However, its role in myocardial ischemia/reperfusion (I/R) injury remains unknown. This study investigated ALK inhibitor drugs ... whether AGGF1 is involved in the pathogenesis of mouse myocardial I/R injury and the underlying mechanisms. Wild-type (WT) ... Treatment of WT mice with anti-AGGF1 neutralizing antibody resulted in exaggeration of myocardial I/R injury but reducing ... "Background -\n\nIn studies investigating foetal malformations associated with antiepileptic drug exposure during pregnancy, the ...
Oxidative Stress and Acute Kidney Injury in Critical Illness: Pathophysiologic Mechanisms-Biomarkers-Interventions, and Future ... Pathophysiology of oxidative stress in reperfusion injury. *Therapeutic interventions targeting increased oxidative burden in ... Furthermore, the impact of several drugs and treatments on the regulation of oxidative stress in critically ill patients has ... Pathophysiologic mechanisms of oxidative stress in critically ill patients with acute or chronic renal failure ...
Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of ... The objective of present study was to assess the effects of MK-886 and DITPA on renal I/R injury. A total of 24 Adult males of ... After the end of reperfusion phase mice were sacrificed, blood samples were collected directly from the heart for determination ... One of the primary causes of ARF is ischemia/reperfusion (I/R). ... 30 minute bilateral renal ischemia and 48 hr reperfusion. Sham ...
... reperfusion itself can enlarge the infarct size, by complex mechanisms collectively termed ischemia/reperfusion injury.3 In a ... Register your specific details and specific drugs of interest and we will match the information you provide to articles from ... Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J ... Protective effect of ischemia postconditioning on reperfusion injury in patients with ST-segment elevation acute myocardial ...
Sildenafil is a drug used to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH) in clinic. The current ... The mechanisms of reduced NO/cGMP/PKG signaling in aging kidney will be determined in Aim 2. These studies will establish the ... Increasing PKG activity protects aging kidney from ischemic-reperfusion induced injury. *Wang, Shuxia (PI) ... Aging is associated with increased incidence of acute kidney injury (AKI). This age-dependent increase in susceptibility to AKI ...
... including sildenafil and vardenafil induce powerful preconditioning-like cardioprotective effect against ischemia/reperfusion ... injury through opening of mitochondrial K(ATP) channels in the heart. The goal of these studies was to demonstrate the ... Both sildenafil and vardenafil protect the ischemic myocardium against reperfusion injury through a mechanism dependent on ... Myocardial Infarction / drug therapy* * Myocardial Infarction / metabolism * Myocardial Infarction / pathology * Myocardial ...
... ischemic reperfusion injury, secondary bleeding and brain tissue edema.. Current Clinical Treatment Status of Acute ... The drug has a half-life of 5 h through liver metabolism and will not remain in the body, resulting in high safety. In addition ... The mechanism of its involvement in the occurrence and development of these diseases may be that after tissue damage, CRP can ... The drug has a half-life of 5 h through liver metabolism and will not remain in the body, resulting in high safety. In addition ...
Lai, R. C., Yeo, R. W., Tan, K. H. & Lim, S. K. Mesenchymal Stem Cell Exosome Ameliorates Reperfusion Injury through Proteomic ... The mechanisms by which MSC-Exo suppress immunity remains unclear. It was found that although human ESC-derived MSC-Exo fail to ... Having a similar structure to synthetic lipid drug delivery vesicles presently in use, the nanoscale exosomes also have ... Exosome Secreted by MSC Reduces Myocardial Ischemia/Reperfusion Injury. Stem Cell Res. 4, 214-222 (2010). ...
These mechanisms explain the clinical efficacy of DN as an anti-MI drug. ... As a means to explore the therapeutic mechanism of ,i,Dioscorea nipponica,/i, (DN), a medicinal plant used to treat myocardial ... This is critical for drug research and development. ... of yam family in myocardial ischemic reperfusion injury," Food ... This is critical for drug research and development. As a means to explore the therapeutic mechanism of Dioscorea nipponica (DN ...
... although past studies have indicated that renal ischemia and reperfusion injury, inflammation and drugs may all be causative. ... Few studies have focused on the mechanism of Fanconi syndrome or PTEC injury in pSS. We observed the downregulation of megalin ... The primary lesion was moderate TIN with minimal glomerular injury and notable proximal tubular injury. Changes included tubule ... The mechanism of drug-induced Fanconi syndrome is not fully understood at this point in time [46]. However, as far as we can ...
