Endothelin 1 - Wikipedia
Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor peptide produced by vascular ... Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension. Use of these antagonists ... Overview of all the structural information available in the PDB for UniProt: P05305 (Endothelin-1) at the PDBe-KB. This article ... The protein encoded by this gene - EDN1 - is proteolytically processed to release endothelin 1. Endothelin 1 is one of three ...
Exhaled nitric oxide and tracheal endothelin-1 in preterm infants with and without RDS
We measured exhaled nitric oxide and tracheal aspirate endothelin-1 to determine relationships between these substances and ... Exhaled nitric oxide and tracheal endothelin-1 in preterm infants with and without RDS Pediatr Pulmonol. 2003 Nov;36(5):421-6. ... We measured exhaled nitric oxide and tracheal aspirate endothelin-1 to determine relationships between these substances and ... Steven L Olsen 1 , Perry L Clark, Donald W Thibeault, Mike Norberg, William E Truog ...
Recombinant Rat Endothelin-1 (Edn1), partial | CSB-MP007400RA | Cusabio
Recombinant Rat Endothelin-1 (Edn1), partial from Cusabio. Cat Number: CSB-MP007400RA. USA, UK & Europe Distribution. ... Recombinant Rat Endothelin-1 (Edn1), partial , CSB-MP007400RA. (No reviews yet) Write a Review Write a Review. ... Recombinant Rat Endothelin-1 (Edn1), partial , CSB-MP007400RA Cusabio Rattus norvegicus Recombinants ... Recombinant Rat Endothelin-1 (Edn1), partial , CSB-MP007400RA. Rating Required Select Rating. 1 star (worst). 2 stars. 3 stars ...
Endothelin (16-21) [121377-67-1]
Endothelin (16-21) is a full agonist at ET-B receptros, but is inactive or weakly active at ET-A receptors. Maggi, C.A.; et al ... Synonym: Endothelin (16-21). CAS Number: [121377-67-1]. Molecular Weight: 795.94. Molecular Formula: C39H57N9O9. * Refer to ... Endothelin (16-21) [121377-67-1]. Catalog Number: P001627. Sequence: His-Leu-Asp-Ile-Ile-Trp. ...
Plasma endothelin-1 concentrations in patients with retinal vein occlusions | British Journal of Ophthalmology
1996) Plasma endothelin in congestive heart failure: effect of the ACE inhibitor, fosinopril. Cardiovasc Res 32:1148-1154. ... 1998) Plasma endothelin-1 concentrations in patients with retinal vein occlusions. Br J Ophthalmol 82:498-503. ... Plasma endothelin concentrations are increased in humans with congestive heart failure. Mayo Clin Proc 67:719-724. ... 1995) Endothelin-1 plasma levels in normal tension glaucoma: abnormal response to postural changes. Graefes Arch Clin Exp ...
Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by...
Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor that also has the ability to induce a burning, non-histaminergic ... but little is known about their role in endothelin-induced itch. ... by activating the endothelin A receptor (ETR) on primary ... ET-1 is released endogenously by several cell-types found in the skin, including macrophages and keratinocytes. Mast cells ... connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1.. ...
HMG-CoA reductase inhibition and PPAR-alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured...
endothelin-1, cyclosporin A, PPAR-alpha activators, ciprofibric acid, HMG-CoA inhibitors, compactin ... Several mechanisms, including endothelin (ET)-1-mediated systemic vasoconstriction, are considered to be responsible for CsA- ... HMG-CoA reductase inhibition and PPAR-alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured ... HMG-CoA reductase inhibition and PPAR-alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured ...
In vitro pharmacologic effect of two endothelin-1 antagonists on equine colonic arteries and veins in: American Journal of...
Then, B-1 (PD 142893) and B-2 (PD 145065) ET-1 antagonists were tested. One ring from each vessel type was used as a control ... Complete blockade of contractions was observed with B-2 (10-5 M). The pA2 values for B-1 were 8.26 and 6.82 for arteries and ... Abstract Objective-To evaluate the effectiveness of 2 potential endothelin (ET)-1 antagonists in blocking the contractile ... Results-Vessels contracted in a concentrationdependent manner to ET-1. Arteries responded slowly but reached greater ...
Endothelin-1 concentration is increased in the aqueous humour of patients with exfoliation syndrome | British Journal of...
Background Endothelin-1 (ET-1) both stimulates nociceptors and sensitizes these to noxious - Stem cell application on skin...
