Impaired CXCR4 Signaling Contributes to the Reduced Neovascularization Capacity of Endothelial Progenitor Cells From Patients...
Transplantation of bone marrow cells as well as circulating endothelial progenitor cells (EPC) enhances neovascularization ... In vitro migratory capacity of CD34+ cells is related to hematopoietic recovery after autologous stem cell transplantation. ... Increasing evidence suggests that transplantation of culture-expanded progenitor cells or bone marrow-derived progenitor cells ... and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med. 1999; 5 ...http://circres.ahajournals.org/content/97/11/1142
Intra-coronary Infusion of Bone Marrow Derived Autologous CD34+ Selected Cells in Patients With Acute Myocardial Infarction
... clinicaltrials.gov Following a Heart attack the acute loss of heart muscle cells results in a cascade of events causing an ... Hematopoietic Stem Cell Transplantation. Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals ... The purpose of this study is to determine whether adult bone marrow derived stem/progenitor cells improve cardiac function and ... Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression ...https://www.bioportfolio.com/resources/trial/108249/Intra-coronary-Infusion-of-Bone-Marrow-Derived-Autologous-CD34-Selected-Cells-in.html
CD34 MicroBead Kit UltraPure, human - Hematopoietic stem cells - MicroBeads and Isolation Kits - Cell separation reagents -...
It is suited for all routine CD34 cell isolations and is the ideal choice for debris-rich, low frequency samples. - Deutschland ... The CD34 MicroBead Kit UltraPure is the latest development for positive selection of CD34+ hematopoietic stem and progenitor ... bone marrow, or apheresis harvest. Hematopoietic progenitors present at a frequency of 0.05-0.2% among peripheral blood ... endothelial progenitor cells, and mature endothelial cells.. The CD34 MicroBead Kit UltraPure contains MicroBeads directly ...https://www.miltenyibiotec.com/DE-en/products/macs-cell-separation/cell-separation-reagents/microbeads-and-isolation-kits/hematopoietic-stem-cells/cd34-microbead-kit-ultrapure-human.html
Aconiti Lateralis Preparata Radix Activates the Proliferation of Mouse Bone Marrow Mesenchymal Stem Cells and Induces...
... hematopoietic progenitor cells, macrophages, endothelial cells, and adipocytes . The purification of mBMMSCs has been more ... To advance the clinical use of stem cell therapy, such as stem cell transplantation, it is important to find substances that ... Although adult stem cell populations are found in most adult tissue, the bone marrow is an ideal source of stem cells because ... Adult stem cells are involved in the repair of tissue and in maintaining a balance between stem cell and differentiated cell ...https://www.hindawi.com/journals/ecam/2013/586741/
Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI) | Circulation
Hematopoietic, vascular and cardiac fates of bone marrow-derived stem cells. Gene Ther. 2002; 9: 648-652. ... Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med ... In patients receiving bone marrow-derived progenitor cells, bone marrow aspirates were obtained in the morning of the day of ... Background- Experimental studies suggest that transplantation of blood-derived or bone marrow-derived progenitor cells ...http://circ.ahajournals.org/content/106/24/3009
Age is a Major Factor in Stem Cell Transplant Success | Cryo-Cell
Cord blood is the youngest stem cells available for harvest. ... reliably with patient survival in stem cell transplantations. ... Hematopoietic stem/progenitor cells, generation of induced pluripotent stem cells, and isolation of endothelial progenitors ... In another study published in the Blood, data from 6,978 unrelated bone marrow transplantations were analyzed. It found younger ... Success in Stem Cell Transplantations. The key to a high survival rate in any stem cell transplantation is the degree of human ...https://www.cryo-cell.com/stem-cell-insider/march-2018/stem-cell-age-major-factor-transplants
Currículo do Sistema de Currículos Lattes (Nance Beyer Nardi)
... and Transplantation of Bone Marrow-Derived Cell Components with Hematopoietic Stem Cell Niche Properties. Stem Cells and ... Mobilization of Endothelial Progenitor Cells. Arquivos Brasileiros de Cardiologia (Impresso). , v. 10, p. 149-153, 2013. ... Two Key Phenomena in Early Culture of Murine Bone Marrow Mesenchymal Stem Cells. Stem Cells and Development. , p. ... Autologous transplantation of bone marrow mononuclear stem cells by mini-thoracotomy in dilated cardiomyopathy: technique and ...http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4787296P6
Arrhythmia in Stem Cell Transplantation
... mononuclear bone marrow cells (BM-MNC), BMC-derived hematopoietic progenitors, and MSCs have reported the safety of these cells ... including that endothelial precursors within bone marrow expressing CD34 and CD133, hematopoietic lineage markers, induce ... bone marrow progenitors, resident cardiac stem cells, human embryonic stem cell (hESCs) and induced pluripotent stem cells ( ... J. Stem Cell Res. Ther. 2014;04. 11. Widimsky P, et al. Intracoronary transplantation of bone marrow stem cells: background, ...http://pubmedcentralcanada.ca/pmcc/articles/PMC4441953/
Immunomodulatory plasticity of mesenchymal stem cells: a potential key to successful solid organ transplantation | SpringerLink
Organ transplantation remains to be a treatment of choice for patients suffering from irreversible organ failure. ... Effects of severe hypoxia on bone marrow mesenchymal stem cells differentiation potential. Stem Cells Int. 2013;2013:11. ... hematopoietic lineage markers), CD31 (endothelial lineage marker), HLA-DR (human leukocyte antigen) . ... Mesenchymal stem cells originally reported by Friedenstein et al. [13, 14], are multipotent progenitor cells accomplished to ...https://link.springer.com/article/10.1186/s12967-018-1403-0
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. - PubMed - NCBI
... cells are required for the homing of haematopoietic stem and progenitor cells. k, Bone marrow homing of haematopoietic ... niche in the bone marrow are unclear, with studies implicating osteoblasts, endothelial and perivascular cells. Here we ... cells and the bone surface 2 h (n = 16), 48 h (n = 30) and 96 h (n = 14) after HSC transplantation into lethally irradiated ... Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.. Méndez-Ferrer S1, Michurina TV, Ferraro F, Mazloom ...https://www.ncbi.nlm.nih.gov/pubmed/20703299?dopt=Abstract
Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells -...
