"People knew there was a connection between enzyme induction and cell wall breakdown," he says. "But finding a regulatory ... she discovered that some bacteria can induce the enzyme beta-lactamase when exposed to antibiotics such cephalosporin, ...

17 Talalay P. Chemoprotection against cancer by induction of phase 2 enzymes. Biofactors. 2000; 12 5-11 ... induction of phase 2 enzymes → activation of GSH metabolism → neuroprotection.. Key words. Rosmarinus officinalis - Lamiaceae ... Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and ... originating from rosemary protects cortical neurons by inducing phase 2 enzymes, the induction of which was initiated by ...

Talalay P. Chemoprotection against cancer by induction of phase 2 enzymes. BioFactors. (2000) 12:5-11. doi: 10.1002/biof. ... induction of phase II enzymes (11), inhibition of cell proliferation (12), anti-cancer (13, 14), anti-angiogenesis (9, 15), and ... The enzyme activities of MMP-2 and MMP-9 in the plasma of the tumor control group were set at 100%. The results showed that Lyc ... NOX enzymes as novel targets for drug development. Semin Immunopathol. (2008) 30:339-63. doi: 10.1007/s00281-008-0123-6 ...

Thyroids: The changes in the liver and thyroids were consistent with liver enzyme induction and secondary thyroid hypertrophy. ... Liver and thyroid effects wereconsistent with liver enzyme induction and secondary thyroid hypertrophy. Atrophy in thethymus, ... Liver and thyroid effects wereconsistent with liver enzyme induction and secondary thyroid hypertrophy. Atrophy in thethymus, ... wereconsistent with liver enzyme induction and secondary to the thyroid hypertrophy. The No Observed Adverse Effect Level ( ...

The induction of these enzymes can cause faster breakdown of a drug that can lead to a reduction in blood levels and thus a ... Consequently, the degree of liver enzyme induction from different St. Johns Wort products is also likely to vary. ... Johns Wort can induce a family of liver enzymes known as P450 enzymes that are responsible for breaking down (metabolizing) a ...

Designing voriconazole treatment for racing pigeons: balancing between hepatic enzyme auto induction and toxicity. . Med Mycol ... Designing voriconazole treatment for racing pigeons: balancing between hepatic enzyme auto induction and toxicity. . Med Mycol ... balancing between hepatic enzyme auto induction and toxicity. Med Mycol 2009;47:276-285. ... balancing between hepatic enzyme auto induction and toxicity. Med Mycol 2009;47:276-285. ...

Other reversible early effects noted were peripheral neuropathy and liver enzyme induction. ...

Influence of chronic angiotensin-converting enzyme inhibition on anesthetic induction. Anesthesiology. 1994;81(2):299-307. ... The attending anesthesiologists are encouraged to target a MAP ≥ 60 mmHg from the time of anesthetic induction until the end of ... Intraoperatively, the anesthesiologists are encouraged to target a MAP of ≥ 80 mmHg from the time of anesthetic induction until ... SBP, systolic blood pressure; ACEi, angiotensin-converting-enzyme inhibitors; ARB, angiotensin II receptor blockers; HR, heart ...

Brodie MJ, Mintzer S, Pack AM, Gidal BE, Vecht CJ, Schmidt D. Enzyme induction with antiepileptic drugs: cause for concern?. ... Liver function tests, because elevated liver enzyme levels, hepatitis, and hyperammonemia may be noted with chronic toxicity ...

Ultimately cancer cells died with the induction of two specific enzymes, caspase-3 and caspase-8, de Mejia said. ... which regulates many genes that affect the process through the production of important enzymes. ...

Three mechanisms have been proposed: the effect of antimicrobials on hepatic enzyme induction, which increases metabolism of ... an inducer of enzymes that metabolizes estrogens, decreases the effectiveness of OCPs. A systematic review concluded that ...

An Nrf2 small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements ... 71, 72]. Under normal condition, antioxidant proteins, such as glutathione (GSH), ROS metabolic enzymes, including glutathione ... Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1. ... and other antioxidant enzyme activities [82]; (6) P38MAPK is crucial in myocardial ischemia and reperfusion [83]. Rhizoma ...

... altered detoxification by induction of phase II enzymes, decreased carcinogen activation by inhibition of phase I enzymes, and ... Structure elucidation of acid reaction products of indole-3-carbinol: Detection in vivo and enzyme induction in vitro ... hepatic shunt enzyme (glucose-6-phosphate dehydrogenase), gluconeogenic enzymes (glucose-6-phosphatase and fructose-1,6- ... For the induction of preadipocytes into adipocytes, 3T3-L1 cells were induced by treatment with 0.5 mM 3-isobutyl-1- ...

In the course of in vitro studies on enzyme induction, coregulation of multiple enzymes and transporters by a single inducer ... Relative induction of CYP1A2, CYP2B6, and CYP3A4 mRNA, enzyme activity, and protein by RIF, OME, and PB is shown in Fig. 4. ... Induction of mRNA, enzyme activity, and protein of CYP1A2 (A), CYP2B6 (B), and CYP3A4 (C) in sandwich cultured human ... 2007) Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations. ...

In addition, there was an increase in liver weight in both rats and dogs, apparently related to hepatic enzyme induction ( ...

