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*  Transgenic Polyoma Middle-T Mice Model Premalignant Mammary Disease | Cancer Research
Growth Regulation.. The growth properties of these premalignant foci were tested further by isolating and transplanting zone 4 ... Abstract LB-332: A novel TIMP-2-mediated cytoplasmic mechanism for the regulation of receptor tyrosine kinase, VEGFR-2 ... These results indicate that the transplanted hyperplasias obey normal tissue regulation and that transgene expression does not ...
http://cancerres.aacrjournals.org/content/61/22/8298?ijkey=d59e21abca55f7abfa32a57ddb9e4c07d9ca0c8b&keytype2=tf_ipsecsha
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TOP1 Down-Regulation.. CPT has been shown to induce transcription-dependent degradation of TOP1 (TOP1 down-regulation) through ... Assay for TOP1 Down-Regulation.. TOP1 down-regulation was monitored as described previously (20) . Briefly, RPMI-8402 cells ... down-regulation) through a ubiquitin/26S proteasome pathway (17, 18, 19) . CPT-induced TOP1 down-regulation, which is ... 5B ⇓ , ARC-111, like CPT, induced TOP1 down-regulation in RPMI-8402 cells as evidenced by the reduction of the Mr 100,000 TOP1 ...
http://cancerres.aacrjournals.org/content/63/23/8400
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Hormonal Regulation of hK9.. We studied KLK9 expression in BG-1 epithelial ovarian cell line and the BT-474, T47-D, and MCF-7 ... KLK9 was also found to be under steroid hormonal regulation in cancer cell lines (14) . Interestingly, KLK8 [tumor-associated ... Our results indicate that KLK9 is under steroid hormone regulation in ovarian and breast cancer cell lines. ...
http://cancerres.aacrjournals.org/content/61/21/7811
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This still leaves a larger question: Why does all this regulation exist in the first place? As Myc is not required in the adult ... Consistent with the predicted role of MYC-335 in tissue-specific regulation of MYC, we observed a modest decrease in Myc ... Role of GWAS SNPs in Gene Regulation. How can the SNPs located far from any oncogene or tumor suppressor alter cancer ... The recent functional analysis of 8q24 variants has already uncovered a new complexity in regulation of a classic oncogene, MYC ...
http://cancerres.aacrjournals.org/content/73/14/4180
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Epigenetic regulation. A, schematic of enriched Histone-DNA methylation probes with respect to transcription start site (TSS) ... Epigenetic regulation of SeOvCa genes. Global hypomethylation and specific promoter hypermethylation in tumor-suppressor genes ... The present study is the first report of probable involvement of epigenetic regulation of these genes in ovarian cancer. ... Further validation of predicted outcomes based on copy number changes and epigenetic regulation presents new viewpoints and ...
http://cancerres.aacrjournals.org/content/70/12/4809
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Regulation of miR-708 locus. Human miR-708 gene is located at chromosomal position 11q14.1. miR-708 is an intronic miRNA that ... miR-708-mediated regulation of survivin is a highly significant finding as this nodal protein orchestrates extensive, tumor- ... Survivin knockdown studies suggest that the proapoptotic role of miR-708 may be mediated primarily through regulation of ... Recent evidence indicates that ZEB transcription factors may also regulate apoptosis and senescence apart from regulation of ...
http://cancerres.aacrjournals.org/content/71/19/6208
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Regulation of SDHD expression by GABPA and GABPB1. To validate the potential regulation of SDHD expression by the ETS ... Still, a direct role for ELF1 or other ETS family transcription factors in the regulation of SDHD in melanoma remains to be ... Consistent with a potential role for GABPA in regulation of SDHD, depletion of GABPA in melanoma cell lines resulted in ... Consistent with a potential role for GABPA in regulation of SDHD, motif analysis of the relatively common C523T and C524T ...
http://cancerres.aacrjournals.org/content/77/7/1649
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Up-Regulation of FGF18 in CRC.. We had previously analyzed expression profiles of 9 adenomas and 11 adenocarcinomas of the ... Impaired regulation of this pathway often is a feature of tumors arising in the colon, liver, prostate, stomach, brain, ... Down-Regulation of Regulatory Subunit Type 1A of Protein Kinase A Leads to Endocrine and Other Tumors ... Fujita M., Furukawa Y., Tsunoda T., Tanaka T., Ogawa M., Nakamura Y. Up-regulation of the ectodermal-neural cortex 1 (ENC1) ...
