Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase...  Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase...
... eIF-2 Kinase ; Animals ; Apoptosis ; Astrocytes ; Cells, Cultured ; Coculture Techniques ; Cytokines ; Humans ... Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase ... NF-kappa B Activation by Double-Stranded-RNA-Activated Protein Kinase (PKR) Is Mediated through NF-kappa B-Inducing Kinase and ... PKR Stimulates NF-kappa B Irrespective of Its Kinase Function by Interacting with the Ikappa B Kinase Complex, 10.1128/mcb. ...
more infohttps://dial.uclouvain.be/pr/boreal/object/boreal:127309
EIF-2 kinase - Wikipedia  EIF-2 kinase - Wikipedia
... heme-regulated inhibitor kinase (HRI) EIF2AK2: the double-stranded RNA-dependent kinase (PKR) EIF2AK3: PEK/PERK EIF2AK4: GCN2 ... eIF-2 Kinase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology portal. ... eIF-2 is a kinase enzyme that phosphorylates eIF-2. There are four forms in mammals: EIF2AK1: ... These are all responsible for the phosphorylation of the alpha subunit of eIF-2 at serine 51, one of the best-characterized ...
more infohttps://en.wikipedia.org/wiki/EIF-2_kinase
eIF-2 Kinase | Harvard Catalyst Profiles | Harvard Catalyst  eIF-2 Kinase | Harvard Catalyst Profiles | Harvard Catalyst
The eIF2-alpha kinase HRI: a potential target beyond the red blood cell. Expert Opin Ther Targets. 2017 12; 21(12):1171-1177. ... "eIF-2 Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "eIF-2 Kinase" by people in Harvard Catalyst Profiles by year, ... A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ...
more infohttps://connects.catalyst.harvard.edu/Profiles/display/Concept/eIF-2%20Kinase
eIF-2 Kinase | Profiles RNS  eIF-2 Kinase | Profiles RNS
Auch CJ, Saha RN, Sheikh FG, Liu X, Jacobs BL, Pahan K. Role of protein kinase R in double-stranded RNA-induced expression of ... "eIF-2 Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "eIF-2 Kinase" by people in this website by year, and whether " ... A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ...
more infohttps://profiles.rush.edu/display/10113
EIF2AK4 - eIF-2-alpha kinase GCN2 - Homo sapiens (Human) - EIF2AK4 gene & protein  EIF2AK4 - eIF-2-alpha kinase GCN2 - Homo sapiens (Human) - EIF2AK4 gene & protein
Converts phosphorylated eIF-2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, ... synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase ... eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability (PubMed:25329545). Plays a role as an activator of ... Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 ( ...
more infohttps://www.uniprot.org/uniprot/Q9P2K8
Gcn1 - eIF-2-alpha kinase activator GCN1 - Mus musculus (Mouse) - Gcn1 gene & protein  Gcn1 - eIF-2-alpha kinase activator GCN1 - Mus musculus (Mouse) - Gcn1 gene & protein
... eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to ... and hence stimulating EIF2AK4/GCN2 kinase activity (By similarity). Participates in the repression of global protein synthesis ... Acts as a positive activator of the GCN2 protein kinase activity in response to amino acid starvation (PubMed:15937339). Forms ... by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 ( ...
more infohttps://www.uniprot.org/uniprot/E9PVA8
eIF-2-alpha kinase GCN2  eIF-2-alpha kinase GCN2
This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation ... regulation of translational initiation by eIF2 alpha phosphorylation 2 negative regulation by host of viral genome replication ... positive regulation of translational initiation in response to starvation 2 regulation of eIF2 alpha phosphorylation by amino ... Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [ ...
more infohttps://pharos.nih.gov/idg/targets/Q9P2K8
Casein kinase II mediates multiple phosphorylation of Saccharomyces cerevisiae eIF-2 alpha (encoded by SUI2), which is required...  Casein kinase II mediates multiple phosphorylation of Saccharomyces cerevisiae eIF-2 alpha (encoded by SUI2), which is required...