At 600 ppm, males showed slightly decreased body weight gain and morphologic evidence of liver enzyme induction. At 2400 ppm ...

Tablets may be affected by the induction or inhibition of drug-metabolizing enzymes. ... Drugs that are Metabolized by and/or Inhibit Cytochrome P450 Enzymes. CYP Enzyme Inducers. (these studies used both drugs at ... CYP Enzyme Inhibitors. Cimetidine. In healthy male patients (n=12), when cimetidine, a weak inhibitor of CYP1A2, CYP2D6, and ...

Urinary D-glucaric acid excretion and plasma antipyrine kinetics during enzyme induction. Br. J. Clin. Pharmacol., 1: 253-257. ...

Induction of rat liver drug-metabolizing enzymes by promethazine. G Fernández and J A Castro ... The perinatal development of epoxide-metabolizing enzyme activities in liver and extrahepatic organs of guinea pig and rabbit. ...

Effect of naturally occurring plant phenolics on the induction of drug metabolizing enzymes by o-toluidine. Toxicology 2003, ... Enzyme-Linked Immunosorbent Assay (ELISA). The amounts of TNF-α, IL-1β, and CYP2E1 in the lysates of small intestines or livers ... Lee, S.E.; Koh, H.; Joo, D.J.; Nedumaran, B.; Jeon, H.J.; Park, C.S.; Harris, R.A.; Kim, Y.D. Induction of SIRT1 by melatonin ... induction of apoptosis, downregulation of the genes involved in cell cycle and angiogenesis, and the stimulation of the ...

By competitive inhibition or by enzyme induction, drugs can either inhibit or accelerate lidocaine metabolism. Sertraline ( ... These enzymes located in the endoplasmic reticulum are referred to as microsomal enzymes. Metabolic drug interactions are ... When two or three drugs are each substrates for the same enzyme, there is a possibility for an adverse drug reaction when used ... When two drugs, both requiring the same enzyme for metabolism, are given concurrently, there is a potential for an adverse drug ...

Mutagenic potential of binary and complex mixtures using different enzyme induction systems. J Toxicol Environ Health A 47:443- ... Induction of c-fos and cytochrome C oxidase subunits I and II by gossypol acetic acid in rat liver cells. Cell Biol Toxicol 14( ... Induction of Cyp1a-1 and Cyp1a-2 gene expression by a reconstituted mixture of polynuclear aromatic hydrocarbons in B6C3F1 mice ... Induction of highly proliferative phenotypes in cultured glomerular mesangial cells by benzo(a)pyrene alone or in combination ...

CONTACT-INDEPENDENT INDUCTION OF PHB DEPOLYMERASE. FIGURE 3. EFFECT OF 3HB CONCENTRATION ON PHB DEPOLYMERASE SYNTHESIS. A. B. ... EVEN AT CONCENTRATIONS AS LOW AS 0.1 mM, 3HB WAS AN EFFECTIVE INDUCER OF ENZYME ACTIVITY. THE LAG TIME FOR INDUCTION WITH 3HB ... THESE CONDITIONS WERE USED FOR MOST OF THE ENZYME INDUCTION EXPERIMENTS DESCRIBED HERE. FUTURE WORK • ISOLATE GLUCOSE KINASE ... PHB AND 3HB ARE EFFECTIVE INDUCERS OF ENZYME ACTIVITY. ENZYME SYNTHESIS DURING GROWTH ON PHB MAY BE INDUCED BY SMALL AMOUNTS OF ...

Cytochrome P450 enzymes in chickens: Characteristics and induction by xenobiotics. Comput. Biochem. Physiol. C Pharmacol. ... Determination of cholinestrase enzyme by kinetic method. Biochem. Pharm., 7: 88-92. ...

Induction of metabolizing Barbiturates Enzymes G. riseofulvin Promote clotting factor Vitamin K Synthesis Reduced absorption ... Warfarin Pharmacogenomics - ... (PK) Drug metabolizing enzymes (DME): Prodrugs = active drugs (Codeine/Morphine) Active drugs ...

Induction by glucocorticoids of angiotensin converting enzyme production from bovine endothelial cells in culture and rat lung ... A variety of growth factors, cytokines, chemokines, enzymes, and other factors (e.g. hypoxia) have been reported to induce ... Recently, it has been proposed that transactivation is responsible for some side effects (e.g. diabetes induction, skin atrophy ... For instance, corticosteroids have been shown to rapidly inhibit the release of proteolytic enzymes by stabilising the rat ...

1993external icon). In addition, individual variability in the induction of metabolic enzymes could cause people to respond ...

Measurement of angiotensin converting enzyme induction and inhibition using quantitative in vitro autoradiography: TISSUE ... ACUTE AND CHRONIC EFFECTS OF ANGIOTENSIN‐CONVERTING ENZYME INHIBITORS ON TISSUE ANGIOTENSIN‐CONVERTING ENZYME. Chai, S. Y., ... Characterization of angiotensin converting enzyme from different rat vascular beds. Jandeleit-Dahm, K., Jackson, B., Paxton, D. ... Inhibition of tissue angiotensin converting enzyme. Quantitation by autoradiography. Sakaguchi, K., Yeen Chai, S., Jackson, B. ...