BiotransformationXenobioticsCytochrome P-450 Enzyme SystemPharmaceutical PreparationsMicrosomes, LiverMetabolic Detoxication, DrugCytochrome P-450 CYP3AAryl Hydrocarbon HydroxylasesHexobarbitalLiverPharmacokineticsMetabolic Detoxication, Phase IIGlucuronosyltransferaseHydroxylationMetabolic Detoxication, Phase IAntipyrineCunninghamellaChromatography, High Pressure LiquidMixed Function OxygenasesDealkylationHepatocytesOxidoreductases, N-DemethylatingKetoconazolePhenobarbitalGlutathione TransferaseReceptors, SteroidCytochrome P-450 CYP1A2Cytochrome P-450 CYP2D6Lipid MetabolismUmbelliferonesEnergy MetabolismDrug InteractionsOxidation-ReductionIsoenzymesGlucuronidesEnzyme InductionCytochrome P-450 CYP1A1Mass SpectrometryOxygenasesCytochrome P-450 CYP2E1Steroid 16-alpha-HydroxylaseCoumarinsHalf-LifeKineticsPharmacogeneticsMicrosomes7-Alkoxycoumarin O-DealkylaseNADPH-Ferrihemoprotein ReductaseBiodegradation, EnvironmentalMolecular StructureCarboxylesteraseSteroid HydroxylasesChromatography, LiquidMetabolic Clearance RateAminopyrine N-DemethylaseSpecies SpecificityStereoisomerismSubstrate SpecificityEnvironmental PollutantsReceptors, Cytoplasmic and NuclearAminopyrineGene Expression Regulation, EnzymologicRats, Sprague-DawleyDextromethorphanP-GlycoproteinArylamine N-Acetyltransferasebeta-NaphthoflavoneCytochromes b5Aniline HydroxylaseMagnetic Resonance SpectroscopyAcetaminophenGas Chromatography-Mass SpectrometryGlutathioneRNA, MessengerCarbon RadioisotopesHydrocarbons, HalogenatedMidazolamTissue DistributionPolymorphism, GeneticMethylcholanthreneMolecular Sequence DataTandem Mass SpectrometryTrichloroethanesBileDrug Evaluation, PreclinicalGlucuronatesAdministration, OralSafety-Based Drug WithdrawalsEnzyme InhibitorsBiological TransportDose-Response Relationship, DrugIntestinesModels, BiologicalProdrugsCytochrome P-450 CYP2B1Drug-Related Side Effects and Adverse ReactionsEthylmorphine-N-DemethylaseMetabolismBiological AvailabilityTime Factors