Identification of antigenic epitopes on the F and G glycoproteins of bovine respiratory syncytial virus and in vitro assessment ... This study was undertaken to identify antigenic epitopes on two of the surface glycoproteins of BRSV, the fusion (F) and ...
A novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to Omicron. Palatnik-de-Sousa I ... It is composed of highly promiscuous and strong HLA binding CD4 and CD8 T cell epitopes of the S, M, N, E, ORF1ab, ORF 6 and ... An extended epitope-conservancy analysis performed using GISAID metadata of 3,630,666 SARS-CoV-2 genomes of these variants and ... Based on the analysis of one genome per WHO clade, the epitopes were 100% conserved among the Wuhan-Hu1, Alpha, Beta, Gamma, ...
The precise epitopes in IA-2 of two different MoAbs (76B and 76F) were also investigated. These precise epitope investigations ... Thus, the overall motif or GAD-6 may correspond to 523-528 aa of GAD-65 (M-S-R-L-S-K). To further define the GAD-6 epitope, ... as public epitopes of SMS patients sera. Sequencing of 76B and 76F MoAbs reactive peptides, which were obtained from the ... The studies described in this thesis have shown that the epitope mapping of different antibodies on GAD-65 and IA-2 may help to ...
Therefore, we developed a new oncolytic vaccine platform that uses the virus as adjuvant for MHC-I tumor epitopes that are ... Furthermore, we observed an increased presence of mature and epitope-specific dendritic cells in the spleens of mice treated ... By using the model epitope SIINFEKL, we studied the efficacy of the peptide-coated conditionally replicating adenoviruses ( ... Oncolytic adenoviruses coated with MHC-I tumor epitopes for a new oncolytic vaccine platform ...
Pathogenicity and Epitope Characteristics Do Not Differ in IgG Subclass-Switched Anti-Desmoglein 3 IgG1 and IgG4 Autoantibodies ... Pathogenicity and Epitope Characteristics Do Not Differ in IgG Subclass-Switched Anti-Desmoglein 3 IgG1 and IgG4 Autoantibodies ... Pathogenicity and Epitope Characteristics Do Not Differ in IgG Subclass-Switched Anti-Desmoglein 3 IgG1 and IgG4 Autoantibodies ...
Conserved epitopes of DENV structural and non-structural proteins for exploring universal vaccine targets. Author(s): Mansi ... Using comparative genomics and immune informatics approach, we could find conserved epitopes which can be explored as peptide ... From our analysis we successfully found 100% conserved epitopes in Envelope protein (RCPTQGE); NS3 (SAAQRRGR, PGTSGSPI); NS4A ( ...
U Kees, P H Krammer; Most influenza A virus-specific memory cytotoxic T lymphocytes react with antigenic epitopes associated ... Most influenza A virus-specific memory cytotoxic T lymphocytes react with antigenic epitopes associated with internal virus ... which are primarily directed towards epitopes on the virus surface glycoproteins. This finding may be relevant for the role of ... indicates that most antigenic epitopes recognized are associated with internal virus determinants. X31 and PR8 share the ...
... and identified 24 additional novel epitopes. With these epitopes, we created a TT epitope pool, which allowed us to ... Forty-seven epitopes were identified following in vitro TT stimulation, with 28 epitopes accounting for 90% of the total ... Herein we defined the human CD4+ T cell epitope repertoire by reevaluation of previously described epitopes and evaluation of ... Despite this diverse range of epitopes, individual responses were associated with only a few immunodominant epitopes, with each ...
... it is now more convenient to design multi-epitope vaccines comprising predicted immuno-dominant epitopes of multiple antigenic ... We have chosen four antigenic proteins of Leishmania donovani and identified their T-cell and B-cell epitopes, ... The vaccine construct is generated by joining the epitopes with specific linkers. The predicted tertiary structure of the ... From: In-silico design of an immunoinformatics based multi-epitope vaccine against Leishmania donovani ...
... one exclusive epitope for invertebrate subfamily and two exclusive epitopes for vertebrate family were predicted. These ... A voting mechanism-based linear epitope (LE) prediction system was applied to identify and endorse LE candidates with a minimum ... which can be considered as exclusive features for in-silico prediction of effective epitopes for vaccine development. ... only for the host-specific subfamily Host-specific characteristics are important features and constraints for effective epitope ...
Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against ... strongly suggesting that they recognize a quaternary epitope encompassing both Gn and Gc. ADI-42898 blocked the cell entry of ...
Given the importance of the cell wall as a drug target, understanding how this fungus maintains integrity and epitope masking ... Exposure levels of this epitope may be important, as Dectin-1 mediates protection from some strains of C. albicans and ... Work we participated in helped elucidate mechanisms involved in baseline fungal epitope masking in the form of Cho1 and ... suggesting that this epitope unmasking could have functional consequences during infection. ...
Shotgun Mutagenesis Epitope Mapping can be used to identify both linear and conformational epitopes at amino-acid resolution, ... What is needed to start a Shotgun Mutagenesis Epitope Mapping project? To begin an epitope mapping project, we require the ... Shotgun Mutagenesis Epitope Mapping is suited to mapping antibody epitopes on any protein target, including GPCRs, ion channels ... How does Integral Molecular perform its Epitope Mapping service? Our epitope mapping approach utilizes Shotgun Mutagenesis, a ...
