Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model | PNAS
... and CNS in an experimental autoimmune encephalomyelitis (EAE) model (30). It was proposed that the ex-FoxP3 cells derive from ... ex-FoxP3 T cells in autoimmune FoxP3-GFPcreKI/Y PD-1 KO mice. (A) FACS analysis of Tregs, ex-FoxP3 T cells, and CD25+ T cells ... resulting in their early death from T-cell-mediated autoimmune destruction, especially autoimmune pancreatitis. ... S5 and Table S2). The presence of CD8+ T cells aggravated the autoimmune phenotype in the colon. The targeting of the colon in ...