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*  Chromosome X-Wide Association Study Identifies Loci for Fasting Insulin and Height and Evidence for Incomplete Dosage...
Genetic effects near ITM2A suggest a lack of dosage compensation. Up to 25% of the chrX loci may not be subject to complete ... 2], we applied three models for dosage compensation: full dosage compensation (FDC), no dosage compensation (NDC) and equal ... Comparison of dosage compensation models. We applied a Bayesian framework [37] to compare full dosage compensation (FDC) and no ... full dosage compensation and no dosage compensation (Table S1). The differences between the model fit were small (as measured ...
https://www.prolekare.cz/casopisy/plos-genetics/2014-2/chromosome-x-wide-association-study-identifies-loci-for-fasting-insulin-and-height-and-evidence-for-incomplete-dosage-compensation-47914
*  Genomewide Nonadditive Gene Regulation in Arabidopsis Allotetraploids | Genetics
... which are caused by mechanisms involving dosage compensation, regulatory incompatibility, genetic alteration, and epigenetic ... Birchler, J. A., 2001 Dosage-dependent gene regulation in multicellular eukaryotes: implications for dosage compensation, ... During autopolyploidization, mechanisms such as dosage compensation (Birchler 2001) are responsible for maintaining expression ... Guo, M., D. Davis and J. A. Birchler, 1996 Dosage effects on gene expression in a maize ploidy series. Genetics 142: 1349-1355. ...
https://www.genetics.org/content/172/1/507?ijkey=227e2abaec9bc9587acbb33d130621eb61d0892b&keytype2=tf_ipsecsha
*  Gene dosage - Wikipedia
Copy-number variation Dosage compensation Genetic association Polyploidy, Aneuploidy Leland H. Hartwell; et al. (2011), ... Gene dosage is the number of copies of a particular gene present in a genome. Gene dosage is known to be related to the amount ... The bacterial chromosome is present only in one copy per cell, but there can still be variation in gene dosage due to DNA ... These slight gene dosage differences are responsible for variation in gene expression depending on the position on the ...
https://en.wikipedia.org/wiki/Gene_dosage
*  A new strategy for isolating genes controlling dosage compensation in Drosophilausing a simple epigenetic mosaic eye phenotype ...
A genetic screen for dominant modifiers of dosage compensation. We carried out a dominant F1 enhancer screen (Figure 1a) on a ... Polytene ChromosomeDosage CompensationPosition Effect VariegationDosage Compensation ComplexMale Specific Lethal ... Genetic screens assaying for male-specific lethality identified the known components of the dosage compensation complex, and ... We developed a new genetic strategy to identify components of the dosage compensation pathway in Drosophila using a simple ...
https://preview-bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-8-80
*  Genome-wide complex trait analysis - Wikipedia
Estimate the genetic variance associated with the X-chromosome; Test the effect of dosage compensation on genetic variance on ... there is no genetic contribution, b) the genetic contribution is entirely in the form of genetic variants not included, or c) ... "Common genetic variants, acting additively, are a major source of risk for autism", Klei et al 2012 "Most genetic risk for ... GCTA requires genetic similarity of all subjects and thus their raw genetic information; due to privacy concerns, individual ...
https://en.wikipedia.org/wiki/Genome-wide_complex_trait_analysis
*  "A Novel SMC-Like Protein Modulates C. Elegans Condensin Functions: A D" by Lucy F. Chao
... a process that down-regulates X gene dosage in XX hermaphrodites to match the dosage in XO males. How the three condensins are ... C. elegans has a third condensin (IDC) that specializes in dosage compensation, ... Caenorhabditis elegans, Chromatin, Chromosome Segregation, Genetic Dosage Compensation, Adenosine Triphosphatases, DNA-Binding ... that specializes in dosage compensation, a process that down-regulates X gene dosage in XX hermaphrodites to match the dosage ...
https://escholarship.umassmed.edu/gsbs_diss/820/
*  Shodhganga@INFLIBNET: Search
Studies on genetic and molecular basis of dosage compensation in Drosophila. Mitra, Nivedita. Mukherjee, A S. ... Understanding the genetic and molecular basis of immune responses in malarial pathogenesis. Basu, Madhumita. Sengupta, ...
http://shodhganga.inflibnet.ac.in/handle/10603/2852/simple-search?filterquery=Molecular&filtername=subject&filtertype=equals
*  Unraveling the Human Genome | Duke magazine
The uncharted machinery of dosage compensation resonated with his (perhaps genetic?) predilection for black-box problems. "I've ... They don't practice such dosage compensation. Because they have only one X chromosome, they need all their X-chromosome genes ... The new findings are only the latest emerging from decades of Willard's research on the phenomenon of dosage compensation. His ... The early researchers believed that dosage compensation completely inactivated or "silenced" one or the other X chromosome. ...
http://dukemagazine.duke.edu/article/unraveling-the-human-genome
*  Rapid regulatory evolution of a nonrecombining autosome linked to divergent behavioral phenotypes | PNAS
... gene expression divergence and dosage compensation can prevail before large-scale genetic degeneration. Our results show ... Our work with this chromosome reveals that rapid changes in gene expression and dosage compensation, not necessarily large- ... such as significant expression divergence between ZAL2 and ZAL2m alleles and signatures of dosage compensation for highly ... We report that this rearrangement shows few signs of large-scale genetic degeneration. Instead, substantial changes have ...
