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*  Arsenic trioxide in the mechanism of drug resistance reversal in MCF-7/ADM cell line of human breast cancer.
To investigate the effect of drug resistance by arsenic trioxide (As(2)O(3)) and its possible mechanism in human breast cancer ... Dose-Response Relationship, Drug. Doxorubicin / pharmacology*. Drug Resistance, Multiple*. Drug Resistance, Neoplasm*. Female. ... OBJECTIVE: To investigate the effect of drug resistance by arsenic trioxide (As(2)O(3)) and its possible mechanism in human ... CONCLUSION: As(2)O(3) is able to enhance the cytotoxicity of ADM and partly reverse the ADM resistance of MCF-7/ADM cell line ...
http://www.biomedsearch.com/nih/Arsenic-trioxide-in-mechanism-drug/12408759.html
*  Resistance to cisplatin and adriamycin is associated with the inhibition of glutathione efflux in MCF-7-derived cells.
The impact of the anti-cancer drugs cisplatin (CDDP) and adriamycin (ADR) was investigated on sensitive and resistant MCF-7- ... Drug Resistance, Multiple. Drug Resistance, Neoplasm*. Flow Cytometry. Glutathione / metabolism*. Humans. Necrosis. Poly(ADP- ... Apoptosis / drug effects. Blotting, Western. Breast Neoplasms / drug therapy, metabolism*, pathology. Chromatography, High ... were resistant to both drugs. This resistance was clearly associated with an unaltered GSH level and with the inhibition of an ...
http://www.biomedsearch.com/nih/Resistance-to-cisplatin-adriamycin-associated/17094488.html
*  Label-free MSE proteomic analysis of chronic myeloid leukemia bone marrow plasma: disclosing new insights from therapy...
Bone Marrow / drug effects*, metabolism, pathology. Drug Resistance, Neoplasm*. Female. Humans. Leukemia, Myelogenous, Chronic ... BCR-ABL Positive / drug therapy*, metabolism, pathology. Lipid Metabolism / drug effects. Lipid Peroxidation / drug effects. ... However, imatinib resistance occurs frequently, resulting in relapse. New treatment strategies are focusing on resistant CML ... lipid metabolism and regulation of the switch from canonical to noncanonical WNT signaling may contribute to CML resistance in ...
http://www.biomedsearch.com/nih/Label-free-MSE-proteomic-analysis/22761178.html
*  RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell...
Drug Resistance, Neoplasm. Glycogen Synthase Kinases / metabolism. Humans. Inhibitory Concentration 50. Pancreatic Neoplasms / ... Apoptosis / drug effects. Blotting, Western. Caspases / metabolism. Cell Line, Tumor. Cell Proliferation / drug effects. ... Next Document: Resistance to the tubulin-binding agents in renal cell carcinoma: no mutations in the class I beta-t.... ... Adenocarcinoma / drug therapy, enzymology, pathology. Antimetabolites, Antineoplastic / pharmacology. ...
http://www.biomedsearch.com/nih/RNA-interference-demonstrates-novel-role/15867245.html
*  PRIMA-1 cytotoxicity correlates with nucleolar localization and degradation of mutant p53 in breast cancer cells.
Breast Neoplasms / metabolism*. Cell Line, Tumor. Cell Nucleus / metabolism*. Drug Resistance, Neoplasm*. Female. Humans. ... 22440896 - Reversal effect of tween-20 on multidrug resistance in tumor cells in vitro.. 2567196 - Biochemical properties of ...
http://www.biomedsearch.com/nih/PRIMA-1-cytotoxicity-correlates-with/20946886.html
*  Reversal of multidrug resistance and inhibition of phosphorylation of AKT in human ovarian cancer cell line by wild-type PTEN...
The reversing effect of wild-type PTEN gene on resistance of C13K cells to cisplatin and its inhibitory effect on the ... Drug Resistance, Multiple / genetics*. Drug Resistance, Neoplasm / genetics*. Female. Humans. Ovarian Neoplasms / metabolism*, ... Reversal of multidrug resistance and inhibition of phosphorylation of AKT in human ovarian cancer cell line by wild-type PTEN ... The reversing effect of wild-type PTEN gene on resistance of C13K cells to cisplatin and its inhibitory effect on the ...
http://www.biomedsearch.com/nih/Reversal-multidrug-resistance-inhibition-phosphorylation/18231751.html
*  Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras ...
