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*  Antibiotics | S-cool, the revision website
Resistance to antibiotics is increasing and has a great impact on the treatment of a disease because it prolongs illness and ... Most antibiotics are used to treat bacterial and fungal infections, there are very few that are effective against viruses. A ... Hospitals try and keep some antibiotics as a last resort and drug companies are continually looking for new ones. ... Some bacteria may contain up to five plasmids, each conferring resistance to a different antibiotic. DNA and therefore plasmids ...
https://www.s-cool.co.uk/a-level/biology/immunity/revise-it/antibiotics
*  Drug-resistance Fears for Deadly Fungal Disease - Healthcanal.com : Healthcanal.com
... the class of drugs used to treat patients with aspergillosis. "This innovative approach to drug resistance detection was made ... UCL Home UCL News Drug-resistant gene goes from pig farms to pati… Drug-resistant gene goes from pig farms to patients ... High frequency triazole resistance found in non-culturable Aspergillus fumigatus from lungs of patients with chronic fungal ... Drug reduces inflammation in stroke patients 03/26/2018 Stroke Large-scale genetic study provides new insight into the causes ...
https://www.healthcanal.com/infections/16998-drug-resistance-fears-for-deadly-fungal-disease.html
*  Pharmaceuticals | Free Full-Text | Pathogenesis and Antifungal Drug Resistance of the Human Fungal Pathogen Candida glabrata
In this comprehensive review, we want to emphasize and discuss the mechanisms underlying virulence and drug resistance of C. ... glabrata infections is its high intrinsic resistance to several antifungal drugs, especially azoles. Further, the development ... represents the second most prevalent cause of candidemia and a better understanding of its virulence and drug resistance ... of antifungal resistance, particularly during prolonged and prophylactic therapies is diminishing efficacies of therapeutic ...
http://mdpi.com/1424-8247/4/1/169/xml
*  Cas5 Couples Stress Responses, Drug Resistance and Cell Cycle Regulation in Fungal Pathogens | Nature Research Microbiology...
Cas5 Couples Stress Responses, Drug Resistance and Cell Cycle Regulation in Fungal Pathogens Poster image is a time-lapse ... Shapiro, R. S., N. Robbins and L. E. Cowen (2011). "Regulatory circuitry governing fungal development, drug resistance, and ... 2011). Given that drug resistant fungal infections are plaguing clinical settings, it is now critical to uncover novel cellular ... 2006), but is required for drug resistance and virulence in C. albicans (Chamilos, Nobile et al. 2009, Pukkila-Worley, Peleg et ...
https://naturemicrobiologycommunity.nature.com/posts/20197-cas5-couples-stress-responses-drug-resistance-and-cell-cycle-regulation-in-fungal-pathogens
*  Baker's yeast helped MSU-based biologists to understand drug resistance in fungi | EurekAlert! Science News
The study showed that the resistance of yeast (and possibly pathogenic fungi) to antimycotic agents is more complex than it was ... MSU-based biologists advanced in understanding of fungal drug resistance mechanisms. To study them the scientists used baker's ... MSU-based biologists advanced in understanding of fungal drug resistance mechanisms. To study them the scientists used baker's ... Drug resistance of pathogenic microorganisms is a serious medical problem. The most widely known threat is antibiotic-resistant ...
https://www.eurekalert.org/pub_releases/2018-07/lmsu-byh071018.php
*  Medical Xpress - chronic obstructive pulmonary disease(... continued page 10)
Drug resistance fears over killer fungal disease. (PhysOrg.com) -- Treatments for the most common airborne fungal disease are ... proving less effective due to increased resistance to the anti-fungal drugs used to combat infections. ... Previously unpublished information from the clinical trial that the U.S. Food and Drug Administration relied on to approve the ... For older adults with chronic conditions, non-drug behavioral treatments may help. When we have several chronic health ...
