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*  Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology | Ebook ...
Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology - Author ... Keywords: Charles Davis, evaluation of drug candidates, assessment of drug candidates, evaluation of potential drug compounds, ... Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology. 101,10€ ... assessment of potential drug compounds, ADMET, drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein ...
https://www.ellibs.com/book/9780470574881/evaluation-of-drug-candidates-for-preclinical-development-pharmacokinetics-metabolism-pharmaceutics-and-toxicology
*  Histopathology of Preclinical Toxicity Studies : Interpretation and Relevance in Drug Safety Evaluation. (eBook, 2014) ...
Interpretation and Relevance in Drug Safety Evaluation.. [Peter Greaves] -- The new 4,SUP,th,/SUP, edition of Histopathology of ... Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety ... drug_safety_evaluation> ;. schema:name "Histopathology of Preclinical Toxicity Studies : Interpretation and Relevance in Drug ... Histopathology of Preclinical Toxicity Studies : Interpretation and Relevance in Drug Safety Evaluation.. Author:. Peter ...
https://www.worldcat.org/title/histopathology-of-preclinical-toxicity-studies-interpretation-and-relevance-in-drug-safety-evaluation/oclc/1054363380
*  Early preclinical evaluation of dihydropyrimidin(thi)ones as potential anticonvulsant drug candidates
... ... which can be relevant due to the fact that the toxicity is a common problem of the available antiepileptic drugs. Furthermore, ... of epileptic patients are still inadequately controlled by standard drug therapy. For this reason, it continues to be important ... of the compounds presented lower toxicity than the antiepileptic drugs lamotrigine, carbamazepine and phenytoin. In addition, ...
https://insights.ovid.com/ejops/201705010/00019515-201705010-00029
*  Pharmacokinetic-Pharmacodynamic Evaluations and Experimental Design Recommendations for Preclinical Studies of Anti...
... which provided estimates of single drug effects together with a quantitative model-based evaluation framework for evaluation of ... Preclinical research is important for defining drugs and regimens which should be carried forward to human studies. This thesis ... Evaluations and Experimental Design Recommendations for Preclinical Studies of Anti-tuberculosis Drugs. Chen, Chunli Uppsala ... tuberculosis, pharmacokinetics-pharmacodynamics, drug-drug interactions, mixed effect models, pharmacometrics National Category ...
http://www.diva-portal.org/smash/record.jsf?pid=diva2:1085581
*  Numerous molecular markets in the pre-clinical evaluation as cancer drug targets.
... numerous molecular markets in the pre-clinical evaluation as cancer drug targets. Save to give specific searches for routine ... Numerous molecular markets in the pre-clinical evaluation as cancer drug targets.. In addition, numerous molecular markets in ... the pre-clinical evaluation as cancer drug targets. Save to give specific searches for routine checking received nm. Contact ...
http://bigsandybasin.org/numerous-molecular-markets-in-the-pre-clinical-evaluation-as-cancer-drug-targets/
*  Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials | Drug Discovery ...
Preclinical Saxfety Evaluation of Biological Oncology Drugs (Theresa Reynolds, BA, DABT (Genentech)). ... Preclinical Safety Evaluation of Immunotoxins (Jennifer G. Brown, PhD, Joycelyn Entwistle, PhD, Nick Glover, PhD, and Glen C. ... Preclinical Safety Study Design Templates and Estimated Costs (Gary W. Wolfe, PhD, DABT (Summit Drug Development Services)). ... Preclinical Evaluation of Cancer Hazard and Risk of Biopharmaceuticals (Joy A. Cavagnaro, PhD, DABT, RAC (Access BIO)). ...
https://www.wiley.com/en-us/Preclinical+Safety+Evaluation+of+Biopharmaceuticals%3A+A+Science+Based+Approach+to+Facilitating+Clinical+Trials-p-9781118679388
*  Preclinical evaluation of long-acting muscarinic antagonists: comparison of tiotropium and investigational drugs. - Semantic...
In this study, we performed a comprehensive preclinical comparison of tiotropium with other long-acting muscarinic antagonists ... Preclinical evaluation of long-acting muscarinic antagonists: comparison of tiotropium and investigational drugs.. @article{ ... Preclinical evaluation of long-acting muscarinic antagonists: comparison of tiotropium and investigational drugs.}, author={ ... Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. *Juergen Wess, R. M. Eglen, Dinesh ...
https://www.semanticscholar.org/paper/Preclinical-evaluation-of-long-acting-muscarinic-of-Casarosa-Bouyssou/0d1b939674cf219317cfe18edc3cccc4dbd17b6f
*  Preclinical safety evaluation of 18F-FHBG: a PET reporter probe for imaging herpes simplex virus type 1 thymidine kinase (HSV1...
Drug Evaluation, Preclinical. Female. Guanine / analogs & derivatives*, diagnostic use, pharmacokinetics, toxicity. Herpesvirus ... Preclinical safety evaluation of 18F-FHBG: a PET reporter probe for imaging herpes simplex virus type 1 thymidine kinase (HSV1- ... Previous Document: Radiosynthesis and preclinical evaluation of 11C-ABP688 as a probe for imaging the metabotropic glut.... ... The Food and Drug Administration has approved FHBG as an Investigational New Drug.. ...
http://www.biomedsearch.com/nih/Preclinical-safety-evaluation-18F-FHBG/16595506.html
*  Preclinical cardiovascular changes in children with obesity: A real-time 3-dimensional speckle tracking imaging study.
