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... the enzyme for NO production, can prevent the induction of LTP under some experimental conditions. Knock-out of both the ... 1996) Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampus. ... 4C,6A,B) and support the idea that PKG and PKA act in parallel to phosphorylate CREB during the induction of L-LTP. ... 1994) Requirement of a critical period of transcription for induction of a late phase of LTP. Science 265:1104-1107. ...
A Tetra(Ethylene Glycol) Derivative of Benzothiazole Aniline Enhances Ras-Mediated Spinogenesis | Journal of Neuroscience
Because BTA-EG4 did not alter the levels of Aβ degradation enzymes (i.e., insulin-degrading enzyme, neprilysin; data not shown ... 3A,B). Long-term potentiation (LTP) was either normal or reduced, depending on the induction protocol (Fig. 3C,D). Unexpectedly ... 3J), which occurred in the absence of a change in the response summation during the induction protocol (Fig. 3K). Collectively ... 2012) Enzyme-Linked Immunosorbent Assay-Based Method to Quantify the Association of Small Molecules with Aggregated Amyloid ...
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The induction of the LTDs of both AMPA and NMDA receptor-mediated EPSPs was blocked by the NMDA receptor antagonist D(-)-2- ... and the consistent parallelism of effects or noneffects on these components by various receptor antagonists and enzyme ...
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2006) Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide. J Neurosci 26:4930-4939. ... 2001) Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation. Science 293:829- ... 2006) FGF signaling is required for β-catenin-mediated induction of the zebrafish organizer. Development 133:3265-3276. ... 2005) Sequential induction of heme oxygenase-1 and manganese superoxide dismutase protects cultured astrocytes against nitric ...
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After induction with 1 mmisopropyl-1-thio-βb-d-galactopyranoside, Apaf-1XL was isolated from bacterial inclusion bodies using ... As an outcome, we used a fluorogenic substrate assay to measure caspase-3-like (DEVDase) enzyme activity levels in the cortical ...
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Aromatase is the key enzyme in the conversion of androgens into estrogen. Previous studies have detected aromatase in several ... This structural plasticity induction is in line with estrogens ability to rapidly influence synaptic functional plasticity and ... Moreover, we found that aromatase, an enzyme critical for estrogen production, is present at presynaptic termini, supporting a ... a key enzyme required for estrogen production, has been found in the cortex (Yague et al., 2006), leading to the suggestion ...
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1986) Induction of nerve growth factor receptor in Schwann cells after axotomy. Proc Natl Acad Sci USA 83:4094-4098. ... Enzyme-linked immunosorbent assay (ELISA) for NGF. Adult female Sprague Dawley rats (n = 5) were decapitated at 7 d after ... 1993) Induction of non-catalytic trkB neurotrophin receptors during axonal sprouting in the adult hippocampus. J Neurosci 13: ... 1994) NOS induction by NGF in basal forebrain cholinergic neurons: evidence for regulation of brain NOS by a neurotrophin. ...
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2003) Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation. J Neurochem 85:348-357. ... 2016) Reversible induction of pain hypersensitivity following optogenetic stimulation of spinal astrocytes. Cell Rep 17:3049- ... 1993) Day-night variations of adenosine and its metabolizing enzymes in the brain cortex of the rat-possible physiological ... Indeed, adenosine level is regulated by complex interactions of production and degradation enzymes as well as equilibrative ...
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The physiological induction of secretion of 5-HT by the natural secretogogue ↑[Ca2+]e was compared with the induction of ... PseudoZ abolished enzyme activity, confirming that the measured activity was that of PKCζ and suggesting that the inhibitor ... 1987a) Induction of a neural phenotype in a serotonergic endocrine cell derived from the neural crest. J Neurosci 7:2874-2883. ... 1995) Induction of a serotonergic and neuronal phenotype in thyroid C-cells. J Neurosci 15:6167-6178. ...
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2005) Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment. J Neurosci 25:3192-3198. ... 2012) Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by ... Rats were placed in induction chamber and administered 5% isoflurane. When deeply anesthetized, rats heads were shaved and ... renin or angiotensin converting enzyme in selected brain areas. Physiol Res 50:473-480. pmid:11702851. ...
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Oxytocin enzyme immunoassay.. Mice were fasted overnight and killed 5 h after an injection of vehicle or leptin (3.5 mg/kg; i.p ... the typical Socs3 induction observed in response to exogenous leptin was completely abolished in Socs3lox/lox mice (Fig. 1D; p ... subjected to an overnight fast was determined by enzyme immunoassay 5 h after injection of vehicle (Veh) or leptin (3.5 mg/kg; ... Mature oxytocin tissue content was then measured 5 h later by enzyme immunoassay (Schaller et al., 2010), and data were ...
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1). Upon induction of primary cilia, bP/rds-HA-FLAG localized to cilia (Fig. 1A, bP/rds-HA-FLAG, green). The cilia localization ... 6E, bP/rds1-288-HA-FLAG) and therefore processed by the Golgi resident enzyme GMII. Therefore, the removal of 289-312 aa ... After cilia induction by culturing in DMEM/F12 with 0.5% FBS for at least 48 h, hTERT-RPE1 cells stably expressing bP/rds-HA- ... 1995) Mapping the distribution of Golgi enzymes involved in the construction of complex oligosaccharides. J Cell Sci 108:1617- ...
