions of flagellin, prying NAIP5 into an open and active conformation. ... Here we report the cryo-electron microscopy structure of the assembled ~1.4-megadalton flagellin-NAIP5-NLRC4 inflammasome, ...
http://science.sciencemag.org/content/358/6365/888
*  Abstract 1610: Targeted cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous bacterial flagellin ...
Targeted cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous bacterial flagellin [abstract]. In ... Abstract 1610: Targeted cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous bacterial flagellin ... Abstract 1610: Targeted cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous bacterial flagellin ... Abstract 1610: Targeted cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous bacterial flagellin ...
http://cancerres.aacrjournals.org/content/77/13_Supplement/1610
*  Impact of HMGB1/TLR Ligand Complexes on HIV-1 Replication: Possible Role for Flagellin during HIV-1 Infection
... Piotr Nowak,1 ... Flagellin, LPS, and CpG-ODN induced stronger HIV-1 replication when incubated together with necrotic extract or recombinant ... We propose that flagellin is an important microbial product, that modulates viral replication and induces adaptive immune ... The presence of systemic anti-flagellin IgG was determined in 51 HIV-1-infected patients and 19 controls by immunoblotting or ...
https://www.hindawi.com/journals/ijmicro/2012/263836/abs/
*  Polymorphism of 41 kD Flagellin Gene and Its Human B-Cell Epitope in Borrelia burgdorferi Strains of China
The 41 kD flagellin of Borrelia burgdorferi (B. burgdorferi) is a major component of periplasmic flagellar filament core and a ... Polymorphism of 41 kD Flagellin Gene and Its Human B-Cell Epitope in Borrelia burgdorferi Strains of China. Huixin Liu,1,2 Wei ... Nonsynonymous mutations and changed human B-cell epitopes exist in 41 kD flagellin of B. burgdorferi sensu lato strains; these ... Some specific mutation sites for each genotype of the 41 kD flagellin genes were found, which could be used for genotyping B. ...
https://www.hindawi.com/journals/bmri/2016/1327320/abs/
*  Flagellin-like protein elisa and antibody
Recombinant Protein and Flagellin-like protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are ... Flagellin-like protein ELISA Kit. Flagellin-like protein Recombinant. Flagellin-like protein Antibody. ... Below are the list of possible Flagellin-like protein products. If you cannot find the target and/or product is not available ...
https://www.mybiosource.com/protein_family.php?root=flagellin-like-protein
*  Flagellin-fused protein targeting M2e and HA2 induces potent humoral and T-cell responses and protects mice against various...
Several studies have shown that immunization of mice with fusion proteins based on flagellin (flagellin-GFP, flagellin-OVA) ... Flagellin bioactivity assay. Flagellin bioactivity was analyzed using HEK-Blue™hTLR5 cells (InvivoGen, USA) according to the ... flagellin, with a recombinant hemagglutinin influenza-flagellin fusion vaccine (VAX125, STF2.HA1 SI). Vaccine. 2011;29(31):4897 ... Mucosal adjuvant activity of flagellin in aged mice. Mech Ageing Dev. 2008;129:271-81.CrossRefPubMedPubMedCentralGoogle Scholar ...
https://link.springer.com/article/10.1186/s12929-018-0433-5
*  Salmonella typhimurium transcytoses flagellin via an SPI2-mediated vesicular transport pathway | Journal of Cell Science
Preparation of anti-flagellin antibody. Flagellin was purified as described (Gewirtz et al., 2001b) and purity was verified as ... Although release of flagellin into the apical reservoir was the same at 37°C and 20°C, transcytosis of flagellin was nearly ... Flagellin is shown in green. Flagellae stain with both CSA and flagellin antibodies and thus appear yellow. The sub-apical ... 3). We observed that flagellin appeared before the bacteria, suggesting that at least the initial burst of flagellin ...
http://jcs.biologists.org/content/117/24/5771?ijkey=554daa51603d38c6b4931537acce6c44e009a8dd&keytype2=tf_ipsecsha
*  Mucosal immunization with purified flagellin from Salmonella induces systemic and mucosal immune responses in C3H/HeJ mice
Flagellin was purified and used in C3H/HeJ mice that do not respond to LPS. Strong immune responses were observed even when the ... Mucosal immunization with purified flagellin from Salmonella induces systemic and mucosal immune responses in C3H/HeJ mice. ... Similarly, mice that had been immunised with purified free flagellin had a lower degree of infection than untreated mice. ... Pharmaceutics, mucosal vaccination, polyacryl starch microparticles, salmonella enteritidis, flagellin, fimbriae, rCTB, LPS, ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:163025
*  Maximal transcriptional activation of piscine soluble Toll-like receptor 5 by the NF-κB subunit p65 and flagellin
... ... Furthermore, it was determined that the level of TRL5S mRNA was up-regulated by p65 and flagellin using a quantitative PCR. ... Wild-type TLR5S promoter activity was increased synergistically by more than 159.5-fold in the presence of flagellin and p65. ... These results suggest that NF-κB and flagellin are essential components that act as a transcription factor and ligand, ...
https://insights.ovid.com/fshimu/201112000/00013844-201112000-00020
*  4D pharma publishes data immuno-oncology MRx0518 flagellin
4D pharma data immuno-stimulatory MRx0518 immuno-oncology cancer flagellin microbiome live biotherapeutic ... The paper 'The flagellin of candidate live biotherapeutic Enterococcus gallinarum MRx0518 is a potent immunostimulant' (Lauté- ... demonstrated that MRx0518 stimulates both the innate and adaptive immune systems and identified the bacterial flagellin (a ...
https://www.4dpharmaplc.com/en/newsroom/press-releases/4d-pharma-publishes-mechanistic-data-mrx0518