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*  Repositorio Institucional de la Universidad de Granada: Promoter DNA Hypermethylation and Gene Repression in Undifferentiated...
Histone-based epigenetic mechanisms are important for regulating this undifferentiated state. Here we report the use of genetic ... Promoter DNA Hypermethylation and Gene Repression in Undifferentiated Arabidopsis Cells. Authors: Berdasco, María. Alcázar, ... Our results suggest that promoter DNA methylation may be another important epigenetic mechanism for the establishment and/or ... Promoter DNA Hypermethylation and Gene Repression in Undifferentiated Arabidopsis Cells. Plos One, 3(10): e3306 (2008). [http ...
http://digibug.ugr.es/handle/10481/30773
*  A semi-quantitative assay of overall DNA methylation status using Methyl-CpG binding protein (MBD1) | BMC Research Notes | Full...
Bird A: DNA methylation patterns and epigenetic memory. Genes Dev. 2002, 16: 6-21. 10.1101/gad.947102.PubMedView ArticleGoogle ... MBD is a family of mammalian proteins whose original function is to recruit transcriptional repression complexes to silence ... DNA methylation of the CpG dinucleotide is one of the most crucial epigenetic modifications in mammals [1]. Its feature is a ... Cipriany BR, Zhao R, Murphy PJ, Levy SL, Tan CP, Craighead HG, Soloway PD: Single molecule epigenetic analysis in a nanofluidic ...
https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-5-234
*  Histone Methyltransferase (Inhibitors Agonists Modulators Antagonists)-MedChemExpress.com
EPZ005687 is a potent and selective inhibitor of Epigenetic Reader Domain with Ki of 24 nM, and has 50-fold selectivity against ... whereas methylation on histones H3K9 and H3K27 is generally associated with gene repression. Histone lysine methylation is ... 100-fold selectivity over other methyltransferases and other non-epigenetic targets. ... leading to chromatin condensation and transcriptional repression. ...
http://update.medchemexpress.com/Targets/Histone%20Methyltransferase.html
*  EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers
Taken together, our study has shed mechanistic insight into EZH2-H3K27me3 epigenetic repression of DLC1 and advocated the ... In this study, we identified the tumor suppressor Deleted in liver cancer 1 (DLC1) as a target of repression by EZH2-mediated ... indicating that EZH2-mediated H3K27me3 epigenetic regulation of DLC1 was a common mechanism in human cancers. Importantly, we ... Citation: Au SL-K, Wong CC-L, Lee JM-F, Wong C-M, Ng IO-L (2013) EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068226
*  Heterochromatin formation in bistable chromatin domains controls the epigenetic repression of clonally variant Plasmodium...
Heterochromatin formation in bistable chromatin domains controls the epigenetic repression of clonally variant Plasmodium ... Heterochromatin formation in bistable chromatin domains controls the epigenetic repression of clonally variant Plasmodium ... Chookajorn, T., Dzikowski, R., Frank, M., Li, F., Jiwani, A.Z., Hartl, D.L., and Deitsch, K.W. (2007) Epigenetic memory at ... Cortés, A., Carret, C., Kaneko, O., Yim Lim, B.Y., Ivens, A., and Holder, A.A. (2007) Epigenetic silencing of Plasmodium ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2011.07574.x/references
*  Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer - Semantic Scholar
... by canonical Wnt and that its epigenetic-dependent loss can be pro-tumourigenic. Our data show the importance of epigenetic ... Genetic and epigenetic alteration of components of the canonical Wnt signalling pathway is one of the primary mechanisms ... Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer. @inproceedings{Lara2010EpigeneticRO, ... title={Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer}, author={Ester Lara and ...
https://www.semanticscholar.org/paper/Epigenetic-repression-of-ROR2-has-a-Wnt-mediated%2C-Lara-Calvanese/0c129db0e05bce70f1a406d0cf9cd79d45ea278a
*  A postprandial FGF19‐SHP‐LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy | The EMBO Journal
A postprandial FGF19‐SHP‐LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy. View ORCID ProfileSangwon ... LSD1 mediates epigenetic repression of SHP‐target autophagy genes. FGF19 treatment or feeding of mice increased occupancy of ... Figure 4. LSD1 mediates epigenetic repression of SHP‐target autophagy genes. Mice were injected via the tail vein with Ad‐GFP ... Here, we identify a new function of an FGF19‐SHP‐LSD1 axis in transcriptional and epigenetic repression of hepatic autophagy in ...
http://emboj.embopress.org/content/early/2017/04/26/embj.201695500.export
*  A Novel Prodrug of Epigallocatechin-3-gallate: Differential Epigenetic hTERT Repression in Human Breast Cancer Cells | Cancer...
