Endoplasmic-reticulum-associated protein degradation (ERAD) designates a cellular pathway which targets misfolded proteins of ... Vembar SS, Brodsky JL (December 2008). "One step at a time: endoplasmic reticulum-associated degradation". Nature Reviews. ... Which E3 ligase finally tags the proteins for the proteasomal degradation?[citation needed] Endoplasmic reticulum JUNQ and IPOD ... and degradation at the endoplasmic reticulum". International Review of Cell and Molecular Biology. 292: 197-280. doi:10.1016/ ...

... cause rhodopsin protein misfolding and trigger endoplasmic reticulum (ER) stress, activating the unfolded protein response (UPR ... Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration Mol Neurobiol. 2015 Aug;52(1): ... IRE1 significantly upregulated ER-associated protein degradation (ERAD), triggering pronounced P23H rhodopsin degradation. ... cause rhodopsin protein misfolding and trigger endoplasmic reticulum (ER) stress, activating the unfolded protein response (UPR ...

IRE1 significantly upregulated ER-associated protein degradation (ERAD), triggering pronounced P23H rhodopsin degradation. ... cause rhodopsin protein misfolding and trigger endoplasmic reticulum (ER) stress, activating the unfolded protein response (UPR ... IRE1 significantly upregulated ER-associated protein degradation (ERAD), triggering pronounced P23H rhodopsin degradation. ... cause rhodopsin protein misfolding and trigger endoplasmic reticulum (ER) stress, activating the unfolded protein response (UPR ...

Hypercapnia Induces Inositol-Requiring Enzyme 1 alpha-Driven Endoplasmic,br/, Reticulum-associated Degradation of the Na,K- ... Hypercapnia Induces Inositol-Requiring Enzyme 1 alpha-Driven Endoplasmic Reticulum-associated Degradation of the Na,K-ATPase ... 2021). Hypercapnia Induces Inositol-Requiring Enzyme 1 alpha-Driven Endoplasmic Reticulum-associated Degradation of the Na,K- ... in the endoplasmic reticulum (ER) may decrease plasma membrane abundance of the transporter. Here, we investigated how ...

Endoplasmic reticulum associated degradation is required for maintaining endoplasmic reticulum homeostasis and viability of ... Endoplasmic reticulum associated degradation is required for maintaining endoplasmic reticulum homeostasis and viability of ... Endoplasmic reticulum associated degradation is required for maintaining endoplasmic reticulum homeostasis and viability of ... Endoplasmic reticulum associated degradation is required for maintaining endoplasmic reticulum homeostasis and viability of ...

Degradation of arylsulfatase A in the endoplasmic reticulum. FEBS J. 2005 Mar;272(5):1179-88. doi: 10.1111/j.1742-4658.2005. ...

... protein processing in endoplasmic reticulum (94 unigenes, 3.83%); non-alcoholic fatty liver disease (NAFLD) (86 unigenes, 3.50 ... fatty acid degradation (36 unigenes, 1.47%); pyruvate metabolism (30 unigenes, 1.22%); valine, leucine, and isoleucine ... degradation (41 unigenes, 1.67%); retinol metabolism (42 unigenes, 1.71%); ...

... is essential for many cellular pathways including but not limited to endoplasmic reticulum-associated degradation (ERAD), DNA ... The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol ... VPS13D interacts with VCP/p97 and negatively regulates endoplasmic reticulum-mitochondria interactions ... INSIG1 degradation activates SREBP1 processing, freeing the transcription factor to translocate to the nucleus to activate ...

Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell. 126:727-739. View this ... Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to ... Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. 7:880-885. View this article via: CrossRef PubMed Google ... Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid. Redox Signal. 9:2277-2294 ...

Endoplasmic Reticulum-Associated Protein Degradation. Logesvaran Krshnan, Michael L. van de Weijer, and Pedro Carvalho. The ... Lipid Transport from Endoplasmic Reticulum to Autophagic Membranes. Takuo Osawa, Kazuaki Matoba, and Nobuo N. Noda. Endoplasmic ... The Endoplasmic Reticulum, Second Edition. Book Series: A Cold Spring Harbor Perspectives in Biology Collection. Subject Area(s ... AMPylation and Endoplasmic Reticulum Protein Folding Homeostasi. Luke A. Perera and David Ron. Regulation and Functions of the ...

Endoplasmic Reticulum-Associated Protein Degradation. Logesvaran Krshnan, Michael L. van de Weijer, and Pedro Carvalho. The ... Lipid Transport from Endoplasmic Reticulum to Autophagic Membranes. Takuo Osawa, Kazuaki Matoba, and Nobuo N. Noda. Endoplasmic ... The Endoplasmic Reticulum, Second Edition. Book Series: A Cold Spring Harbor Perspectives in Biology Collection. Subject Area(s ... AMPylation and Endoplasmic Reticulum Protein Folding Homeostasi. Luke A. Perera and David Ron. Regulation and Functions of the ...

Endoplasmic reticulum. ERAD. Endoplasmic reticulum associated protein degradation. GFAP. Glial fibrillary acidic protein. GRP78 ... Protein kinase-like endoplasmic reticulum kinase. PAS. periodic acid Schiff. PD. Parkinsons disease. PDI. Protein disulphide ... and its correlation with endoplasmic reticulum stress and unfolded protein response (UPR), providing a comprehensive ...

