Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19. Nat Med. 2022 Feb 17. ... Some of these children have underlying conditions (DiGeorge syndrome, trisomy 21) characterized by defective immunity, whereas ...

Joe explores cytokine storm syndromes, specifically hemophagocytic lymphohistiocytosis (HLH), a severe hyperinflammatory ...

AMP AIM: Disease Teams for Rheumatoid Arthritis, Lupus, Psoriatic Spectrum Diseases, and Sjögrens Syndrome (UC2, Clinical ...

COVID-19 disease and Multisystem Inflammatory Syndrome in children. NCT04844242 Principal Investigator ... and multi-system inflammatory syndrome in children (MIS-C) ... in children with Paediatric Inflammatory Multisystem Syndrome ...

... thus preventing hemolytic uremic syndrome (HUS) from developing. Investigators are further defining the ways by which the Shiga ...

... acute Inflammatory immune reconstitution syndrome (IRIS) or chronic treated HIV. We work on pathogenesis, genetics and ... My primary research interests are in hyperinflammatory syndromes including those related to people with HIV/AIDS and others ... the inflammatory complications in people with HIV either in the form of acute Inflammatory immune reconstitution syndrome (IRIS ... immune reconstitution inflammatory syndrome (IRIS), Kaposi sarcoma... ...

... for activating PI3K delta syndrome). ...

... gastrointestinal and lung syndromes resulting from radiation exposure; toxicological, pharmacological, and drug candidate ...

... and a natural history study for patients with systemic capillary leak syndrome. ...

NIH Awards Will Fund Post-Treatment Lyme Disease Syndrome Research. July 21, 2023 ... has awarded five projects for research to better understand Post-treatment Lyme Disease Syndrome (PTLDS), which is a collection ...

Scientists from NIAID and the National Human Genome Research Institute at the NIH identified a novel, genetic human immunodeficiency called PASLI disease.

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Images not listed below are believed to be in the public domain.Cover: National Library of Medicine (NLM), National Institutes of Health (NIH), B016393Page 4: Figure 1.A. Courtesy of the Kinyoun Family Archives private document collection Page 4: Figure 1.C. Courtesy of the Kinyoun Family Archives private document collection

Tuberculosis (TB) is a priority for NIAID. It is the leading infectious cause of death worldwide. We aim to improve diagnosis, prevention and treatment of TB.

The Safety and Pharmacovigilance Team (SPT) within OPCRO serve as subject matter experts and advisors to DAIDS and external stakeholders in matters related to safety and pharmacovigilance. A cross section of DAIDS SPT responsibilities includes:

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Our research program is focused on the design, implementation, and interpretation of screening efforts to identify and determine interactions among the components in TLR and inflammasome signaling networks. We use high-throughput genetic screening to identify key pathway regulators and a combination of cell biology, biochemistry, and molecular biology to characterize their function.

I am studying the initial contact of Brugia malayi whole worm antigen preps with human lymphatic endothelial cells and examining the effects of this contact on signalling molecules on these cells to understand what initial contacts do that make the changes that end up resulting in inflammation and pathology in lymphatic filariasis.. ...

Shi is working on the design and structural characterization of novel malaria vaccines to display antigens on nanoparticles. He is seeking to develop a next generation of malaria vaccine to be able to elicit both humoral and cell-mediated immunity for better protection.. ...

Dashboard of NIH Intramural COVID-19 Projects (NIH-only) The COVID-19 Scientific Interest Group, in collaboration with the Trans-NIH Preclinical Working Group, created an NIH Intramural Research Program (IRP) inventory and dashboard of COVID-19 projects. Currently, this dashboard can be accessed only by NIH leadership and the researchers who contributed information to it.

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Resources for NIAID grantees about the first events that occur after applications go through peer review and are approved for funding.

Helen Su, M.D., Ph.D., is the Chief of the Human Immunological Diseases Section (HIDS). The goals of HIDS are to understand the molecular mechanisms regulating the human immune system and how their derangements cause disease, with the objective of improving diagnosis and treatment. We study patients with a spectrum of poorly characterized, inherited immunodeficiencies and autoimmune diseases, who lack molecular diagnoses. We are particularly interested in combined immunodeficiencies that lead to susceptibility to virus infections and the new biological insights that studying these patients can provide.

Research focus on validation of MS disease mechanisms and therapeutic targets within the context of interventional clinical trials and longitudinal follow-up of patients on FDA-approved disease-modifying treatments.. Special Interest: Health promotion/prevention, health education and medication adherence. 2022-Family Nurse Practitioner- Associate Investigator, National Institutes of Health. 2018-Clinical Research Neuroscience Nurse, National Institutes of Health. 2013- Expert Neuroscience Nurse, Johns Hopkins. ...

NIAID published the PAR-23-275, NIAID and NIDDK Research Opportunities for New and At-Risk Investigators to Promote Workforce Diversity (R01, Clinical Trial Optional) notice of funding opportunity (NOFO) on September 13, 2023.

C. Jason Liang, Ph.D., is a Mathematical Statistician in the Biostatistics Research Branch at the National Institute of Allergy and Infectious Diseases.

NIAID urges AstraZeneca to work with the Data and Safety Monitoring Board (DSMB) to review the efficacy data from its COVID-19 vaccine clinical trial and ensure the most accurate, up-to-date efficacy data be made public as quickly as possible.

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