Pthaladyn-29 displays borderline selectivity for dynamin I relative to dynamin II (. 5−10 fold). Only pthaladyn-23 (dynamin I ... The Pthaladyns: GTP Competitive Inhibitors of Dynamin I and II GTPase Derived from Virtual Screening. Odell, Luke R Chemistry, ... Thus the pthaladyns are the first GTP competitive inhibitors of dynamin I and II GTPase and may be effective new tools for the ... We report the development of a homology model for the GTP binding domain of human dynamin I based on the corresponding crystal ...
Dynamin is part of the "dynamin superfamily," which includes classical dynamins, dynamin-like proteins, Mx proteins, OPA, ... Dynamin I is expressed in neurons and neuroendocrine cells Dynamin II is expressed in most cell types Dynamin III is strongly ... Dynamin is the only molecular motor known to have a twisting activity. Dynamin is a right-handed helix and has a right-handed ... Dynamin is a GTPase responsible for endocytosis in the eukaryotic cell. Dynamins are principally involved in the scission of ...
Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. This protein regulates ... This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of ... Satoh M, Hamamoto T, Seo N, Kagawa Y, Endo H (Jan 2003). "Differential sublocalization of the dynamin-related protein OPA1 ... Misaka T, Miyashita T, Kubo Y (May 2002). "Primary structure of a dynamin-related mouse mitochondrial GTPase and its ...
The shibire gene encodes the GTPase dynamin. Recent studies have shown that dynamin forms rings at the neck of invaginated ... The function of dynamin in endocytosis.. De Camilli P1, Takei K, McPherson PS. ...
The structures reveal that IniA folds as a bacterial dynamin-like protein (BDLP) with a canonical GTPase domain followed by two ... which folds as a bacterial dynamin-like protein and show that IniA mediates membrane fission in vitro. ... However, many other dynamin superfamily members, including dynamins themselves, also mediate membrane fission. Here, we ... Mycobacterial dynamin-like protein IniA mediates membrane fission. *Manfu Wang1,2,3. na1, ...
This volume provides methods and protocols on dynamin superfamily GTPases. Chapters are divided into three parts; detailing ... Dynamin Superfamily GTPases. Book Subtitle. Methods and Protocols Editors. * Rajesh Ramachandran Series Title. Methods in ... Authoritative and cutting-edge, Dynamin Superfamily GTPases: Methods and Protocols to ensure successful results in the further ... Purification of the Dynamin-Related Protein Vps1 Using Mammalian and Bacterial Expression Systems ...
BAR proteins and dynamin at clathrin coated endocytic pits as revealed by studies of cells that lack dynamin (dynamin 1,2 ... Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in membrane remodelling, has a critical ... Dynamin polymerization occurs as a result of interactions between the stalks of dynamin monomers (interface 2) and between ... At synapses that lack the great majority of their normal dynamin content (for example, from dynamin 1 knockout neurons or even ...
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
A new study has found compelling evidence that links dynamin-binding protein (DNMBP) to congenital bilateral cataracts and ... Dynamin-binding protein linked to congenital cataracts. Baylor College of Medicine. Journal. American Journal of Human Genetics ... A new study has now found compelling evidence that links dynamin-binding protein (DNMBP) to congenital bilateral cataracts and ...
... including dynamin 1 and the mitochondrial dynamin DRP1 (5, 15). Whether other dynamins are increased and/or contribute to ... Dynamin 2 the rescue for centronuclear myopathy. Alexis R. Demonbreun1 and Elizabeth M. McNally1,2 1Department of Medicine and ... Suppression of dynamin GTPase activity by sertraline leads to inhibition of dynamin-dependent endocytosis. Biochem Biophys Res ... Mutations in dynamin 2 cause dominant centronuclear myopathy. Nat Genet. 2005;37(11):1207-1209.. View this article via: PubMed ...
... are mediated by members of the dynamin superfamily (1). Dynamins and dynamin-like proteins are mechanochemical GTPases that ... Here we show that two dynamin-like proteins, DynA and DynB, play critical roles in this process. Dynamins are a family of large ... GTP binding is important for dynamin function and interaction. (A) Spore length analysis showing the extent to which dynamin P- ... However, in evolutionary terms, dynamins are of bacterial origin, and yet the biological functions of bacterial dynamins remain ...
Buy our Dynamin 3 peptide. Ab4986 is a blocking peptide and has been validated in BL. Abcam provides free protocols, tips and ... Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.. Contains 1 dynamin-type G (guanine ...
An autosomal dominant form of CNM results from mutations in the gene encoding dynamin 2 (DNM2), and loss-of-function mutations ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
The deformation of Dynamin helices is highly concerted and damped by the friction between membrane and Dynamin. However ... This work gives a quantitative picture of the energy landscape of Dynamin-mediated fission: the height of the energy barrier of ... Dynamin is a guanosine triphosphatase (GTPase) implicated in vesicle scission during Clathrin-mediated endocytosis. It ... The dynamics of constriction is investigated by monitoring the rotations of microbeads attached along Dynamin-coated tubes ...
Here, we focused on amphiphysin 2 (BIN1, also known as bridging integrator-1) and dynamin 2 (DNM2), two ubiquitous proteins ...
