"Viable offspring derived from fetal and adult mammalian cells." Nature 385 (1997): 810-3. ... Embryos Under the Microscope: The Diverging Meanings of Life. Cambridge, MA: Harvard University Press, 2014. ... Stem cells--Research Stem Cells Nobel Prizes Embryology Developmental Biology Embryos Cell differentiation Cell culture ... After analysis, Yamanaka and Takahashi found that the four embryos contained iPS cells that contributed to all three germ ...
Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Nichols, J., Zevnik, ... Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4 [6]. ...
CRISPR Barcodes Map Mammalian Development in Exquisite Detail. For the first time, scientists have wielded CRISPR to track a ... mammals development from a single egg into an embryo with millions of cells. Nature. From ACM News , August 13, 2018 ...
Chromatin remodeling of prostaglandin signaling in smooth muscle enables mouse embryo passage through the female reproductive ... Mammalian Developmental Biology Section. of the Laboratory of Cellular & Developmental Biology Jurrien Dean, M.D., NIH ...
... zebrafish embryos can be used for functional screening of mechanosensitive genes that regulate EC apoptosis in mammalian ... Specifically, suppression of blood flow in zebrafish embryos (by targeting cardiac troponin) enhanced that rate of EC apoptosis ...
... the prevailing dogma that said the seeds of symmetry breaking occur relatively late in the development of the mammalian embryo ... As the embryo grows into a ball of cells, only a tiny group of cells within that ball will go on to make the embryo proper, and ... I knew from experiments by many of my colleagues and in my own laboratory that mouse embryos, and most likely human embryos too ... A renowned biologists cutting-edge and unconventional examination of human reproduction and embryo research ...
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Dolly is not the first reported mammalian clone, but the first one which involved neither forced twinning of an embryo, or ...
Mammalian eggs lack polarity and symmetry is broken during early embryogenesis. This results in the formation of a blastocyst ... Our group aims to understand the principle of multi-cellular self-organisation using early mouse embryos as a model system. ... The group studies a population of coupled genetic oscillators in the vertebrate embryo termed the segmentation clock. This ... Looking at the molecular, cellular and systems levels, the Hiiragi group studies how, early in mammalian development, the ...
Pluripotent epiblast cells of early mammalian embryos give rise to all the lineages that make up a fetus. How these cells ... advantages of using the pig embryo as a model for non-rodent mammalian development to complement studies on human embryos ... We use pig embryos as a model for non-rodents species, because of the shared embryology with humans. I will present data ... Indeed, human and mouse embryos differ substantially during the period when the epiblast develops, and this seems to impact how ...
Understanding Cortical Development and Disease: From Embryos to Brain Organoids. Speaker: Paola Arlotta. Harvard University ... Much remains unknown regarding the cellular and molecular mechanisms governing mammalian brain development. Focusing on the ... cellular diversity in vivo and consider to what extent processes of cortical development can be replicated outside the embryo, ...
... such as in vitro embryo production and embryo transfer, brought about by the cattle industry [19]. Additionally, the efficiency ... I believe that the reprogramming errors are not the only cause of these low rates of cloning: the mammalian SCNT fails with a ... I believe that the mammalian cloning fails with such a high frequency mainly due to the damage caused by the aggressive ... N. Rodríguez-Osorio, R.Urrego, J. B. Cibelli, K. Eilertsen, E. Memili: Reprogramming mammalian somatic cells Theriogenology 78( ...
... where he applied his previous experience to the production of mammalian embryos by nuclear transfer. Dolly the Sheep, the first ... It was a seminal demonstration of the ability of the mammalian egg to reprogram a somatic nucleus back to a pluripotent state. ... Much of this research was presented and discussed at the annual meeting of the International Embryo Transfer Society where he ... after he came to Roslin Institute where in a series of papers he put the intellectual framework into the method of mammalian ...
Mimicking the in vivo environment of the oviduct in microfluidic channels for the in vitro culture of mammalian embryos using ... Development of a microfluidic chip powered by EWOD for in vitro manipulation of bovine embryos Adriana Karcz (UGent) , Ann Van ... in-vitro fertilization, cryopreservation, vitrification, blastocyst, cleavage-stage embryos, implantation, metaanalysis, ... oocytes, embryo development, fertilization, in-vitro, ivf, stage, aneuploidy, assisted oocyte activation, blastocysts, ca2+ ...
Prior to this, it was not known how mammals reproduced and the discovery of the mammalian egg provided crucial insights into ... His observations and studies focused on animal embryos, not plants. Therefore, the statement is false. ... In 1827, Karl Von Baer made the discovery of the mammalian egg. This significant finding revolutionized the understanding of ... In 1827, Karl von Baer discovered mammalian eggs. This discovery was significant because it challenged the prevailing belief at ...