http://cancerres.aacrjournals.org/content/63/19/6116
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Posttranslational Regulation of MMP-2 Expression.. One mechanism by which Akt might regulate MMP-2 expression is by the ... Liu W., Li J., Roth R. A. Heregulin regulation of Akt/protein kinase B in breast cancer cells. Biochem. Biophys. Res. Commun., ... Howard E. W., Bullen E. C., Banda M. J. Regulation of the autoactivation of human 72-kDa progelatinase by tissue inhibitor of ... Hotary K., Allen E., Punturieri A., Yana I., Weiss S. J. Regulation of cell invasion and morphogenesis in a three-dimensional ...
http://cancerres.aacrjournals.org/content/61/20/7647
*  A Role for Id-1 in the Aggressive Phenotype and Steroid Hormone Response of Human Breast Cancer Cells | Cancer Research
Regulation of Id-1 Expression by Sex Steroid Hormones.. E2 and Pg are important regulators of normal breast development, as ... 4E) ⇓ . Although we cannot rule out the possibility that the rapid down-regulation of Id-1 by Pg is enhanced by accelerated ... Saisanit S., Sun X. H. Regulation of the pro-B-cell specific enhancer of the Id1 gene involves the C/EBP family of proteins. ... In some cells, Id expression is induced by mitogens, including serum (3 , 25, 26, 27) . We, therefore, examined the regulation ...
http://cancerres.aacrjournals.org/content/60/5/1332?ijkey=5f2caa5b49870a11f66eaf77bc6eab4e7070a98c&keytype2=tf_ipsecsha
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Regulation of TCF/LEF target gene expression by TNIK. DLD1 or HCT-116 cells were transfected with siRNA against TNIK (12 or 13 ... Regulation of Wnt signaling by the nuclear pore complex. Gastroenterology 2008;134:1961-71, 71 e1-4. ... Regulation of β-catenin-evoked transcriptional activity by TNIK. We then investigated the effects of TNIK on the ...
http://cancerres.aacrjournals.org/content/70/12/5024
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CD133 promoter regulation in cancer stem cells. Because CD133 is applied as a marker for CSCs in colon cancer, we analyzed ... Promoter regulation exists for human CD133 (31) and could result in differential Sv expression (32-34). Moreover, several mouse ... In addition, regulation of differential CD133 splicing by distinct promoters has not been shown yet. The seven reported Svs of ... Promoter regulation of CD133 in normal human colon. Human CD133 is a highly complex gene that contains five promoters, ...
http://cancerres.aacrjournals.org/content/70/2/719
*  Negative Regulation of AKT Activation by BRCA1 | Cancer Research
Negative Regulation of AKT Activation by BRCA1. Tao Xiang, Amiko Ohashi, Yuping Huang, Tej K. Pandita, Thomas Ludwig, Simon N. ... Negative Regulation of AKT Activation by BRCA1. Tao Xiang, Amiko Ohashi, Yuping Huang, Tej K. Pandita, Thomas Ludwig, Simon N. ... Negative Regulation of AKT Activation by BRCA1. Tao Xiang, Amiko Ohashi, Yuping Huang, Tej K. Pandita, Thomas Ludwig, Simon N. ... S1B), suggesting that regulation of pAKT by BRCA1 is independent of PTEN. Knockdown of Brca1 in MEFs with or without Pten gene ...
http://cancerres.aacrjournals.org/content/68/24/10040
*  Regulation of the Fanconi Anemia/BRCA pathway | Cancer Research
The precise role of the USP1 protease in regulation the of the FA/BRCA pathway will be discussed. ...
http://cancerres.aacrjournals.org/content/65/9_Supplement/1475.2
*  Activator Protein 2α Inhibits Tumorigenicity and Represses Vascular Endothelial Growth Factor Transcription in Prostate Cancer...
... we decided to additionally investigate VEGF regulation by AP-2 in prostate cancer. To confirm the down-regulation of VEGF in ... Down-Regulation of VEGF Expression in AP-2-Transfected Cells.. Because VEGF was down-regulated by 14.7-fold in the AP-2- ... Jean D., Gershenwald J. E., Huang S., Luca M., Hudson M. J., Tainsky M. A., Bar-Eli M. Loss of AP-2 results in up-regulation of ... Tellez C., Bar-Eli M. Role and regulation of the thrombin receptor (PAR-1) in human melanoma. Oncogene, 22: 3130-3137, 2003. ...
http://cancerres.aacrjournals.org/content/64/2/631?ijkey=4fb8e7ccd20dad7756fb230ecfba87bdf07c41f4&keytype2=tf_ipsecsha
*  More articles from Poster Presentations - Oncogene Function, Regulation, and Targeting | Cancer Research
Priya Chatterji, Kathryn Hamilton, Sarah Andres, Rei Mizuno, Philip Hicks, Arjun Jeganathan, Monte M. Winslow, Antoni Castells, Miriam Cuatrecasas, Blair Madison, Anil Rustgi ...
