Farnesyltranstransferase - Wikipedia
Anti-cancer therapy: targeting the mevalonate pathway
geranylgeranyl diphosphate synthase | Lanosterol biosynthesis pathway | IUPHAR/BPS Guide to PHARMACOLOGY
CoP: Co-expressed Biological Processes
CoP: Co-expressed Biological Processes
Kinetic analysis of zinc ligand mutants of mammalian protein farnesyltransferase.
Protein farnesyltransferase (FTase) is a zinc metalloenzyme that catalyzes the prenylation of several proteins that are important in cellular regulatory events. A specific residue of FTase, Cys299 in the beta subunit previously identified as essential for zinc binding and catalysis, had been tentatively assigned as one of the zinc ligands. This assignment was subsequently confirmed in the X-ray structure of FTase, which also identified two additional residues, Asp297 and His362 in the beta subunit, as the remaining protein-derived metal ligands. To more fully explore the role of zinc in the catalytic mechanism of FTase, site-directed mutagenesis was performed on these two zinc ligands. Although the abilities of all the mutants to bind the farnesyl diphosphate substrate were similar to that of the wild-type enzyme, all the mutants displayed markedly reduced enzymatic activities and zinc affinities. Steady-state and pre-steady-state kinetic analyses of the residual activities indicated that the ...
Genopole | Estudo Geral
Blondel, S.; Egesipe, A-L; Picardi, P.; Jaskowiak, A-L; Notarnicola, M.; Ragot, J.; Tournois, J.; Le Corf, A.; Brinon, B.; Poydenot, P.; Georges, P.; Navarro, C.; Pitrez, P. R. ; Ferreira, L. ; Bollot, G.; Bauvais, C.; Laustriat, D.; Mejat, A.; De Sandre-Giovannoli, A.; Levy, N.; Bifulco, M.; Peschanski, M.; Nissan, X. ...
Bio2Vec
Eric Oldfield - Research & Scholarship
- University of Illinois Urbana-Champaign
Stampolaki, M., Malwal, S. R., Alvarez-Cabrera, N., Gao, Z., Moniruzzaman, M., Babii, S. O., Naziris, N., Rey-Cibati, A., Valladares-Delgado, M., Turcu, A. L., Baek, K. H., Phan, T. N., Lee, H., Alcaraz, M., Watson, S., van der Watt, M., Coertzen, D., Efstathiou, N., Chountoulesi, M., Shoen, C. M., & 13 othersPapanastasiou, I. P., Brea, J., Cynamon, M. H., Birkholtz, L. M., Kremer, L., No, J. H., Vázquez, S., Benaim, G., Demetzos, C., Zgurskaya, H. I., Dick, T., Oldfield, E. & Kolocouris, A. D., Feb 10 2023, In: ACS Infectious Diseases. 9, 2, p. 342-364 23 p.. Research output: Contribution to journal › Article › peer-review ...
The farnesyltransferase inhibitor manumycin A is a novel trypanocide with a complex mode of action including major effects on...
Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia<...
Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation<...
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras...
Enhanced Specificity of Mint Geranyl Pyrophosphate Synthase by Modifying the R-Loop Interactions<...
Farnesyltransferase inhibitors as radiation sensitizers. - Department of Oncology
Alkyl and Aryl Transferases | Profiles RNS
Keith Gagnon's research topics | Profiles RNS
In this concept cloud, the sizes of the concepts are based not only on the number of corresponding publications, but also how relevant the concepts are to the overall topics of the publications, how long ago the publications were written, whether the person was the first or senior author, and how many other people have written about the same topic. The largest concepts are those that are most unique to this person ...
MeSH Browser
BTS1 - PET10 | S. cerevisiae SSL interaction - Slorth
FPS1 - RPS24A | S. cerevisiae SSL interaction - Slorth
Hydrophobicity and functionality maps of farnesyltransferase | Caflisch - UZH
Publication Detail
GGPS1-associated muscular dystrophy with and without hearing loss - PubMed
On the use of lonafarnib in myelodysplastic syndrome and chronic myelomonocytic leukemia - PubMed
Code System Concept
MeSH Browser
Farnesyltranstransferase Preferred Term Term UI T234352. LexicalTag NON. ThesaurusID NLM (2006). Farnesyltransferase Term UI ... Farnesyltranstransferase Preferred Concept UI. M0204347. Registry Number. EC 2.5.1.29. Scope Note. An enzyme that catalyzes the ... Farnesyltranstransferase. Tree Number(s). D08.811.913.225.437. Unique ID. D051231. RDF Unique Identifier. http://id.nlm.nih.gov ...