https://medicalxpress.com/conditions/chronic-obstructive-pulmonary-disease/page10.html
*  Hsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi | Science
Fungal drug resistance is also of great economic and biomedical importance; few clinically useful drugs exist and resistance ... In the evolution of fungal drug resistance, new traits are also lost when Hsp90 function is compromised. Here, however, Hsp90 ... Hsp90 potentiates resistance to different drugs in C. albicans and A. terreus. Resistance of C. albicans clinical isolate T118 ... 5). Thus, Hsp90 has profound but distinct effects on drug resistance in evolutionarily distant fungal pathogens. ...
https://science.sciencemag.org/content/309/5744/2185?ijkey=76919a51d8ae467bc32d508e9df5b9e047716616&keytype2=tf_ipsecsha
*  Group Kuchler
... use reverse genetics approaches to identify virulence and antifungal drug resistance genes in the most prevalent human fungal ... use reverse genetics approaches to identify virulence and antifungal drug resistance genes in the most prevalent human fungal ... The group Kuchler coordinates the FP7 Marie Curie ITN 'Molecular Mechanisms of Fungal Pathogen Host Interactions' (ImResFun). ... We study the molecular mechanisms of fungal pathogenicity and fundamental problems in infection biology, using a combination of ...
https://www.mfpl.ac.at/de/gruppen/mfpl-gruppen/group-info/kuchler.html
*  Home Page ::: Current Topics in Medicinal Chemistry
Emerging Virulence, Drug Resistance and Future Anti-fungal Drugs for Candida Pathogens. , 2018; 18(9): 759 - 778. Vartika ... Prediction of Drug-Drug Interactions Related to Inhibition or Induction of Drug-Metabolizing Enzymes. , 19(5): 319 - 336. ... Prediction of Drug-Drug Interactions Related to Inhibition or Induction of Drug-Metabolizing Enzymes. ... drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and ...
https://benthamscience.com/journals/current-topics-in-medicinal-chemistry/
*  Structural and Functional Study of Yer067w, a New Protein Involved in Yeast Metabolism Control and Drug Resistance
Stress, drugs, and evolution: The role of cellular signaling in fungal drug resistance. Eukaryot Cell. 2008;7:747-764. [PMC ... Therefore, the characterization of new fungal-specific proteins involved in the development of drug resistance is of ... As both classes of drugs act on components of the same pathway, the mechanisms of resistance developed against one kind of drug ... No differences in drug resistance between BY4741 and the mutants were evident when yeast cells were grown in the presence of ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2887356/
*  Antifungal Drug Treatment Archives - YeastInfection.Org by Eric Bakker N.D.
Anti-Fungal Drug Resistance. June 22, 2013. by Eric Bakker N.D. ... Yeast Infection Drug Treatment Chart *Anti-Fungal Drug ... A lesser-known fact is that the anti-fungal drugs the doctor prescribes to you may well interact with other drugs or ... All anti-fungal drugs can have the tendency to give side-effects, ranging from the mild to the extreme. Here are some of the ... Anti-Fungal Drug Interactions. June 22, 2013. by Eric Bakker N.D. ...
https://www.yeastinfection.org/category/yeast-infection-treatment/antifungal-drug-treatment/
*  Fluconazole Archives - Progressive Radio Network
Millions at risk as deadly fungal infections acquire drug resistance Scientists have warned that potentially deadly fungal ... Combination therapyDeathDrug resistanceFluconazoleFungusInfectionMultiple organ dysfunction syndromeMycosisPittsburgh Tribune- ... More than a million people die of fungal infections every year, including about 7,000 in the UK, and deaths are likely to ... increase as resistance continues to rise. Researchers say the widespread use of fungicides on crops is one … Read More ...