Drug Evaluation, Preclinical. Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic ... Summary of "Preclinical cardiovascular changes in children with obesity: A real-time 3-dimensional speckle tracking imaging ... Preclinical cardiovascular changes in children with obesity: A real-time 3-dimensional speckle tracking imaging study.. 08:00 ... All Topics Biotechnology Biotech Business Biotech Products Cancer Cardiovascular Dermatology Drug Discovery Endocrinology ...
https://www.bioportfolio.com/resources/pmarticle/2182052/Preclinical-cardiovascular-changes-in-children-with-obesity-A-real-time-3-dimensional.html
*  Defining limits of treatment with humanized neutralizing monoclonal antibody for West Nile virus neurological infection in a...
Dose-Response Relationship, Drug. Drug Evaluation, Preclinical. Female. Humans. Mesocricetus. Random Allocation. Time Factors. ... Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-04 ...
http://www.biomedsearch.com/nih/Defining-limits-treatment-with-humanized/17452485.html
*  Sm-p80-based schistosomiasis vaccine: double-blind preclinical trial in baboons demonstrates comprehensive prophylactic and...
Drug Evaluation, Preclinical. Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic ... All Topics Biotechnology Biotech Business Biotech Products Cancer Cardiovascular Dermatology Drug Discovery Endocrinology ... All Topics Biotechnology Biotech Business Biotech Products Cancer Cardiovascular Dermatology Drug Discovery Endocrinology ... Home » Topics » Vaccines » Research » Sm-p80-based schistosomiasis vaccine: double-blind preclinical trial in baboons ...
https://www.bioportfolio.com/resources/pmarticle/2133900/Sm-p80-based-schistosomiasis-vaccine-double-blind-preclinical-trial-in-baboons-demonstrates.html
*  DNAJB4 | Cancer Genetics Web
Drug Evaluation, Preclinical. *Neoplasm Metastasis. *Neoplastic Cell Transformation. *Tumor Suppressor Gene. *Hepatocellular ... The HLJ1-targeting drug screening identified Chinese herb andrographolide that can suppress tumour growth and invasion in non- ... Among the herbal drugs identified, the andrographolide (from Andrographis paniculata [Burm. f.] Nees.) most significantly ... Here, we describe the identification of a novel drug-like heat shock response inducer for the therapeutic induction of ...
http://www.cancerindex.org/geneweb/DNAJB4.htm
*  Evaluation of protective efficacy of CC-2 formulation against topical lethal dose of T-2 toxin in mice. | CureHunter
Evaluation of protective efficacy of CC-2 formulation against topical lethal dose of T-2 toxin in mice. - Mona Agrawal, Deepak ... Body Weight (drug effects) *Chlorobenzenes (pharmacology) *Drug Evaluation, Preclinical. *Glutathione (metabolism) *Lethal Dose ... Evaluation of protective efficacy of CC-2 formulation against topical lethal dose of T-2 toxin in mice.. Abstract. T-2 toxin is ... Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find ...
http://www.curehunter.com/public/pubmed22245378.do
*  Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis. | CureHunter
... a potential drug target for human trypanosomiasis. - Leah S Torrie, Susan Wyllie, Daniel Spinks, Sandra L Oza, Stephen Thompson ... Drug Evaluation, Preclinical. *Enzyme Inhibitors (chemistry, pharmacology, therapeutic use) *Humans. *Protozoan Proteins ( ... Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.. Abstract. In the search ... Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find ...
http://www.curehunter.com/public/pubmed19828449.do
*  Pre-exposure Prophylaxis Prevents Intravaginal HIV-1 Tr | Open-i
Drug Evaluation, Preclinical. *Emtricitabine. *Female. *Fetal Tissue Transplantation. *Genitalia, Female/immunology/virology ... We also show that pre-exposure prophylaxis with antiretroviral drugs is a highly effective method for preventing vaginal HIV-1 ... We also show that pre-exposure prophylaxis with antiretroviral drugs is a highly effective method for preventing vaginal HIV-1 ... BLT mice are susceptible to intravaginal infection makes this system an excellent candidate for preclinical evaluation of both ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2194746_pmed.0050016.g002&req=4
*  The mammalian target of rapamycin (mTOR) signaling casc | Open-i
... are effective anticancer agents in a broad range of preclinical models. ... are effective anticancer agents in a broad range of preclinical models. ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC3412949_cncr0118-1486-f1&req=4
*  cardiovascular physiologic phenomena
A postgraduate course in preclinical drug evaluation. Jeffrey Atkinson. Laboratoire de Pharmacologie EA 3448, Faculte de ... Evaluation of the teaching strategy of cardiovascular system in a problem-based curriculum: student perception. Marwan F Abu- ... GPCRs: Evolving Concepts and Drug Discovery. Paul Insel; Fiscal Year: 2004. ..Attendees will thus have the chance to learn and ... Examining the cognitive processes that give rise to automatic self-evaluation will enhance psychology's understanding of how to ...