The stem cell-derived embryos could shed new light on the earliest stages of human pregnancy ... a professor in mammalian development and stem cell biology in Cambridges Department of Physiology, Development, and ... The new model embryos, which bypass the need for sperm or egg cells, were developed in the lab alongside natural mouse embryos ... Mouse embryos recently generated from stem cells in a lab show more brain development than any synthetic mouse embryos created ...
... caused deformations to fish embryos just hours after they received a dose in new studies by researchers at the University of ... a mammalian species that even a seemingly low dose of the drug for the mother could result in much higher levels for the embryo ... Zebrafish embryos were seen to be affected within hours by the components of the drug Primodos The components of a ... This too is new information and if the same thing happens in mammals, these drugs could build up in the embryo to much higher ...
While this approach does allow cryopreservation of cells in suspension and some small aggregates, such as mammalian embryos, it ... Ice-free cryopreservation of mouse embryos at -196 degrees C by vitrification. Nature. 1985 Feb 14-20. 313 (6003):573-5. [QxMD ... CPA solutions have reduced the cooling rate considerably and have allowed limited successful vitrification of mouse embryos, [ ...
This is true in lower mammalian embryogenesis (such as mice), but not in human development. Rather, in humans, the embryo ... When scientists extract stem cells from these early-stage embryos, however, the embryos are destroyed, and this is a matter of ... a new human embryo - IF IF IF the totipotent cell is separated from the whole intact embryo and IF IF IF the natural biological ... then one of those cells divides producing a three-cell embryo, then the other cell divides producing a 4-cell embryo, etc. ...
"E-cigarette aerosol exposure can cause craniofacial defects in Xenopus laevis embryos and mammalian neural crest cells" by ... E-cigarette aerosol exposure can cause craniofacial defects in Xenopus laevis embryos and mammalian neural crest cells ... "This means that if a chemical perturbs a frog embryo, its likely to do the same thing to a human embryo," she said. ... the researchers exposed frog embryos and samples of mammalian neural crest cells to saline infused with e-cigarette vapor. ...
C. Ufer, C. C. Wang, A. Borchert, D. Heydeck, and H. Kuhn, "Redox control in mammalian embryo development," Antioxidants and ... S.-H. Song, J. J. Lim, J. K. Bang et al., "Evaluation of sperm deoxyribonucleic acid (DNA) damage and effects on embryo ... V. Burruel, K. Klooster, C. M. Barker, R. R. Pera, and S. Meyers, "Abnormal early cleavage events predict early embryo demise: ... S. D. Perreault, R. A. Wolff, and B. R. Zirkin, "The role of disulfide bond reduction during mammalian sperm nuclear ...
Individual embryos were genotyped by PCR to identify MEFs that were of the wild type (CENP-E+/+) or were CENP-E-conditional/ ... CENP-E stimulates mammalian BubR1 kinase activity Mammalian CENP-E interacts with the checkpoint kinase BubR1, as has been ... Mammalian BubR1 kinase activity is stimulated by CENP-E. (A) BubR1 was immunoprecipitated from CENP-E+/+ (lanes 1-3) and CENP-E ... Mammalian BubR1 kinase activity is stimulated by CENP-E. (A) BubR1 was immunoprecipitated from CENP-E+/+ (lanes 1-3) and CENP-E ...
... development of the longitudinal smooth muscle of the foetal mammalian gut and its cholinergic excitatory, adrenergic inhibitory ... B, Quantification of NG sensory neurons from E12.5 Control and ΔSN embryos (n = 6/3 for Control embryo, n = 8/4 for ΔSN embryo ... R26tdTom embryos (n = 3/3 for vGlut2Cre;R26tdTom, n = 3/3 for AdvillinCre;R26tdTom; number of DRGs per embryo/number of embryos ... embryos with TrkA staining. TrkA+ spinal sensory axons in ΔSE embryos project in a similar pattern as those in Control embryo. ...
... can be used to predict embryo quality and ultimately the embryo transfer (ET) results. This technology, if success, will for ... DESCRIPTION (provided by applicant): Project Summary We propose to develop a non-invasive method to predict mammalian oocyte ... Non-invasive method to evaluate the quality of human oocytes and embryos SBC: Renova Life Inc. Topic: NICHD ...
... and/or the construction of stem cell-derived mammalian embryo-like structures, are always encouraged to apply for Postdoctoral ... lineage differentiation and the morphogenesis of nascent organs in mammalian models, ...
... is conducting pioneering research to investigate how genes regulate stem cell behavior in the context of the mammalian embryo, ...
... and implantation of early mammalian embryo. The current knowledge about the ligands engaged by L-selectin during normal and ... pathways are required for defense against fungal and bacterial infection in Drosophila was pivotal in studies of both mammalian ...