A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis | PNAS  A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis | PNAS
eukaryotic initiation factor-2α;. NF-κB,. nuclear factor-κB;. IκB,. inhibitor of NF-κB. ... PKR can mediate inhibition of protein synthesis through phosphorylation of eukaryotic initiation factor-2α (eIF-2α), which, in ... IFN regulatory factor;. TNF-α,. tumor necrosis factor-α;. pIC,. poly(I)·poly(C);. LPS,. lipopolysaccharide;. eIF-2α,. ... Proposed mediators of the apoptotic responses to stress-related stimuli, such as tumor necrosis factor-α (TNF-α), ...
more infohttps://www.pnas.org/content/94/7/3279?ijkey=3685b7ce09ffb719b3eaefeff809323e15198032&keytype2=tf_ipsecsha
Eukaryotic Initiation Factors
     Summary Report | CureHunter  Eukaryotic Initiation Factors Summary Report | CureHunter
Peptide initiation factors from eukaryotic organisms. Over twelve factors are involved in PEPTIDE CHAIN INITIATION, ... TRANSLATIONAL in eukaryotic cells. Many of these factors play a role in controlling the rate of MRNA TRANSLATION. ... Eukaryotic Peptide Initiation Factors; Initiation Factors, Chloroplast; Initiation Factors, Eukaryotic; Initiation Factors, ... Eukaryotic Initiation Factors. Subscribe to New Research on Eukaryotic Initiation Factors Peptide initiation factors from ...
more infohttp://www.curehunter.com/public/keywordSummaryD039642-Eukaryotic-Initiation-Factors.do
The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double...  The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double...
In addition, domain 3 and eukaryotic initiation factor 2α both interact with PKR through the same region within PKR, which we ... eukaryotic initiation factor 2; IFN, interferon; MEF, mouse embryo fibroblast; PACT, protein activator of PKR; PKR, double- ... stranded-RNA-dependent protein kinase; TNF-α, tumour necrosis factor-α; TRBP, TAR (trans-activation-responsive RNA of HIV-1) ... Our results have shown that, unlike the N-terminal conserved domains 1 and 2, the third conserved domain of PACT is dispensable ...
more infohttp://www.biochemj.org/content/366/1/175
Dynamic Shuttling of Tia-1 Accompanies the Recruitment of mRNA to Mammalian Stress Granules | JCB  Dynamic Shuttling of Tia-1 Accompanies the Recruitment of mRNA to Mammalian Stress Granules | JCB
Abbreviations used in this paper: ARE, AU-rich element; eIF, eukaryotic initiation factor; HA, hemagglutinin; PABP-I, poly(A)+ ... 1978) Binding and release of eukaryotic initiation factor eIF-2 and GTP during protein synthesis initiation. Proc. Natl. Acad. ... In mammalian cells, the assembly of SGs is initiated by the phosphorylation of eukaryotic initiation factor (eIF)-2α (Kedersha ... 1998) Characterization of the hemin-sensitive eukaryotic initiation factor 2a kinase from mouse nonerythroid cells. J. Cell ...
more infohttp://jcb.rupress.org/content/151/6/1257?ijkey=91c3ebd19dd51844960e0ea04d7acc1de62b1796&keytype2=tf_ipsecsha
UniProt: SUI1 YEAST  UniProt: SUI1 YEAST
DE RecName: Full=Eukaryotic translation initiation factor eIF-1; DE AltName: Full=Protein translation factor SUI1; GN Name=SUI1 ... DR GO; GO:0003743; F:translation initiation factor activity; IDA:SGD. DR GO; GO:0031369; F:translation initiation factor ... Eukaryotic translation initiation factor FT eIF-1. FT /FTId=PRO_0000130566. FT MOD_RES 2 2 N-acetylserine. FT {ECO:0000244, ... "Identification of a translation initiation factor 3 (eIF3) core RT complex, conserved in yeast and mammals, that interacts with ...
more infohttp://www.genome.jp/dbget-bin/www_bget?uniprot:SUI1_YEAST
EIF3C (eukaryotic translation initiation factor 3, subunit C)  EIF3C (eukaryotic translation initiation factor 3, subunit C)
... eukaryotic translation initiation factor 3, subunit C), Authors: Daniel R Scoles. Published in: Atlas Genet Cytogenet Oncol ... RNA binding translation initiation factor activity translation initiation factor activity protein binding cytosol eukaryotic ... RNA binding translation initiation factor activity translation initiation factor activity protein binding cytosol eukaryotic ... initiation factor 3 complex translational initiation translational initiation translational initiation translation initiation ...
more infohttp://atlasgeneticsoncology.org/Genes/GC_EIF3C.html
Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase...  Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase...
