The binding of HP1a at pericentromeric heterochromatin is required to establish clustering of pericentromeric regions. Moreover ... which suggests that a different molecular mechanism segregates active chromosome regions. Our work identifies HP1a as an ... arms is responsible for overall chromosome folding and has an important role in the formation of B-compartment regions. However ... including clustering of pericentromeric regions, the folding of chromosome arms and the segregation of chromosomes into active ...

Spanning the Euchromatic Region" (PDF). Science. 258 (5079): 60-66. doi:10.1126/science.1359640. PMID 1359640. Retrieved 4 ... "The sex-determining region of the human Y chromosome encodes a finger protein". Cell. 51 (6): 1091-1104. doi:10.1016/0092-8674( ... "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825-837. ... the deletion of the AZFc region of the Y chromosome. The lab also found that aberrant crossing over within the Y chromosomes ...

... with euchromatic X chromosomes) with a male from Andean region. As expected, the X chromosome appears euchromatic in the hybrid ... A: First meiotic metaphase in an insect obtained by crossing a female from Andean region (with C-banded X chromosomes) with a ... D: First meiotic metaphase in an insect obtained by crossing a female from non-Andean region ( ... the other one is completely euchromatic (C-morph); the resulting bivalent is asymmetric. C: Selected bivalent with a diagram of ...

In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human ... Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms ... Finishing the euchromatic sequence of the human genome International Human Genome Sequencing Consortium. Nature. 2004. . ... Finishing the euchromatic sequence of the human genome]. Hattori M. Hattori M. Tanpakushitsu Kakusan Koso. 2005 Feb;50(2):162-8 ...

A lack of euchromatic histone methyltransferase 1 enzyme impairs proper control of the activity of certain genes in many of the ... The deletion occurs near the end of the long (q) arm of the chromosome at a location designated q34.3, a region containing a ... However, the loss of other genes in the same region may lead to additional health problems in some affected individuals. ... Affected individuals are missing at least 352,000 base pairs, also written as 352 kilobases (kb), in the q22.3 region of ...

Rat BMSCs pretreated with the euchromatic histone lysine methyltransferase 2 (G9a) inhibitor BIX01294 were transfected with a T ... The sinus nodal region tissue was fixed in 4% paraformaldehyde for 24 h at room temperature. After dehydration using an ... It may be hypothesized that the reduced enrichment of H3K9me2 in the HCN4 promoter region led to changes in chromosome state, ... 3C). These results demonstrated that G9a changed the enrichment level of H3K9me2 in the HCN4 promoter region, which suggested ...

We observed elevated prediction of pathogenicity in active euchromatic regions (Fig. 9, Outer track, Bright regions; ... As expected the ISV predictions in the regions were in line with the functional and nucleotide content of the affected regions ... S10) compared to the heterochromatic regions (Fig. 9, Outer track, Dark regions; Supplementary Fig. S10) according to G-banding ... while the bright regions are mostly euchromatic and rich for GC pairs34. Since GC content is strongly correlated with ...

MCB/m-banding allows for differentiation of chromosome region-specific areas at the band and sub-band level at a resolution of ... which can specifically characterize the centromere near euchromatic material; the heterochromatin-M-FISH,[25] which is specific ... detecting copy number variant regions in the human genome on a single-cell level.[23] ... for all larger heterochromatic regions in the human karyotype; or the 9het-mix,[26] which enables subdifferentiation of ...

These R-bands are approximately the reverse of G-bands (the R stands for "reverse"). The dark regions are euchromatic and the ... The bright regions tend to be euchromatic, early-replicating and GC rich. ... These latter include methods which reveal centromeric bands, C-bands, and nucleolus organizer regions, NORs (at terminal ... Q-bands are like fluorescent G-bands, but certain heterochromatic regions are more brightly stained with Q-banding. ...

In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human ... Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms ... Finishing the euchromatic sequence of the human genome International Human Genome Sequencing Consortium. Nature. 2004. . ... Finishing the euchromatic sequence of the human genome]. Hattori M. Hattori M. Tanpakushitsu Kakusan Koso. 2005 Feb;50(2):162-8 ...

A lack of euchromatic histone methyltransferase 1 enzyme impairs proper control of the activity of certain genes in many of the ... The deletion occurs near the end of the long (q) arm of the chromosome at a location designated q34.3, a region containing a ... However, the loss of other genes in the same region may lead to additional health problems in some affected individuals. ... Affected individuals are missing at least 352,000 base pairs, also written as 352 kilobases (kb), in the q22.3 region of ...

... a nuclear protein known to bind matrix attachment regions, is a key event in initiating myogenic differentiation. The deletion ... Matrix attachment region (MAR) binding proteins represent a group of factors proposed to act as modifiers of the chromatin loop ... SATB2 was mainly relegated to the euchromatic nuclear space; however, there was a significant subfraction of SATB2 co-staining ... This duality of MAR protein function depends on the proximity of gene promoters and insulator regions relative to the position ...

Transcription, therefore, tends to occur predominantly in euchromatic regions of the genome, which are rich in genes. By ...