... traumatic brain injury, stroke, sickle cell anemia and a host of other conditions. The primary mechanism of action of VitalHeme ... reperfusion injury and damaging inflammatory reactions caused by superoxide generation. The leading use of nanoRBC is in ... IVS offers services using the LITATM for testing efficacy and safety of drug candidates. The LITATM will be available soon for ... Its secondary mechanism is blocking the toxicity of cell-free hemoglobin. By these mechanisms, nanoRBC interferes with the ...
Like a predominance of current study focuses on malignancy ischemia-reperfusion injury and neurodegenerative disease we will be ... Owing to its integral involvement in mechanisms Rabbit polyclonal to Dynamin1. of both cell death and survival autophagy has ... become a highly sought-after drug target for a wide range of diseases including many forms of malignancy stroke ... Keywords: autophagy pharmacological therapy malignancy ischemia reperfusion stroke neurodegeneration neuropathology Letrozole ...
Clinical manifestations and basic mechanisms of myocardial ischemia/reperfusion injury. Ci Ji Yi Xue Za Zhi. 2018;30(4):209-215 ... Drugs. 2014;74(9):971-980. *Kantor PF, Lucien A, Kozak R, Lopaschuk GD. The antianginal drug trimetazidine shifts cardiac ... Protective effects of embelin on myocardial ischemia-reperfusion injury following cardiac arrest in a rabbit model. ... The protective effect of trimetazidine on myocardial ischemia/reperfusion injury through activating AMPK and ERK signaling ...
... and to delineate the mechanism of the cytoprotective effect of prostaglandin E1 in hepatic ischemia-reperfusion injury. ". 11/ ... Drug Context: Research Results. *Lipids: 18571*Fatty Acids: 6864*Unsaturated Fatty Acids: 3881*Eicosanoids: 1470*Prostaglandins ... Reperfusion Injury 07/01/2005 - "HSPs might therefore play an important role in the protective effects of PGE1 against ischemia ... reperfusion injury of the liver.". 05/05/2015 - "Myocardial microcirculation of reperfusion injury in patients with STEMI, ...
... yet there is no exact guideline for choosing the most appropriate drug. A systematic review and meta-analysis on all available ... Efficacy and mechanism of nicorandil in perioperative protection of skeletal muscle from ischaemia and reperfusion injury in a ... Cardiovascular drugs and therapy. 2006; 20 (3):167-175 21. Babbitt DG, Virmani R, Forman MB. Intracoronary adenosine ... Zhou H, Ma Q, Zhu P, Ren J, Reiter RJ, Chen Y . Protective role of melatonin in cardiac ischemia‐ reperfusion injury: from ...
... and mechanisms underlying cardiomyocyte and cardiac fibroblast crosstalk during ischemia/reperfusion injury. We also discuss ... and ample pre-clinical research has attempted to identify drugs or techniques to mitigate cardiac damage. However, despite ... and mechanisms underlying cardiomyocyte and cardiac fibroblast crosstalk during ischemia/reperfusion injury. We also discuss ... and mechanisms underlying cardiomyocyte and cardiac fibroblast crosstalk during ischemia/reperfusion injury. We also discuss ...
Prevention of renal ischemia-reperfusion-induced injury in rats by picroliv. Biochem Pharmcol 2000;59(10):1315-22. ... Nimesulide belongs to a group of anti-inflammatory drugs that are in common use in our society. Like all non-steroidal anti- ... Borku M, Guzel M, Karakurum MC, Ural K, Aktas S. Nimesulide-induced acut biliary tract injury and renal faliure in akitten: a ... Modi CM, Mody SK, Patel HB, Dudhatra GB, Kumar A, Avale M. Toxicopathological overview of analgesic and anti-inflammatory drugs ...
It has many uses, and is available as both a prescription drug and a dietary supplement. ... N-acetyl-L-cysteine for preventing lung reperfusion injury after liver ischemia-reperfusion: a possible dual protective ... Taking N-acetyl cysteine by mouth seems to help prevent side effects of the cancer drug ifosfamide. But a drug called mesna ... Shaikh, Z. A., Vu, T. T., and Zaman, K. Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal ...
... and apoptosis at different time points after retinal ischemia reperfusion injury in rats. Sixty-six male SPF Sprague-Dawley ... Since many studies select only one specific time point to apply drugs and then assess the therapeutic effect of drugs. But in ... Many studies select only one specific time point to apply drugs and then assess the therapeutic effect of drugs; however, the ... JAK-STAT signaling pathway hallmark proteins and apoptosis at different time points after retinal ischemia reperfusion injury ...