CMV epitope selection and its use in T cell reconstitution in patients undergoing haematopoietic stem cell transplantation. ... CMV epitope selection and its use in T cell reconstitution in patients undergoing haematopoietic stem cell transplantation. ... CMV epitope selection and its use in T cell reconstitution in patients undergoing haematopoietic stem cell transplantation.. ... By using overlapping 15mer peptides both the IE1 and pp65 antigens were mapped and new epitopes are described that could be ...
Using the polymerase chain-reaction to modify expression plasmids for epitope mapping. Nucleic Acids Researc , 17 (8) 3319 - ... Using the polymerase chain-reaction to modify expression plasmids for epitope mapping ... Using the polymerase chain-reaction to modify expression plasmids for epitope mapping. ...
In our cohort of subjects with chronic HCV infection (genotype 1b or 3a), it is a frequently recognized CD8 epitope in HLA-A*01 ... The aim of this study was to characterize the forces that contribute to viral evolution in an HLA-A*01-restricted epitope in ... This epitope represents a potentially attractive target for vaccination strategies since it is conserved across all genotypes. ... can result from mutational escape in targeted T-cell epitopes. Recent studies suggest that T-cell immune pressure is an ...
Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyefitis. ... Dive into the research topics of Functional evidence for epitope spreading in the relapsing pathology of experimental ...
The amino acid sequence of the peptide epitope was compared to six other known virus peptides known to be restricted by HLA B8 ... The dominant epitope was mapped using recombinant vaccinia viruses that expressed fragments of the NP and then synthetic ... One of the predicted epitope peptides was made and shown to be recognized by specific CTL. These and the two others were shown ... and a sequence homology was identified, which predicted nonamer and octamer epitope sequences. Probable anchor residues were ...
A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in ... as MAGE-A3 epitopes [32]. The peptides of the predicted epitopes were then synthesized for MHC-I binding and peptides exchange ... E) Summary of the predicted HLA-A2 restricted T cell epitopes from MAGE-A3. (F-G) Comparison of the predicted MAGE-A3 epitopes ... CD8(+) T-Cell Epitope Variations Suggest a Potential Antigen HLA-A2 Binding Deficiency for Spike Protein of SARS-CoV-2. Front ...
Precise location of linear epitopes on the capsid surface of feline calicivirus recognized by neutralizing and non-neutralizing ... Precise location of linear epitopes on the capsid surface of feline calicivirus recognized by neutralizing and non-neutralizing ...
"Epitopes, B-Lymphocyte" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Epitopes, B-Lymphocyte" by people in this website by year, and ... Epitopes recognized by the B-cell receptor are located on the surface of the antigen. ... Below are the most recent publications written about "Epitopes, B-Lymphocyte" by people in Profiles. ...
Ron-Harel N, Santos D, Ghergurovich J, Sage P, Reddy A, Lovitch S, Dephoure N, Satterstrom K, Sheffer M, Spinelli J, Gygi S, Rabinowitz J, Sharpe A, Haigis M. Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metab. 2016;24(1):104-17. PMCID: ...
Ontology of Immune Epitopes metasource: Fairsharing.org version: FAIRsharing.org: ONTIE; Ontology of Immune Epitopes; DOI: ... Ontology of Immune Epitopes metasource: Fairsharing.org version: FAIRsharing.org: ONTIE; Ontology of Immune Epitopes; DOI: ... Immune Epitope Database. The IEDB provides the scientific community with a central repository of freely accessible epitope data ... Ontology of Immune Epitopes Names. More detailed information about this field from each metasource. × ...
title = "Epitopes",. abstract = "Epitopes are three-dimensional structures on the surface of biological molecules that mediate ... Epitopes. / Muller, C.P. Encyclopedia of Life Sciences (ELS). London: John Wiley & Sons, Ltd, 2001. p. 1-11.. Research output: ... Epitopes. In Encyclopedia of Life Sciences (ELS). London: John Wiley & Sons, Ltd. 2001. p. 1-11 doi: 10.1038/npg.els.0000514 ... N2 - Epitopes are three-dimensional structures on the surface of biological molecules that mediate specific recognition by the ...
Resolving SARS-CoV-2 CD4+ T cell specificity via reverse epitope discovery. Pogorelyy et al.. Published:. 23 June 2022, Version ...
Check out our selection of Epitope Tags - Bioreagent - Online purchasing ...
Epitope Tag Antibodies. An epitope is an antigenic determinant, a biological structure or sequence to which an antibody binds. ... The use of epitope tags eliminates the additional step of using a different antibody for each newly purified protein. The most ... NovoPro offers highly specific antibodies to all of these epitope tags. Our tagged antibodies are manufactured under extensive ... commonly used epitope tags include His (6-Histidine), HA (Hemagglutinin), cMyc, GST, and Flag (DYKDDDDK) tag. ...
T cell epitope recognition involved in the low-responsiveness to a region of hen egg lysozyme (46-61) in C57BL/6 mice. ... Dive into the research topics of T cell epitope recognition involved in the low-responsiveness to a region of hen egg lysozyme ...
... epitopes of high variability, and (ii) conserved epitopes of low immunogenicity. This requires vaccines directed against the ... The identification of epitopes of limited variability offers a mechanism by which a universal influenza vaccine can be created ... Here we report the identification of such an epitope of limited variability in the head domain of the H1 haemagglutinin protein ... We show that the epitope mediates immunity to historical influenza strains not previously seen by a cohort of young children. ...