World Journal of Methodology - Baishideng Publishing Group
Increased 15-lipoxygenase-1 expression in chondrocytes contributes to the pathogenesis of osteoarthritis | Cell Death & Disease
... the release of matrix-degrading enzymes, the production of reactive oxygen species (ROS), cell proliferation and apoptosis, we ... To further investigate the effects of 15-LO-1 on chondrocyte functions, such as extracellular matrix (ECM) secretion, ... noncollagenous proteins and proteoglycans in the extracellular matrix of cartilage. Arthritis Res 2001; 3: 342-347. ... such as extracellular matrix (ECM) secretion, the release of matrix-degrading enzymes, the production of reactive oxygen ...
Frontiers | Extracellular Control of Radial Glia Proliferation and Scaffolding During Cortical Development and Pathology
Secreted molecules also contribute to the extracellular matrix (fibronectin, laminin, reelin). Classical short range factors ... Fewer studies have identified the influence of the extracellular environment on this architecture. This review will focus on ... This review will focus on extracellular factors which influence RG morphology and pyramidal neuronal migration during normal ... Changes in one or several of these components influencing the RG extracellular environment can disrupt the development or ...
Plus it
Extracellular matrix protein content in the main pulmonary artery. a) Area occupied by mucopolysaccharide as a percentage of ... suggesting that an imbalance in extracellular matrix protein content may modulate the mechanical properties of the vessels wall ... Deposition of extracellular matrix in pulmonary arteries has been shown in animal models of hypoxia-induced pulmonary ... Exposure to hypoxia modifies the mechanical properties of large pulmonary arteries, presumably by altering extracellular matrix ...
Cells | Free Full-Text | Global Responses of Il-1β-Primed 3D Tendon Constructs to Treatment with Pulsed Electromagnetic Fields
... including extracellular matrix remodeling and negative regulation of apoptosis. Further, we show that members of the ... both of which promote tendon extracellular matrix degradation. Pulsed electromagnetic field (PEMF) therapy is often used for ... ultimately resulting in the activation of matrix metalloproteinases and a diminished collagen synthesis, ... Nevertheless, several of the genes identified belong to either extracellular matrix proteins (e.g., Col9a3), are involved in ...
Migration creates cancer cell vulnerabilities | National Institutes of Health (NIH)
To migrate to another area, cancer cells must move through a dense scaffolding of proteins called the extracellular matrix. The ... They designed a microfluidic device to watch cells move through pore sizes that mimic those in the extracellular matrix in ... By labeling nuclear proteins with green and red fluorescent tags, the researchers were able to watch as the torn nuclei let ... Green fluorescent protein spills from the ruptured nucleus into the cytoplasm, then is reimported into the nucleus once the ...
RFA-CA-06-014: Tumor Microenvironment Network (TMEN) (U54)
Additional components are: the extracellular matrix, growth factors/cytokines, and other proteins produced locally and/or ... identifying the matrix molecules present in the stroma, and the critical soluble molecules, such as growth factors, cytokines, ... a) Characterization of the functions of and interactions among the component cells and matrix molecules in normal organ and ... Developing novel in vitro 3-dimensional matrix reconstitution and organotypic models or animal models; ...
Ebook - Polarity Index in Proteins-A Bioinformatics Tool | Bentham Science
Phosphorylated Extracellular Matrix Proteins of Bone and Dentin. × Phosphorylated Extracellular Matrix Proteins of Bone and ... The phosphorylated proteins of the extracellular matrix of bone and teeth play a crucial structural role in the two tissues. ... Phosphorylated Extracellular Matrix Proteins of Bone and Dentin is the second volume of the e-book series Frontiers between ... Phosphorylated extracellular matrix proteins have been implicated in nucleation and mineralization of skeletal tissues. This e- ...
Biomarkers Search
Expression of extracellular matrix proteins in ovarian serous tumors.. Salani R; Neuberger I; Kurman RJ; Bristow RE; Chang HW; ... 6. Determination of BRAF V600E (VE1) protein expression and BRAF gene mutation status in codon 600 in borderline and low-grade ... 8. Characterization of active mitogen-activated protein kinase in ovarian serous carcinomas.. Hsu CY; Bristow R; Cha MS; Wang ...
Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES) | National Institute of...
MATRICES) studies the transition of tissue from healthy to a diseased state and the underlying mechanisms driving disease ... Of particular interest are enzymes known as proteases, which degrade extracellular matrices and other proteins. The MATRICES ... Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES). Share:. ... Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES) * Section on ...
positive regulation of aortic smooth muscle cell differentiation - Ontology Report - Rat Genome Database
RCSB PDB - 1TEN: STRUCTURE OF A FIBRONECTIN TYPE III DOMAIN FROM TENASCIN PHASED BY MAD ANALYSIS OF THE SELENOMETHIONYL PROTEIN
STRUCTURE OF A FIBRONECTIN TYPE III DOMAIN FROM TENASCIN PHASED BY MAD ANALYSIS OF THE SELENOMETHIONYL PROTEIN ... The crystal structure of one such domain from the extracellular matrix protein tenascin was determined. The structure was ... STRUCTURE OF A FIBRONECTIN TYPE III DOMAIN FROM TENASCIN PHASED BY MAD ANALYSIS OF THE SELENOMETHIONYL PROTEIN. *PDB DOI: https ... Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein.. Leahy, D.J., ...
