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Functional dyadicity and heterophilicity of gene-gene interactions in statistical epistasis networks | BioData Mining | Full...  Functional dyadicity and heterophilicity of gene-gene interactions in statistical epistasis networks | BioData Mining | Full...
DyadicityHeterophilicityEpistasisGene-gene interactionsGenetic association studiesStatistical epistasis networksFunctional ... Most existing epistasis network methodologies construct genetic interaction networks by assigning vertices as genetic ... Epistasis - the essential role of gene interactions in the structure and evolution of genetic systems. Nat Rev Genet. 2008; 9: ... Statistical epistasis networks reduce the computational complexity of searching three-locus genetic models. Proc Pac Symp ...
more infohttps://biodatamining.biomedcentral.com/articles/10.1186/s13040-015-0062-4
Single nucleotide polymorphisms linked to quantitative trait loci for grain quality traits in wheat  Single nucleotide polymorphisms linked to quantitative trait loci for grain quality traits in wheat
Keywords: Triticum Aestivum; Epistasis; Grain Quality Traits; Qtl X Environments; Interaction; Snp ... a high-density genetic map with single nucleotide polymorphism (SNP) and simple sequence repeat (SSR) markers was developed ...
more infohttp://krex.k-state.edu/dspace/handle/2097/33970
A combined strategy for quantitative trait loci detection by genome-wide association | BMC Proceedings | Full Text  A combined strategy for quantitative trait loci detection by genome-wide association | BMC Proceedings | Full Text
... epistasis test). Only pairs that were significant for the first test enter the epistasis test. When either SNP1 or SNP2 is a ... At first, a variance components linkage analysis [4] was used to evaluate the significance of the additive genetic variance ... before the epistasis test. When both SNP1 and SNP2 are qSNPs, only the epistasis test is needed. To avoid spurious interactions ... The -LOG10 (P) value for epistasis tests are in brackets.. c: estimate of the "1/2" genotype in contrast to the "1/1" genotype ...
more infohttps://bmcproc.biomedcentral.com/articles/10.1186/1753-6561-3-S1-S6
Hitchhiker's Guide to the Galaxy  on Pleiotropy  Hitchhiker's Guide to the Galaxy on Pleiotropy
Genetic architecture. *Canalisation. *Genetic assimilation. *Dominance. *Epistasis. * Fitness landscape/evolutionary landscape ... Beadle, G. W.; Tatum, E. L. (1941). "Genetic control of biochemical reactions in Neurospora". Proc. Natl. Acad. Sci. USA. 27: ... Pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. The underlying mechanism is genes that ... Sickle cell anemia is a genetic disease that causes deformed red blood cells with a rigid, crescent shape instead of the normal ...
more infohttp://hitchhikersgui.de/Pleiotropy
Epistasis, Genetic | Harvard Catalyst Profiles | Harvard Catalyst  Epistasis, Genetic | Harvard Catalyst Profiles | Harvard Catalyst
Genetic" by people in Harvard Catalyst Profiles by year, and whether "Epistasis, Genetic" was a major or minor topic of these ... "Epistasis, Genetic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Epistasis, Genetic" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Epistasis, Genetic". ...
more infohttps://connects.catalyst.harvard.edu/Profiles/display/Concept/Epistasis,%20Genetic
Widespread genetic epistasis among cancer genes « Research Papers « Institute for Genomics and Systems Biology  Widespread genetic epistasis among cancer genes « Research Papers « Institute for Genomics and Systems Biology
Widespread genetic epistasis among cancer genes. by Kevin White, Megan McNerney, Wang X, Fu AQ ... Quantitative genetic epistasis has been hypothesized to be an important factor in the development and progression of complex ... However, as cancer mutations are uncovered at an unprecedented rate, determining which combinations of genetic alterations ... indicating that genetic interaction mapping may be leveraged to improve risk assessment. As many of these interacting gene ...
more infohttp://www.igsb.org/papers/widespread-genetic-epistasis-among-cancer-genes
On the relationship between epistasis and genetic variance heterogeneity.  On the relationship between epistasis and genetic variance heterogeneity.
