Patent US6147109 - Upregulation of Type III endothelial cell Nitric Oxide Synthase by HMG-CoA ... - Google Patents
... preventing conditions that result from the abnormally low expression and/or activity of endothelial cell Nitric Oxide Synthase ... In the instant invention, HMG-CoA reductase inhibitors are found to upregulate endothelial cell Nitric Oxide Synthase activity ... In addition, fatty acids such as oleic acid may be used in the preparation of injectables. Carrier formulation suitable for ... citric acid in a salt; boric acid in a salt; and phosphoric acid in a salt. ...http://www.google.com/patents/US6147109?dq=%22robert+sheehan%22
Crystal structure of β‐ketoacyl‐acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing...
A detailed comparison of amino acid sequences of condensing enzymes, i.e. β‐ketoacyl synthases of fatty acid and polyketide ... type and mutant enzymes. Biochemistry, 28, 5735-5742. ... ketoacyl synthase domain of rat fatty acid synthase (Joshi et ... Funabashi H, Kawaguchi A, Tomoda H, Omura S, Okuda S and Iwasaki S (1989) Binding site of cerulenin in fatty acid synthase. J ... Joshi AK, Witkowski A and Smith S (1997) Mapping of functional interactions between domains of animal fatty acid synthase by ...http://emboj.embopress.org/content/17/5/1183
Fatty Acid Synthesis Inhibitors -Pipeline Insights, 2015 | Global Market Research Reports
... provides the in-depth analysis of the pipeline assets across the Fatty Acid Synthesis Inhibitors. The main objective of this ... Fatty Acid Synthesis Inhibitors Assessment by Molecule Type • Fatty Acid Synthesis Inhibitors Assessment by Stage and Molecule ... Previous: Fatty Acid Synthase (FAS) Inhibitors -Pipeline Insights, 2015 * Next: Fc-Gamma Receptor Antagonist -Pipeline Insights ... Fatty Acid Synthesis Inhibitors Overview. • Fatty Acid Synthesis Inhibitors Disease Associated. • Fatty Acid Synthesis ...http://www.gosreports.com/fatty-acid-synthesis-inhibitors-pipeline-insights-2015/
Patent US6348642 - Ricinus communis β-ketoacyl-ACP synthase nucleic acids - Google Patents
Also of interest are plants, plant parts and plant cells comprising the nucleic acid sequences. ... compositions and methods of use of Ricinus communis cDNAs encoding β-ketoacyl-ACP synthase, are provided. ... synthase III-type or in a combination of these enzymes.. Thus, over-expression of synthase I could serve to increase fatty acid ... 4. Labeling Synthase II. To label synthase II with 3H-cerulenin in a mixture of synthase I and synthase II, synthase I must ...http://www.google.com/patents/US6348642?dq=Frischling
Daidzein Modulations of Apolipoprotein B and Fatty Acid Synthase mRNA Expression in Chick Liver Vary Depending on Dietary...
