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Cullin-RING ubiquitin ligases: global regulation and activation cycles | Cell Division | Full Text
Eukaryotic species contain multiple cullins, with five major types in metazoa. Each cullin forms a distinct class of CRL ... a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the ... Eukaryotic species contain multiple cullins, with five major types in metazoa. Each cullin forms a distinct class of CRL ... homologous to eight subunits of the 19S proteasome lid complex and to three subunits of the eIF3 translation initiation factor ...https://celldiv.biomedcentral.com/articles/10.1186/1747-1028-3-7
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth |...
... and eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1). The role of mTORC1 in the regulation of lipid ... which phosphorylates the α-subunit of the eukaryotic translation initiation factor-2 (eIF2α) on serine 51. This inhibits the ... ER-stress also activates the eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3 also known as PERK), ... activation of eIF2α phosphorylation by the eukaryotic translation initiation factor 2 alpha kinase 4 (GCN2) induced expression ...https://cancerandmetabolism.biomedcentral.com/articles/10.1186/2049-3002-1-3
Determination of the Proteomic Response To Lapatinib Treatment Using A Comprehensive and Reproducible Ion-current-based...
EF1G Elongation factor 1-gamma 10. 2.20E-04. -1.36. O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 2. 2.60E- ... EIF3X Putative eukaryotic translation initiation factor 3 subunit 2. 2.10E-02. -1.43. ... HER2, a member of the Human Epidermal growth factor Receptor (HER) family, is overexpressed in approximately 25% of breast ... 2.Hudziak R M, Schlessinger J, Ullrich A.Increased expression of the putative growth factor receptor p185HER2 causes ...https://openaccesspub.org/jpgr/article/50
Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript,...
... eukaryotic initiation factor 5A and its involvement in P. falciparum DNA polymerase and topoisomerase I and II . In ... Eukaryotic translation initiation factor 3 subunit 10 (PFL0625c) was used as endogenous control, since its transcript was not ... Oakley M, Kumar S, Anantharaman V, Zheng H, Mahajan B, Haynes J, Moch J, Fairhurst R, McCutchan T, Aravind L: Molecular factors ... Specific DNA-binding by Apicomplexan AP2 transcription factors. Proc Natl Acad Sci USA. 2008, 105 (24): 8393-8398. 10.1073/pnas ...https://0-bmcgenomics-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2164-11-235
Eukaryotic translation initiation factor 2 alpha kinase 3; PRKR-like endoplasmic reticulum kinase; heme-regulated EIF2-alpha ... Activated mTOR phosphorylates ribosomal protein S6 kinase 1 (S6K1) and the eukaryotic translation initiation factor 4E binding ... and other transcription factors. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be ... Epidermal growth factor receptor, HER1 Human to Mouse Sequence Homology:. 90.30%. Notable Upstream Kinase(s):. EGFR/HER2 ( ...https://sandbox.biolegend.com/en-ie/phospho
BrainStars Marker Genes
eukaryotic translation initiation factor 2 alpha kinase 3. 1.21369. 17. 1436717_x_at Hbb-y. hemoglobin Y, beta-like embryonic ... TF=Transcription Factor; Ch=Channel; GPCR=GPCR; CA=Cell Adhesion; EM=Extracellular Matrix; SP=Structural Protein; Ng= ... 3. 1457014_x_at Slc16a8. solute carrier family 16 (monocarboxylic acid transporters), member 8. 1.48924. SLC ...http://poabf.brainstars.org/marker/high/LG
TGME49_058740 eukaryotic translation initiation factor 2A, putative. *TGME49_058770 UDP-N-acetyl-D-galactosamine:polypeptide N- ... TGME49_074190 eukaryotic initiation factor 2B epsilon subunit, putative. *TGME49_075480 myb-like DNA-binding domain-containing ... TGME49_115150 eukaryotic translation initiation factor 4E, putative. *TGME49_115170 soluble liver antigen/liver pancreas ... TGME49_035970 eukaryotic translation initiation factor 2 gamma subunit, putative. *TGME49_036040 (Aldolase I, aldolase, ...http://apiloc.biochem.unimelb.edu.au/apiloc/apiloc/proteome/T.+gondii+MudPIT+Insoluble+Fraction
ALTERNATIVELY SPLICED mRNA ISOFORMS AS PROGNOSTIC INDICATORS FOR METASTATIC CANCER - Patent application
... scaffold attachment factor A); scaffold attachment factor B2; WD repeat domain 79; eukaryotic translation initiation factor 2C ... splicing factor, arginine/serine-rich 4; eukaryotic translation initiation factor 4 gamma, 1; phenylalanyl-tRNA synthetase, ... eukaryotic translation initiation factor 3, subunit B; poly-U binding splicing factor 60 KDa; stem-loop binding protein; DCP2 ... eukaryotic translation initiation factor 2-alpha kinase 2; DEAD (Asp-Glu-Ala-Asp) box polypeptide 28; zinc finger protein 346; ...http://www.patentsencyclopedia.com/app/20140066319
Anti JAB1 Antibody | Bio-Rad Antibodies (formerly AbD Serotec)
eukaryotic translation initiation factor 3 complex. Related reagents. GO:0006366. transcription from RNA polymerase II promoter ...https://www.bio-rad-antibodies.com/human-jab1-antibody-ahp2486.html
NAVER Academic > Search...