A Novel Prodrug of Epigallocatechin-3-gallate: Differential Epigenetic hTERT Repression in Human Breast Cancer Cells. Syed M ... A Novel Prodrug of Epigallocatechin-3-gallate: Differential Epigenetic hTERT Repression in Human Breast Cancer Cells ... A Novel Prodrug of Epigallocatechin-3-gallate: Differential Epigenetic hTERT Repression in Human Breast Cancer Cells ... A Novel Prodrug of Epigallocatechin-3-gallate: Differential Epigenetic hTERT Repression in Human Breast Cancer Cells ...
http://cancerpreventionresearch.aacrjournals.org/content/early/2011/03/14/1940-6207.CAPR-11-0009
*  Directed Differentiation of Patient-Specific Induced Pluripotent Stem Cells Identifies the Transcriptional Repression and...
This study investigated the altered control of transcriptional and epigenetic programs that may affect the development of HLHS ... Quantitative gene expression analysis demonstrated that HLHS-derived iPS cells showed transcriptional repression of NKX2-5, ... findings suggest that patient-specific iPS cells may provide molecular insights into complex transcriptional and epigenetic ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102796
*  Epigenetic transcriptional repression of tumor suppresor genes and its reversion by drugs.
... Repositori DSpace/Manakin. Valencià ... Epigenetic transcriptional repression of tumor suppresor genes and its reversion by drugs.. Mostra el registre complet de ... This fact has driven the search for drugs that induce selectively changes in the epigenetic patterns of the tumor cells and ... This fact has driven the search for drugs that induce selectively changes in the epigenetic patterns of the tumor cells and ...
http://roderic.uv.es/handle/10550/15125
*  Press releases - Article | Friedrich Miescher Institute
Epigenetic repression suppresses genomic instability. Susan Gasser and her group at the FMI have found the pathway through ... Keeping them silent is the task of a universally conserved epigenetic modification on histone H3: the methylation of lysine 9. ... interests focus on how nuclear organization impinges on mechanisms of repair and replication fork stability and on epigenetic ...
http://www.fmi.ch/news/releases/articles/gasser.161010.html
*  Centennial | Genetics
Selfish DNA and Epigenetic Repression Revisited. Susan M. Gasser. Genetics November 2016 204: 837-839; doi: 10.1534/genetics. ...
http://www.genetics.org/content/centennial
*  GeneArt TALs for Plant Engineering | Thermo Fisher Scientific - AU
Epigenetic repression of transcription. *Heritable knockdown of gene expression. Native TAL MCS. Native. (MCS). Steric ... Steric repression & custom design. *Transient knockdown of gene expression. *Target any locus in the genome with the effector ... repression & custom design. *Transient knockdown of gene expression. *Target any locus in the genome with the effector domain ...
https://www.thermofisher.com/au/en/home/life-science/genome-editing/geneart-tals/geneart-tals-plant-engineering.html
*  Hong JA[au] - PubMed - NCBI
Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis.. Xi S, Xu H, Shan J, Tao Y, Hong JA ... Cigarette smoke mediates epigenetic repression of miR-217 during esophageal adenocarcinogenesis.. Xi S, Inchauste S, Guo H, ... Asbestos Induces Epigenetic Repression of Ras Association Domain-Containing Protein 1, p16 Kinase 4a Inhibitor, and p14 ... Pulmonary Metastases Exhibit Epigenetic Clonality: Implications for Precision Cancer Therapy.. Reardon ES, Hong JA, Straughan ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Hong+JA%5Bau%5D&dispmax=50
*  Mir-9/mir-79 microRNA precursor family - Wikipedia
"Xenoestrogen-induced epigenetic repression of microRNA-9-3 in breast epithelial cells". Cancer Res. 69 (14): 5936-45. doi: ... 2007). "Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer". The Journal of Pathology. 214 (1): 17-24 ... Lehmann U, Hasemeier B, Christgen M, Müller M, Römermann D, Länger F, Kreipe H (2008). "Epigenetic inactivation of microRNA ... been shown that human miR-9 expression levels are reduced in many breast cancer samples due to hypermethylation an epigenetic ...
