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*  The Genetic Architecture of Degenerin/Epithelial Sodium Channels in Drosophila
Evolution of the epithelial sodium channel and the sodium pump as limiting factors of aldosterone action on sodium transport. ... Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Physiol. Rev. 82: ... The Genetic Architecture of Degenerin/Epithelial Sodium Channels in Drosophila. Kathleen M. Zelle,1 Beika Lu,1,2 Sarah C. ... Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC). Adv. Genet. 76: 1-26 [PMC free article] [PubMed] ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3583452/?lang=en-ca
*  Epithelial sodium channel - Wikipedia
The epithelial sodium channel (short: ENaC, also: amiloride-sensitive sodium channel) is a membrane-bound ion channel that is ... and are also thought to form sodium channels. The epithelial sodium(Na+) channel (ENac) family belongs to the ENaC/P2X ... Ion Channel Diseases Epithelial sodium channel at the US National Library of Medicine Medical Subject Headings (MeSH) This ... Horisberger JD, Chraïbi A (2004). "Epithelial sodium channel: a ligand-gated channel?". Nephron. Physiology. 96 (2): 37-41. doi ...
https://en.wikipedia.org/wiki/Epithelial_sodium_channel
*  The Genetic Architecture of Degenerin/Epithelial Sodium Channels in Drosophila | G3: Genes | Genomes | Genetics
2011 Evolution of the epithelial sodium channel and the sodium pump as limiting factors of aldosterone action on sodium ... 2002 Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Physiol. Rev. ... 1995 Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel. Am. J. Physiol. 268: C1157- ... The Genetic Architecture of Degenerin/Epithelial Sodium Channels in Drosophila. Kathleen M. Zelle, Beika Lu, Sarah C. Pyfrom ...
http://www.g3journal.org/content/3/3/441.long
*  Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface | Biochemical Journal
The human ENaC (epithelial sodium channel), a complex of three subunits, provides the rate-limiting step for sodium uptake in ... Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface. Dominik Wiemuth, Ying Ke, Meino Rohlfs, Fiona J. ... Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface. Dominik Wiemuth, Ying Ke, Meino Rohlfs, Fiona J. ... Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface Message Subject (Your Name) has forwarded a page to ...
http://www.biochemj.org/content/405/1/147
*  Four subunits (αβγδ) of the epithelial sodium channel (ENaC) are expressed in the human eye in various locations. | Sigma...
The epithelial sodium channel (ENaC) is typically expressed in sodium-absorbing epithelia. Several reports suggest that ENaC is ... Anti-γ-Epithelial Cell Sodium Channel antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution ... Four subunits (αβγδ) of the epithelial sodium channel (ENaC) are expressed in the human eye in various locations.. [Bettina ... with distinct localization of subunits possibly reflecting different functional states of the channel. The (patho-) ...
https://www.sigmaaldrich.com/catalog/papers/22167092
*  Endothelial Epithelial Sodium Channel Inhibition Activates Endothelial Nitric Oxide Synthase via Phosphoinositide 3-Kinase/Akt...
Renal sodium handling: the role of the epithelial sodium channel. J Am Soc Nephrol. 2005; 16: 3151-3153. ... Kellenberger S, Schild L. Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared ... The epithelial sodium channel (ENaC) is present in distal nephron segments and the colonic epithelium, where it mediates ... Garty H, Palmer L. Epithelial sodium channels: function, structure, and regulation. Physiol Rev. 1997; 77: 359-396. ...
http://hyper.ahajournals.org/content/53/6/1000
*  Novel mutations responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial...
Previously we showed that mutations in the epithelial sodium channel (ENaC) alpha-, beta-, and gamma-subunits are responsible ... responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel ... responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel ... responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel ...
http://discovery.ucl.ac.uk/406/
*  Recherche uO Research: Epithelial Sodium Channels in the Brain: Effect of High Salt Diet on Their Expression
Epithelial Sodium Channels in the Brain: Effect of High Salt Diet on Their Expression. Description. Title: Epithelial Sodium ... Hypothesis: 1. Epithelial sodium channels are expressed in the brain. 2. Expression of ENaC is increased in the kidneys and ... Statement of the problem: The epithelial sodium channels (ENaC) play an important role in regulation of blood pressure (BP). ... Channels in the Brain: Effect of High Salt Diet on Their Expression. ...