Eukaryotic Initiation Factor-4E, metabolism, Humans, Insulin... ... and Mnk-mediated eukaryotic translation initiation factor 4E ... Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic ... start page previous page 1 2 3 4 5 next page end page ... of mammalian target of rapamycin induces phosphatidylinositol 3 ...http://academic.naver.com/search.naver?field=3&query=MOLECULAR+AND+CELLULAR+BIOLOGY+27%EA%B6%8C+21%ED%98%B8
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase...
... an event that leads to 4E-BP1 dissociation from the eukaryotic initiation factor eIF4E and a subsequent "disinhibition" of ... 3D and data not shown). However, when produced in 786-O cells, this PTEN mutant did not induce a G1 block (Fig. 3A). Thus, both ... 3,4,5-tetrakisphosphate;. PtdIns,. phosphatidylinositol 3,4,5-trisphosphate;. CD,. Cowden's disease;. HA,. hemagglutinin;. GST, ... 3D). We next asked whether the G129E mutant might be defective in dephosphorylating [3H]IP4, as a measure of lipid phosphatase ...https://www.pnas.org/content/96/5/2110?ijkey=0c3c53643e6bd55694baf42a3dbd443262929ca2&keytype2=tf_ipsecsha
Peter Sarnow | Stanford Medicine Profiles
Enterovirus 71 contains a type IIRES element that functions when eukaryotic initiation factor eIF4G is cleaved VIROLOGY ... Curiously, the mRNAs that encode eukaryotic initiation factor 4GI (eIF4GI) and 4GII (eIF4GII), two proteins with high identity ... Evidence for involvement of trans-acting factors in selection of the AUG start codon during eukaryotic translational initiation ... OGFOD1, a Novel Modulator of Eukaryotic Translation Initiation Factor 2 alpha Phosphorylation and the Cellular Response to ...https://med.stanford.edu/profiles/peter-sarnow
Neighborhood of EIF3S6 eukaryotic translation initiation factor 3, subunit 6 48kDa in the MORF expression compendium. ... TFT: transcription factor targets C4: computational gene sets CGN: cancer gene neighborhoods CM: cancer modules C5: GO gene ... eukaryotic translation initiation factor .... EIF3S3. 8667. EIF3H. eukaryotic translation initiation factor .... EIF3S4. 8666. ... eukaryotic translation initiation factor .... EIF3S6. 3646. EIF3E. eukaryotic translation initiation factor .... EIF3S7. 8664. ...http://software.broadinstitute.org/gsea/msigdb/cards/MORF_EIF3S6.html
Bone Marrow Mesenchymal Stem Cells (BM-MSCs) Improve Heart Function in Swine Myocardial Infarction Model through Paracrine...