Drug Resistance, Neoplasm* / genetics. Etoposide / pharmacology. Humans. Neuroblastoma / genetics, metabolism*, pathology. ... Cell Proliferation / drug effects. Cell Survival / drug effects. Cell Transformation, Neoplastic / genetics, metabolism*. ... Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras ( ... These results show that the ERas/PI3K pathway may provide resistance to chemotherapy and promote transforming activity in ...
http://www.biomedsearch.com/nih/Resistance-to-chemotherapeutic-agents-promotion/20811723.html
*  Preclinical modeling of EGFR inhibitor resistance in head and neck cancer.
Drug Resistance, Neoplasm / drug effects. Head and Neck Neoplasms / drug therapy*, metabolism. Humans. Inhibitory Concentration ... A consistent mechanism of resistance to EGFR targeting agents has not yet been identified in HNSCC likely due, in part, to the ... We attempted to generate models of cetuximab resistance in HNSCC cell line-derived xenografts and heterotopic tumorgrafts ... Carcinoma, Squamous Cell / drug therapy*, metabolism. Cell Line, Tumor. ...
http://www.biomedsearch.com/nih/Preclinical-modeling-EGFR-inhibitor-resistance/22785204.html
*  Lund University Publications
Discovery of a novel B-Raf fusion protein related to c-Met drug resistance Dillon, Roslyn; Nilsson, Carol L LU ; Shi, Stone D-H ... iframe src="https://lup.lub.lu.se/search/publication?embed=1&q=keywords+exact+%22Drug+Resistance%2C+Neoplasm%22&hide_pagination ... MicroRNA expression profiles associated with development of drug resistance in Ehrlich ascites tumor cells Husted, Susanne; ... Adaptive mitochondrial reprogramming and resistance to PI3K therapy Ghosh, Jagadish C; Siegelin, Markus D; Vaira, Valentina; ...
https://lup.lub.lu.se/search/publication?q=keywords+exact+%22Drug+Resistance%2C+Neoplasm%22
*  Pancreatic cancer stem cells: emerging target for designing novel therapy.
Drug Resistance, Neoplasm / drug effects, genetics. Epithelial-Mesenchymal Transition / drug effects*, genetics. Humans. Models ... Neoplastic Stem Cells / drug effects*, metabolism, pathology. Pancreatic Neoplasms / drug therapy*, genetics, pathology. Signal ... Pancreatic cancer (PC) has a high mortality due to both intrinsic (de novo) and extrinsic (acquired) drug resistance, leading ... play critical roles in drug resistance, invasion, and metastasis. ...
http://www.biomedsearch.com/nih/Pancreatic-cancer-stem-cells-Emerging/22445908.html
*  Leicester Research Archive: BAK and NOXA are critical determinants of mitochondrial apoptosis induced by bortezomib in...
Drug Resistance, Neoplasm. en. dc.subject. Embryo, Mammalian. en. dc.subject. Fibroblasts. en. ... the potential mechanisms underlying resistance to this targeted drug in MPM are still unknown. Functional genetic analyses were ... However, MPM tissues from patients who failed to respond to bortezomib and MPM cell lines selected for resistance to bortezomib ... and the observed loss of BAK expression or NOXA transactivation may be relevant mechanisms of resistance in the clinic.. en. ...