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C, Induction of astroglial EPO expression is associated with the preceding induction of HIF-1 binding activity. Astrocytes were ... with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21waf1/ ... and that induction of Ras in an NMDA- and NO-dependent manner is sufficient and necessary for tolerance inductionin vitro ( ... 1999) Fetal anemia and apoptosis of red cell progenitors in STAT5a−/−/5b−/− mice: a direct role for STAT5 in Bcl-XL induction. ...
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To explore whether positive feedback regulation is disrupted in Jak2 G−/− mice, a surge induction paradigm was used (Christian ... Estradiol was measured with an estradiol enzyme immunoassay kit (Cayman Chemical) according to the manufacturers directions. ... immunostaining in GnRH neurons was assessed by dual labeling immunohistochemistry after mice underwent the surge induction ...
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1996) Induction of apoptosis by c-Fos protein. Mol Cell Biol 16:211-218. ... 3D,G). Furthermore, Akt phosphorylates and inhibits glycogen synthase kinase-3 (GSK-3), an enzyme thought to contribute to tau ... 1998) Co-ordinated and cellular-specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic- ... 2001) β-Site APP cleaving enzyme mRNA expression in APP transgenic mice: anatomical overlap with transgene expression and ...
Genome-Wide Analysis of Differential Gene Expression and Splicing in Excitatory Neurons and Interneuron Subtypes | Journal of...
1-4). These targets include voltage- and ligand-gated ion channels, enzymes, GPCRs and others. This indicates the potential for ... can oppose seizure induction in animal models (Khoshkhoo et al., 2017). Given the roles in diverse nervous system diseases, it ...
Novel Hippocampal Interneuronal Subtypes Identified Using Transgenic Mice That Express Green Fluorescent Protein in GABAergic...
Induction of hippocampal and cortical EGFP expression was found to begin at approximately postnatal day 5. This developmental ... All other enzymes involved in nucleic acid manipulations were from American Allied Biochemical (Aurora, CO), Ambion (Austin, TX ...
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TNFα or IL-1β released into the culture medium was measured with respective rat enzyme-linked immunosorbent assay kits from R&D ... Phosphatidylinositol 3-Kinase Regulates the Induction of Long-Term Potentiation through Extracellular Signal-Related Kinase- ... 1997) Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinsons disease. ... and the latter preventing the assembly of the multi-subunit enzyme complex (Stolk et al., 1994). As shown in Figure 5B, both ...
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2000) Induction of vanilloid receptor channel activity by protein kinase C. Nature 408:985-990. ... In contrast to PKC, which is considered a classical translocation enzyme involved in heat sensitization (Cesare et al., 1999), ... Potential mutants were identified by restriction enzyme digestion asHindIII-resistant plasmids and confirmed by DNA sequencing ... PKA action crucially depends on a functional anchoring of the enzyme to its target via a specific group of A-kinase anchoring ...
Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic...
Pitossi F, del Rey A, Kabiersch A, Besedovsky H (1997) Induction of cytokine transcripts in the central nervous system and ... Contaminating genomic DNA was degraded during extraction with Qiagen DNase1 enzyme. The typical yield for brain tissue was ∼5 ... Xu WB, Haddad EB, Tsukagoshi H, Adcock I, Barnes PJ, Chung KF (1995) Induction of macrophage inflammatory protein 2 gene ... and this may occur through IL-1β-activated pathways such as induction of inducible COX-2 (Serou et al., 1999), tissue ...
Brain-Derived Neurotrophic Factor Controls Cannabinoid CB1 Receptor Function in the Striatum | Journal of Neuroscience
2005) Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus. ... The supernatants were collected and used for quantification of BDNF by using a two-site enzyme immunoassay kit (Promega). BDNF ... 2010) Brain-derived neurotrophic factor signaling modulates cocaine induction of reward-associated ultrasonic vocalization in ...
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For spinal LTP induction experiments, the magnitude of LTP was the average of the last 5 min of the field EPSP (fEPSP) ... reduces the expression of vasopressin in the hypothalamic paraventricular nucleus and of catecholamine biosynthetic enzymes in ... In addition, 10 μm NE was perfused for 10 min before the subthreshold stimulation in some LTP induction experiments. ... 2F), suggesting that GluA1 phosphorylation could lower the threshold for spinal LTP induction, thereby accounting for the ...
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2007) Induction of calcium influx through TRPC5 channels by cross-linking of GM1 ganglioside associated with alpha5beta1 ... an enzyme that hydrolyzes polysialic acid-containing gangliosides to GM1 ganglioside (Geisler et al., 2001; Vyas et al., 2002 ... Fluorescent photomicrograph showing Neu3 sialidase enzyme on an adult retinal axon. The ratio of GM1/GD1a ganglioside is ... on axons is important for growth cone production and that conversion of axonal gangliosides to GM1 by the axonal surface enzyme ...
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The enzyme activity reached a maximum in 2 min and declined afterward, although a 30% activation of the enzyme above basal was ... Phosphatidylinositol 3-Kinase Regulates the Induction of Long-Term Potentiation through Extracellular Signal-Related Kinase- ... Enzyme activation at lower (nanomolar) and inhibition at higher (micromolar) concentrations of tubulin-GppNHp were observed ( ... When tested, tubulin-GppNHp, but not tubulin-GDP, tubulin-GDPβS, or tubulin stripped of nucleotide, activated the enzyme ( ...