MeSH Browser
Farnesyltranstransferase Preferred Term Term UI T234352. LexicalTag NON. ThesaurusID NLM (2006). Farnesyltransferase Term UI ... Farnesyltranstransferase Preferred Concept UI. M0204347. Registry Number. EC 2.5.1.29. Scope Note. An enzyme that catalyzes the ... Farnesyltranstransferase. Tree Number(s). D08.811.913.225.437. Unique ID. D051231. RDF Unique Identifier. http://id.nlm.nih.gov ...
School of Chemical Sciences - Research & Scholarship
- University of Illinois Urbana-Champaign
Schatz, G. C., McCoy, A. B., Shea, J. E., Murphy, C. J., Scholes, G., Batista, V., Bhattacharyya, K., Bisquert, J., Crawford, D., Cuk, T., Dickson, R., Fairbrother, H., Forsyth, M., Fourkas, J., Geiger, F., Gewirth, A., Goodson, T., Goward, G. R., Guo, H., Hartland, G. V., & 20 othersJungwirth, P., Link, S., Liu, G. Y., Liu, Z. P., Mennucci, B., Minton, T., Mullin, A. S., Prezhdo, O., Schneider, W. F., Schwartz, B., Snider, N., Solomon, G., Weitz, E., Yang, X., Yethiraj, A., Zaera, F., Zanni, M., Zhang, J., Zhong, H. & Zwier, T., Jul 18 2019, In: Journal of Physical Chemistry Letters. 10, 14, p. 4051-4062 12 p.. Research output: Contribution to journal › Editorial › peer-review ...
The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis<...
CoP: Co-expressed Biological Processes
CoP: Co-expressed Biological Processes
DeCS
Farnesyltranstransferase - Preferred Concept UI. M0204347. Scope note. An enzyme that catalyzes the synthesis of geranylgeranyl ... Farnesyltranstransferase Entry term(s). Farnesyl Diphosphate Geranylgeranyl Diphosphate Synthase Farnesyl Diphosphate- ... Farnesyltranstransferase Entry term(s):. Farnesyl Diphosphate Geranylgeranyl Diphosphate Synthase. Farnesyl Diphosphate- ...
PROTOCOL SPECIFIC RESEARCH SUPPORT - Albert Einstein College of Medicine
Almo, S. C., Hogue-Angeletti, R., Augenlicht, L. H., Condeelis, J. S., Desai, K., Edelmann, W., Goldman, I. D., Greally, J. M., Herbst, L. H., Keller, S. M., Kim, M. Y., Mahmood, R., Montagna, C., Morrow, B. E., Pollard, J. W., Porcelli, S. A., Rohan, T. E., Scharff, M. D., Seither, R., Skoultchi, A. I., Sparano, J. A., Stanley, P. M., Chu, E. E., Bresnick, A. R., Skoultchi, A. I., Adedimeji, A. A., Beck, A. P., Blanchard, J. S., Halmos, B. B., Morrow, B. B., Diamond, B. B., Rapkin, B. D., Chu, E., Montagna, C. C., Stein, D. T., Gaertner, D. D. J., Chu, E., Ho, G. Y. F., Goel, S., Hosgood, H. D. H., Strickler, H. H. D., Pollard, J. J. W., Condeelis, J. S., Dutcher, J. P., Greally, J. J., Backer, J. M., Sparano, J., Aguirre-ghiso, J. J. A., Gritsman, K., Herbst, L. H., Augenlicht, L. H., Cannizzaro, L. A., Hackett, L. L. E., Scharff, M. D., Brenowitz, M. D., Kim, M. M. Y., Ohri, N. N., Stanley, P., Gupta, R. R. K., Seither, R. R. L., Depinho, R. R. A., Kucherlapati, R. R. S., Schramm, V. L., ...
NDF-RT Code NDF-RT Name
Pesquisa | Portal Regional da BVS