Epistasis and genetic variance heterogeneity are two non-additive genetic inheritance patterns that are often, but not always, ... and genetic variance heterogeneity, and a brief discussion about how genetic processes other than epistasis can also give rise ... Epistasis, gene action, genetic variance heterogeneity, genotype-phenotype maps, non-additive, quantitative genetics HSV ... On the relationship between epistasis and genetic variance heterogeneity.. Forsberg, Simon K. G. Uppsala universitet, ...
more infohttp://uu.diva-portal.org/smash/record.jsf?faces-redirect=true&language=no&searchType=SIMPLE&query=&af=%5B%5D&aq=%5B%5B%5D%5D&aq2=%5B%5B%5D%5D&aqe=%5B%5D&pid=diva2%3A1153928&noOfRows=50&sortOrder=author_sort_asc&sortOrder2=title_sort_asc&onlyFullText=false&sf=all
Importance of epistasis as the genetic basis of heterosis in an elite rice hybrid | PNAS  Importance of epistasis as the genetic basis of heterosis in an elite rice hybrid | PNAS
Importance of epistasis as the genetic basis of heterosis in an elite rice hybrid. S. B. Yu, J. X. Li, C. G. Xu, Y. F. Tan, Y. ... Population genetic analyses have also established that epistasis, functioning to assemble and maintain favorable multilocus ... Importance of epistasis as the genetic basis of heterosis in an elite rice hybrid ... Based on this perspective, epistasis should be one of the most important genetic components in the inheritance of quantitative ...
more infohttps://www.pnas.org/content/94/17/9226?ijkey=8fa1947a05a9db476c5849668faba7c7079df1bb&keytype2=tf_ipsecsha
Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism...  Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism...
Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism ... In contrast, the l allele of the 5-HTTLPR also emerged as a genetic risk factor for depression in carriers of one or two Met ...
more infohttps://insights.ovid.com/pnpbp/201203300/00079304-201203300-00009
An omnibus permutation test on ensembles of two-locus analyses can detect pure epistasis and genetic heterogeneity in genome...  An omnibus permutation test on ensembles of two-locus analyses can detect pure epistasis and genetic heterogeneity in genome...
... to detect pure epistasis in the presence of genetic heterogeneity. The performance of 2LOmb is evaluated in various simulation ... the findings indicate the detection of pure epistasis in the presence of genetic heterogeneity and provide an alternative ... Since 2LOmb analysis cannot solely distinguish genetic association due to pure epistasis from genetic association due to LD, it ... This signifies the presence of both pure epistasis and genetic heterogeneity. The evidence of genetic association for these ...
more infohttps://springerplus.springeropen.com/articles/10.1186/2193-1801-2-230
supplementary - BIO 390 GENETICS FROM GENE TO PHENOTYPE DOMINANCE EPISTASIS GENE INTERACTION O VERVIEW Genetic and...  supplementary - BIO 390 GENETICS FROM GENE TO PHENOTYPE DOMINANCE EPISTASIS GENE INTERACTION O VERVIEW Genetic and...
BIO 390 - GENETICS FROM GENE TO PHENOTYPE DOMINANCE, EPISTASIS, GENE INTERACTION O VERVIEW - Genetic and environmental ... Modified genetic ratios reveal gene interactions, including epistasis. ... OVERVIEW - Genetic and environmental contributions interact to determine phenotype. - Mutations in same the gene usually result ...
more infohttps://www.coursehero.com/file/6325911/supplementary/
On epistasis, or how genetic analysis can mislead us about biological processes. | Martinez-Arias Lab  On epistasis, or how genetic analysis can mislead us about biological processes. | Martinez-Arias Lab
One thought on "On epistasis, or how genetic analysis can mislead us about biological processes." * Pingback: What do genetic ... On epistasis, or how genetic analysis can mislead us about biological processes.. Posted on January 30, 2013. by admin ... Combinatorial synthesis of genetic networks. Science 296, 1466-1470). Epistasis is a tool, and it needs to be complemented by ... Epistasis: the essential role of gene interactions in the structure and evolution of genetic systems. Nature Rev. Genet. 9, 855 ...