Fatty Liver;Apolipoprotein B mRNA;Fatty Acid Synthase mRNA; ... Daidzein Modulations of Apolipoprotein B and Fatty Acid ... Synthase mRNA Expression in Chick Liver Vary Depending on Dietary Protein Levels - Daidzein;Low Protein Diet;Chick; ... Feeding daidzein to late pregnant sows influences the estrogen receptor beta and type 1 insulin-like growth factor receptor ... Daidzein;Low Protein Diet;Chick;Fatty Liver;Apolipoprotein B mRNA;Fatty Acid Synthase mRNA; ...http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=E1DMBP_2006_v19n2_236
Beta-ketoacyl-ACP synthase - Wikipedia
... synthase from the mitochondrial type II fatty acid synthase". Protein Science. 16 (2): 261-272. doi:10.1110/ps.062473707. ISSN ... "Regulating effect of β-ketoacyl synthase domain of fatty acid synthase on fatty acyl chain length in de novo fatty acid ... synthase from the mitochondrial type II fatty acid synthase". Protein Science. 16 (2): 261-72. doi:10.1110/ps.062473707. PMC ... "fatty acid transport tunnels" within the beta-ketoacyl-ACP synthase domain that lead to one of many "fatty acid cavities", ...https://en.wikipedia.org/wiki/Beta-ketoacyl-ACP_synthase
Fatty Acid Synthase: Association with Insulin Resistance, Type 2 Diabetes, and Cancer | Clinical Chemistry
Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die ... Menendez JA, Lupu R. Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase ... Fatty Acid Synthase: Association with Insulin Resistance, Type 2 Diabetes, and Cancer. Javier A. Menendez, Alejandro Vazquez- ... Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes. Diabetologia 2007;50 ...http://clinchem.aaccjnls.org/content/55/3/425.full
IUCr) Acta Crystallographica Section F Volume 71, Part 11, November 2015
Bacterial and fungal type I fatty-acid synthases (FAS I) are evolutionarily connected, as bacterial FAS I is considered to be ... Crystallization and X-ray diffraction studies of a complete bacterial fatty-acid synthase type I. ...http://journals.iucr.org/f/issues/2015/11/00/
KEGG BRITE: KEGG Orthology (KO) - Pelodiscus sinensis (Chinese soft-shelled turtle)
... fatty acid synthase, animal type [EC:126.96.36.199] K00844 HK; hexokinase [EC:188.8.131.52] K00844 HK; hexokinase [EC:184.108.40.206] K00844 HK ... 102458578 FASN; fatty acid synthase 102447192 HK2; hexokinase-2 102451343 HK1; hexokinase 1 102451581 HKDC1; putative ... 102461748 GSK3B; glycogen synthase kinase 3 beta 102449457 GYS2; glycogen synthase 2 102462946 GYS1; glycogen [starch] synthase ... glycogen synthase kinase 3 beta [EC:220.127.116.11] K00693 GYS; glycogen synthase [EC:18.104.22.168] K00693 GYS; glycogen synthase [EC: ...http://www.genome.jp/kegg-bin/get_htext?pss00001+102462946
KEGG BRITE: KEGG Modules
K00665 FASN; fatty acid synthase, animal type [EC:22.214.171.124] K00667 FAS2; fatty acid synthase subunit alpha, fungi type [EC:2.3. ... K00668 FAS1; fatty acid synthase subunit beta, fungi type [EC:126.96.36.199] K11533 fas; fatty acid synthase, bacteria type [EC:2.3. ... M00083 Fatty acid biosynthesis, elongation [PATH:map01212 map00061] M00085 Fatty acid biosynthesis, elongation, mitochondria [ ... M00415 Fatty acid biosynthesis, elongation, endoplasmic reticulum [PATH:map01212 map00062] M00113 Jasmonic acid biosynthesis [ ...http://www.genome.jp/kegg-bin/get_htext?ko00002+K11262
ASMscience | Assembly of Peptide Anti
The tyrocidine system is particularly well understood with respect to variants of the product that exhibit amino acid ... One hallmark of nonribosomal peptide antibiotics is the presence of D-amino acids, often in substantial abundance. This chapter ... The animal fatty acid synthase: one gene, one polypeptide, seven enzymes. FASEB J. 8:1248-1259.. ... Refined crystal structure of type III chloramphenicol acetyltransferase at a 1.75 A resolution. J. Mol. Biol. 213:167-186.. ...http://www.asmscience.org/content/book/10.1128/9781555817992.chap30
Reynolds KA[au] - PubMed - NCBI
Identification and Characterization of FabA from the Type II Fatty Acid Synthase of Streptomyces coelicolor. ... Characterization of FabG and FabI of the Streptomyces coelicolor dissociated fatty acid synthase. ... Cognitive adaptation theory as a predictor of adjustment to emerging adulthood for youth with and without type 1 diabetes. ... Conserved amino acid networks modulate discrete functional properties in an enzyme superfamily. ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Reynolds+KA%5Bau%5D&dispmax=50