https://lra.le.ac.uk/handle/2381/32687?mode=full
*  Hypoxia results in chemoresistance of human OS cells to | Open-i
Mentions: Hypoxia has been shown to promote resistance to cytotoxic drugs in other human OS cell lines [12]. Thus we asked ... Mentions: Hypoxia has been shown to promote resistance to cytotoxic drugs in other human OS cell lines [12]. Thus we asked ... we show that hypoxia results in resistance of human OS cells to doxorubicin-mediated toxicity (6-13 fold increase, p,0.01). ... we show that hypoxia results in resistance of human OS cells to doxorubicin-mediated toxicity (6-13 fold increase, p,0.01). ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4210185_pone.0111431.g004&req=4
*  RAC1 inhibitor suppressed gefitinib-resistant non-small | Open-i
Cell Line, Tumor/drug effects. *Cell Movement/genetics. *Drug Resistance, Neoplasm/genetics ... Carcinoma, Non-Small-Cell Lung/drug therapy*/genetics/metabolism/pathology. *Lung Neoplasms/drug therapy*/genetics/metabolism/ ... Carcinoma, Non-Small-Cell Lung/drug therapy*/genetics/metabolism/pathology. *Lung Neoplasms/drug therapy*/genetics/metabolism/ ... the acquisition of drug resistance has been known to limit the efficacy of EGFR-TKI therapy.In addition, these suppressions by ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4317907_cas0105-0788-f5&req=4
*  c-Kit and miR-34a modulate the apoptotic response to ch | Open-i
Drug Resistance, Neoplasm. *Humans. *Molecular Sequence Data. *Neoplasm Invasiveness. *Neoplastic Stem Cells/metabolism/ ... Mentions: Recently, c-Kit was shown to mediate chemo-resistance in ovarian tumor initiating cells [19]. Therefore, we asked ... Mentions: Recently, c-Kit was shown to mediate chemo-resistance in ovarian tumor initiating cells [19]. Therefore, we asked ... Furthermore, ectopic expression of c-Kit conferred resistance of colorectal cancer (CRC) cells to treatment with 5-fluorouracil ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC3824539_oncotarget-04-1399-g004&req=4
*  "Targeting Drug Resistance in Chronic Myeloid Leukemia: A Dissertation" by Leyuan Ma
Resistance to TKIs frequently occurs, but the mechanisms remain elusive. First, to uncover survival pathways involved in TKI ... resistance in CML, I conducted a genome-wide RNAi screen in human CML cells to identify genes governing cellular sensitivity to ... Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Antineoplastic Agents, Drug Resistance, Neoplasm, Chronic Myeloid Leukemia ... Dissertations, UMMS; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Antineoplastic Agents; Drug Resistance, Neoplasm ...
https://escholarship.umassmed.edu/gsbs_diss/870/
*  Loriaux, M. M.<...
... in acute myeloid leukaemia bone marrow stromal cell exosome content coincide with gains in tyrosine kinase inhibitor resistance ... Neoplasms Medicine & Life Sciences Mutation Medicine & Life Sciences Therapeutics Medicine & Life Sciences ...
https://ohsu.pure.elsevier.com/en/persons/marc-loriaux
*  acute basophilic leukemia morphologic abnormality 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Drug Resistance, Neoplasm. Humans. Imatinib Mesylate. Immunophenotyping. In Situ Hybridization, Fluorescence. Male. Reverse ... Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. ... played a role in the imatinib relapse and resistance and in the disease progression. ...
http://www.bmlsearch.com/?kwr=acute+basophilic+leukemia+morphologic+abnormality+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  adult pleomorphic rhabdomyosarcoma 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Drug Resistance, Neoplasm. Humans. Male. *[Email] Email this result item Email the results to the following email address: [X] ... Neoplasm Recurrence, Local. Neoplasm Staging. Retrospective Studies. *[Email] Email this result item Email the results to the ... MeSH-major] Neoplasm Invasiveness / pathology. Rhabdomyosarcoma / pathology. Vulvar Neoplasms / pathology. *[MeSH-minor] Adult ... Nose Neoplasms / pathology. Prognosis. Rhabdomyosarcoma / pathology. Skin Neoplasms / pathology. *[Email] Email this result ...
