A catechol estrogen is a steroidal estrogen that contains catechol (1,2-dihydroxybenzene) within its structure. The catechol ... Similarly to estradiol and estrone, catechol estrogens possess estrogenic activity. 2-Hydroxylated catechol estrogens are weak ... The catechol estrogens are formed from estradiol and estrone by cytochrome P450 enzymes predominantly in the liver but also in ... Under poor conditions of inactivation by phase II enzymes, catechol estrogens can undergo oxidation to reactive quinones and ...

Dive into the research topics of Catechol estrogens: Presence in brain and endocrine tissues. Together they form a unique ...

... the most abundant circulating estrogen conjugates. The identity of the conjugated estrogens formed by all known overexpressed ... inactivate and facilitate the excretion of estrogens to glucuronides (-G), ... Estrogens, Catechol / metabolism * Estrone / chemistry * Estrone / metabolism* * Female * Gene Expression Regulation, ... the most abundant circulating estrogen conjugates. The identity of the conjugated estrogens formed by all known overexpressed ...

Catechol-O-methyl transferase. Catechol-O-methyltransferase is one of several enzymes that degrade catecholamines such as ... Sudden estrogen withdrawal, fluctuating estrogen, and periods of sustained estrogen low levels correlates with significant mood ... The actions of estrogen are mediated by the Estrogen receptor. Estrogen receptor ... Hyperestrogenemia (elevated levels of estrogen) may be a result of exogenous administration of estrogen or estrogen-like ...

Preparation and Oxidation Chemistry of the Catechol Estrogens: Relevance to Estrogen-Related Carcinogenesis and Potential for ... "estrogen". Leptin, Estrogens and Cancer. Journal: Mini-Reviews in Medicinal Chemistry. Volume: 6 Issue: 8 Year: 2006 Page: 897 ... Estrogen Receptors as Therapeutic Targets in Breast Cancer. Journal: Current Topics in Medicinal Chemistry. Volume: 6 Issue: 3 ... Molecular Modeling Studies of Estrogen Receptor Modulators. Journal: Current Computer-Aided Drug Design. Volume: 2 Issue: 3 ...

These two catechol estrogens are converted to methylated metabolites by catechol-O-methyltransferase (COMT). 4-OHE2 has been ... 4-Hydroxyestradiol Induces γ-H2AX in the Presence of an Inhibitor of Catechol-O-methyltransferase in Human Breast Cancer MCF-7 ...

... analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid. Andrology 1, 192-205 ...

... which deactivates potentially genotoxic catechol estrogens. A SNP in ESR1 (IVS1-397, C>T) may affect estrogen binding to ERa, ... affect metabolism of estrogens to catechol estrogens, which are further oxidized to genotoxic quinones. A SNP-induced amino ... Polymorphisms in the estrogen metabolism genes CYP17, CYP1B1, CYP1A2, COMT and ER alpha and susceptibility to primary ... We evaluated the associations of polymorphisms in genes important in estrogen metabolism with the risk of glioma in women. ...

... estriol and other estrogens), oxidation to nonestrogenic substances (catechol-estrogens, which interact with catecholamine ... Estrogens occur naturally in several forms. The primary source of estrogen in normally cycling adult women is the ovarian ... Estrogen drug products act by regulating transcription of a limited number of genes. Estrogens diffuse through cell membranes, ... In contrast, synthetic estrogens, such as ethinyl estradiol and the nonsteroidal estrogens, are degraded very slowly in the ...

16α-hydroxyestrone and catechol estrogens. While 16α-hydroxyestrone has relatively weak affinity for estrogen receptor, it has ... Life-time exposure to estrogens is linked to the risk of several cancers. Estrone is only a weak agonist of estrogen receptor ... Estrogens are female sex hormones that have genotoxic and proliferation-enhancing effects in cells. ... Generally, subfamily UGT1A enzymes conjugate the 3-hydroxyls of estrogens, while the activity of subfamily UGT2B is directed ...

Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer. ... The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase. ...

... and catechol-O-methyltransferase. In fact, pulmonary hypertension associated with liver disease, which also predominantly ... In vitro, oestrogen is mitogenic and promotes proliferation of pulmonary vascular smooth muscle cells, while the anti-oestrogen ... Oestrogens and most oestrogen metabolites are pro-proliferative. However, not all oestrogen metabolites are equal in their ... Greenlee H, Chen Y, Kabat GC, et al. Variants in estrogen metabolism and biosynthesis genes and urinary estrogen metabolites in ...

... study aimed to investigate the main effect of polymorphisms in genes involved in xenobiotic metabolism and estrogen ... Dawling S, Roodi N, Mernaugh RL, Wang X, Parl FF: Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens ... Newbold RR, Liehr JG: Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogens. Cancer Res. 2000, 60: 235-237. ... an increased accumulation of the reactive catechol oestrogen intermediates and thus facilitating the development of oestrogen- ...

4-catechol estrogen (4-hydroxyestrone), estriol and 17-epiestriol, and hyodeoxycholic acid(HDCA), but the UDPGTh2 isozyme was ...

As a research scientist who had spent 20+ years researching and publishing on the role of estrogen and progestogen binding to ... These were the Womens Health Initiative (WHI) and Million Womens studies of women using FDA-approved estrogens and ... High levels of 4-catechol estrogens ratchet that up to extreme warning [5] as we have found that 4-catechol estrogens are much ... Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators. Proc Natl Acad Sci USA. 1997;94: ...