Similar articles for PubMed (Select 16210318) - PubMed - NCBI
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis. ... Structural analysis of fatty acids of a mutant strain deviod of methoxy- and ketomycolates. ... p-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosis.. Stadthagen G, Korduláková J, Griffin R, Constant P, Bottová I, ... Structure and mechanism of MbtI, the salicylate synthase from Mycobacterium tuberculosis.. Zwahlen J, Kolappan S, Zhou R, ...https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=16210318
Fatty acid synthase - Wikipedia
... although the structural arrangement of fungal and mammalian synthases differ). A Type I fatty acid synthase system is also ... Fatty Acid Synthase: RCSB PDB Molecule of the Month. *3D electron microscopy structures of fatty acid synthase from the EM Data ... FASN, fatty acid synthase, Fasn, A630082H08Rik, FAS, OA-519, SDR27X1, Fatty acid synthase. ... "Human fatty acid synthase: assembling recombinant halves of the fatty acid synthase subunit protein reconstitutes enzyme ...https://en.wikipedia.org/wiki/Fatty_acid_synthase
Publications | The Dana and Yossie Hollander
Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 angstrom resolution. Nature Communications. 9. ... Tomer Shpilka; Evelyn Welter; Noam Borovsky; Nira Amar; Frida Shimron; Yoav Peleg; Zvulun Elazar (2015). Fatty acid synthase is ... active M-tuberculosis fatty acid synthase I in E-coli. PLoS One. 13:(9) ... Tamar Unger; J A Mietz; M Scheffner; C L Yee; P M Howley (1993). Functional domains of wild-type and mutant p53 proteins ...https://www.weizmann.ac.il/ISPC/publications?qt-view__publications__page=26
The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant...
2004) Microbial type I fatty acid synthases (FAS): Major players in a network of cellular FAS systems. Microbiol Mol Biol Rev ... Fatty acid synthesis is presumably accomplished with the multidomain fatty acid synthase I (Blon_2284) which is common to ... neuraminic acid as a sole carbon source. 13C-Labeled fatty acids were produced during growth (Fig. S10C) demonstrating that ... 3). The acetate derived from sugars via the bifid shunt is both secreted and incorporated de novo fatty into acids where it is ...https://www.pnas.org/content/105/48/18964?ijkey=17982947af3464c51c25607a4b9b61a3fb5eee30&keytype2=tf_ipsecsha
Methods of treating cancer and other disorders - Wake Forest University Health Sciences
Active compounds useful for inhibiting fatty acid synthase in a subject in need thereof are described. The active compounds are ... Fatty acid synthase: association with insulin resistance, Type 2 diabetes, and cancer. Clinical Chemistry. 2009: 55(3): 425-438 ... acetic acid, oxalic acid, tartaric acid, succinic acid, maleic acid, fumaric acid, gluconic acid, citric acid, malic acid, ... Inhibitors of fatty acid synthase for prostate cancer. DTIC Report. May 2010. Yang W et al. Fatty acid synthase is upregulated ...http://www.freepatentsonline.com/10071076.html
ASMscience | The Molecular Genetics o
... which are long-chain α-alkyl β-hydroxy fatty acids, constitute up to 60% of the cell wall and are principally responsible for ... The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis. Proc Natl Acad Sci USA 104: 14628 ... Point mutations within the fatty acid synthase type II dehydratase components HadA or HadC contribute to isoxyl resistance in ... The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by ...http://www.asmscience.org/content/book/10.1128/9781555818845.chap29
Phosphopantetheinyl Transferase CfwA/NpgA Is Required for Aspergillus nidulans Secondary Metabolism and Asexual Development |...
A second group contains eukaryotic PPTases that are integral domains of type I fatty acid synthases. The third class consists ... 193 amino acids) similar to Ppt2p from yeast, which is involved in the activation of a mitochondrial fatty acid synthase (53). ... A novel function of yeast fatty acid synthase. Subunit alpha is capable of self-pantetheinylation. Eur. J. Biochem. 267:2666- ... Aspergillus has distinct fatty acid synthases for primary and secondary metabolism. Proc. Natl. Acad. Sci. USA 93:14873-14877. ...https://ec.asm.org/content/6/4/710.full
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR...