Chang Raymond C. C., Wong Ada K. Y., Ng Ho-Keung, Hugon Jacques, Phosphorylation of eukaryotic initiation factor-2α (eIF2α) is ... Zhang X., Luhrs K.J., Ryff K.A., Malik W.T., Driscoll M.J., Culver B., Suppression of nuclear factor kappa B ameliorates ... Liao Yung-Feng, Wang Bo-Jeng, Cheng Hui-Ting, Kuo Lan-Hsin, Wolfe Michael S., Tumor Necrosis Factor-α, Interleukin-1β, and ... Levels of tumor necrosis factor-α (TNFα), interleukin (IL)-1β, and IL-6 were assessed by ELISA. Levels of PT451-PKR and ...
more infohttps://dial.uclouvain.be/pr/boreal/object/boreal:127309
7-methylguanosine-capped green fluorescent protein mRNA/human eukaryotic initiation factor 4E@triethylene tetramine-substituted...  7-methylguanosine-capped green fluorescent protein mRNA/human eukaryotic initiation factor [email protected] tetramine-substituted...
Page contains details about 7-methylguanosine-capped green fluorescent protein mRNA/human eukaryotic initiation factor [email protected] ... 7-methylguanosine-capped green fluorescent protein mRNA/human eukaryotic initiation factor [email protected] tetramine-substituted ... 7-methylguanosine-capped green fluorescent protein mRNA/human eukaryotic initiation factor [email protected] tetramine-substituted ...
more infohttp://nano.nature.com/nano/GR-M9068701
Eukaryotic translation initiation factor 3 subunit e controls intracellular calcium homeostasis by regulation of cav1.2 surface...  Eukaryotic translation initiation factor 3 subunit e controls intracellular calcium homeostasis by regulation of cav1.2 surface...
eIF3e (Eukaryotic translation initiation factor 3 subunit E) is part of the protein translation initiation complex, but its ... Eukaryotic translation initiation factor 3 subunit e controls intracellular calcium homeostasis by regulation of cav1.2 surface ... The factor interacted with CaV1.2 and regulated CaV1.2 traffic bidirectionally. eIF3e silencing impaired CaV1.2 internalization ... Genetic and Environmental Risk Factors in the Development of Obesity. *Gestational diabetes mellitus - prevalence in southern ...
more infohttps://www.ludc.lu.se/erik-renstrom/publication/1897f189-99e2-4c4e-b5de-455a090dc03c
Biological relevance and therapeutic potential of the hypusine modification system  - Zurich Open Repository and Archive  Biological relevance and therapeutic potential of the hypusine modification system - Zurich Open Repository and Archive
Hypusine modification of the eukaryotic initiation factor 5A (eIF-5A) is emerging as a crucial regulator in cancer, infections ... Hypusine modification of the eukaryotic initiation factor 5A (eIF-5A) is emerging as a crucial regulator in cancer, infections ...
more infohttp://www.zora.uzh.ch/id/eprint/111316/
5??-Reductase | healthweblognews.info | Page 3  5??-Reductase | healthweblognews.info | Page 3
A multitude of stress indicators activate a number of of a couple of eukaryotic initiation aspect 2? (eIF2?)2 kinases (1). ... stress signaling pathways converge on the phosphorylation of translation initiation factor eIF2?. AAR pathway demonstrating ... The hypoxia inducible transcription factor HIF1 activates autophagy an over-all catabolic. January 17, 2017 1:52 pm ⋅ admin ... Based on the baseline features reported no factor was noticed among individuals assigned to the short or long term length of ...
