Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-2 | Cancer Research
Schmitt C. A., Rosenthal C. T., Lowe S. W. Genetic analysis of chemoresistance in primary murine lymphomas. Nat. Med., 6: 1029- ... The NF-κB and Sp1 elements are conserved in the human IgH enhancers as well as in the murine IgH enhancers, suggesting that ... Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-2. Caroline A. Heckman, ... Enhancer HS4 was the most active one with the bcl-2 promoter. To locate the elements that contributed to this activity, we ...http://cancerres.aacrjournals.org/content/63/20/6666.long
Biomedicines | Free Full-Text | Decoding the Pluripotency Network: The Emergence of New Transcription Factors | HTML
SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state. PLoS Genet. 2013, 9 ... Genetic ablation of GCNF caused embryonic lethality in mice, in which Oct4 expression was no longer restricted to the germ cell ... Similar to the Oct4-Sox2 element, the Esrrb-Sox2 element possesses a spacer of 2 to 8 bp . A recent study demonstrated that ... Its genetic ablation causes mouse embryos to die at the epiblast stage around E6.5-E7 . ICM formation in the mutant embryos ...http://www.mdpi.com/2227-9059/1/1/49/htm
Sandwalk: Are most transcription factor binding sites functional?
I didn't dare ask them if they could explain the genetic switch. Mark Ptashne would not be amused. 1. I started working on DNA ... We found that functional TF binding is enriched in regulatory elements that harbor a large number of TF binding sites, at sites ... with predicted higher binding affinity, and at sites that are enriched in genomic regions annotated as "active enhancers.". ... The interactions of transcription factors (TFs) with DNA regulatory elements clearly play an important role in determining gene ...http://sandwalk.blogspot.cz/2017/06/are-most-transcription-factor-binding.html
Sandwalk: Are most transcription factor binding sites functional?
I didn't dare ask them if they could explain the genetic switch. Mark Ptashne would not be amused. 1. I started working on DNA ... We found that functional TF binding is enriched in regulatory elements that harbor a large number of TF binding sites, at sites ... with predicted higher binding affinity, and at sites that are enriched in genomic regions annotated as "active enhancers.". ... The interactions of transcription factors (TFs) with DNA regulatory elements clearly play an important role in determining gene ...http://sandwalk.blogspot.fi/2017/06/are-most-transcription-factor-binding.html
Modified binding of proteins from calcitonin-negative tumor cells to the neuroendocrine-specific CANNTG motif of the calcitonin...
... cell line TT is modulated by a neuroendocrine-specific enhancer fragment (nucleotides -965 to -905) containing two CANNTG ... Enhancer Elements, Genetic*. Gene Expression Regulation, Neoplastic*. Hela Cells. Humans. Molecular Sequence Data. ... In CT-negative MTC cells (RO-D81), the Ets response element was active but the two copies of E2 were not. Similar results were ... Previous Document: Identification of positive and negative regulatory elements involved in the retinoic acid/cAMP induc.... ...http://www.biomedsearch.com/nih/Modified-binding-proteins-from-calcitonin/8265349.html
Pluripotential reprogramming of the somatic genome in hybrid cells occurs with the first cell cycle.
Oct4-green fluorescent protein (GFP) transgenes that do not contain the proximal enhancer (PE) region are widely used to ... Enhancer Elements, Genetic. Female. Gene Expression Regulation. Genome. Green Fluorescent Proteins / genetics. Hybrid Cells / ... Oct4-green fluorescent protein (GFP) transgenes that do not contain the proximal enhancer (PE) region are widely used to ...http://www.biomedsearch.com/nih/Pluripotential-reprogramming-somatic-genome-in/18065396.html
Characterization of CEE-target gene interaction dista | Open-i
Enhancer elements are essential for tissue-specific gene regulation during mammalian development. Although these regulatory ... Enhancer elements are essential for tissue-specific gene regulation during mammalian development. Although these regulatory ... Because of this long-range action, the annotation of enhancer element-target promoter pairs remains elusive. Here, we developed ... Because of this long-range action, the annotation of enhancer element-target promoter pairs remains elusive. Here, we developed ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3643598_gkt188f6p&req=4
Catalytic and binding properties (A) βW183 mutants are | Open-i
Enhancer Elements, Genetic. *Eukaryota/enzymology. *Holoenzymes/metabolism. *Molecular Sequence Data. *Mutation. *Promoter ... An aromatic residue switch in enhancer-dependent bacterial RNA polymerase controls transcription intermediate complex activity. ... An aromatic residue switch in enhancer-dependent bacterial RNA polymerase controls transcription intermediate complex activity ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3675486_gkt271f2p&req=4
Recent Articles | Agarose And Developmental Biology | The Scientist Magazine®| Page 9
Researchers show that genetic enhancer elements likely contribute to face shape in mice. ... In mice and flies, the Arc protein forms capsids and carries genetic information. ...https://www.the-scientist.com/?articles.list/tagNo/2915,5/tags/agarose,developmental-biology/pageNo/9/
Recent Articles | Lost Colony And Developmental Biology | The Scientist Magazine®| Page 9
Researchers show that genetic enhancer elements likely contribute to face shape in mice. ...https://www.the-scientist.com/?articles.list/tagNo/1434,5/tags/Lost-Colony,developmental-biology/pageNo/9/
ZFIN Publication: Rastegar et al., 2002
Enhancer Elements, Genetic*. *Hepatocyte Nuclear Factor 3-beta. *Intracellular Signaling Peptides and Proteins ... A floor plate enhancer of the zebrafish netrin1 gene requires Cyclops (Nodal) signalling and the winged helix transcription ... Rastegar, S., Albert, S., Le Roux, I., Fischer, N., Blader, P., Müller, F., and Strähle, U. (2002) A floor plate enhancer of ... we scanned the netrin1 locus for regulatory regions and identified an enhancer that drives expression in the floor plate and ...http://zfin.org/ZDB-PUB-030117-10
ZFIN Publication: Gehrke et al., 2015
Animals; Enhancer Elements, Genetic; Fishes/anatomy & histology*; Fishes/genetics; Gene Expression Regulation, Developmental ( ... Animals; Enhancer Elements, Genetic; Fishes/anatomy & histology*; Fishes/genetics; Gene Expression Regulation, Developmental; ... Moreover, gar enhancers drive reporter gene expression in both the wrist and digits of mouse embryos in patterns that are ... Deep conservation of wrist and digit enhancers in fish. Gehrke, A.R., Schneider, I., de la Calle-Mustienes, E., Tena, J.J., ...http://zfin.org/ZDB-PUB-141224-10
Max Planck Society - eDoc Server
Enhancer Elements, Genetic; Gene Expression; *Histone Code; Histones/metabolism; Mice; *Promoter Regions, Genetic; Protein ... If it is H3K4me1, the region is an enhancer, and if it is H3K4me3, the region is a promoter'. To test our model, we used ... Thus, the decrease of the DNA methylation switches smoothly the state of the enhancers from a primed to an active state. We ... National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran. Department of Stem Cells and Developmental ...http://edoc.mpg.de/display.epl?mode=doc&id=744102&col=77&grp=4088
Welcome to LibAge, the ageing reference resource
Entries tagged Enhancer Elements, Genetic (45). Sort:. Number of citations. Author. Title. Year. PubMed ID. ... 816: Ackermann and Brack (1996) "A strong ubiquitous promoter-enhancer for development and aging of Drosophila melanogaster." ... A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments ...http://libage.ageing-map.org/entries/tags/683/
"The chemotherapeutic agent DMXAA potently and specifically activates t" by Zachary J. Roberts, Nadege Goutagny et al.
Animals; Antineoplastic Agents; Cells, Cultured; Cytokines; DNA; Enhancer Elements, Genetic; Female; Gene Expression Regulation ...https://escholarship.umassmed.edu/infdis_pp/79/
Response Elements | Profiles RNS
Regulatory Elements, Transcriptional [G05.360.340.024.340.137.750]. *Enhancer Elements, Genetic [G05.360.340.024.340.137. ... "Response Elements" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Response Elements" by people in this website by year, and ... Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders. Proc ...https://profiles.umassmed.edu/display/122399
Response Elements | Harvard Catalyst Profiles | Harvard Catalyst
Regulatory Elements, Transcriptional [G05.360.340.024.340.137.750]. *Enhancer Elements, Genetic [G05.360.340.024.340.137. ... Dual functionality of cis-regulatory elements as developmental enhancers and Polycomb response elements. Genes Dev. 2017 03 15 ... "Response Elements" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject ... Elements of Grant Writing Tips and work plans for the grant writing process. ...https://connects.catalyst.harvard.edu/Profiles/display/Concept/Response%20Elements
Zwart W[au] - PubMed - NCBI
Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9. ... Estrogen receptor α wields treatment-specific enhancers between morphologically similar endometrial tumors. ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Zwart+W%5Bau%5D&dispmax=50
"Genetic signature to provide robust risk assessment of psoriatic arthr" by Matthew T Patrick, Philip E Stuart et al.