http://prn.fm/tag/fluconazole/
*  Baker's Yeast Leads Biologists to Understand Drug Resistance in Fungi
Biologists at Lomonosov Moscow State University advanced in understanding of fungal drug resistance mechanisms. ... Baker's Yeast Leads Biologists to Understand Drug Resistance in Fungi. Wed, 07/11/2018 - 8:00am Comments by Lomonosov Moscow ... Drug resistance of pathogenic microorganisms is a serious medical problem. The most widely known threat is antibiotic-resistant ... In 2016 a team from Belozersky Institute of Physico- Chemical Biology proposed a method of suppressing multiple drug resistance ...
https://www.laboratoryequipment.com/news/2018/07/bakers-yeast-leads-biologists-understand-drug-resistance-fungi
*  Microorganisms | Free Full-Text | Biofilm Specific Activity: A Measure to Quantify Microbial Biofilm | HTML
... complex 3-D biofilm structures characterized by the production of extracellular polymeric compounds and an increased resistance ... to drugs. The quantification of biofilm relays currently on a number of different approaches and techniques, often leading to ... Jabra-Rizk, M.A.; Falkler, W.A.; Meiller, T.F. Fungal biofilms and drug resistance. Emerg. Infect. Dis. 2004, 10, 14. [Google ... Mukherjee, P.K.; Chandra, J. Candida biofilm resistance. Drug Resist. Updates 2004, 7, 301-309. [Google Scholar] [CrossRef] [ ...
https://www.mdpi.com/2076-2607/7/3/73/htm
*  Frontiers | Evaluation of the Effects of Photodynamic Therapy Alone and Combined with Standard Antifungal Therapy on Planktonic...
In addition, the combination of PDT and antifungal drugs represents an attractive alternative to the current antifungal ... Desai, J. V., Mitchell, A. P., and Andes, D. R. (2014). Fungal biofilms, drug resistance, and recurrent infection. Cold Spring ... Davies, D. (2003). Understanding biofilm resistance to antibacterial agents. Nat. Rev. Drug Discov. 2, 114-122. doi: 10.1038/ ... and Exophiala spp., which has the potential to reduce treatment times, drug dosages, drug toxicity and improve patient ...
https://www.frontiersin.org/articles/10.3389/fmicb.2016.00617/full
*  Frontiers | The Hsp90 Co-chaperones Sti1, Aha1, and P23 Regulate Adaptive Responses to Antifungal Azoles | Microbiology
However, the roles of its many co-chaperones in antifungal resistance are unknown. In this study, by susceptibility test of ... to antifungal drugs and other stresses, we demonstrate that the Hsp90 co-chaperones Sti1 (Hop1 in yeast), Aha1, and P23 (Sba1 ... These results indicate that Hsp90-cochaperones Aha1, Sti1, and P23 are critical for the basal azole resistance and could be ... However, the roles of its many co-chaperones in antifungal resistance are unknown. In this study, by susceptibility test of ...
https://www.frontiersin.org/articles/10.3389/fmicb.2016.01571/full
*  Polyenes | definition of Polyenes by Medical dictionary
Fungal Biofilms and drug resistance. As a class, the echinocandins possess a mechanism of action that is distinct from those of ... The polyenes cause the fungal cell to die by intercalating into ergosterol-containing membranes, the major sterol in fungal ... Antifungal drugs (azoles, pyrimidines, echinodians, polyenes, allylamines, and other antifungal drugs). Global Infectious ... Polyenes bind directly to the unique fungal sterol ergosterol and compromise membrane function.. Ocular mycoses: infection of ...
http://medical-dictionary.thefreedictionary.com/Polyenes
*  Northern blot analysis | Article about Northern blot analysis by The Free Dictionary
Fungal Biofilms and drug resistance. We have not quantified the response by DD RT-PCR and Northern blot analysis compared with ...
https://encyclopedia2.thefreedictionary.com/Northern+blot+analysis
*  Infections Blog Sites - Blog Top Sites
She also explains.. the ever rising anti-fungal drug resistance.. Owner: ssdhospital ... With the onset of the rainy season, there is a rise in fungal infections on our skin. In this.. column, Dr Sneh Thadani ... explains the reasons and prevention for fungal infections. ...