https://en.wikipedia.org/wiki/Mir-9/mir-79_microRNA_precursor_family
*  JCI Insight - Inhibition of the methyltranferase EZH2 improves aortic performance in experimental thoracic aortic aneurysm
Schematic representation of epigenetic repression in TAA. (A) Contractile genes (e.g., TAGLN, MYH11, SMTN) responsible for ... We found that repression of SM22α was enforced by increased activity of the methyltransferase EZH2. TGF-β effectors such as ... Epigenetic silencing of contractile loci may explain the ineffectual nature of TGF-β signaling in improving contractile protein ... Deficient canonical TGF-β signaling may induce epigenetic remodeling of VMSCs and set the stage for compensatory upregulation ...
https://insight.jci.org/articles/view/97493
*  CSHAsia 2012 Conference on Epigenetics, Chromatin & Transcription
Abstract title:Genetic determinants of epigenetic repression Ali Shilatifard, Stowers Institute for Medical Research, USA. ... Abstract title:Epigenetic mechanism: silent nucleosomal structures and non-coding RNAs. Marjori Matzke, Austrian Academy of ... Abstract title:Epigenetic Reprogramming in Mammalian Development Bing Ren, Ludwig Institute for Cancer Research, USA. Abstract ... Abstract title:Epigenetic regulation of T cell differentiation Bing Zhu, National Institute of Biological Sciences, Beijing, ...
http://www.csh-asia.org/EPITRANS12.html
*  BCL6 Gene - GeneCards | BCL6 Protein | BCL6 Antibody
Interacts with NOTCH1 NCID and SIRT1; leads to a epigenetic repression of selective NOTCH1-target genes. Interacts (nor via BTB ... through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very ... through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very ... including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation ...
http://www.genecards.org/cgi-bin/carddisp.pl?gene=BCL6&keywords=kr-znf3
*  Siegfried JM[au] - PubMed - NCBI
Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Siegfried+JM%5Bau%5D&dispmax=50
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. ... These morphological changes likely reflect epigenetic modifications, such as changes in DNA methylation, histones and miRNA ...
https://www.jove.com/visualize/abstract/20625516/sulforaphane-causes-epigenetic-repression-htert-expression-human
*  Frontiers | The Genome Conformation As an Integrator of Multi-Omic Data: The Example of Damage Spreading in Cancer | Genetics
In particular, the integration of data about cancer mutations, gene functional annotations, genome conformation, epigenetic ... In particular, the integration of data about cancer mutations, gene functional annotations, genome conformation, epigenetic ... genome conformation and epigenetic patterns), which exploits a multi-layer network approach to analyse, visualize and obtain ... genome conformation and epigenetic patterns), which exploits a multi-layer network approach to analyse, visualize and obtain ...
https://www.frontiersin.org/articles/10.3389/fgene.2016.00194/full
*  ERC FUNDED PROJECTS | ERC: European Research Council
Indeed, these immature cell identities are largely independent from canonical epigenetic repression; hence, current models ... Indeed, these immature cell identities are largely independent from canonical epigenetic repression; hence, current models ... Summary The generation of animals by nuclear transfer demonstrated that the epigenetic state of somatic cells could be reset to ... The generation of animals by nuclear transfer demonstrated that the epigenetic state of somatic cells could be reset to an ...
https://erc.europa.eu/projects-figures/erc-funded-projects/results?items_per_page=50&%3Bamp%3Bdestination=projects-figures/erc-funded-projects/canbuild&%3Bamp%3Bf%5B0%5D=country%3AFinland&%3Bamp%3Bf%5B1%5D=country%3ANorway&%3Bf%5B0%5D=country%3ALithuania&f%5B0%5D=tid%253Aparents_all%3A74
*  Frontiers | PML Degradation: Multiple Ways to Eliminate PML | Oncology
The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression. Science 330, 521-525. ... The PML gene rarely undergoes somatic mutations in tumors other than APL and its promoter does not undergo epigenetic silencing ... The SUMO E3-ligases PIASs have been mainly implicated in the regulation of innate immunity through epigenetic mechanisms (Liu ... 2006). PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature 442, 779-785. ...
https://www.frontiersin.org/articles/10.3389/fonc.2013.00060/full