https://www.labome.org/topics/physical/natural/biological/circulatory/cardiovascular/cardiovascular-physiologic-phenomena-19998.html
*  Characterization of Diagnostic Tools and Potential Treatments for Alzheimer's Disease : PET ligands and BACE1 inhibitors
Alzheimer's disease, amyloid-beta, drug therapy, pharmacology, preclinical drug evaluation National Category Other Chemistry ... In addition, such methodology may be useful for evaluation of new drugs aiming at reduction of amyloid plaque load. The ... are promising imaging tools aimed at supporting the diagnosis of Alzheimer's disease and the evaluation of new drugs aiming to ... Taken together, the pre-clinical profile of AZD2184 in relation to the reference ligand PIB, suggests that (11)C-labeled ...
http://www.diva-portal.org/smash/record.jsf?pid=diva2:1040100
*  Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer...
Finally, Temozolomide (TMZ) is an important drug in the treatment of glioblastomas but its activity is reduced by resistance ... Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer ... drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of ... In this thesis, various pharmacological strategies designed to enhance the activity of existing therapeutic drugs were ...
https://bradscholars.brad.ac.uk/handle/10454/13842
*  Plus it
Orthotopic models of cancer for preclinical drug evaluation: advantages and disadvantages. Eur J Cancer 2004;40:852-7. ... Conclusions: Taken together, preclinical orthotopic ovarian tumor grafts are useful tools for drug development, providing hard ... Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: better than commonly perceived- ... Anticancer drug development: the grand challenges. Nat Rev Drug Discov 2010;9:253-4. ...
http://clincancerres.aacrjournals.org/content/18/19/5399
*  Preclinical Cancer Therapy in a Mouse Model of Neurofibromatosis-1 Optic Glioma | Cancer Research
The use of Nf1+/−GFAPCKO mice for preclinical drug evaluation. As we enter into an era of biologically targeted therapeutics, ... Based on tumor proliferation, location, and penetrance, we selected one of these Nf1 GEM models for preclinical drug evaluation ... To select an optimal model for preclinical evaluation, we analyzed the histology and natural history of the three previously ... The mighty mouse: genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov 2006; 5: 741-54. ...
http://cancerres.aacrjournals.org/content/68/5/1520
*  astrocytic tumor spinal cord 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Drug Evaluation, Preclinical / methods. Etanercept. Hippocampus / metabolism. Hippocampus / pathology. Male. Random Allocation ... Astrocytes / drug effects. Cell Differentiation / drug effects. Cell Differentiation / physiology. Female. Immunohistochemistry ... Chio CC, Lin JW, Chang MW, Wang CC, Kuo JR, Yang CZ, Chang CP: Therapeutic evaluation of etanercept in a model of traumatic ... Spinal Cord Neoplasms / drug therapy. Spinal Cord Neoplasms / metabolism. *[Email] Email this result item Email the results to ...
http://www.bmlsearch.com/?kwr=astrocytic+tumor+spinal+cord+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  benign cartilaginous tumor 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Drug Evaluation, Preclinical / methods. Humans. Male. Mice. Mice, Nude. Tumor Cells, Cultured. Xenograft Model Antitumor Assays ... Drug Delivery Device. A1.3.2. Research Device. A1.3.3. Clinical Drug. A1.4. Substance. A1.4.1. Chemical. A1.4.1.1. Chemical ... Evaluation Studies. Festschrift. Government Publications. Guideline. Historical Article. Interactive Tutorial. Interview. ... Cell Survival / drug effects. Cyclooxygenase 2 Inhibitors / blood. Cyclooxygenase 2 Inhibitors / therapeutic use. Disease ...
http://www.bmlsearch.com/?kwr=benign+cartilaginous+tumor+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  Preclinical toxicity evaluation of AAV for pain: evidence from human AAV studies and from the pharmacology of analgesic drugs |...
... and from the clinical pharmacology of conventional analgesic drugs. Thereby, we identified required preclinical studies and ... Preclinical toxicity evaluation of AAV for pain: evidence from human AAV studies and from the pharmacology of analgesic drugs. ... Rosenblum IY, Johnson RC, Schmahai TJ: Preclinical safety evaluation of recombinant human interleukin-10. Regul Toxicol ... Preclinical toxicity assessment. Additional studies required. For the IT route of AAV delivery, preclinical animals studies are ...
https://molecularpain.biomedcentral.com/articles/10.1186/1744-8069-10-54
*  Evaluation of envelope vaccines derived from the South African subtype C human immunodeficiency virus type 1 TV1 strain
Drug Evaluation, Preclinical. dc.subject. Gene Deletion. dc.subject. Gene Products, env. ... Evaluation of envelope vaccines derived from the South African subtype C human immunodeficiency virus type 1 TV1 strain. dc. ... Evaluation of envelope vaccines derived from the South African subtype C human immunodeficiency virus type 1 TV1 strain. ...
https://scholar.sun.ac.za/handle/10019.1/14151?show=full