In doing so, they found that Cinnamons sequences spanned about 65% of the euchromatic (gene-containing) regions of the feline ...

This is of particular interest for the late replicating, normally heterochromatic, regions, the location of sequences that are ... while the other replisome was euchromatic and interacted with early replicating elements. These observations raise the question ...

The higher residence time in heterochromatin and chromosomes, compared with euchromatic regions, correlates with an increased ... HMGA1a-GFP disappeared from the peripheral regions and became enriched in the more-axial regions of the chromosomal arms (Fig. ... 7B, Table 1). After inhibition of PKC, full recovery of a bleached region already occurred in 17-25 seconds. A similar ... Phosphorylation of HMG-I by protein kinase C attenuates its binding affinity to the promoter regions of protein kinase C gamma ...

Certain genomic regions apparently cannot be cloned in any of the large-insert vectors routinely used in high-throughput ... A working draft version of at least 90% of the euchromatic part of the human genome will be completed in 2000, and the complete ... Such gaps may arise from an inability to clone a region in any available vector system or to an inability to obtain sequence ... SCOPE Overall, there are at present no methods that can be successfully used to resolve all difficult-to-sequence regions, and ...

... circRNA euchromatic histone lysine methyltransferase 1; circHIPK3, circRNA homeodomain interacting protein kinase 3; circMET, ... circRNA Williams-Beuren syndrome chromosome region 17 (circ_0080425) was increased in kidney tissues from streptozotocin (STZ)- ... circRNA euchromatic histone lysine methyltransferase 1; circEIF4G2, circRNA eukaryotic translation initiation factor 4 gamma 2 ... circRNA Williams-Beuren syndrome chromosome region 17, circ_0080425; circWDR77, circRNA WD repeat domain 77, hsa_circ_0013509; ...

... targets CTCF in euchromatic regions of the genome. Our results support the conclusion that Cr(VI) treatment promotes the ... Differentially bound CTCF sites were enriched by Cr(VI) treatment within transcription-related regions, specifically ... transcription start sites and upstream genic regions. Functional annotation of the affected genes highlighted biological ...

Our findings revealed that meta-QTL WM2.2 consists of three regions, WM2.2a (4.27-5.76 Mb; euchromatic), WM 2.2b (12.19 to ... WM2.2a region is most likely associated with avoidance mechanisms while WM2.2b and WM2.2c regions trigger physiological ... The whole-genome resequencing of ICY and CY inbred lines revealed an ICY/CY-specific region of approximately 27.60-27.88 Mb on ... The apple (Malus x domestica) scab (Venturia inaequalis) resistance genes Rvi4 and Rvi15 were mapped to a similar region on the ...

By SNP array analysis and FISH the deletion was shown to comprise nearly 10.7 Mb of euchromatic material. This region harbors ... A 10.7 Mb interstitial deletion of 13q21 without phenotypic effect defines a further non-pathogenic euchromatic variant. ... Both cases indicate that this 13q21 deletion can be added to the growing list of euchromatic imbalances without obvious ... A 10.7 Mb interstitial deletion of 13q21 without phenotypic effect defines a further non-pathogenic euchromatic variant ...

... with euchromatic X chromosomes) with a male from Andean region. As expected, the X chromosome appears euchromatic in the hybrid ... A: First meiotic metaphase in an insect obtained by crossing a female from Andean region (with C-banded X chromosomes) with a ... D: First meiotic metaphase in an insect obtained by crossing a female from non-Andean region ( ... the other one is completely euchromatic (C-morph); the resulting bivalent is asymmetric. C: Selected bivalent with a diagram of ...

The assemblies effectively cover the euchromatic regions of the human chromosomes. More than 90% of the genome is in scaffold ... The public data were shredded into 550-bp segments to create a 2.9-fold coverage of those genome regions that had been ... A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole- ... The M1 muscarinic receptor is predominantly expressed in the brain in regions involved in cognition, and therefore selective ...

Within the euchromatin regions, is a gene called Sex determining region Y (SRY). In humans, absence of Y chromosome inevitably ... The NRY is divided equally into functional genes (euchromatic) and non-functional genes (heterochromatic). ... Present at both ends of the Y chromosome are the pseudoautosomal regions (PARs) that are similar with regions on the X ... Current analysis of Y chromosomes has revealed numerous genes and regions with potential genetic function; some genes with or ...

... thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing ... Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for ...

... thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing ... Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for ...

In contrast, the absence of HP1 and H3K9me from the dot chromosome in D. virilis suggests that this region is euchromatic. D. ... Remnants of DNA transposons make up only 6.3% of the D. virilis dot chromosome fosmids, but 18.4% of the homologous regions ... Euchromatic domains on the major chromosomes in both species have very few DNA transposons (less than 0.4 %). ... The D. virilis dot chromosome fosmids have a high repeat density (22.8%), similar to homologous regions of D. melanogaster ( ...

From its initial release in 2000 through 2022, the human reference genome has covered only the euchromatic fraction of the ... unlocking all regions of the genome to variational and functional studies for the first time. However, this complete genome ... genome, leaving important heterochromatic regions unfinished. Addressing this remaining 8% of the genome, the section assembled ...