IPR000375 Dynamin_central. IPR001401 Dynamin_GTPase. IPR019762 Dynamin_GTPase_CS. IPR022812 Dynamin_SF. IPR030381 G_DYNAMIN_dom ... IPR000375 Dynamin_central. IPR001401 Dynamin_GTPase. IPR019762 Dynamin_GTPase_CS. IPR022812 Dynamin_SF. IPR030381 G_DYNAMIN_dom ... "UNC119 inhibits dynamin and dynamin-dependent endocytic processes.". Karim Z., Vepachedu R., Gorska M., Alam R.. Cell. Signal. ... PS00410 G_DYNAMIN_1, 1 hit. PS51718 G_DYNAMIN_2, 1 hit. PS51388 GED, 1 hit. PS50003 PH_DOMAIN, 1 hit. ...
IPR000375 Dynamin_central. IPR001401 Dynamin_GTPase. IPR019762 Dynamin_GTPase_CS. IPR022812 Dynamin_SF. IPR030381 G_DYNAMIN_dom ... IPR000375 Dynamin_central. IPR001401 Dynamin_GTPase. IPR019762 Dynamin_GTPase_CS. IPR022812 Dynamin_SF. IPR030381 G_DYNAMIN_dom ... PS00410 G_DYNAMIN_1, 1 hit. PS51718 G_DYNAMIN_2, 1 hit. PS51388 GED, 1 hit. PS50003 PH_DOMAIN, 1 hit. ... PS00410 G_DYNAMIN_1, 1 hit. PS51718 G_DYNAMIN_2, 1 hit. PS51388 GED, 1 hit. PS50003 PH_DOMAIN, 1 hit. ...
Figure 2: (a) Comparison of the proposed models for the DNM1L (left) and dynamin (right) oligomers. (b) The proposed ... we proposed an oligomerization model for DNM1L which differs from that of dynamin and might be adapted to the remodelling of ... Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein. EMBO J 32(9):1280-92. ... arrangement of the DNM1L and dynamin domains in the two oligomers is schematically depicted. ...
Mouse monoclonal Dynamin 1 antibody [D5]. Validated in WB, IP, IHC, Flow Cyt and tested in Mouse, Rat. Cited in 4 publication(s ... Dynamin 1 was immunoprecipitated using 0.5mg Mouse Brain tissue lysate, 5µg of Mouse monoclonal to Dynamin 1 and 50µl of ... All lanes : Anti-Dynamin 1 antibody [D5] (ab13251) at 5 µg/ml. Lane 1 : Brain (Mouse) Tissue Lysate Lane 2 : Brain (Rat) Tissue ... Belongs to the dynamin family.. Contains 1 GED domain.. Contains 1 PH domain. ...
Dual roles of dynamin and other epilepsy-related genes in neuronal excitability. The homology of the dynamin protein is highly ... waiting to be pinched off by dynamin (Koenig and Ikeda 1989). When flies are returned to permissive temperatures, dynamin ... 2004 The dynamin superfamily: universal membrane tubulation and fission molecules? Nat. Rev. Mol. Cell Biol. 5: 133-147. ... Beyond dynamin: Rab mutations also suppress parabss1/+ bang sensitivity. To more broadly determine whether the suppression of ...
All dynamin inhibitors reported to date block the function of both dynamin I and dynamin II with approximately similar potency. ... The Rhodadyn C10™ dynamin inhibitor complements a range of other dynamin inhibitors available in the Abcam Biochemicals range ... The introduction of these potent dynamin inhibitors is a great addition to our dynamin tool box. They will allow researchers to ... which potently inhibits clathrin-mediated endocytosis via dynamin inhibition. The Rhodadyn C10™ dynamin inhibitor was recently ...
View our 11 Dynamin Inhibitors products for your research including Dynamin Inhibitors Small Molecules and Dynamin Inhibitors ... Dynamin inhibitory peptide, myristoylated (control) Control peptide version of dynamin inhibitory peptide, myristoylated (Cat. ...
Dynamin I (Dyn1) is expressed exclusively in neurons (Obar et al., 1990), dynamin II (Dyn2) is found in all tissues (Cook et al ... Additional unidentified dynamin family members are likely to exist as well. It is unclear if the different dynamin gene ... To verify that dynamin associates with caveolae, an anti-dynamin antibody was used to immunoisolate caveolar membranes from a ... Characterization of dynamin-specific antibodies. (a) Diagram depicting the portions of dynamin to which anti-peptide antibodies ...
Dynamin 2 was detected with the anti-dynamin 2 antibody Dyn 2 (i, vii, and viii) or the pan anti-dynamin antibody MC63 (iii); ... We report here that dynamin 2, a ubiquitously expressed dynamin isoform, has a role in phagocytosis in macrophages. Dynamin 2 ... Dynamin 2 was found to be expressed in murine RP macrophages and the RAW-TT10 macrophage cell line, whereas dynamin 1 was not ... The effect of dynamin 1 on phagocytosis was assessed with three dominant-negative mutants of dynamin 1 expressed in pCMV5: DI ...