... the mesenterium and subcutaneum as well as the hypothalamus of obese Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats at ... Expression of fourteen novel obesity-related genes in zucker diabetic fatty rats ... However, LYPLAL1, TFAP2B, SEC16B and FAIM2 were significantly lower expressed in the kidney fat of ZDF than ZL rats. NEGR1 was ... Interestingly, the expression pattern in the hypothalamus showed no differences between obese ZDF and lean ZL rats. ...

... in Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats. At the age of 6 weeks, ZDF (n = 30) and ZL (n = 30) groups were each ... in Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats. At the age of 6 weeks, ZDF (n = 30) and ZL (n = 30) groups were each ... in Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats. At the age of 6 weeks, ZDF (n = 30) and ZL (n = 30) groups were each ... in Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats. At the age of 6 weeks, ZDF (n = 30) and ZL (n = 30) groups were each ...

... following the development of a mathematical model for MMC in Zucker Diabetic Fatty (ZDF) rats, as a representative T2DM animal ... The levels of methionine and homocysteine were elevated approximately two- and three-fold, respectively, in ZDF rats, while ... there were no changes observed in the normal control rats. These results can be interpreted to mean that both methionine and ... performed simulations to compare the changes in plasma methionine and homocysteine concentrations between ZDF and normal rats, ...

"Leptin receptor missense mutation in the fatty Zucker rat". Nature Genetics. 13 (1): 18-19. doi:10.1038/ng0596-18. PMID 8673096 ...

Zucker diabetic fatty. h. human. r. rat. m. mouse. OGTT. oral glucose tolerance test. PF-04971729. (1S,2S,3S,4R,5S)-5-[4-Chloro ... gavage of tofogliflozin increased renal glucose clearance and lowered the blood glucose level in Zucker diabetic fatty rats. ... Tofogliflozin competitively inhibited SGLT2 in cells overexpressing SGLT2, and Ki values for human, rat, and mouse SGLT2 ... Tofogliflozin also improved postprandial glucose excursion in a meal tolerance test with GK rats. In db/db mice, 4-week ...

The Zucker diabetic fatty rat offered such a model system. Immunodetectable membrane PKC-alpha, -beta, -epsilon, and -zeta were ... Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not ... Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not ... Normalization of circulating glucose in the rat model by either insulin or phlorizin treatment did not result in a reduction in ...

Here we show that PNN abundance within the Arc is markedly reduced in the Zucker diabetic fatty (ZDF) rat model of T2D, ... show that FGF1-induced diabetes remission in rats requires remodelling of perineuronal nets that enmesh glucoregulatory neurons ... at a dose that induces sustained diabetes remission in male ZDF rats. Combined with previous work localizing this FGF1 effect ... compared with normoglycaemic rats, correlating with altered PNN-associated sulfation patterns of chondroitin sulfate ...

... dyslipidemia and high blood pressure in young diabetic obese rats. ... Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic fatty rats. Journal of Pineal Research, ... Trials with rats. University of Granada researchers have analyzed in young Zucker diabetic obese rats the effects of melatonin ... Melatonin was found to be beneficial for young rats that had not still developed any metabolic or heart disease. Researchers ...

Diabetes has been linked to an impaired ability to oxidize fatty acids. Fat oxidation can be assessed clinically by a ... Diabetes has been linked to an impaired ability to oxidize fatty acids. Fat oxidation can be assessed clinically by a ... Profiling of Zucker diabetic fatty rats in their progression to the overt diabetic state. Metabolism (2000) 49:684-8. doi: ... Fatty acids, obesity, and insulin resistance: time for a reevaluation. Diabetes (2011) 60:2441-9. doi: 10.2337/db11-0425 ...

In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate ... 41], who used the well-established Zucker diabetic fatty (ZDF) rat model. Chronic (3 months) in vivo treatment of ZDF rats with ... Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes. Kidney Int 2000;57:167-82.10.1046/j. ... Long-term treatment of obese fa/fa Zucker rats (a strain that is characterized by hyperphagia and obesity due to a mutation in ...

Kusano, S.; Abe, H. Antidiabetic activity of white skinned sweet potato (Ipomoea batatas L.) in obese Zucker fatty rats. Biol. ... Prasad, K. Secoisolariciresinol diglucoside from flaxseed delays the development of type 2 diabetes in Zucker rat. J. Lab. Clin ... Docosahexaenoic acid (DHA) is an ω-3 long-chain polyunsaturated fatty acid (LC-PUFA) belonging to the essential fatty acids ... of the cells to fatty acids when the excessive fatty acids overwhelm the storage capacity of adipose tissue and free fatty ...

... on the pro/antioxidant status of different tissues in obese Zucker rats. ,i,Methods,/i,. Eight-week-old male Zucker rats (,i,fa ... M. S. Phillips, Q. Liu, H. A. Hammond et al., "Leptin receptor missense mutation in the fatty Zucker rat," Nature Genetics, vol ... on the pro/antioxidant status of different tissues in obese Zucker rats. Methods. Eight-week-old male Zucker rats (fa/fa, ) ... H. A. Durham and G. E. Truett, "Development of insulin resistance and hyperphagia in Zucker fatty rats," American Journal of ...

6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in zucker diabetic Fatty rats. ...

Oral administration of the potassium salt remarkably improved the plasma glucose levels of female Zucker diabetic fatty rats at ... Moreover, it did not cause a plasma volume increase or a cardiac enlargement in Wistar-Imamichi rats, even at 100 mg/kg. ...

... on lipid metabolism in Zucker fatty rats. Journal of molecular endocrinology, 25(3), 287-298. https://doi.org/10.1677/jme. ... In obese Zucker rats administered a daily, 500mcg oral dose of AOD9604, body weight gains were significantly decreased compared ... hGH is known to induce fat loss by increasing circulating levels of free fatty acids (FFAs) by increasing lipolysis and through ...