A novel form of hereditary myeloperoxidase deficiency linked to endoplasmic reticulum/proteasome degradation. J Clin Invest. ... Quality control in the endoplasmic reticulum: lessons from hereditary myeloperoxidase deficiency. J Lab Clin Med. 1999 Sep. 134 ...

Mutations in NGLY1 cause an inherited disorder of the endoplasmic reticulum-associated degradation pathway. Enns, Gregory M; ... PURPOSE: The endoplasmic reticulum-associated degradation pathway is responsible for the translocation of misfolded proteins ... across the endoplasmic reticulum membrane into the cytosol for subsequent degradation by the proteasome. ... ...

Title: Hypercapnia Induces Inositol-Requiring Enzyme 1α-Driven Endoplasmic Reticulum-associated Degradation of the Na,K-ATPase ... Hypercapnia Induces Inositol-Requiring Enzyme 1alpha-Driven Endoplasmic Reticulum-associated Degradation of the Na,K-ATPase ...

MET Suppresses Epithelial VEGFR2 via Intracrine VEGF-induced Endoplasmic Reticulum-associated Degradation ... Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers ... Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers ... Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers ...

... a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation. Mol. Cell. Biol. 2002, 22, 626-634. [ ... Shih, Y.T.; Hsueh, Y.P. VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation. Nat. ...

... degradation of proinsulin increases via the endoplasmic reticulum pathway, resulting in decreased insulin secretion. That may ... A. Bartolome, C. Guillen, and M. Benito, "Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic ... activating autophagy decreases endoplasmic reticulum (ER) stress and improves insulin sensitivity [17, 18]. In short, these ... The degradation of insulin particles is mainly mediated by microautophagy and endocytosis, while proinsulin degradation is ...

Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity. ...

09123 Folding, sorting and degradation. 04141 Protein processing in endoplasmic reticulum. 4340379. 04120 Ubiquitin mediated ...

4A). Moreover, Beclin-1, Atg-5 and Atg-12 expression levels were upregulated; p62 degradation and LC3 cleavage were observed at ... Park SH, Park HS, Lee JH, Chi GY, Kim GY, Moon SK, Chang YC, Hyun JW, Kim WJ and Choi YH: Induction of endoplasmic reticulum ... Pinton P, Ferrari D, Rapizzi E, Di Virgilio F, Pozzan T and Rizzuto R: The Ca2+ concentration of the endoplasmic reticulum is a ... Schönthal AH: Endoplasmic reticulum stress and autophagy as targets for cancer therapy. Cancer Lett. 275:163-169. 2009. View ...

2015) IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol 17(12): 1546-55. ... 53 mechanisms of protein degradation,54 and epithelial polarization.55 ...

VCP participates in the final step of ubiquitination and endoplasmic reticulum-associated degradation of HMGCR (3-hydroxy-3- ... two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation. Mol. Biol. Cell 2009, 20, 3330-3341. [Google ... VCP (Transitional endoplasmic reticulum ATPase) promotes protein sorting at the level of the Golgi apparatus where it acts as a ... Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation. Genes Dev. 2013, 27, 900-915. [ ...

... were mislocalized to the endoplasmic reticulum (ER), where they are tagged for proteasomal degradation. The L89P mutant was ...

Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation. The. J ... SCFβTrCP-mediated degradation of SHARP1 in triple-negative breast cancer *Juliana Haydeé Enriqué Steinberg ... have a cytoplasmic localization while others have a transmembrane domain that serves as anchorage to the endoplasmic reticulum ...

"NGLY1 deficiency causes impaired protein degradation and increased endoplasmic reticulum stress." J Clin Invest. 2019; 129(12): ... "NGly1-deficiency disrupts protein homeostasis and promotes endoplasmic reticulum stress." Genet. 2019;211(3):745-760. [PubMed] ... These mutations lead to a deficiency in the function of the NGLY1 enzyme, which is responsible for the degradation of misfolded ... NGLY1 is a rare genetic condition that affects the function of genes involved in the degradation of glycoproteins. Individuals ...

The endoplasmic reticulum is involved in protein and lipid synthesis and may serve as a source of nutrients for both of these ... This niche is bound by a protective membrane which protects the pathogen from degradation and allows it to replicate. However, ... The studies reported in this paper demonstrate that both of these pathogens interact with the endoplasmic reticulum of the host ... Here, we demonstrate that the ApV and AmV extensively interact with the host endoplasmic reticulum (ER) in endothelial, myeloid ...

The endoplasmic reticulum (ER) regulates protein folding, maturation, misfolded protein degradation, and regulation of new ... Endoplasmic reticulum stress in liver disease. J Hepatol. 2011;54:795-809. [PubMed] [DOI] [Cited in This Article: ] [Cited by ... The Endoplasmic Reticulum. The Cell: A Molecular Approach. Sunderland: Sinauer Asssociates 2000; . [PubMed] [DOI] [Cited in ... Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy. J Hepatol. 2013;59:98-104 ...