IJMS | Free Full-Text | Protective Effects of Rhodiola Crenulata Extract on Hypoxia-Induced Endothelial Damage via Regulation...
Human umbilical vein endothelial cells were pretreated with or without RCE and then exposed to hypoxia (1% O2) for 24 h. Cell ... In this study, we aimed to examine the effects of RCE in endothelial cells challenged with hypoxic exposure and to elucidate ... In summary, we showed that RCE protected endothelial cells from hypoxic insult and suggested that R. crenulata might be useful ... We found that hypoxia-induced cell death, impaired NO production, and oxidative stress. These responses were significantly ...
IJMS | Free Full-Text | Cannabidiol-from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer
Endothelial cells. HUVEC. √. √. 1-19 µM. CBD inhibited cell proliferations and exhibited potent antiangiogenic properties ... Table 3. Role of CBD among various cancer cell lines.. Type/Cancer Cell Line. Cell Line. In vitro. In vivo. Conc.. Conclusion. ... The MTT screening showed that the IC50 values were 2 µM (MDA-MB-231 cells) and 5 µM (T-47D cells). At the same time, both cell ... Using MDA-MB-231 and MCF-7 cells, Shrivastava et al. have explained that CBD induces cell death in selected cancer cells. Among ...
Cells | Free Full-Text | Serum of Post-COVID-19 Syndrome Patients with or without ME/CFS Differentially Affects Endothelial...
PCS (n = 17), PCS/CFS (n = 13), and healthy controls (HC, n = 14) were screened for serum anti-endothelial cell autoantibodies ... Therefore, we investigated the effects of patients sera on endothelia cells (ECs) in vitro. ... endothelial dysfunction (ED) has been demonstrated in these patients, but the mechanisms remain elusive. ... sera from both patient cohorts induced the release of molecules involved in inhibition of nitric oxide-mediated endothelial ...
Biomolecules | Free Full-Text | The Use of Euterpe oleracea Mart. As a New Perspective for Disease Treatment and Prevention
Immortalized human umbilical vein endothelial cells (HUVEC) were treated with different concentrations of EO seed extract (0.1 ... Decreased cell viability of lung cancer cell line (A549). Regulation of cell cycle, prevention of cell growth and increase in ... The anthocyanin-rich extract was applied to cell cultures of C-6 rat brain microglia cells and MDA-468 breast cancer cells at ... and colon fibroblast cells (CCD-18Co). The extract inhibited the growth of SW-480 cells more than that of HT-29 cells but had ...
IJMS | Free Full-Text | Anti-Angiogenic Therapy: Current Challenges and Future Perspectives
Most of the anti-angiogenic agents approved for cancer treatment rely on targeting vascular endothelial growth factor (VEGF) ... Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and oxygen supply to the tumor cells ... are essential for endothelial tip cell activation (endothelial cell (EC)) that respond and guide EC migration in the direction ... are essential for endothelial tip cell activation (endothelial cell (EC)) that respond and guide EC migration in the direction ...
Antioxidants | Free Full-Text | Anti-Inflammatory and Reactive Oxygen Species Suppression through Aspirin Pretreatment to Treat...
Endothelial cells store IL-8 in their storage vesicles. When endothelial cells are seriously damaged, IL-8 is released. Thus, ... Kiefmann, R.; Heckel, K.; Schenkat, S.; Dörger, M.; Wesierska-Gadek, J.; Goetz, A.E. Platelet-endothelial cell interaction in ... BALF cells were collected with centrifugation at 500× g at 4 °C. The number of BALF cells was determined using a hemocytometer ... The possible mechanisms by which platelets contribute to ARDS include the activation of endothelial cells by release of ...
Pharmaceuticals | October 2022 - Browse Articles
... cerebral microvascular endothelial cells inhibit apoptosis and promote synaptic remodeling through exosome-mediated cell-cell ... are responsible for cell-cell, cell-protein interactions, and cell motility. A wound healing test confirmed their regulation by ... Brain Microvascular Endothelial Cell-Derived Exosomes Protect Neurons from Ischemia-Reperfusion Injury in Mice by Jin Sun ... Exosomes derived from brain endothelial cells (EC-Exo) protect neurons from hypoxic injury. However, the biological role of ...
Nutrients | Free Full-Text | Mediterranean Diet and Endothelial Function: A Review of its Effects at Different Vascular Bed...
In this review, we will review the evidence for its regulation of endothelial function, a key element in the early and late ... affecting both blood circulating cells and endothelial cells. In this cellular pro-apoptotic stage, endothelial cells and ... Endothelial progenitor cells (EPC) play an important role, since the circulating cells are stem cells derived from bone marrow ... The aged cell, especially at the endothelial level, may also influence endothelial function. In this context, a study by Gomez- ...