Bile acid synthesis is under negative feedback control through activation of the nuclear receptor farnesoid X receptor ( ... Bile acids are synthesized from cholesterol in the liver and further metabolized by the gut microbiota into secondary bile ... 18372209 - Regulation of type ii fatty acid synthase in gram-positive bacteria.. 18502109 - Hypertriglyceridemia and ... 7454129 - Pathophysiology of long-chain polyene fatty acids in heart muscle.. 22406769 - Quantitative proteomics and ...http://www.biomedsearch.com/nih/Gut-Microbiota-Regulates-Bile-Acid/23395169.html
Lipid Metabolism sub-cluster 88
The intraplastidic fatty acid biosynthetic pathway in plants is catalysed by type II fatty acid synthase (FAS). The last step ... we focus on fatty acid binding proteins (Fabps) that bind to fatty acids such as arachidonic acid and docosahexianoic acid and ... The unsaturated fatty acid (linoleic acid) sustained-release microspheres were prepared with linoleic acid (LA) using alginate- ... The liver is the central organ of fatty acid and triglyceride metabolism. Oxidation and synthesis of fatty acids and ...http://www.biomedsearch.com/cluster/14/Lipid-Metabolism/sub-88-p9.html
KEGG BRITE: KEGG Orthology (KO) - Camelus ferus (Wild Bactrian camel)
... fatty acid synthase, animal type [EC:188.8.131.52] K12406 PKLR; pyruvate kinase isozymes R/L [EC:184.108.40.206] K00844 HK; hexokinase [ ... fatty acid synthase, animal type [EC:220.127.116.11] K11262 ACACA; acetyl-CoA carboxylase / biotin carboxylase 1 [EC:18.104.22.168 22.214.171.124 ... fatty acid transporter), member 5 [EC:126.96.36.199] K08749 SLC27A6; solute carrier family 27 (fatty acid transporter), member 6 ... fatty acid transporter), member 2 [EC:6.2.1.- 188.8.131.52] K08772 SLC27A3; solute carrier family 27 (fatty acid transporter), ...http://www.genome.jp/kegg-bin/get_htext?cfr00001+102511249
Enoyl-acyl carrier protein reductase (fabI) plays a determinant role in completing cycles of fatty acid elongation in...
... was investigated in the type II, dissociated, fatty acid synthase system of Escherichia coli. All of the proteins required to ... We conclude that FabI is the only enoyl-ACP reductase involved in fatty acid synthesis in E. coli and that the activity of this ... FabI was verified to be the only enoyl-ACP reductase required for the synthesis of fatty acids by demonstrating that purified ... catalyze one cycle of fatty acid synthesis from acetyl-CoA plus malonyl-CoA to butyryl-ACP in vitro were purified. These ...https://www.semanticscholar.org/paper/Enoyl-acyl-carrier-protein-reductase-%28fabI%29-plays-a-Heath-Rock/3125ee1e48a0a0bfdf572db6a81da315577c204d
A QSAR Study of Matrix Metalloproteinases Type 2 (MMP-2) Inhibitors with Cinnamoyl Pyrrolidine Derivatives.
A multivariate PLS-QSAR study with a data set of 31 cinnamoyl pyrrolidine derivatives described as type 2 matrix ... Multivariate SAR/QSAR of 3-aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase (FAS) inhibitorsEur J Med ... the cinnamic acid, an inhibitor of the A5491 human lung gland cancer, and the caffeic acid, an MMP-2 inhibitor (Fig. 2). The ... These enzymes are able to degrade a broad range of matrix substrates, including gelatin, type IV collagen of basal laminae, as ...http://www.biomedsearch.com/nih/QSAR-Study-Matrix-Metalloproteinases-Type/22896815.html
The genome of the basal agaricomycete Xanthophyllomyces dendrorhous provides insights into the organization of its acetyl-CoA...
... fatty acid synthesis operates with a multi-enzyme fatty acid synthase (FAS) comples (type I) with discrete functional domains ... Fatty acid metabolism. A. Biosynthesis of cytoplasmic fatty acids (palmitic, oleic and linoleic acid) in Xanthophyllomyces ... Schweizer E, Hofmann J. Microbial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems. ... type II) encoded by separate genes . In X. dendrorhous, the dominating fatty acids are palmitic, oleic and linoleic acid ( ...https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-1380-0