Table of Contents - June 15, 2002, 22 (12) | Journal of Neuroscience
The Neural Cell Adhesion Molecule L1 Potentiates Integrin-Dependent Cell Migration to Extracellular Matrix Proteins Karsten ... Protein Kinase Modulation of Dendritic K+ Channels in Hippocampus Involves a Mitogen-Activated Protein Kinase Pathway Li-Lian ... Regulation by Protein Kinase A Switching of Axonal Pathfinding of Zebrafish Olfactory Sensory Neurons through the Olfactory ... A Novel Function of Monomeric Amyloid β-Protein Serving as an Antioxidant Molecule against Metal-Induced Oxidative Damage Kun ...
Interdisciplinary Research - Program Highlights
Networked-based characterization of extracellular matrix proteins from adult mouse pulmonary and aortic valves. Journal of ... called the extracellular matrix (ECM), that are critical for heart valve function. The researchers found several proteins that ... The defective RNA cannot be used make the FMR1 protein needed for neurons to develop normally. Instead, the defective protein ... Regulation of Proteins Plays an Important Role in Aging. Dr. Gordon Lithgow and colleagues at the Buck Institutes Geroscience ...
NIDCR Names Deputy Scientific Director | National Institute of Dental and Craniofacial Research
Youngs lab explores the mechanisms that control the function of extracellular matrix proteins found in the skeleton and teeth ... She studies matrix components known as small leucine-rich proteoglycans (SLRPs) and has focused on mechanistic analysis of ... Her postdoctoral work in the LDBA Branch from 1981 to 1983 investigated the structure, function, and regulation of matrix genes ... or clinical research in inflammation and/or skeletal matrix biology. ...
KAKEN - Research Projects | 変異型FGFR3で発症する致死型軟骨無形成症の病理組
Journal Article] Pereriostin is an extracellular matrix protein required for eruption of incisors in mice.2006. *. Author(s). ... Journal Article] Histochemical evidence of osteoclastic degradation of extracellular matrix in osteolytic metastasis ... Journal Article] Histological evidence of the altered distribution of osteocytes and bone matrix synthesis in klotho-deficient ... Journal Article] Histological observations on multiple matrix degradation of osteolytic bone metastasis by breast carcinoma ...
DailyMed - GINTUIT- allogeneic cultured keratinocytes and fibroblasts in bovine collagen cellular sheet
... and contains extracellular matrix proteins. Growth factors, cytokines, and extracellular matrix proteins are known to be ... human extracellular matrix proteins, and bovine collagen for topical application in the oral cavity. GINTUIT appears off-white ... human extracellular matrix proteins, and bovine collagen. Approximately 4 million cells are initially used to manufacture the ... human extracellular matrix proteins, and bovine collagen. Approximately 4 million cells are initially used to manufacture the ...
The Journal of Contemporary Dental Practice
Copper, lysyl oxidase, and extracellular matrix protein cross-linking. Am J Clin Nutr. 1998 May;67(5 Suppl):996S-1002S. Review. ... Role of selected nutrients in synthesis, accumulation, and chemical modification of connective tissue proteins. Physiol Rev. ... Effect of diet on bone matrix constituents. J Am Coll Nutr. 1991 Jun;10(3):242-6. Review. ... Analysis of cartilage differentiation from skeletal muscle grown on bone matrix. III. Environmental regulation of ...
Liver, Stellate Cell - Hyperplasia - Nonneoplastic Lesion Atlas
arrow) and produce extracellular matrix proteins and collagen (scar tissue) in response to hepatic injury. Distinction from ...
The muscular dystrophies | The BMJ
Dystrophin and other associated proteins form a link between the extracellular matrix (endomysium) and intracellular F-actin ( ... Around 50% of cases are caused by a specific deficiency of the extracellular muscle protein known as laminin α 2 chain, or ... The protein is located on the inner surface of the nuclear membrane in skeletal and cardiac muscle. In cardiac muscle it is ... Using protein studies and gene studies it is possible in the majority of cases to establish the precise diagnosis of a ...
Surveillance Report #116 | National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Vol. 39 No. 1 (2002) | Brazilian Journal of Veterinary Research and Animal Science
Neurofascin (NFASC) (NM 001160331) Human Recombinant Protein - TP328652 | OriGene
Recombinant protein of human neurofascin (NFASC), transcript variant 2, 20 µg ... This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative ... View other "Neurofascin" proteins (9) Special Offer: Buy 2 proteins and get the third protein free. Use code: "3for2". Get ... Protein Sequence (showhide) >RC228652 representing NM_001160331. Red=Cloning site Green=Tags(s). ...
NIOSHTIC-2 Search Results - Full View
The Scl1 protein selectively binds to human extracellular matrix (ECM) component, cellular fibronectin (cFn). Objective: To ... Conclusions: Here, we (i) established that the Scl1 surface protein is an essential determinant of GAS biofilm, (ii) showed ... The group A streptococcal collagen-like protein-1 (SCL1) is a key surface adhesin for biofilm formation. ... has been identified in human clinical specimens of the skin in the form of microcolonies encapsulated in an extracellular ...
Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions |...
We identified the extracellular matrix protein agrin in the muscularis mucosae (MM) of SSL biopsies but not in other polyps or ... To identify novel biomarkers for SSLs, we evaluated the expression of extracellular matrix (ECM) proteins upregulated in ... Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver ... Extracellular matrix and colorectal cancer: how surrounding microenvironment affects cancer cell behavior? ...
SMART: WAP domain annotation
Solution structure of the extracellular matrix protein anosmin-1. 2rel. SOLUTION STRUCTURE OF R-ELAFIN, A SPECIFIC INHIBITOR OF ... Click on the protein counts, or double click on taxonomic names to display all proteins containing WAP domain in the selected ... A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors. ... However the WAP domain is not exclusive to WAP proteins, but it is found in many other proteins, a number of which have been ...