IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans | BMC Biology | Full Text
IMPACT inhibits the ISR pathway, thus limiting the activation of stress response factors that are beneficial during aging and ... Impt-1 knockdown exacerbated DR-induced longevity and required several DR-activated transcription factors to extend lifespan, ... Translation initiation at non-AUG codons mediated by weakened association of eukaryotic initiation factor (eIF) 2 subunits. ... Kubota H, Sakaki Y, Ito T. GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its ...
Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer | BMC Biology | Full Text
... increased phosphorylated eukaryotic translation initiation factor 2 alpha (p-eIF2α) and CCAAT/Enhancer-binding protein ... transferase activates stem-like cell potential in hepatocarcinoma through O-GlcNAcylation of eukaryotic initiation factor 4E. J ... OGT is directly linked to Yamanaka factors like octamer-binding transcription factor 4 (Oct4) and SRY (sex determining region Y ... Cells rely on growth factor signaling to take up nutrients and in the absence of glucose hematopoietic cells reduce the amount ...
Type IV collagen drives alveolar epithelial-endothelial association and the morphogenetic movements of septation | BMC Biology ...
Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature. Mech Dev. 2005;122(7-8): ... NimbleGen Eukaryotic Gene Expression HD2 12-Plex Array Delivery) which covers 22,000 open reading frames. Microarray raw data ... Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early ... Fibroblast growth factor signaling in myofibroblast differs from lipofibroblast during alveolar septation in mice. Am J Physiol ...