Surgeries | Free Full-Text | Ionizing Radiation Mediates Dose Dependent Effects Affecting the Healing Kinetics of Wounds...
This study provides a detailed characterization of the dose-dependent impact of ionizing radiation on skin cells (45, 60, or 80 ... Influence of endothelial cells on vascular smooth muscle cells phenotype after irradiation: Implication in radiation-induced ... Radiation effects on the cytoskeleton of endothelial cells and endothelial monolayer permeability. Int. J. Radiat. Oncol. Biol ... This could be due to apoptosis or altered endothelial cell function caused directly by ionizing radiation or by the presence of ...
Nutrients | Free Full-Text | Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia...
Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N. Engl. J. Med. 2003, 348, 593-600. [ ... Fatty Liver and Endothelial Dysfunction. Patients with NAFLD have endothelial dysfunction and a significant decrease in ... The regeneration of the endothelial monolayer, when it is damaged, is performed by circulating bone marrow derived-endothelial ... Decreased circulating endothelial progenitor cell levels and function in patients with nonalcoholic fatty liver disease. PLoS ...
CIMB | Free Full-Text | A Potential Role of the CD47/SIRPalpha Axis in COVID-19 Pathogenesis
Calu-3 cells, and air−liquid interface cultures of primary human bronchial epithelial cells. Moreover, SARS-CoV-2 infection ... are elevated in SARS-CoV-2-infected Caco-2 cells, ... to mediate immune escape in cancer and virus-infected cells, ... THBS1/CD47 signaling drives endothelial cell senescence. [45]. TSP1 promotes ageing-associated human and mouse endothelial cell ... Thrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells. Cell Death ...
Toxics | Free Full-Text | Effects of Acrylamide-Induced Vasorelaxation and Neuromuscular Blockage: A Rodent Study
Wilson, C.; Lee, M.D.; McCarron, J.G. Acetylcholine released by endothelial cells facilitates flow-mediated dilatation. J. ... These three factors induce endothelial-dependent vasorelaxation, activate endothelial NOS, and produce nitric oxide [38]. ... Cell Biol. 2015, 93, 192-198. [Google Scholar] [CrossRef]. *Elhelaly, A.E.; AlBasher, G.; Alfarraj, S.; Almeer, R.; Bahbah, E.I ... Acrylamide affacted proliferation and differentiation of the neural progenitor cell line C17.2 and the neuroblastoma cell line ...
Dentistry Journal | Free Full-Text | Indocyanine Green-Assisted and LED-Light-Activated Antibacterial Photodynamic Therapy...
Matrix Metalloproteinase-8 Is Expressed in Rheumatoid Synovial Fibroblasts and Endothelial Cells. J. Biol. Chem. 1997, 272, ... Treatment targeting highly reduces possible side effects, in addition to the fact that mammalian cells are much more resistant ... Antibacterial ROS itself is widely in use in nature, including in the bacterial elimination of human white blood cell ... The biomodulating effects of the 810 nm infrared light promotes human dental pulp stem cell enhancement, leading to ...
Antioxidants | Free Full-Text | Redox for Repair: Cold Physical Plasmas and Nrf2 Signaling Promoting Wound Healing
It discusses new links between plasma treatment of cells and tissues, and the perception and intracellular translation of ... Nrf2 regulates angiogenesis: Effect on endothelial cells, bone marrow-derived proangiogenic cells and hind limb ischemia. ... Liu, Z.J.; Velazquez, O.C. Hyperoxia, endothelial progenitor cell mobilization, and diabetic wound healing. Antioxid. Redox ... Bonay, M.; Deramaudt, T.B. Nrf2: New insight in cell apoptosis. Cell Death Dis. 2015, 6, e1897. [Google Scholar] [CrossRef] [ ...
Cancers | Free Full-Text | Cyclic Hypoxia: An Update on Its Characteristics, Methods to Measure It and Biological Implications...
Importantly, even within tumors, oxygen levels fluctuate due to changes in red blood cell flux, vascular remodeling and ... MCF-7 cancer stem cells and the impact of their microenvironment on angiogenesis using human umbilical vein endothelial cells ( ... brightly stained cells were more radiosensitive than dimly stained cells, suggesting that brightly stained cells were more ... Clonogenic assays show that cells pre-treated with cyclic hypoxia are more radioresistant when compared to cells pre-treated ...