https://ruor.uottawa.ca/handle/10393/20074
*  JCI - Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension
Dysfunction of the epithelial sodium channel expressed in the kidney of a mouse model for Liddle syndrome. J Am Soc Nephrol. ... Activation of the epithelial sodium channel (ENaC) by serine proteases. Annu Rev Physiol. 2009;71:361-379.. View this article ... Liddle's syndrome: heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel. Cell. ... Salt-induced hypertension in a mouse model of liddle syndrome is mediated by epithelial sodium channels in the brain. ...
https://www.jci.org/articles/view/61110
*  Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the beta-subunit of the amiloride...
The amiloride-sensitive epithelial sodium channel (ENaC) is a heteromultimer of three homologous subunits (alpha-, beta-, and ... The amiloride-sensitive epithelial sodium channel (ENaC) is a heteromultimer of three homologous subunits (alpha-, beta-, and ... type 1 in mice expressing low levels of the beta-subunit of the amiloride-sensitive epithelial sodium channel Pradervand, S. ; ... type 1 in mice expressing low levels of the beta-subunit of the amiloride-sensitive epithelial sodium channel ...
https://infoscience.epfl.ch/record/115123
*  "Polymorphisms of SCNNIG . . ." by Xin Xu, Tianhua Niu et al.
It consists of at least 3 subunits (a, /?, and y) of similar structure and plays an important role in sodium and fluid ... Defects of this channel have been critically implicated in Liddle syndrome (pseudoaldosteronism) and pseudohypoaldosteronism ... The amiloride-sensitive epithelial sodium channel is a highly selective sodium channel that constitutes the rate-limiting step ... The amiloride-sensitive epithelial sodium channel is a highly selective sodium channel that constitutes the rate-limiting step ...
https://digitalcommons.wayne.edu/humbiol/vol71/iss5/4/
*  Unique eyelid manifestations in type 1 pseudohypoaldosteronism | ADC Fetal & Neonatal Edition
Autosomal-recessive PHA1 that involves a genetic defect in the epithelial sodium channel that affects all aldosterone target ...
http://fn.bmj.com/content/97/6/F462
*  2nsq - Proteopedia, life in 3D
The ubiquitin E3 protein ligase Nedd4-2 is a physiological regulator of the epithelial sodium channel ENaC, which is essential ... 14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ... Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination. Circ Res. 2004 Aug 6;95(3):284-91 ... 14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ...
http://proteopedia.org/wiki/index.php/2nsq
*  Acid Sensing Ion Channels (ASIC)
Acid sensing ion channels are voltage-indipendent, proton activated receptors that belong to the epithelial sodium channel ( ... proton-activated receptors that belong to the epithelial sodium channel/degenerin family of ion channels and are implicated in ... ACID SENSIG ION CHANNEL (ASIC 1a). Acid-sensing ion channels (ASICs) are voltage-independent, ... Even the earliest papers describing H+-activated channels recognized that the channels might function as nociceptors. ...
http://flipper.diff.org/app/items/5368
*  "Psalmotoxin-1 and nonproton ligand interactions with acid-sensing ion " by Rachel N. Smith B.S.
... sodium-selective channels activated by extracellular protons. Although ASICs are intriguing molecular targets for ... We then theorized that direct activation of rASIC3 by GMQ is possible due the channel's interaction with extracellular calcium ... Taken together, we identified that channel state influences nonproton ligand interaction with ASICs, and the transmembrane ... despite having no direct modulation effect on the channel. We proposed that nonproton ligand activation of ASIC1 may be state ...
https://digitalcommons.hsc.unt.edu/theses/826/
*  Prostasin: An Epithelial Sodium Channel Regulator
"Camostat attenuates airway epithelial sodium channel function in vivo through the inhibition of a channel-activating protease ... Prostasin: An Epithelial Sodium Channel Regulator. Shakti Aggarwal,1 Pradeep K. Dabla,2 and Sarika Arora1 ... J. M. Hollier, D. F. Martin, D. M. Bell et al., "Epithelial sodium channel allele T594M is not associated with blood pressure ... S. H. Donaldson, A. Hirsh, D. C. Li et al., "Regulation of the epithelial sodium channel by serine proteases in human airways ...