http://www.bmlsearch.com/?kwr=adult+pleomorphic+rhabdomyosarcoma+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  acute myeloblastic leukaemia without maturation 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Drug Resistance, Neoplasm. Gene Expression Profiling. Humans. RNA, Messenger / biosynthesis. Reverse Transcriptase Polymerase ... Neoplasm Proteins / genetics. Oncogenes. RNA, Neoplasm / antagonists & inhibitors. RNA, Neoplasm / genetics. *[Email] Email ... Chemical-registry-number] 0 / CCAAT-Enhancer-Binding Proteins; 0 / CEBPA protein, human; 0 / DNA, Neoplasm; 0 / Neoplasm ... Neoplasm Proteins / genetics. *[MeSH-minor] Acute Disease. Adolescent. Child. Child, Preschool. Clinical Trials as Topic / ...
http://www.bmlsearch.com/?kwr=acute+myeloblastic+leukaemia+without+maturation+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  adult acute myeloid leukemia cellular diagnosis 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
MeSH-major] Drug Resistance, Multiple. Drug Resistance, Neoplasm. Multidrug Resistance-Associated Proteins / metabolism. P- ... Apoptosis / drug effects. Drug Resistance, Neoplasm / drug effects. Gene Expression Regulation, Neoplastic / drug effects. ... Drug Resistance, Neoplasm. Leukemia, Myeloid / drug therapy. Leukemia, Myeloid / epidemiology. Neoplasm Recurrence, Local / ... Neoplasm Proteins / metabolism. *[MeSH-minor] Adolescent. Adult. Aged. Antigens, CD34 / metabolism. Drug Resistance, Neoplasm. ...
http://www.bmlsearch.com/?kwr=adult+acute+myeloid+leukemia+cellular+diagnosis+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  Effects of ω3PUFAs on HMGCoAR transcription, phosphory | Open-i
Drug Resistance, Multiple. *Drug Resistance, Neoplasm. *Gene Expression Regulation, Neoplastic. *HT29 Cells ... Background: The activity of P-glycoprotein (Pgp) and multidrug resistance related protein 1 (MRP1), two membrane transporters ... Background: The activity of P-glycoprotein (Pgp) and multidrug resistance related protein 1 (MRP1), two membrane transporters ... restored the antitumor effects of different chemotherapeutic drugs, restored a proper tumor-immune system recognition in ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4225767_1476-4598-12-137-3&req=4
*  NaK alpha1-subunit and in vitro growth inhibition of ca | Open-i
Cell Proliferation/drug effects. *Dose-Response Relationship, Drug. *Drug Resistance, Neoplasm. *Glycosylation ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC3722118_1476-4598-12-33-2&req=4
*  Expression levels of stem cell genes and activation of | Open-i
Drug Resistance, Neoplasm. *Flow Cytometry. *Gene Expression Regulation, Neoplastic. *Humans. *Matrix Metalloproteinase 2/ ... and enhanced resistance to chemotherapeutic drugs. Notably, CD24+ cells produce tumors following inoculation of as few as 500 ... and enhanced resistance to chemotherapeutic drugs. Notably, CD24+ cells produce tumors following inoculation of as few as 500 ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4067285_pone.0099412.g002&req=4
*  miR-33a and TWIST levels in osteosarcoma (OS) cells. Re | Open-i
Drug Resistance, Neoplasm. *Female. *Gene Expression Regulation, Neoplastic. *Humans. *Male. *RNA Interference ... Our in vitro data indicate that miR-33a promotes OS cell resistance to cisplatin by down-regulating TWIST; on the other hand, ... Our in vitro data indicate that miR-33a promotes OS cell resistance to cisplatin by down-regulating TWIST; on the other hand, ... miR-33a is up-regulated in chemoresistant osteosarcoma and promotes osteosarcoma cell resistance to cisplatin by down- ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC3974149_1756-9966-33-12-5&req=4
*  Next page) Thyrosine kinase inhibitors (TKI) increases | Open-i
... caused drug-resistance in association with an increase in levels of DNA methyltransferases (DNMT) and a decrease in levels of ... caused drug-resistance in association with an increase in levels of DNA methyltransferases (DNMT) and a decrease in levels of ... Downregulation of miR-217 correlates with resistance of Ph(+) leukemia cells to ABL tyrosine kinase inhibitors. ... Downregulation of miR-217 correlates with resistance of Ph(+) leukemia cells to ABL tyrosine kinase inhibitors. ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4317938_cas0105-0297-f1&req=4