http://www.blogtopsites.com/tag/infections
*  Logo diagrams of flanking extein sequences for 483 rand | Open-i
Drug Resistance, Fungal/drug effects/genetics. *Inteins/physiology. *Kanamycin/pharmacology. *Kinetics. Related in: MedlinePlus ... Therefore, we developed a genetic selection for splicing-dependent kanamycin resistance with no significant bias when six amino ... Therefore, we developed a genetic selection for splicing-dependent kanamycin resistance with no significant bias when six amino ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC3585056_zbc0121341460003&req=4
*  Molecules | Free Full-Text | Anti-Candida Activity of Bursera morelensis Ramirez Essential Oil and Two Compounds, α-Pinene and...
The abuse of antifungals has contributed to the development of resistance. B. morelensis has demonstrated antibacterial and ... Tscherner, M.; Schwarzmüller, T.; Kuchler, K. Pathogenesis and antifungal drug resistance of the human fungal pathogen Candida ... Fungal Biol. 2010, 114, 189-197. [Google Scholar] [CrossRef] [PubMed]. *Liesche, J.; Marek, M.; Günther-Pomorski, T. Cell wall ... Fungal Genet. Biol. 1999, 28, 135-145. [Google Scholar] [CrossRef] [PubMed]. *Gale, C.; Gerami-Nejad, M.; McClellan, M.; ...
http://www.mdpi.com/1420-3049/22/12/2095/htm
*  Gene Expression of Pneumocystis murina after Treatment with Anidulafungin Results in Strong Signals for Sexual Reproduction,...
Hsp90 orchestrates stress response signaling governing fungal drug resistance. PLoS Pathog 5:e1000471. doi:10.1371/journal.ppat ... Hsp90p helps to cope with stress induced by drug exposure and has been implicated in drug resistance mechanisms (5). Together, ... The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation. Nat Commun ... Preclinical drug discovery for new anti-pneumocystis compounds. Curr Med Chem 16:2514-2530. doi:10.2174/092986709788682038. ...
https://aac.asm.org/content/62/5/e02513-17
*  Extracellular DNA Release Acts as an Antifungal Resistance Mechanism in Mature Aspergillus fumigatus Biofilms | Eukaryotic Cell
Hsp90 governs dispersion and drug resistance of fungal biofilms. PLoS Pathog. 7: e1002257. doi:10.1371/journal.ppat.1002257 .. ... Genetic basis of Candida biofilm resistance due to drug-sequestering matrix glucan. J. Infect. Dis. 202: 171-175. ... Fungal biofilm resistance. Int. J. Microbiol. 2012: 528521. doi:10.1155/2012/528521 .. ... Biofilm matrix of Candida albicans and Candida tropicalis: chemical composition and role in drug resistance. J. Med. Microbiol. ...
https://ec.asm.org/content/12/3/420
*  Phys.org - drug(... continued page 12)
MSU-based biologists have reported new understanding of fungal drug resistance mechanisms. To study them, the scientists used ... The drug is unlikely to have any side effects and has the great advantage that no resistance development can occur. Researchers ... Drug. A drug, broadly speaking, is any substance that, when absorbed into the body of a living organism, alters normal bodily ... Data-sharing website may speed the response to new illegal drugs. The drug overdose epidemic currently gripping the nation is ...
https://phys.org/tags/drug/page12.html
*  Phys.org - pathogenic fungi
MSU-based biologists have reported new understanding of fungal drug resistance mechanisms. To study them, the scientists used ... Baker's yeast helps biologists to understand drug resistance in fungi. ... Fungal infections represent an increasing health crisis, especially for immune-deficient patients. American scientists now ... Novel mechanism in bacterial-fungal symbiosis could have biodiesel production applications. To answer the challenge of ...
https://phys.org/tags/pathogenic+fungi/