"β-Cells possess inherent mechanisms to adapt to overnutrition and the prevailing concentrations of glucose, fatty acids, and ... Unger RH: How obesity causes diabetes in Zucker Diabetic Fatty rats. Trends Endocrinol Metab ... Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc Natl Acad Sci U S A ... Colquhoun A: Induction of apoptosis by polyunsaturated fatty acids and its relationship to fatty acid inhibition of carnitine ...

Dietary conjugated linoleic acid alleviates nonalcoholic fatty liver disease in Zucker (fa/fa) rats. J.Nutr. 2005;135(1):9-13. ... Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem.Biophys. ... Ruth, M. R., Taylor, C. G., Zahradka, P., and Field, C. J. Abnormal immune responses in fa/fa Zucker rats and effects of ... effects of conjugated fatty acids from safflower oil in a rat two-stage carcinogenesis model in female Sprague-Dawley rats. ...

... and normalized oxidative stress on renal function in a test group of Zucker diabetic fatty rats.. 14-Jun-2019 11:05:33 AM EDT ...

... the effects of rosiglitazone were studied on the TGF-β/SMAD signaling pathway in Zucker diabetic fatty (ZDF) male rats. One ... diabetic rats treated with MC powder, diabetic rats treated with an ointment containing MC, diabetic rats treated with povidone ... Streptozotocin was used to induce diabetes, and the rats were divided into normal control group (non-diabetic), diabetic rats ( ... leading to an increase in bioactive GLP-1 and pancreatic β cell mass in Otsuka Long-Evans Tokushima Fatty (OLETF) rats (Yang et ...

Validated Species: Human, Mouse, Rat + more. Sample size available. Range of directly conjugated antibodies available. ... IN ZUCKER DIABETIC FATTY RATS. Am. J Physiol. Renal Physiol. 2014-09-03 [PMID: 25186297] ... Rat. Xing J, Lu J, Li J. Role of TNF-a in Regulating the Exercise Pressor Reflex in Rats With Femoral Artery Occlusion. Front ... Rat. Tucker JJ, Riggin CN, Connizzo BK et al. Effect of overuse-induced tendinopathy on tendon healing in a rat supraspinatus ...

Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Pancreatic Islets from Zucker Diabetic Fatty Rats. Obes Surg. ... Effect of Roux-en-Y gastric bypass on liver mitochondrial dynamics in a rat model of obesity. Physiol Rep. 2018 Feb;6(4). doi: ... Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats. PLoS One. 2015 Oct 5;10(10): ... Gastric bypass surgery is protective from high-fat diet-induced non-alcoholic fatty liver disease and hepatic endoplasmic ...

Anti-diabetic activity of chromium picolinate and biotin in rats with type 2 diabetes induced by high-fat diet and ... and Glut-2 in livers of zucker diabetic fatty rats. Mol Nutr Food Res 54, 1371-1380.Google Scholar ... The rats were divided into five groups as follows: (1) non-diabetic rats fed a regular diet; (2) diabetic rats fed a HFD; (3) ... Long-Term Supplementation with Chromium Malate Improves Short Chain Fatty Acid Content in Sprague-Dawley Rats. Biological Trace ...

In the last decade, it has been shown that metformin, thiazolidinediones, vitamin E, ezetimibe, n-3 polyunsaturated fatty acids ... Nonalcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are multidisciplinary liver diseases that ... S. Gómez-Zorita, "Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing ... L. Bujanda, E. Hijona, M. Larzabal et al., "Resveratrol inhibits nonalcoholic fatty liver disease in rats," BMC ...

PURPOSE: Fatty Zucker rats have been used to examine the effects of obesity, and diabetes on the physiological mechanisms ... eight 6-weekold male genetically obese Zucker rats (fa/fa) and eight Zucker lean rats (+/fa) were trained with positive ... 5 of 8 lean Zucker rats were able to approach the 50-lifts/session goal with a mean range of 47-51. The 3 other lean rats ... All rats successfully acquired the weight-lifting movement. However, of the obese Zucker rats only 2 were able to approach the ...

The first group was for Non-Infected Rats, and the second group was for type 2 Zucker Diabetic Fatty Rats. Approval for this ... signaling in young type 2 Zucker diabetic fatty rat heart. ...

... adipose tissue resistin expression is increased in both ob/ob mice and Zucker diabetic fatty rats. These data demonstrate that ...

... and fa/fa fatty Zucker rat.. In animal models, the antidiabetic activity of rosiglitazone was shown to be mediated by increased ... In addition, PPARγ-responsive genes also participate in the regulation of fatty acid metabolism. ... and circulating free fatty acids. TZDs generally decrease triglycerides and increase high-density lipoprotein cholesterol (HDL- ... The ligands for these receptors are free fatty acids (FFAs) and eicosanoids. When activated, the receptor migrates to the DNA, ...

Five-week-old Zucker Diabetic Fatty (ZDF) rats were fed a diet containing (R)-alpha-lipoic acid (LA, approximately 200mg/kg ... Rats, Zucker, Thioctic Acid, Triglycerides. Abstract. Elevated blood triacylglycerol (TG) is a significant contributing factor ... AMP-Activated Protein Kinases, Animals, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Energy Intake, Fatty Acids ... LA-induced TG lowering was not due to the anorectic properties of LA, as pair-fed rats developed hypertriglyceridemia. Livers ...

Postprandial Insulin Resistance in Zucker Diabetic Fatty Rats is Associated with Parasympathetic-Nitric Oxide Axis Deficiencies ... Hepatic-dependent and -independent insulin actions are impaired in the obese Zucker rat model. Macedo, M. P. B. D. L., Afonso, ...