https://www.hindawi.com/journals/jbm/2013/179864/ref/
*  Species: Epithelial sodium channel (IPR001873) | InterPro | EMBL-EBI
Species: Epithelial sodium channel (IPR001873). Key Species. Key species. Number of proteins. FASTA. Protein IDs. ...
http://www.ebi.ac.uk/interpro/entry/IPR001873/taxonomy
*  epithelial Sodium Channel gamma: Novus Biologicals
Browse our epithelial Sodium Channel gamma all backed by our Guarantee+. ... epithelial Sodium Channel gamma available through Novus Biologicals. ...
https://www.novusbio.com/gene-id/6340
*  An oxygen-sensitive mechanism in regulation of epithelial sodium channel | PNAS
Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial ... 2007) The epithelial sodium channel (ENaC) traffics to apical membrane in lipid rafts in mouse cortical collecting duct cells. ... Epithelial sodium channels (ENaCs) are of immense importance, controlling Na+ transport across epithelia and thus playing a ... 2002) Endogenously expressed epithelial sodium channel is present in lipid rafts in A6 cells. J Biol Chem 277:33541-33544. ...
http://www.pnas.org/content/106/8/2957
*  Base of the thumb domain modulates epithelial sodium channel gating. - PubMed - NCBI
Base of the thumb domain modulates epithelial sodium channel gating.. Shi S1, Ghosh DD, Okumura S, Carattino MD, Kashlan OB, ... The activity of the epithelial sodium channel (ENaC) is modulated by multiple external factors, including proteases, cations, ... self-inhibition responses of wild type channels, α furin mutant (αR205A, R231A (αR/A)) channels, and channels with the α furin ... 3W refers αY418WβY356WγY375W channels. The ILSS/Ibasal for wild-type channels was 2.16 ± 0.06 (n = 125). C, time constants of ...
https://www.ncbi.nlm.nih.gov/pubmed/21367859
*  Epithelial Sodium Channels and Hypertension | Drug Metabolism & Disposition
Of the renal sodium transporters, the amiloride-sensitive epithelial sodium channels (ENaC), which are responsible for the rate ... Epithelial Sodium Channels and Hypertension Message Subject (Your Name) has forwarded a page to you from Drug Metabolism & ... Epithelial Sodium Channels and Hypertension. Yan Ru Su and Anil G. Menon ... Epithelial Sodium Channels and Hypertension. Yan Ru Su and Anil G. Menon ...
http://dmd.aspetjournals.org/content/29/4/553.abstract
*  Frontiers | Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines | Immunology
Cytokines and chemokines affect alveolar amiloride-sensitive epithelial sodium channels (ENaC) which play a crucial role in ... Reabsorption is a two-step process: first, sodium enters via sodium-permeable channels in the apical membranes of alveolar type ... via sodium-permeable channels in the apical membranes of alveolar type 1 and 2 cells followed by active extrusion of sodium ... Cytokines and chemokines affect alveolar amiloride-sensitive epithelial sodium chan... ...
https://www.frontiersin.org/articles/10.3389/fimmu.2017.00766/full
*  New Insights into the Epithelial Sodium Channel Using Directed Mutagenesis | IntechOpen
New Insights into the Epithelial Sodium Channel Using Directed Mutagenesis , IntechOpen, Published on: 2013-02-05. Authors: ... 1995A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte ... 1998Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus ... The epithelial sodium channel (ENaC) has been used for decades as a therapeutic target against type 1 hypertension and Liddle ...
https://www.intechopen.com/books/genetic-manipulation-of-dna-and-protein-examples-from-current-research/new-insights-into-the-epithelial-sodium-channel-using-directed-mutagenesis/
*  Epithelial sodium channel blocker - Wikipedia
An epithelial sodium channel blocker is a sodium channel blocker that is selective for the epithelial sodium channel. An ... Sagnella GA, Swift PA (2006). "The renal epithelial sodium channel: genetic heterogeneity and implications for the treatment of ...
https://en.wikipedia.org/wiki/Epithelial_sodium_channel_blocker
*  Liddle's syndrome: heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel |...
Public Health Sodium Hypertension Sodium Channel Human Hypertension These keywords were added by machine and not by the authors ... Liddle's syndrome: heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel. ...
https://link.springer.com/article/10.1007/BF00866777