Results Endothelin receptors in dorsal root ganglion neurons The expression of endothelin receptor subtypes in the rat lumbar ... Background Endothelin-1 (ET-1) both stimulates nociceptors and sensitizes these to noxious. * Post author By exposed ... Background Endothelin is certainly among the many regional mediators that are essential in pain era as well as the modulation ... The endothelins ET-1 ET-2 and ET-3 are vasoactive peptides originally cloned from endothelial cells [1] but also made by ...
Characterization of endothelin-converting enzyme from endothelial cells and rat brain: detection of the formation of...
Using the endothelin-1 (ET-1)-stimulated elevation in cGMP in LLC-PK1 cells as a biological detector system for the conversion ... Characterization of endothelin-converting enzyme from endothelial cells and rat brain: detection of the formation of ... Characterization of endothelin-converting enzyme from endothelial cells and rat brain: detection of the formation of ... Characterization of endothelin-converting enzyme from endothelial cells and rat brain: detection of the formation of ...
Advanced ChemTech - [Ala18] Endothelin-1, human
Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes | Journal of...
Endothelin and cardiac arrhythmias: do endothelin antagonists have a therapeutic potential as antiarrhythmic drugs? Cardiovasc ... Endothelin and cardiac arrhythmias: do endothelin antagonists have a therapeutic potential as antiarrhythmic drugs? Cardiovasc ... Both effects of endothelin-1 were blocked by an antagonist of phospholipase C, suggesting that Ins(1,4,5)P3 and/or ... Endothelin-1 augmented the amplitude of pacing-evoked Ca2+ signals (positive inotropy), and caused an increasing frequency of ...
Pertussis toxin sensitive endothelin-1 coupling to inositol phosphate formation via a GTP-binding protein: comparison in SHR...
Nixon, G F and Pyne, N J and Wadsworth, R M and Hamilton, C A and Reid, J L (1995) Pertussis toxin sensitive endothelin-1 ... Endothelin-1 produced a reduction in the extent of ADP-ribosylation of Gi alpha and this was of similar magnitude in both SHR ... Endothelin-1 (10(-6) M) stimulated IP formation was decreased in cells from SHR compared to WKY (WKY 1117 +/- 157, SHR 668 +/- ... Pertussis toxin sensitive endothelin-1 coupling to inositol phosphate formation via a GTP-binding protein: comparison in SHR ...
Regulation of phospholipases C and D in rat ventricular myocytes: stimulation by endothelin-1, bradykinin and phenylephrine. -...
Clerk, A. and Sugden, P. H. (1997) Regulation of phospholipases C and D in rat ventricular myocytes: stimulation by endothelin- ... Regulation of phospholipases C and D in rat ventricular myocytes: stimulation by endothelin-1, bradykinin and phenylephrine. ... We have measured activation of these phospholipases by endothelin-1 (ET-1), bradykinin (BK), or phenylephrine (PE) in ... ET-1, BK or PE. Experiments with Ro-31-8220 showed that the stimulation of PLD by ET-1 and BK was mediated through activation ...
Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex...
The aim of this study was to determine the involvement of vasoactive substances endothelin-1 (ET-1) and nitric oxide (NO) ... The NOx/ET-1 ratio appears to be disturbed in the intermediate stage of CRPS, resulting in vasoconstriction and consequently in ... Included were 29 patients with CRPS 1 who were diagnosed during the acute stage of their disease and observed during follow-up ... In complex regional pain syndrome type 1 (CRPS1) pro-inflammatory mediators and vascular changes play an important role in the ...
Incremental importance of peak-exercise plasma levels of endothelin-1 and natriuretic peptides in chronic heart failure - UEA...
Incremental importance of peak-exercise plasma levels of endothelin-1 and natriuretic peptides in chronic heart failure ... Chronic heart failure (CHF) studies investigating the clinical, hemodynamic, and therapeutic importance of endothelin-1 (ET-1 ... Incremental importance of peak-exercise plasma levels of endothelin-1 and natriuretic peptides in chronic heart failure. ... Peak exercise plasma levels of ANP and ET-1 are potentially more reliable and important than their resting levels as markers of ...
"Inhibition of Mutant EGFR in NSCLC Promotes Endothelin-1-Mediated NSCL" by Stephen Ollosi
Endothelin-1 and Hypertension | Encyclopedia MDPI
... endothelin-converting enzyme; ETA, endothelin receptor subtype A; ETB1, endothelin receptor subtype B1; ETB2 endothelin ... Dhaun, N.; Goddard, J.; Kohan, D.E.; Pollock, D.M.; Schiffrin, E.L.; Webb, D.J. Role of endothelin-1 in clinical hypertension: ... endothelin-1 hypertension oxidative stress low-grade inflammation endothelial dysfunction arterial stiffness ... Speed, J.S.; Fox, B.M.; Johnston, J.G.; Pollock, D.M. Endothelin and renal ion and water transport. Semin. Nephrol. 2015, 35, ...