... and glyceraldehyde-3-phosphate dehydrogenase (GAPDH)) and 70-kDa ribosomal protein S6 kinase (p70s6k) in BM-MSCs injected areas ... eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1)/70-kDa ribosomal protein S6 kinase (p70s6k) signal ... Paracrine factors released by GATA-4 overexpressed mesenchymal stem cells increase angiogenesis and cell survival. Am J Physiol ... and secrete a wide array of paracrine factors3,20. In 2001, Orlic et al. reported that intramyocardial injection of ...https://www.nature.com/articles/srep28250?error=cookies_not_supported&code=1ddb4851-3790-4ea5-b253-cbc0b75e8a6e
Results for smart00487
Eukaryotic initiation factor 4A-like NUK-34; AltName: Full=Eukaryotic translation initiation factor 4A isoform 3; AltName: Full ... gi,46397463,sp,P60842.1,IF4A1_HUMAN RecName: Full=Eukaryotic initiation factor 4A-I; Short=eIF-4A-I; Short=eIF4A-I; AltName: ... gi,45645183,sp,Q14240.2,IF4A2_HUMAN RecName: Full=Eukaryotic initiation factor 4A-II; Short=eIF-4A-II; Short=eIF4A-II; AltName ... gi,20532400,sp,P38919.4,IF4A3_HUMAN RecName: Full=Eukaryotic initiation factor 4A-III; Short=eIF-4A-III; Short=eIF4A-III; ...http://bioinf.umbc.edu/dmdm/genes_domains.php?search_term=smart00487
Draft Genome Sequence of Wickerhamomyces ciferrii NRRL Y-1031 F-60-10
Eukaryotic translation initiation factor 3 subunit A (UNIPROT: K0KKS6). Organism: Wickerhamomyces ciferrii (strain F-60-10 / ... Eukaryotic Cell, 11(12), p 1582-1583.. J. Schneider, et al., "Draft Genome Sequence of Wickerhamomyces ciferrii NRRL Y-1031 F- ... Eukaryotic Cell, 11(12), 1582-1583. doi:10.1128/EC.00258-12. Schneider, J., Andrea, H., Blom, J., Jaenicke, S., Rückert, C., ... Eukaryotic Cell 11, 1582-1583.. Schneider, J., et al., 2012. Draft Genome Sequence of Wickerhamomyces ciferrii NRRL Y-1031 F-60 ...https://pub.uni-bielefeld.de/publication/2544774
PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy | Molecular Cancer | Full Text
... eukaryotic translation initiation factor 2 subunit 1; ATF4: activating transcription factor 4; GSK3β: glycogen synthase kinase ... Activated PERK phosphorylates eukaryotic translation initiation factor-2α (EIF2α) and nuclear factor erythroid-derived 2-like 2 ... such as eukaryotic translation initiation factor 2 subunit 1 (EIF2S1), activating transcription factor 4 (ATF4), and Nrf2 (13, ... Eukaryotic translation initiation factor-2α kinase 3/protein kinase RNA-like endoplasmic reticulum kinase ...https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-017-0657-0
Identification of differentially expressed proteins in spontaneous thymic lymphomas from knockout mice with deletion of p53....
... eukaryotic translation initiation factor 2 subunit 1, triosephosphate isomerase, nucleoside diphosphate kinase B and in tumour ... eukaryotic translation initiation factor 3 subunit 2, peroxiredoxin-2, ADP-ribosylation factor 1, ubiquitin-conjugating enzyme ... The p53 protein is a ubiquitous transcription factor that is normally expressed at very low levels. In a majority of ... Table 3 caption: Differentially regulated proteins in the SM7 tumour [table omitted]. Commonly differentially regulated ...https://www.highbeam.com/doc/1G1-182001456.html
Publications - Mayo Clinic
The estrogen metabolite 2-methoxyestradiol regulates eukaryotic initiation factor 4E (eIF4E) and inhibits protein synthesis in ... Osteitis fibrosa is mediated by Platelet-Derived Growth Factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in ... Non-invasive screening method for simultaneous evaluation of in vivo growth factor release profiles from multiple ectopic bone ... MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor ...http://www.mayo.edu/research/searchpublications/publications?authid=12834807
New target for anticancer drugs: RNA » Science Abode
These short RNA tags bind to a protein, eIF3 (eukaryotic initiation factor 3), that regulates translation at the ribosome, ... The mRNA is then shuttled out of the nucleus to the cytoplasm, where a so-called initiation complex gloms onto mRNA and escorts ... "This really highlights that it is a major regulator in translation rather than simply a scaffolding factor." Lee zeroed in on ... The protein eIF3 is one component of the initiation complex, and is itself made up of 13 protein subunits. It was already known ...http://scienceabode.com/2016/04/21/new-target-for-anticancer-drugs-rna/