Biomolecules | Free Full-Text | Endothelial-Cell-Derived Human Secretory Leukocyte Protease Inhibitor (SLPI) Protects...
Stable endothelial cells overexpressing human SLPI were generated from an endothelial cell line (EA.hy926). The cytoprotective ... The manipulation of endothelial cells to secrete protective factors could enhance cardioprotection. Secretory leukocyte ... effect was determined by cell survival assay. The results showed that endothelial-derived recombinant human SLPI (rhSLPI) ... 3 or treatment with conditioned medium enhanced cell viability by 10.51-16.7% (co-culture) and 15.25-20.45% (conditioned medium ...
Antioxidants | Free Full-Text | NADPH Oxidase Mediates Oxidative Stress and Ventricular Remodeling through SIRT3/FOXO3a Pathway...
Apocynin improved SIRT3 and Mn-SOD expression in H9c2 cells transfected with SIRT3 siRNA. In our diabetic mouse model, apocynin ... acetylation in ventricular tissue and H9c2 cells. Reactive oxygen species (ROS) overproduction promoted ventricular structural ... and diabetes with apocynin and the H9c2 cell line was used as an in vitro model for investigation. We examined the molecular ... Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols. Endothelium 2002, 9, 191- ...
Nutrients | Free Full-Text | Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks...
Hormones, growth factors, morphogens could unwontedly protect tumour cells or induce cancer cell proliferation and are thus ... Basal and inducible anti-inflammatory epoxygenase activity in endothelial cells. Biochem. Biophys. Res. Commun. 2014, 446, 633- ... Fuchs, E. The Tortoise and the Hair-Slow-Cycling Cells in the Stem Cell Race.pdf. Cell 2009, 137, 811-819. [Google Scholar] [ ... Hair shafts were removed with a cell strainer and HF cells were centrifuged for 5 min at 500 rpm. The cell pellets were washed ...
Cells | Free Full-Text | Functional Genomic Screening in Human Pluripotent Stem Cells Reveals New Roadblocks in Early...
... stage resulted in a decreased proportion of PDX1/NKX6-1-positive cells in SLC22A1 KO lines, and in DSC2 KO lines when ... with their ability to proliferate indefinitely and to differentiate into virtually all cell types of the human body, provide a ... particularly the loss of SLC22A1 and DSC2 led to impaired differentiation efficiency into CXCR4/KIT-positive DE cells. qPCR ... we employed a human pancreatic differentiation platform complemented with an shRNA screen in human pluripotent stem cells (PSCs ...
Life | Free Full-Text | High Dose Intravenous Vitamin C as Adjunctive Therapy for COVID-19 Patients with Cancer: Two Cases
Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin. Biochem. Biophys. Res. Commun. 2018, 495, ... Cell 2017, 170, 1079-1095.e20. [Google Scholar] [CrossRef][Green Version]. *Kuck, J.L.; Bastarache, J.A.; Shaver, C.M.; Fessel ... The patients total white blood cell count (WBC) elevated to 18.09 g/L, neutrophil count elevated to 14.87 g/L, and lymphopenia ... Ascorbate regulates haematopoietic stem cell function and leukaemogenesis. Nature 2017, 549, 476-481. [Google Scholar] [ ...
Molecules | Free Full-Text | Evaluation of Amino-Functional Polyester Dendrimers Based on Bis-MPA as Nonviral Vectors for siRNA...
siRNA-transfection was successful in C6 and U87 cell lines using the G3 and G4 dendrimers followed by a decrease of ... in cell cultures. The study encompassed dendrimers of generation one to four (G1-G4), modified to bear 6-48 amino end-groups, ... Biodegradable polymeric vectors for gene delivery to human endothelial cells. Bioconjug. Chem. 2006, 17, 1162-1169. [Google ... In order to study the dendrimers ability to enter cells and their localization, C6 and U87 cells were exposed to the rhodamine- ...
Cancers | Free Full-Text | Liquid Biopsies beyond Mutation Calling: Genomic and Epigenomic Features of Cell-Free DNA in Cancer
Cell-free DNA (cfDNA) analysis using liquid biopsies is a non-invasive method to gain insights into the biology, therapy ... DNA contributions from vascular endothelial cells (8.6%) and hepatocytes (1.2%) were also observed. The application of their ... Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes. Nat. Med. 2020, 26, 1041-1043. [Google ... Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease. Nat. Commun ...