Extracellular ATP ; Purinergic receptor ; Purinergic signalling ; Myocardial remodelling; mechanism of action; drug repurposing ... ischemia/reperfusion injury, fibrosis, hypertrophy, and atrophy. Finally, we summarize current pharmacological intervention ... This review outlines the sources of ATP released under physiological and pathological stress and its cell-specific mechanism of ... A better understanding of ATP communication in myocardial remodelling could be worthwhile for future drug development and ...
... and severity of reperfusion-induced arrhythmias, and preventing endothelial cell dysfunction. Although the exact mechanism of ... including cardiac failure and those related to ischemia/reperfusion injury. While ischemic preconditioning significantly ... Most significantly, the hormetic dose response imposes constraints upon the magnitude of a drug to induce a desired effect. For ... Different mechanisms by which mammalian cells respond to some kinds of stresses are shown. Upon stresses such as cold-shock, ...
Because anti‑ICAM antibodies appear to block an early step in reperfusion‑related injury, they present a hopeful mechanism for ... The exact mechanism of action of lubeluzole, a drug effective in animal models, is unclear. The drug may block sodium channels ... The drug also was investigated in subarachnoid hemorrhage and in traumatic brain injury, without convincing evidence of benefit ... Several drugs with novel mechanisms to modulate neurotransmission or ion channels have recently completed clinical trials. ...
The drug also modulates nitric oxide synthase (NOS) expression and reduces ischemic-reperfusion injuries in rat hearts . ... Mechanism of Action of Rosuvastatin. Rosuvastatin is a competitive inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes ... Drug Interactions of Rosuvastatin. Rosuvastatin may interact with following drugs, suppliments & may change the efficasy of ... Folinic Acid; Uses, Dosage, Side Effects, Drug Interactions Alogliptin; Uses, Dosage, Side Effects, Drug Interactions Antacids ...
Drug Chem Toxicol. 2015;38(1):22-31. *Prentice H, Modi JP, Wu JY. Mechanisms of neuronal protection against excitotoxicity, ... This ischemia-reperfusion injury results in massive release of glutamate and produces deadly excitotoxicity.25 ... Kurihara K. Umami the fifth basic taste: history of studies on receptor mechanisms and role as a food flavor. Biomed Res Int. ... These statements have not been evaluated by the Food and Drug Administration.. These products are not intended to diagnose, ...
Cardioprotective effect of resvaratrol pretreatment on myocardial ischemia-reperfusion induced injury in rats. Vascul Pharmacol ... Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this ... The mechanisms involved may include the inhibition of the oxidation of low-density lipoprotein and inhibition of platelet ... and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package ...
... mechanisms and pathology of cardiac function, cardiac growth and ischemia-reperfusion injury; role of growth factors in ... computational drug discovery and drug repositioning, network medicine, systems biology of disease and drug response anil.jegga@ ... My lab investigates the mechanism behind HSC injury and functional decline with bone marrow transplantation in order to provide ... Our lab is interested in the molecular mechanisms of sensory neuron plasticity after peripheral injuries in adults and neonates ...
Research focus: Mechanisms of toxicity of drugs and environmental chemicals; mechanism underlying pro-oxidant drug-induced ... ischemia-reperfusion injury, and peripheral artery disease. ... Research focus: Mechanisms of long term kidney allograft injury ... role of microRNAs at the synapse in drug addiction, mechanisms and role in gene regulation; Prenatal drug exposure and synaptic ... Research focus: Design and synthesis of multifunctional antioxidants and enzyme inhibitors; the mechanism of action drugs and ...
... gamma and NF-kappa B in the hippocampus of rats with global cerebral ischemia/reperfusion injury (GCIRI) after treatment with ... Therefore, it is of great importance to investigate the molecular mechanisms of such injury caused by ischemic cerebrovascular ... The above results indicate that PPAR-α, -β and especially PPAR-γ may be important targets for GCIRI research and drug therapy. ... Global cerebral ischemia/reperfusion injury (GCIRI) occurs in patients who are successfully resuscitated from various clinical ...
... warm ischemia and reperfusion injury with emphasis on cryonics technology ... Currently, the only accepted drugs used for stroke therapy are thrombolytics, anticoagulants and antiplatelet drugs. ... NO REFLOW MECHANISMS. Nitric oxide normally functions to not only reduce platelet aggregation & leukocyte adhesion to the ... ISCHEMIC INJURY IN BRAIN AND ELSEWHERE *REPERFUSION INJURY AND NO REFLOW *STROKE THERAPY *HIBERNATION AND ESTIVATION *ORGAN ...