Furthermore, yeast casein kinase II phosphorylates recombinant wild-type eIF-2 alpha protein in vitro but does not ... Casein kinase II mediates multiple phosphorylation of Saccharomyces cerevisiae eIF-2 alpha (encoded by SUI2), which is required ... Casein kinase II mediates multiple phosphorylation of Saccharomyces cerevisiae eIF-2 alpha (encoded by SUI2), which is required ... Casein kinase II mediates multiple phosphorylation of Saccharomyces cerevisiae eIF-2 alpha (encoded by SUI2), which is required ...
more infohttps://mcb.asm.org/content/14/8/5139?ijkey=4c6ee272bca45101b0fc42460186fea965535300&keytype2=tf_ipsecsha
IFN-γ inhibits MCMV replication in both BMMϕ and MEFs | Open-i  IFN-γ inhibits MCMV replication in both BMMϕ and MEFs | Open-i
... protein kinase RNA activated (PKR), RNaseL, and Mx1, and did not involve IFN-gamma-induced soluble mediators.These studies in ... protein kinase RNA activated (PKR), RNaseL, and Mx1, and did not involve IFN-gamma-induced soluble mediators.These studies in ... protein kinase RNA activated (PKR), RNaseL, and Mx1, and did not involve IFN-gamma-induced soluble mediators. To characterize ... protein kinase RNA activated (PKR), RNaseL, and Mx1, and did not involve IFN-gamma-induced soluble mediators. To characterize ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2195910_JEM000130.f6a&req=4
Mutation of the mivaRNAI 5′- or 3′-seed sequence af | Open-i  Mutation of the mivaRNAI 5′- or 3′-seed sequence af | Open-i
Further, by depletion of protein kinase R (PKR) in HEK293 cells, we show that the suppressive effect of VA RNAI on the ... Further, by depletion of protein kinase R (PKR) in HEK293 cells, we show that the suppressive effect of VA RNAI on the ... by depletion of protein kinase R (PKR) in HEK293 cells, we show that the suppressive effect of VA RNAI on the interferon- ... by depletion of protein kinase R (PKR) in HEK293 cells, we show that the suppressive effect of VA RNAI on the interferon- ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3643585_gkt172f3p&req=4
Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells | Blood Journal  Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells | Blood Journal
... and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian ... eIF-2α is phosphorylated in multiple myeloma cells treated with a variety of cytotoxic agents. The indicated multiple myeloma ... Purification and activation of the double-stranded RNA-dependent eIF-2 kinase DAI. Mol Cell Biol. 1989;9: 1576-1586. ... In addition to ER stress, the phosphorylation of eIF-2α can be induced by other cellular stresses, such as amino acid ...
more infohttp://www.bloodjournal.org/content/107/12/4907?ijkey=d45449bf0458567cbe74a62343a895cb3e1b9907&keytype2=tf_ipsecsha&sso-checked=true
Gcn2 - Wikipedia  Gcn2 - Wikipedia
"Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase". ... Heme-regulated inhibitor kinase) or EIF2AK1 PKR (Protein kinase R) PERK (PKR-like ER-localized eIF2α kinase) EIF2AK4 Zaborske ... Protein kinase GCN2 is a multidomain protein and its C-terminus contains a region homologous to histidyl-tRNA synthetase (HisRS ... So the recycling of eIF2, needed for TC formation, is inhibited by phosphorylation of eIF-2α, which in the end leads to a ...