Pharmacological assessment of Ca2+ dependence of endothelin-1-induced response in rat aorta - McMaster Experts
In rat aorta, endothelin-1 (ET-1) induced a slowly developing and sustained contraction in Ca(2+)-containing normal Krebs, ... Pharmacological assessment of Ca2+ dependence of endothelin-1-induced response in rat aorta Journal Articles ... When ET-1-precontracted tissues were washed with Ca(2+)-free Krebs +50 microM EGTA, the tissues spontaneously and slowly ... Thus, the first component of the biphasic contraction may be due to refilling of ET-1-sensitive Ca2+ store via the internal ...
Research Articles about Endothelin-1 - ijSciences Publications
Keywords: Essential hypertension, Microalbuminuria, Interleukin-6, Endothelin-1, Nitric Oxide, Coronary heart disease ... Association of Microalbuminuria and IL-6, ET-1 and NO in Patients with Essential Hypertension. Author(s): Yuan Wang, Jianhui ... Yuan Wang, Association of Microalbuminuria and IL-6, ET-1 and NO in Patients with Essential Hypertension, International Journal ...
Polyclonal Antibody to Endothelin 1 (EDN1) - danabio
1:250-2500 Immunohistochemistry: 5-20µg/mL;1:25-100 Immunocytochemistry: 5-20µg/mL;1:25-100 Optimal working dilutions must be ... Polyclonal Antibody to Endothelin 1 (EDN1). PAA482Gu01 * $36000 $360.00 Unit price/ per ... Western blotting: 0.2-2µg/mL;1:250-2500 Immunohistochemistry: 5-20µg/mL;1:25-100 Immunocytochemistry: 5-20µg/mL;1:25-100 ...
Rat Big Endothelin-1 ELISA Kit (ET-1)
... big endothelin-1) in rat plasma, cell culture supernatant, tissue extracts and serum. ... Rat big endothelin-1 ELISA kit can measure concentrations of big ET-1 ( ... Rat Big Endothelin-1 ELISA Kit (ET-1). Full Name: Rat Big Endothelin-1 ELISA Kit (ET-1). Reactivity: Rat. Sample Type: Plasma, ... The action of endothelin is mediated through binding of two receptors ETA and ETB. Activation of ETA can lead to sodium ...
SBP0105 - Endothelin 1, dog, human, porcine, rat - Severn Biotech
Home » Catalogue Peptides » Endothelins and Related Peptides » SBP0105 - Endothelin 1, dog, human, porcine, rat ... SBP0105 - Endothelin 1, dog, human, porcine, rat. MW: 2492.2. H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His ... 20x TBS Powder Sachet (1 sachet makes 20L) - Pack of 10 Sachets ... SBP0105 - Endothelin 1, dog, human, porcine, rat. *SBP0106 - N- ... Endothelins and Related Peptides *SBP0104 - Big Endothelin-1, human. * ...
Effects of endothelin-1 on calcium and potassium currents in undiseased human ventricular myocytes - Repository of the Academy...
Our aim was to study the effects of endothelin-l (ET-1, 8 nmol/l) on the L-type calcium current (ICa-L) and various potassium ... Endothelins have been reported to exert a wide range of electrophysiological effects in mammalian cardiac cells. These results ... Effects of endothelin-1 on calcium and potassium currents in undiseased human ventricular myocytes ... Effects of endothelin-1 on calcium and potassium currents in undiseased human ventricular myocytes. Pflugers Archiv - European ...
Polyphenols restore endothelial function in DOCA-salt hypertension: Role of endothelin-1 and NADPH oxidase | Documents -...
The endothelin-converting enzyme-1/endothelin-1 pathway plays a critical role in inflammation-associated premature delivery in...
ELISA Kit FOR Endothelin-converting enzyme 1 (ECE1) | Technique alternative | 01012041394 - Polabo
ESC 365 - Endothelin-1 receptor antagonist and adrenomedullin improve functional recovery after myocardial infarction
Endothelin-1 (ET-1) promotes a proinflammatory microglia phenotype in diabetic conditions. | Palmetto Profiles
Endothelin-1 (ET-1) promotes a proinflammatory microglia phenotype in diabetic conditions. Can J Physiol Pharmacol. 2020 Sep; ... Endothelin-1 (ET-1) promotes a proinflammatory microglia phenotype in diabetic conditions. ... Endothelin-1 (ET-1) promotes a proinflammatory microglia phenotype in diabetic conditions. ...