... vascular endothelial cells (ECs). Thus, transplantation of genetically modified bone marrow progenitors may represent a vehicle ... The bone marrow contributes different cell types to the tumor stroma, including hematopoietic cells and, as recently suggested ... Unexpectedly, we did not find bone marrow-derived ECs in tumor vessels when we transplanted bone marrow progenitors ... Thus, TEM cells may account for the proangiogenic activity of bone marrow-derived cells in tumors, may represent a new target ...https://infoscience.epfl.ch/record/178294
An Integrated Platform for Isolation, Processing, and Mass Spectrometry-based Proteomic Profiling of Rare Cells in Whole Blood ...
2005) Autologous hematopoietic stem cell transplantation for autoimmune diseases. Bone Marrow Transplant. 35, 869-879. ... 2007) Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 109 ... 2007) Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 109 ... of the total cell population), namely endothelial progenitor cells (EPCs) and hematopoietic stem cells (HSCs) (37) were ...http://www.mcponline.org/content/14/6/1672.full
Exogenous endothelial cells as accelerators of hematopoietic reconstitution | Journal of Translational Medicine | Full Text
... factors at accelerating bone marrow reconstitution and shortening the neutropenic period post-transplantation, significant ... potential to actively repair the hematopoietic stem cell niche. Here we overview the field of hematopoietic growth factors, ... forth the rationale of utilizing exogenous endothelial cells as a novel cellular therapy for acceleration of hematopoietic ... A possible means of accelerating hematopoietic reconstitution would be administration of cells capable of secreting ...https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-10-231
Context- and Cell-Dependent Effects of Delta-Like 4 Targeting in the Bone Marrow Microenvironment - Semantic Scholar
In vitro treatment of endothelial cells with anti-Dll4 reduced Akt phosphorylation while maintaining similar levels of Erk 1/2 ... effects of systemic anti-Dll4 treatment result from qualitative vascular changes and also direct hematopoietic cell modulation ... The present study focused on the effects of systemic anti-Dll4 targeting in the bone marrow (BM) microenvironment. Here we show ... Finally, anti-Dll4 treatment of donor BM improved the hematopoietic recovery of lethally irradiated recipients in a transplant ...https://www.semanticscholar.org/paper/Context--and-Cell-Dependent-Effects-of-Delta-Like-Rem%C3%A9dio-Carvalho/47ffb94a5f2c637be4e0f590ef728eb8013a87c3
Current Stem Cell Delivery Methods for Myocardial Repair
... of microvascular function in the infarct-related artery by intracoronary transplantation of bone marrow progenitor cells in ... "Transcoronary transplantation of autologous mesenchymal stem cells and endothelial progenitors into infarcted human myocardium ... "Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium," Nature, vol. 428, no. 6983, pp. 668-673, ... Bone-Marrow-Derived Stem Cells (Autologous). Bone marrow stem cells (BMSCs) are among the best described multipotent stem cells ...https://www.hindawi.com/journals/bmri/2013/547902/
Microfluidics-based super-resolution microscopy enables nanoscopic characterization of blood stem cell rolling | Science...
Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow. Proc. Natl ... as this property can be used in treating blood disorders by bone marrow transplantation, in which transplanted HSPCs travel ... Hematopoietic progenitor cell rolling in bone marrow microvessels: Parallel contributions by endothelial selectins and vascular ... Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells. ...http://advances.sciencemag.org/content/4/7/eaat5304.full
Dose-Dependent Contribution of CD34-Positive Cell Transplantation to Concurrent Vasculogenesis and Cardiomyogenesis for...
Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological ... Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature. 2004; 428: 668-673. ... hematopoietic and endothelial lineage cells1,2 are derived from common progenitor cells (hemangioblasts).3-6 In adults, CD34+ ... Allogeneic bone marrow stem cell transplantation following CD34+ immunomagnetic enrichment in patients with inherited metabolic ...http://circ.ahajournals.org/content/113/10/1311.full
Patente US7429488 - Method for processing lipoaspirate cells - Google Patentes
... a patient include a mixture of adipose tissue and stem cells so that the composition has a higher concentration of stem cells ... The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to ... Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the ... Cells present in processed lipoaspirate tissue are used to treat patients. ...http://www.google.es/patents/US7429488?dq=flatulence
CD117 MicroBeads, mouse - Hematopoietic stem cells - MicroBeads and Isolation Kits - Cell separation reagents - MACS Cell...
... differentiated embryonic stem cell cultures1 , or amniotic fluid-derived stem cells2 . ... CD117 MicroBeads have been successfully used for the isolation of a variety of tissue stem cells, e.g. ... CD117 MicroBeads have been developed for the positive selection of hematopoietic stem and progenitor cells from mouse bone ... MicroBeads have been developed for the positive selection of hematopoietic stem and progenitor cells from mouse bone marrow . ...https://www.miltenyibiotec.com/LU-en/products/macs-cell-separation/cell-separation-reagents/microbeads-and-isolation-kits/hematopoietic-stem-cells/cd117-microbeads-mouse.html
The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST...
Synergistic neovascularization by mixed transplantation of early endothelial progenitor cells and late outgrowth endothelial ... after autologous hematopoietic stem cell transplantation in multiple sclerosisJournal of NeuroimmunologyYear: 20041531-21901942 ... comparison of the efficacy of transplantation of bone marrow-derived mesenchymal stem cells and unrestricted somatic stem cells ... Effect of transplantation with autologous bone marrow stem cells on acute myocardial infarctionInternational Journal of ...http://www.biomedsearch.com/nih/Influence-Autologous-Bone-Marrow-Stem/25294955.html
Protocols and Video Articles Authored by Melissa H. Wong
... suggest that adult bone marrow-derived hematopoietic stem cells may serve as a reservoir for endothelial cell progenitors. ... Self-renewal of stem cells with hematopoietic and endothelial cell potential was revealed by serial transplantation studies. ... Next to the hematopoietic stem cell, epithelial stem cells are one of the most widely studied stem cell populations. Even so, ... in contrast to bone marrow-derived hepatocytes, bone marrow-derived endothelial cells are not the products of cell fusion. The ...https://www.jove.com/author/Melissa++H._Wong
Bone Marrow Cell Trafficking Analyzed by 89Zr-oxine Positron Emission Tomography in a Murine Transplantation Model | Clinical...
... hematopoietic stem/progenitor cells in the bone marrow-ablated hosts. C, Similarly, CD45.2+ donor-derived cells reconstituted ... such as the bone marrow, spleen, and liver (24). Endothelial cells, osteoblasts, and reticular cells produce CXCL12 in these ... Bone marrow cell tracking by microPET/CT. 89Zr-oxine-labeled bone marrow cells (2 × 107 cells at 16.6 kBq/106 cells) were ... Bone marrow cells labeled with 89Zr-oxine show rapid homing to the bone marrow. To examine the dynamics of bone marrow cell ...http://clincancerres.aacrjournals.org/content/23/11/2759
Jonathan R. Keller, Ph.D. | Center for Cancer Research - National Cancer Institute
Understanding how stem cells self-renew and commit to specific cell lineages remains a central question in stem cell biology. ... The laboratory is currently focused on understanding the cellular and molecular regulation of hematopoietic ... The balance between maintaining stem cells and their more differentiated progeny is critical for the development and function ... Hematopoietic malignancies 5) Molecular regulation of self renewal and cell fate 6) Bone marrow transplantation ...https://ccr.cancer.gov/Mouse-Cancer-Genetics-Program/jonathan-r-keller?qt-staff_profile_tabs=2
Muse cell - Wikipedia
Mesenchymal stem cell transplantation: Muse cells exist within cultured MSCs such as bone marrow mesenchymal stem cells and ... endothelial progenitor markers). This indicates that Muse cells do not belong to previously investigated stem cell types. Muse ... Muse cells do not express CD34 (markers for hematopoietic stem cells, adipose stem cells, VSELs) and CD117 (hematopoietic stem ... Bone marrow-derived mesenchymal stem cells Fibroblasts Adipose-derived stem cells Bone marrow: Bone marrow mononucleated cells ...https://en.wikipedia.org/wiki/Muse_cell
Aberrant Kinetics of Bone Marrow-Derived Endothelial Progenitor Cells in the Murine Oxygen-Induced Retinopathy Model | IOVS |...
... resident and inflammatory bone marrow derived cells in the sclera by bone marrow and haematopoietic stem cell transplantation. ... Retinal Cell Biology , October 2011. Aberrant Kinetics of Bone Marrow-Derived Endothelial Progenitor Cells in the Murine Oxygen ... Yang J Ii M Kamei N . CD34 cells represent highly functional endothelial progenitor cells in murine bone marrow. PLoS One. 2011 ... 21 Extrinsic transplantation of BM-derived hematopoietic stem/progenitor cells (HSPCs), the Lin− cells and Lin−/Sca-1+ (LS) ...https://iovs.arvojournals.org/article.aspx?articleid=2186603