more infohttps://en.wikipedia.org/wiki/Gcn2
Uridine affects liver protein glycosylation, insulin signaling, and heme biosynthesis.  - PubMed - NCBI  Uridine affects liver protein glycosylation, insulin signaling, and heme biosynthesis. - PubMed - NCBI
D) Western blots of eIF-2α kinases. (E, F) Quantitative analysis of protein expression (E) and phosphorylation (F) levels of ... UPase1-/- mice exhibit activation of the liver HRI-eIF-2α-ATF4 heme-deficiency stress response pathway. UPase1-/- mice also ... Evaluation of the effects of uridine on ER stress and regulation of eIF-2α. ... and activates the HRI-eIF-2α-ATF4 heme-deficiency stress response pathway. Short-term uridine administration is also associated ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/24918436
Christina Chan - Publications
     - MSU Scholars  Christina Chan - Publications - MSU Scholars
The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells. ... Kidambi, S., Lee, I. & Chan, C., Jan 24 2008, In : Advanced Functional Materials. 18, 2, p. 294-301 8 p.. Research output: ... Kidambi, S., Lee, I. & Chan, C., Dec 22 2004, In : Journal of the American Chemical Society. 126, 50, p. 16286-16287 2 p.. ... Wang, X., Wu, M., Li, Z. & Chan, C., Jul 7 2008, In : BMC Systems Biology. 2, 58. Research output: Contribution to journal › ...
more infohttps://scholars.opb.msu.edu/en/persons/christina-chan-2/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&page=1
Stress signaling from the endoplasmic reticulum] by Fumihiko Urano  Stress signaling from the endoplasmic reticulum]" by Fumihiko Urano
Protein-Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Stress, ...
more infohttps://escholarship.umassmed.edu/pgfe_pp/143/
Initiation and Termination of Translation  Initiation and Termination of Translation
eIF-3p66 (eIF-3p66) Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein ... protein kinase that promotes avoidance of the essential amino acid-deficient diet - blocks translation initiation through eIF2a ... Eukaryotic initiation factor 3 p40 subunit (eIF-3p40) Component of the eukaryotic translation initiation factor 3 (eIF-3) ... Eukaryotic initiation factor 4B (eIF-4B) RNA recognition motif protein Eukaryotic initiation factor 4E binds to the mRNA 5' cap ...
more infohttps://www.sdbonline.org/sites/fly/aignfam/translation.htm
Bin Gong, MD, PhD - Publications
     - UTMB Research Expert Profiles  Bin Gong, MD, PhD - Publications - UTMB Research Expert Profiles
Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma. Kunkeaw, N ... The Dominant-negative inhibition of double-stranded RNA-Dependent protein kinase PKR increases the efficacy of rift valley ... The dominant-negative inhibition of double-stranded RNA-dependent protein kinase PKR increases the efficacy of rift valley ... 176 (1-2) (2013) 241-250]. Ren, J., Kolli, D., Deng, J., Fang, R., Gong, B., Xue, M., Casola, A., Garofalo, R., Wang, T. & Bao ...
more infohttps://researchexperts.utmb.edu/en/persons/bin-gong/publications/
Diversity in viral anti-PKR mechanisms: a remarkable case of evolutionary convergence  Diversity in viral anti-PKR mechanisms: a remarkable case of evolutionary convergence
Subjects: eIF-2 Kinase; Molecular; Genetic Variation; Sindbis Virus; Inbred C57BL; Mice; Biología y Biomedicina / Biología ... Suppression of NYVAC infection in hela cells requires RNase L but is independent of protein kinase R activity  ... Most viruses express during infection products that prevent or neutralize the effect of the host dsRNA activated protein kinase ...
more infohttps://repositorio.uam.es/xmlui/handle/10486/666281
sg:pub.10.1038/s41467-019-08908-5 - Springer Nature SciGraph  sg:pub.10.1038/s41467-019-08908-5 - Springer Nature SciGraph
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more infohttps://scigraph.springernature.com/pub.10.1038/s41467-019-08908-5
Table of Contents | Molecular and Cellular Biology  Table of Contents | Molecular and Cellular Biology
Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinases. ... Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck). J D Marth, J A Cooper ... DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog. M J ... c-fps/fes gene product expressed ectopically in rat fibroblasts is nontransforming and has restrained protein-tyrosine kinase ...
more infohttps://mcb.asm.org/content/8/2