more infohttp://amapress.gen.cam.ac.uk/?p=914
Estimation and interpretation of genetic effects with epistasis using the NOIA model  Estimation and interpretation of genetic effects with epistasis using the NOIA model
... Alvarez-Castro, J.M. ... especially concerning epistasis. Then, we present methods for the use of genetic modeling in QTL analyses. In particular, we ... Second, we make the required theory handy for the reader to relate the genetic concepts to the particular mathematical ... by providing graphical interpretations and a diagram summarizing the key features for applying genetic modeling with epistasis ...
more infohttp://du.diva-portal.org/smash/record.jsf?pid=diva2%3A528100&c=27&searchType=ORGANISATION&language=en&query=&af=%5B%5D&aq=%5B%5B%7B%22organisationId%22%3A%229436%22%7D%5D%5D&aq2=%5B%5B%5D%5D&aqe=%5B%5D&noOfRows=50&sortOrder=author_sort_asc&sortOrder2=title_sort_asc&onlyFullText=false&sf=all
Testing the DISC1 pathway for functional genetic variation and epistasis in major - William McCombie  Testing the DISC1 pathway for functional genetic variation and epistasis in major - William McCombie
Testing the DISC1 pathway for functional genetic variation and epistasis in major McCombie, William Richard Porteous, David J. ... Testing the DISC1 pathway for functional genetic variation and epistasis in major. McCombie, William Richard; Porteous, David J ... Testing the DISC1 pathway for functional genetic variation and epistasis in major. McCombie, William Richard; Porteous, David J ... Testing the DISC1 pathway for functional genetic variation and epistasis in major. McCombie, William Richard; Porteous, David J ...
more infohttp://grantome.com/grant/NIH/R01-MH102068-01
Cancer type‐dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types...  Cancer type‐dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types...
This plasticity of epistasis across cell types is likely to be a basic feature of genetic architecture in multicellular ... Figure 4. Implications of cell type‐specific epistasis for evolution, for other genetic diseases, and for cancer therapy. *. ... This plasticity of epistasis across cell types has important implications for cancer therapy, genetic architecture and ... Cancer type‐dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types ...
more infohttp://msb.embopress.org/content/11/7/824
Cancer type‐dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types...  Cancer type‐dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types...
Cancer type‐dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types ...
more infohttp://msb.embopress.org/content/11/7/824.transparent-process
Microbiome interactions shape host fitness | PNAS  Microbiome interactions shape host fitness | PNAS
Mathematics of Genetic Epistasis Allow Quantification of Context Dependence in Microbiome Interactions.. Our results indicate ... genetic epistasis provides a template. We make the explicit analogy between genes in a genome and microbial species in a ... we calculated the impact of bacterial interactions on fly fitness by adapting the mathematics of genetic epistasis to the ... S13 A-C), which is analogous to conditional epistasis in genetics (21). This context is visualized in Fig. 5 and SI Appendix, ...
more infohttps://www.pnas.org/content/115/51/E11951
Aquaculture | FAO TERM PORTAL | Food and Agriculture Organization of the United Nations  Aquaculture | FAO TERM PORTAL | Food and Agriculture Organization of the United Nations
Genetic variance IIA Integrated irrigation-aquaculture VI Epistasis genetic variance IPM Integrated pest management ...
more infohttp://www.fao.org/faoterm/collection/aquaculture/en/?lang=zh&id_lang=TERMS_C
Shyam Visweswaran, MD, PhD | Department of Biomedical Informatics  Shyam Visweswaran, MD, PhD | Department of Biomedical Informatics
Learning genetic epistasis using Bayesian network scoring criteria. Jiang X, R.E. Neapolitan, M.M. Barmada, S.Visweswaran. ... Learning genetic epistasis using Bayesian network scoring criteria. BMC Bioinformatics; 2011: 12(89). PMID: 21453508 ... Application of a spatially-weighted Relief algorithm for ranking genetic predictors of disease. BioData Mining. 2012 Dec 3;5(1 ... Application of a spatially-weighted Relief algorithm for ranking genetic predictors of disease. ...
more infohttp://www.dbmi.pitt.edu/publications/41?page=3
Genetic Determinants of the Network of Primary Metabolism and Their Relationships to Plant Performance in a Maize Recombinant...  Genetic Determinants of the Network of Primary Metabolism and Their Relationships to Plant Performance in a Maize Recombinant...