Polymorphisms of catechol estrogens metabolism pathway genes and breast cancer risk in Mexican women. 2012. 2. 10.1016/j.breast ... Catechol-O-methyltransferase and pain.. 2010. 6. -. Francesco Benedetti. The catechol-O-methyltransferase Val(108/158)Met ... The Role of Catechol-O-Methyl Transferase Val(108/158)Met Polymorphism (rs4680) in the Effect of Green Tea on Resting Energy ... Catechol-O-methyltransferase and pain. 2010. 1. -. Zsofia Nemoda. Assessing genetic polymorphisms using DNA extracted from ...

... alteration in UGTs involved in the inactivation of estradiol and its catechol-reactive metabolites may modify estrogen exposure ... different menopausal status and support that interindividual differences in estrogen glucuronidation influence local estrogen ... This finding is consistent with a role for estrogen-UGT in modulating the action of endogenous hormones in breast cancer risk ... and, consequently, estrogen-related cancer risk. We investigated UGT1A1 as a first candidate gene. UGT1A1 is a major UGT ...

Schistosome and liver fluke derived catechol-estrogens and helminth associated cancers. Correia da Costa, J. M., Vale, N., ... The role of estrogens and estrogen receptor signaling pathways in cancer and infertility: The case of schistosomes. Botelho, M ... Estrogen-like metabolites and DNA-adducts in urogenital schistosomiasis-associated bladder cancer. Gouveia, M. J., Santos, J., ...

4-catechol estrogens and estriol su.... Gene Name. UGT2B7. Uniprot ID. P16662. Uniprot Name. UDP-glucuronosyltransferase 2B7. ...

Estrogen disrupting pesticides in nebraska groundwater: Trends between pesticide-contaminated water and estrogen-related ... Benzene and dopamine catechol quinones could initiate cancer or neurogenic disease. Zahid, M., Saeed, M., Rogan, E. G. & ... Estrogen-DNA Adducts and Breast Cancer Risk in Premenopausal Asian Women. Lin, C. H., Zahid, M., Kuo, W. H., Hu, F. C., Wang, M ... Unbalanced estrogen metabolism in thyroid cancer. Zahid, M., Goldner, W., Beseler, C. L., Rogan, E. G. & Cavalieri, E. L., Dec ...

Thibodeau, P.A., Bissonnette, N., Kocsis Bédard, S., Hunting, D. and Paquette, B.*. (1998). Induction by estrogens of ... catechol--methyltransferase is not involved. Thorax 55 574-578. ... and antioxidant properties of estrogens. The Journal of Steroid ...

The estrogens estrone (E1) and estradiol (E2) can form catechol estrogen (CE) metabolites, catechol estrogen quinones [E1(E2)-3 ... The estrogens estrone (E1) and estradiol (E2) can form catechol estrogen (CE) metabolites, catechol estrogen quinones [E1(E2)-3 ... The estrogens estrone (E1) and estradiol (E2) can form catechol estrogen (CE) metabolites, catechol estrogen quinones [E1(E2)-3 ... The estrogens estrone (E1) and estradiol (E2) can form catechol estrogen (CE) metabolites, catechol estrogen quinones [E1(E2)-3 ...

Magnesium - Cofactor for the enzyme that removes toxic forms of estrogen (catechol-O-methyltransferase); Estrogen alters ... Vitamin K - Inhibits estrogen activity by binding to estrogen receptors; Lowers the ratio of estradiol (strong estrogen) to ... Choline - Estrogen stimulates the breakdown of phosphatidylcholine (cell membrane) so those with low estrogen (postmenopausal ... Zinc - Estrogen lowers risk of zinc deficiency; Zinc dependent proteins metabolize estrogen.26,27,28 ...

Estrogen produced in men are essential for health and any imbalance can lead to medical complications. Learn with Wild Warrior ... Carcinogenicity of catechol estrogens in Syrian hamsters. (https://www.ncbi.nlm.nih.gov/pubmed/3009986/) ... Estrogens are hormones that are naturally produced by the body in both men (yes men, you need estrogen too) and women, and are ... This combination of estrogen reducing action is believed to improve the androgen to estrogen ratios in the body helping to ...

Then, the bioconversion of catechol estrogens was evaluated. PP00124 showed to be an efficient catalyst for the degradation of ... Here estrogens act as pro-cancerogenic agents and endocrine disruptors interfering with the sexual development of aquatic ... Here, we have confirmed the requirement of the ipf cluster for the generation of isobutyl catechol and have identified the ... Environmental bacteria play a vital role in estrogens degradation. Their wide reservoir of enzymes, such as ring cleavage ...

Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. Metabolism. 2007; 56(7):887-894. ... the catechol estrogen metabolites of CYP1B1 hamper the docetaxel-mediated tubulin polymerization. They also presumed that the ... Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis. Cancer Prev Res (Phila ... It is involved in the hydroxylation of estrogen and activation of environmental carcinogens [3]. CYP1B1 expression can be ...

... all of which are also known as catechol estrogens how to remain intimate when taking tamoxifen I have an appointment tomorrow ... The goal of hormonal therapy is to lower the levels of estrogen and progesterone in the body or to block these hormones from ...

Estrogens, Catechol. *Guaiacol. *Nordihydroguaiaretic Acid. *Methyl Ethers. *Anisoles. *Bis(Chloromethyl) Ether. *Enflurane ...

Polymorphisms of the estrogen-metabolizing genes CYP17 and catechol-O-methyltransferase and risk of epithelial ovarian cancer. ... Expression of human estrogen receptor-alpha and -beta, progesterone receptor, and androgen receptor mRNA in normal and ...

Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence. [PMID 18715757. ] Genetic ... PMID 24320736] Role of single nucleotide polymorphisms in estrogen-metabolizing enzymes and susceptibility to uterine leiomyoma ... Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and ... PMID 20667552] Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis ...