... "energy metabolism"[MeSH Terms] OR ("energy"[All Fields] AND "metabolism"[All Fields]) OR "energy metabolism"[All Fields]). ... Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via ... Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via ... Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes. ...
Thyroid and Glucose and Energy Metabolism. Official Title ICMJE Peripheral Thyroid Hormone Conversion and Glucose and Energy ... Thyroid and Glucose and Energy Metabolism. The safety and scientific validity of this study is the responsibility of the study ... Fasting venous blood samples will be collected for the determination of the parameters of lipid, glucose and energy metabolism. ... Resting Energy Expenditure at Levothyroxine Treatment Phase [ Time Frame: One month of therapy. ] ...
Cleidocranial dysplasia (CCD) is an autosomal dominant human disorder characterized by abnormal bone development that is mainly due to defective intramembranous bone formation by osteoblasts. Here, we describe a mouse strain lacking the E3 ubiquitin ligase RNF146 that shows phenotypic similarities to CCD. Loss of RNF146 stabilized its substrate AXIN1, leading to impairment of WNT3a-induced β-catenin activation and reduced Fgf18 expression in osteoblasts. We show that FGF18 induces transcriptional coactivator with PDZ-binding motif (TAZ) expression, which is required for osteoblast proliferation and differentiation through transcriptional enhancer associate domain (TEAD) and runt-related transcription factor 2 (RUNX2) transcription factors, respectively. Finally, we demonstrate that adipogenesis is enhanced in Rnf146-/- mouse embryonic fibroblasts. Moreover, mice with loss of RNF146 within the osteoblast lineage had increased fat stores and were
The resulting cellular energy imbalance may promote energy failure and stimulation of angiogenesis. In the first paper, energy ... Energy metabolism requires supply of glucose and oxygen. In atherosclerotic plaques and cancer tumors, there are local areas ... Energy metabolism, Hypoxia, Reactive oxygen species, Intussusceptive angiogenesis Subject categories. Cardiac and ... In summary, this thesis provides evidence of energy deficiency in human atherosclerotic plaques, new insights into ROS ...
Astrocyte glycogen and brain energy metabolism Glia. 2007 Sep;55(12):1263-71. doi: 10.1002/glia.20557. ... In the case of CNS white matter, this source of energy can extend axon function for 20 min or longer. Likewise, during periods ... of intense neural activity when energy demand exceeds glucose supply, astrocyte glycogen is degraded to lactate, a portion of ...
Fasting venous blood samples will be collected for the determination of the parameters of lipid, glucose and energy metabolism. ... Resting Energy Expenditure at Levothyroxine Treatment Phase [ Time Frame: One month of therapy. ]. *Resting Energy Expenditure ... Lipid Metabolism. Gluconeogensis. Thyrotropin Releasing Hormone. Deiodinase. Replacement Thyroid Hormone Therapy. Thyroidectomy ... T3 administration bypasses peripheral metabolism and therefore will allow us to assess the role of the peripheral thyroid ...
Cardiac energy substrate selection is a dynamic balance influenced by developmental, physiological, and pathological cues. In ... Alterations in activity or expression of nuclear receptors (PPARs and ERRs) and PGC-1α mediate these shifts in energy substrate ... The mitochondrion serves a critical role as a platform for energy transduction, signaling, and cell death pathways relevant to ... This review focuses on the molecular regulatory events and downstream effector pathways involved in mitochondrial energy ...
Thyroid and Glucose and Energy Metabolism. The safety and scientific validity of this study is the responsibility of the study ... Fasting venous blood samples will be collected for the determination of the parameters of lipid, glucose and energy metabolism. ... Resting Energy Expenditure at Levothyroxine Treatment Phase [ Time Frame: One month of therapy. ]. *Resting Energy Expenditure ... Lipid Metabolism. Gluconeogensis. Thyrotropin Releasing Hormone. Deiodinase. Replacement Thyroid Hormone Therapy. Thyroidectomy ...
... to generate ATP for energy. Unlike in normal cells, glycolysis is enhanced and OXPHOS capacity is reduced in various cancer ... Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review) Oncol Lett. 2012 Dec;4(6):1151-1157. doi: ... Understanding the features and complexity of the cancer energy metabolism will help to develop new approaches in early ... to generate ATP for energy. Unlike in normal cells, glycolysis is enhanced and OXPHOS capacity is reduced in various cancer ...
... and these SCFAs become important energy sources for the host. The gut microbiota affects nutrient acquisition and energy ... In this review, we summarize the identification, structure, and activities of GPR43, with a focus on host energy regulation, ... In this review, we summarize the identification, structure, and activities of GPR43, with a focus on host energy regulation, ... The gut microbiota affects nutrient acquisition and energy regulation of the host and can influence the development of obesity ...
Effect of parathyroid hormone on energy metabolism of skeletal muscle.. Baczynski R, Massry SG, Magott M, el-Belbessi S, Kohan ... The present study examined the effect of 1-84 PTH and its amino-terminal fragment (1-34 PTH) on energy production, transfer, ... Our data demonstrate that both 1-84 and 1-34 PTH impair energy production, transfer, and utilization. These biochemical ...
Cardiac Energy Metabolism in Heart Failure. Grant Number: 5P01HL074237-09. PI Name: Stanley. Project Title: Cardiac Energy ... The consequences of metabolic dysfunction in HF are poorly understood, but there is strong evidence that energy metabolism can ... and the effects of manipulating energy metabolism on cardiac function and HF progression. This Program Project is composed of ... Causal relationships will be explored between altered energy substrate metabolism and oxidative stress in HF. Project 4: " ...
Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism. Message Subject (Your Name) has forwarded ... Mitochondria use energy derived from fuel combustion to create a proton electrochemical gradient across the mitochondrial inner ... This intermediate form of energy is then used by ATP synthase to synthesize ATP. Uncoupling protein-1 (UCP1) is a brown fat- ... In rodents, UCP1 activity and brown fat contribute importantly to whole-body energy expenditure. Recently, two additional ...
A Novel Link Between Circadian Clocks and Adipose Tissue Energy Metabolism Message Subject (Your Name) has forwarded a page to ... Body weight and body fat reflect the balance between energy intake and energy expenditure. Impaired lipolytic rate alone should ... PER2 controls lipid metabolism by direct regulation of PPARγ. Cell Metab 2010;12:509-520pmid:21035761. ... 1). Clock genes are involved in regulating glucose metabolism in the liver. Gluconeogenesis is impaired in both ClockΔ19 mutant ...
Brain Energy Metabolism in Individuals With Major Depressive Disorder Receiving Escitalopram. The safety and scientific ...
Light-Driven Changes in Energy Metabolism Directly Entrain the Cyanobacterial Circadian Oscillator ... Light-Driven Changes in Energy Metabolism Directly Entrain the Cyanobacterial Circadian Oscillator ... Light-Driven Changes in Energy Metabolism Directly Entrain the Cyanobacterial Circadian Oscillator ... Light-Driven Changes in Energy Metabolism Directly Entrain the Cyanobacterial Circadian Oscillator ...
... a large number of animal studies have highlighted a role for melatonin in the regulation of both glucose metabolism and energy ... a large number of animal studies have highlighted a role for melatonin in the regulation of both glucose metabolism and energy ... melatonin has also been identified as an important regulator of glucose metabolism. Recent genomic studies have also shown that ... summarizes the current knowledge on the role that melatonin and its associated receptors play in the regulation of metabolism. ...
Intracellular edema and dehydration: effects on energy metabolism in alveolar macrophages. By NJ Lewiston, J Theodore, ED Robin ... Intracellular edema and dehydration: effects on energy metabolism in alveolar macrophages. By NJ Lewiston, J Theodore, ED Robin ... Intracellular edema and dehydration: effects on energy metabolism in alveolar macrophages Message Subject. (Your Name) has ... The effects of intracellular edema and dehydration on energy metabolism in alveolar macrophages were studied. Intracellular ...
... Belanger, Mireille; Allaman, Igor; Magistretti, ... This review focuses on the cellular aspects of brain energy metabolism, with a particular emphasis on the metabolic ... The energy requirements of the brain are very high, and tight regulatory mechanisms operate to ensure adequate spatial and ... Astrocytes a type of glial cell have emerged as active players in brain energy delivery, production, utilization, and storage. ...
Taken together, BH4 activates BAT and regulates systemic energy metabolism; this suggests an approach for metabolic disorders, ... strongly suggesting that BH4-induced BAT has a critical role in the regulation of systemic energy metabolism. Both NA derived ... Brown adipose tissue (BAT) is a central organ that acts to increase energy expenditure; its regulatory factors could be ...
Abnormal Left Ventricular Energy Metabolism in Obese Men With Preserved Systolic and Diastolic Functions Is Associated With ... Abnormal Left Ventricular Energy Metabolism in Obese Men With Preserved Systolic and Diastolic Functions Is Associated With ... Abnormal Left Ventricular Energy Metabolism in Obese Men With Preserved Systolic and Diastolic Functions Is Associated With ... Abnormal Left Ventricular Energy Metabolism in Obese Men With Preserved Systolic and Diastolic Functions Is Associated With ...
Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism. Arata Fukushima,1,2 Liyan Zhang, ... Effect of fatty acids on human bone marrow mesenchymal stem cell energy metabolism and survival. PLoS One. 2015;10(3):e0120257 ... Acetylation and succinylation contribute to maturational alterations in energy metabolism in the newborn heart. Am J Physiol ... Acetylation control of cardiac fatty acid β-oxidation and energy metabolism in obesity, diabetes, and heart failure. Biochim ...
Adrenoceptor blockage and skeletal muscle energy metabolism during endurance exercise ... Adrenoceptor blockage and skeletal muscle energy metabolism during endurance exercise. Journal of Applied Physiology 78(1): 307 ...
... some of the most salient features emerging from recent studies and aims at providing an integration of brain energy metabolism ... into the understanding of the cellular and molecular bases of the coupling between neuronal activity and energy metabolism and ... of higher cognitive functions in humans is associated with an increased glucose utilization and expression of energy metabolism ... detect signals that monitor energy delivery and use in register with neuronal activity. Recent technological advances in ...
Asymmetric Arginine Dimethylation Modulates Mitochondrial Energy Metabolism and Homeostasis in Caenorhabditis elegans. Liang ... Asymmetric Arginine Dimethylation Modulates Mitochondrial Energy Metabolism and Homeostasis in Caenorhabditis elegans ... Asymmetric Arginine Dimethylation Modulates Mitochondrial Energy Metabolism and Homeostasis in Caenorhabditis elegans ... Asymmetric Arginine Dimethylation Modulates Mitochondrial Energy Metabolism and Homeostasis in Caenorhabditis elegans ...
Forkhead Transcription Factors Coordinate Expression of Myocardial KATP Channel Subunits and Energy Metabolism. Pierre Philip- ... PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc Med. 2000; 10: 238-245. ... Thus, FoxF2 and -O are key transcription factors coordinating expression of KATP channels and energy metabolism. ... The capability of adapting cellular function and energy metabolism to varying physiological and pathological conditions is ...
Forkhead Transcription Factors Coordinate Expression of Myocardial KATP Channel Subunits and Energy Metabolism. Pierre Philip- ... Forkhead Transcription Factors Coordinate Expression of Myocardial KATP Channel Subunits and Energy Metabolism ... Forkhead Transcription Factors Coordinate Expression of Myocardial KATP Channel Subunits and Energy Metabolism ... Forkhead Transcription Factors Coordinate Expression of Myocardial KATP Channel Subunits and Energy Metabolism ...
PGC-1beta in the regulation of hepatic glucose and energy metabolism. J. Biol. Chem.278:30843-30848. ... Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth. Heart Failure Rev.7:175-185. ... Collectively, these results identify ERRα as a critical regulator of energy metabolism in heart and skeletal muscle. ... We hypothesized that ERR isoforms serve as key regulators of heart and skeletal muscle energy metabolism downstream of PGC-1α. ...
Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells.. ... mitochondrial energy metabolism is impaired. Here, we studied early metabolic changes and mitochondrial adaptations in human ... mitochondrial energy metabolism was augmented in contrast to the previously described mitochondrial dysfunction in beta cells ...
Early changes in hepatic energy metabolism and lipid content in recent-onset type 1 and 2 diabetes mellitus.. ... However, longitudinal studies of diabetes-related NAFLD and its relationship to hepatic energy metabolism are lacking.This ...