Brain Sciences | Free Full-Text | The Role of Citicoline in Neuroprotection and Neurorepair in Ischemic Stroke
Endothelial progenitor cells (EPCs) are circulating immature pluripotential hematopoietic cells capable of differentiating into ... endothelial differentiation and functional capacity of endothelial progenitor cells after ischemic stroke. Microvasc. Res. 2010 ... The pericyte is a pluripotent stem cell in the brain with the potential of differentiating into cells of neural lineage such as ... CDP-choline treatment increases circulating endothelial progenitor cells in acute ischemic stroke. Neurol. Res. 2011, 33, 572- ...
Nutrients | Free Full-Text | Acute Responses to Low and High Intensity Exercise in Type 1 Diabetic Adolescents in Relation to...
Glucose variability inversely associates with endothelial progenitor cells in type 1 diabetes. Endocrine 2015, 48, 342-345. [ ... Chiu, K.C.; Chu, A.; Go, V.L.; Saad, M.F. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am ... Infante, M.; Ricordi, C.; Sanchez, J.; Clare-Salzler, M.J. Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function ... Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the insulin-producing beta cells of the pancreas are ...
IJMS | Free Full-Text | CCL2 Inhibition of Pro-Resolving Mediators Potentiates Neuroinflammation in Astrocytes
However, CCL2 has also been proven to exert different types of actions on these cells, including the modification of their ... In the CNS, CCR2 is present in astrocytes, endothelial cells, microglia, and neurons [3]. The accumulation of CCL2 is ... Cell Neurosci. 2021, 15, 673549. [Google Scholar] [CrossRef] [PubMed]. *Sofroniew, M.V. Astrocyte Reactivity: Subtypes, States ... Cell Cultures. Rat cortical astrocytes were obtained as described previously [26]. Briefly, 1-day-old Wistar rats (Harlan) were ...
Viruses | Free Full-Text | Animal Models of Dengue Virus Infection
Non-human primates (NHPs) can sustain viral replication in relevant cell types and develop a robust immune response, but they ... Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease. Cell Host ... T cells can help CD8+ T cell responses after vaccination but are not necessary for Ab production and CD8+ T cell response after ... have been shown to cross-react with different coagulation components and cells, such as endothelial cells, platelets and ...
Beverages | Free Full-Text | l-Theanine as a Functional Food Additive: Its Role in Disease Prevention and Health Promotion
... l-Theanine promotes nitric oxide production in endothelial cells through eNOS phosphorylation. J. Nutr. Biochem. 2013, 24, 595- ... 48-h l-THE treatment induced in vitro and ex vivo growth of human non-small cell lung cancer A549 and leukemia K562 cell lines ... Dendritic cells were purified with l-THE solution (200 μmol/L) that resulted in partial recovery of dendritic cell function, ... Administration of l-THE (400 μg/mL) was found to induce cell death of four cancer cell lines: breast 23 (MCF-7), colon (HT-29 ...
Polymers | Free Full-Text | Graphene Oxide–Protein-Based Scaffolds for Tissue Engineering: Recent Advances and...
Novel strategies and approaches based on stem cell therapy, as well as the involvement of the extracellular matrix in the ... Herein, recent applications and the biological activity of nanocomposite bioconjugates are analyzed with respect to cell ... Moreover, as a chemoattractant, it attracts smooth muscle cells, endothelial cells, and monocytes. Elastin is essentially ... The cells can be directly collected from the target organ, developed from precursor or stem cells, or harvested from cell lines ...
Toxics | Free Full-Text | Characterization of Potential Adverse Outcome Pathways Related to Metabolic Outcomes and Exposure to...
Evaluation of cellular response to perfluorooctane sulfonate in human umbilical vein endothelial cells. Toxicol. Vitr. 2012, 26 ... Furthermore, in rat cell lines, cell death and the activation of the aryl hydrocarbon receptor (AhR) were reported in some ... Cell. Endocrinol. 2015, 400, 90-101. [Google Scholar] [CrossRef]. *Yamamoto, J.; Yamane, T.; Oishi, Y.; Kobayashi-Hattori, K. ... Organism From Which Cells Were Originally Derived. Frequency (%). Main Event Identified (Number of Publ.. Associated with Event ...
Pharmaceutics | Free Full-Text | Candida glabrata Antifungal Resistance and Virulence Factors, a Perfect Pathogenic Combination
Desai, C.; Mavrianos, J.; Chauhan, N. Candida glabrata Pwp7p and Aed1p are Required for Adherence to Human Endothelial Cells. ... The genus Candida species can induce their capture through phagocytes in endothelial and epithelial cells, using them as a " ... endothelial, and epithelial cells. It is activated by proteolysis through C. glabrata yapsins (CgYps), a family of ... that are relevant for adherence in endothelial cells and are not observed in S. cerevisiae nor C. albicans. Such proteins are ...