http://cancerres.aacrjournals.org/content/by/section/Poster%20Presentations%20-%20Oncogene%20Function%2C%20Regulation%2C%20and%20Targeting
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Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proc Natl Acad Sci U S A 2001;98:974-79. ... Senescence regulation in spleens of Smurf2-deficient mice. As the majority of tumors found in Smurf2-deficient mice were B-cell ... Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell 2009;137:295-307. ... Smurf2 up-regulation activates telomere-dependent senescence. Genes Dev 2004;18:3028-40. ...
http://cancerres.aacrjournals.org/content/72/11/2714
*  Abstract 4075: Regulation of NKX3.1 by RMND5 proteins. | Cancer Research
Abstract 4075: Regulation of NKX3.1 by RMND5 proteins.. Alison Louw, Marc A. Thomas, Jennet Harvey and Jacqueline M. Bentel ... Abstract 4075: Regulation of NKX3.1 by RMND5 proteins. Message Subject (Your Name) has forwarded a page to you from Cancer ... Regulation of NKX3.1 by RMND5 proteins. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for ...
http://cancerres.aacrjournals.org/content/73/8_Supplement/4075
*  Microenvironment regulation of VEGF alternative splicing in malignancy | Cancer Research
Microenvironment regulation of VEGF alternative splicing in malignancy Message Subject (Your Name) has forwarded a page to you ... Microenvironment regulation of VEGF alternative splicing in malignancy. Ana Paula Elias and Sergio Dias ...
http://cancerres.aacrjournals.org/content/67/9_Supplement/1368
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Regulation of ErbB2/Neu levels by the UPR. To gain further insight into the regulation of Neu protein levels upon glucose ... Down-regulation of PGC-1alpha expression in human hepatocellular carcinoma]. Zhonghua Zhong Liu Za Zhi 2008;30:593-7. ... HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature 2008;451:1008-12. ... Regulation of ErbB2/Neu levels by the UPR. A, acute glucose deprivation reduces Neu protein levels. NT2196-PGC-1α and control ...
http://cancerres.aacrjournals.org/content/72/6/1538
*  Translation Regulation as a Therapeutic Target in Cancer | Cancer Research
Translation Regulation as a Therapeutic Target in Cancer Message Subject (Your Name) has forwarded a page to you from Cancer ... Translation Regulation as a Therapeutic Target in Cancer. Michal Grzmil and Brian A. Hemmings ...
http://cancerres.aacrjournals.org/content/early/2012/07/30/0008-5472.CAN-12-0026
*  The Cap 'n' Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and...
Regulation of GSH Biosynthetic Proteins in Nrf2(−/−) Mice.. Immunoblotting for GCSh, GCSl, and GS was undertaken because these ... Regulation of intestinal antioxidant and detoxication enzymes by Nrf2 has been assessed using a mouse line bearing a targeted ... Li Y., Jaiswal A. K. Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human ... Nguyen T., Rushmore T. H., Pickett C. B. Transcriptional regulation of a rat liver glutathione S-transferase Ya subunit gene. ...
http://cancerres.aacrjournals.org/content/61/8/3299?ijkey=f6d9b50c791d61d3c3f5a1c64da58b5283ba5d6b&keytype2=tf_ipsecsha
*  More articles from Poster Presentations - Metabolic Regulation and Cancer Therapy 2 | Cancer Research
Alessandra Romano, Floriana Cremasco, Antonella Chiechi, Francesca Paradiso, Enrico Milan, Francesca Fontana, Jose M. Manteiga, Francesco Di Raimondo, Alexander I. Spira, Amy Van Meter, Emanuel Chip Petricoin, Virginia Espina, Lance A. Liotta, Simone Cenci ...
http://cancerres.aacrjournals.org/content/by/section/Poster%20Presentations%20-%20Metabolic%20Regulation%20and%20Cancer%20Therapy%202
*  More articles from Poster Presentations - MicroRNA Regulation of Cancer Biology 2 | Cancer Research
Abstract 1471: miR-148a-3p regulation of OTX2 and PRC2 in group 3 and 4 medulloblastoma Qingfu Xu, Kimberly Wang, Sama Ahsan, ... Abstract 1472: Alternate translation initiation regulation of PRDX5 mRNA by miR6855,-,3p in basal,-,like breast cancer cells ...
http://cancerres.aacrjournals.org/content/by/section/Poster%20Presentations%20-%20MicroRNA%20Regulation%20of%20Cancer%20Biology%202