2008). Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems. Nat. Rev. Genet. 9 ... Regulatory or enzymatic interactions can generate genetic epistasis through functional epistasis, for instance, transcription ... 1997). Importance of epistasis as the genetic basis of heterosis in an elite rice hybrid. Proc. Natl. Acad. Sci. USA 94: 9226- ... QTL Identification and Genetic Epistasis for Maize Metabolic Variation. We mapped QTL associated with variation in the levels ...
more infohttp://www.plantcell.org/content/27/7/1839.full
Multicohort Analysis of Whole-Blood Gene Expression Data Does Not Form a Robust Diagnostic for Acute Respiratory Distress...  Multicohort Analysis of Whole-Blood Gene Expression Data Does Not Form a Robust Diagnostic for Acute Respiratory Distress...
Epistasis, Genetic. A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a ... Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during ... Ectopic Gene Expression is often induced artificially by genetic techniques.. ...
more infohttps://www.bioportfolio.com/resources/pmarticle/1941738/Multicohort-Analysis-of-Whole-Blood-Gene-Expression-Data-Does-Not-Form-a.html
Bevacizumab, Pemetrexed Disodium, and Cisplatin or Erlotinib Hydrochloride and Bevacizumab in Treating Patients With Stage IV...  Bevacizumab, Pemetrexed Disodium, and Cisplatin or Erlotinib Hydrochloride and Bevacizumab in Treating Patients With Stage IV...
Epistasis, Genetic. A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a ... Ectopic Gene Expression is often induced artificially by genetic techniques.. ...
more infohttps://www.bioportfolio.com/resources/trial/65347/Bevacizumab-Pemetrexed-Disodium-and-Cisplatin-or-Erlotinib-Hydrochloride-and-Bevacizumab-in-Treating.html
Abstract Presentation Assignments: B | ASHG 2013 Annual Meeting  Abstract Presentation Assignments: B | ASHG 2013 Annual Meeting
Identification of genetic epistasis in .... PLATFORM. Session #56. Haplotypes, Imputation and Interactions. 353. Friday, ... Genetic Research and diagnostic using .... POSTER. Clinical Genetic Testing. 2609W. Wednesday, Oct. 23. Convention Center, ... NAT1 in an important genetic effect .... PLATFORM. Session #25. Genetic Interactions in Complex Traits. 143. Thursday, October ... Genetic testing for mitochondrial .... PLATFORM. Session #11. The Shifting Landscape of Genetic Testing: Approaches and Success ...
more infohttp://www.ashg.org/2013meeting/abstracts/assignments/B.shtml
Are Genetic Interactions Influencing Gene Expression Evidence for Biological Epistasis or Statistical Artifacts? | Haldane's...  Are Genetic Interactions Influencing Gene Expression Evidence for Biological Epistasis or Statistical Artifacts? | Haldane's...
... dx.doi.org/10.1101/020479 Interactions between genetic variants, also called epistasis, are pervasive in model organisms; ... Are Genetic Interactions Influencing Gene Expression Evidence for Biological Epistasis or Statistical Artifacts? Alexandra Fish ... Are Genetic Interactions Influencing Gene Expression Evidence for Biological Epistasis or Statistical Artifacts?. Posted on ... Interactions between genetic variants, also called epistasis, are pervasive in model organisms; however, their importance in ...
more infohttps://haldanessieve.org/2015/06/10/are-genetic-interactions-influencing-gene-expression-evidence-for-biological-epistasis-or-statistical-artifacts/