PsC when using 200 genetic markers. Among the top 5% of our PsA prediction we achieve ,90% precision with 100% specificity and ... Currently, no systematic strategy is available that utilizes the differences in genetic architecture between PsA and cutaneous- ... Combining statistical and machine-learning techniques, we show that the underlying genetic differences between psoriasis ... Arthritis, Psoriatic; Biomarkers; Cohort Studies; Enhancer Elements, Genetic; Gene Expression Profiling; Genetic Loci; Humans; ...https://scholarlycommons.henryford.com/dermatology_articles/41/
McDonnell, Donald Patrick | Duke Cancer Institute
Enhancer Elements, Genetic. Enzyme Activation. Enzyme Inhibitors. Enzyme-Linked Immunosorbent Assay. Estradiol ... In these studies, we found that increasing concentrations of 27HC, both by genetic and pharmacological means, led to decreased ...https://dukecancerinstitute.org/member/mcdonnell-donald
Rapid tissue-specific expression assay in living embryos.
Enhancer Elements, Genetic. Gene Expression Regulation. Genes, Reporter. Homeodomain Proteins. Immunohistochemistry. Organ ...https://pearl.plymouth.ac.uk/handle/10026.1/6650
Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression.
Enhancer Elements, Genetic. Gene Expression Regulation, Neoplastic. Genetic Predisposition to Disease. Humans ... resides in an enhancer element 47 kb upstream of the transcription start site of c-Myc-interacting CDCA7L. The G-risk allele, ... Here by using genetic association data and functional characterization, we demonstrate that rs4487645 G,T, the most highly ... associated with increased CDCA7L expression (P=1.95 × 10-36), increases IRF4 binding and the enhancer interacts with the CDCA7L ...https://repository.icr.ac.uk/handle/internal/362
"Proximity among distant regulatory elements at the beta-globin locus r" by Christopher R. Vakoc, Danielle L. Letting et al.
... providing general insights into long-range enhancer function. ... Recent evidence suggests that long-range enhancers and gene ... Animals; Base Sequence; Binding Sites; Carrier Proteins; Cell Line; DNA; DNA-Binding Proteins; Enhancer Elements, Genetic; ... Recent evidence suggests that long-range enhancers and gene promoters are in close proximity, which might reflect the formation ... Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1 ...http://escholarship.umassmed.edu/pgfe_pp/132/
MIR retrotransposon sequences provide insulators to the human genome.
Insulators are regulatory elements that help to organize eukaryotic chromatin via enhancer-blocking and chromatin barrier ... The activity of predicted MIR insulators was experimentally validated using in vitro and in vivo enhancer-blocking assays. MIR ... Although there are several examples of transposable element (TE)-derived insulators, the contribution of TEs to human ... Enhancer Elements, Genetic * Gene Expression Regulation * Genome, Human * Humans * Insulator Elements * MD Multidisciplinary ...http://vivo.mblwhoilibrary.org/display/publication39478
Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics
Short Talk: Functional Genetic Screens for Enhancer Elements in the Human Genome Using CRISPR-Cas9. ... Enhancer Structure and Function in Health and Disease Sarah C. Pyfrom, Washington University in St. Louis, USA Short Talk: ... Biogenesis and Mechanism of Action of Enhancer RNAs. Shelley L. Berger, University of Pennsylvania, USA CBP Senses its ... Enhancer Mechanisms Underlying the Erythroid Transcriptome. Warren S. Pear, University of Pennsylvania, USA Modular Domains ...http://www.keystonesymposia.org/index.cfm?e=web.meeting.program&meetingid=1395