more infohttp://healthweblognews.info/category/5-reductase/page/3/
Stringent Response: Antibiotics affecting ribosomes protein composition  Stringent Response: Antibiotics affecting ribosome's protein composition
These leaderless mRNAs can be translated without the help of any initiation factors, by bacterial and eukaryotic ribosomes ... That usually means that the ribosome is stalled at a certain step, be it initiation or elongation or ribosomal recycling.. ... Exhibit A: kasugamycin, an antibiotic that inhibits translation initiation in bacteria by interfering with binding of the the ... mRNA can bind to mammalian 80S ribosomes and direct polypeptide synthesis in the absence of translation initiation factors. ...
more infohttp://stringentresponse.blogspot.com/2011/05/antibiotics-affecting-ribosomes-protein.html
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in...  Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in...
Phosphorylation of eukaryotic initiation factor-2 (eIF2) by pancreatic eIF2 kinase (PEK), induces a program of translational ... Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in ...
more infohttps://www.uniprot.org/citations/11907036
Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in...  Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in...
1993) Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 ... 1993) Mutations in the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) that overcome the inhibitory ... 1998) Phosphorylation of eukaryotic initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA ... 1993) Purification and characterization of eukaryotic initiation factor (eIF)-2 alpha kinases from Ehrlich ascites tumor cells. ...
more infohttps://mcb.asm.org/content/18/12/7499?ijkey=40fdf07f18ea631c83f427a26a272d5044949d5e&keytype2=tf_ipsecsha
The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and...  The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and...
The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and ... The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and ... The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and ... The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and ...
more infohttps://mcb.asm.org/content/22/11/3864?ijkey=3d043a6ba9cfa30b3fee142e30ea580ccbd679f6&keytype2=tf_ipsecsha
Eukaryotic translation initiation factor 2-alpha kinase 1 (Q9BQI3) | InterPro | EMBL-EBI  Eukaryotic translation initiation factor 2-alpha kinase 1 (Q9BQI3) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
more infohttps://www.ebi.ac.uk/interpro/protein/Q9BQI3
The Plasmodium eukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary glands  ...  The Plasmodium eukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary glands ...
... We show that sporozoite latency is an active process controlled by a eukaryotic initiation factor-2α (eIF2α) kinase (IK2) and a ... 2010) The Plasmodium eukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary ... Plasmodium sporozoites exploit the mechanism that regulates stress responses in eukaryotic cells. ...
more infohttp://eprints.gla.ac.uk/35853/
Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3 - CAGS  Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3 - CAGS
Mutations in the gene encoding the eukaryotic translation initiation factor 2-a kinase 3 (EIF2AK3, also called PERK or PEK) ... 2000) explored the gene encoding the eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) since it resides in ... Delepine M, Nicolino M, Barrett T, Golamaully M, Lathrop GM, Julier C. EIF2AK3, encoding translation initiation factor 2-alpha ... 2001; 21(1-2):73-4. * Bonthron DT, Dunlop N, Barr DG, El Sanousi AA, Al-Gazali LI. Organisation of the human PAX4 gene and its ...
more infohttp://www.cags.org.ae/ctga/details.aspx?id=593&pg=12&se=Latest
EIF2S2 - Eukaryotic translation initiation factor 2 subunit 2 - Homo sapiens (Human) - EIF2S2 gene & protein  EIF2S2 - Eukaryotic translation initiation factor 2 subunit 2 - Homo sapiens (Human) - EIF2S2 gene & protein
Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 ... eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex ... In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of ... and release of an eIF-2-GDP binary complex. ... sp,P20042,IF2B_HUMAN Eukaryotic translation initiation factor 2 ...
more infohttp://www.uniprot.org/uniprot/P20042
RCSB PDB - Protein Feature View 









 - Eukaryotic translation initiation factor 4E-binding protein 2 - Q13542 (4EBP2...  RCSB PDB - Protein Feature View - Eukaryotic translation initiation factor 4E-binding protein 2 - Q13542 (4EBP2...
Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates ... leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse ... growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. UniProt ... EIF4G3 to bind and consequent initiation of translation (PubMed:7935836, PubMed:24207126, PubMed:21661078, PubMed:25533957). ...
more infohttp://www.rcsb.org/pdb/protein/Q13542