http://www.pnas.org/content/115/11/2794.short?rss%3D1
*  Calico Cats Are A Walking Genetics Lesson | American Council on Science and Health
The black and orange patches that define the coloring of a calico cat beautifully illustrate the genetic mechanism known as ' ... "dosage compensation.". You see, almost all calico cats are female which means that they have two X chromosomes in every cell. ( ... The calico cat is one example of an important genetic process that is incredibly fascinating at the same time. Indeed, this ... The black and orange patches that define the coloring of a calico cat beautifully illustrate the genetic mechanism known as " ...
https://www.acsh.org/news/2016/07/27/calico-cats-are-a-walking-genetics-lesson
*  Interaction of incontinentia pigmenti and factor VIII mutations in a female with biased X inactivation, resulting in...
Dosage Compensation, Genetic, Factor VIII, Family Health, Female, Genetic Carrier Screening, Hemophilia A, Heterozygote, Humans ...
https://www.imm.ox.ac.uk/publications/827575
*  The androgen receptor and DXS15-134 markers show a high rate of discordance for germline X chromosome inactivation | Journal of...
Mary Lyon formalised the role of X inactivation and its relationship to dosage compensation of X chromosome genetic material in ... 1992) Genetic variation at five trimeric and tetrameric repeat loci in four human population groups. Genomics 12:241-253. ... of X chromosome gene expression between male and female cells and is therefore considered a mechanism for dosage compensation. ... to the point of non-random X chromosome inactivation is a known mechanism associated with the development of X linked genetic ...
http://jmg.bmj.com/content/38/7/474
*  Genetic Data Preserved by Two Vital Proteins
... cohesin and condensin were found in the organization of chromosome which could aid in better understanding of genetic diseases. ... The protein is called Dosage Compensation Complex (DCC). The binding of DCC to specific sites on the promoter correlates with ... Causes for genetic disorders. Genetic disorders are caused by changes in the structure or number of the chromosomes or in the ... Quiz on Genetic Disorders. genetic mutations and these mutations may be small, affecting just one gene or affecting entire ...
http://www.medindia.net/news/healthinfocus/genetic-data-preserved-by-two-vital-proteins-162820-1.htm
*  GENETIC EPIDEMIOLOGY GLOSSARY [M.Tevfik DORAK]
Dosage compensation: The phenomenon in women, who have two copies of genes on the X chromosome, of having the same level of the ... links to freeware population genetic data analysis software: Arlequin 2000, PopGene, GDA, Genetix, Tools for Population Genetic ... Genetic heterogeneity. Distinct alleles at the same or different loci that give rise independently to the same genetic disease ... The lack of genetic determinism is behind the lack of progress with risk prediction for complex diseases. See Genetic ...
http://dorakmt.tripod.com/epi/glosge.html
*  cytology, genetics, evolution & plant breeding, prof. p.k. gupta
Dosage Compensation and Genetic Imprinting; 10. Maternal Effects, Cytoplasmic Inheritance and Organellar Genetics; 11. ... Genetic Code, Overlapping Genes and Split Genes; 23. Recombinant DNA, PCR and DNA Chips/Microarrays; 24. Synthesis, Isolation ...
http://rastogipublications.com/index.php?route=product/product&path=33&product_id=136
*  Genetic Requirements for Inheritance of RNAi in C. elegans | Science
... in a wide variety of organisms and are responsible for such diverse phenomena as chromosomal dosage compensation, genetic ... 1). The persistence of genetic interference raised the possibility that an active genetic process was required for the ... Genetic crosses designed to follow the requirements for rde-1, rde-2, rde-4, and mut-7 in (A) F2 and (B) F1 interference. (A) ... Genetic schemes to determine whether the wild-type activities of rde-1, rde-2,mut-7, and rde-4 are sufficient in the injected ...
https://science.sciencemag.org/content/287/5462/2494?ijkey=6825a8f33108718a7a7a00dfb087b6a30123a7dd&keytype2=tf_ipsecsha
*  General lack of global dosage compensation in ZZ/ZW systems? Broadening the perspective with RNA-seq | BMC Genomics | Full Text
This work demonstrates that the study of dosage compensation has become amenable to species where previously no genetic ... It further allows assessing the validity of microarray-based inference on dosage compensation with a novel technology. We here ... Massively parallele transcriptome sequencing allows re-assessing the degree of dosage compensation with a novel tool in well- ... Microarray-based studies in several independent male heterogametic XX/XY systems suggest that dosage compensation mechanisms ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-12-91
*  Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage...
The lines show the regions of the expected values of the effects under either full dosage compensation (FDC) or no dosage ... By using a linear mixed model, we estimate that on average 2.6% of the additive genetic variance in these twelve traits is ... Posterior probability of no dosage compensation (NDC) model at the three lead SNPs when the other candidate is full dosage ... Comparison of the dosage compensation models in the three associated loci applying Bayesian framework. ...
https://www.ncbi.nlm.nih.gov/pubmed/24516404
*  Interactive Fly, Drosophila
First of all, genetic destruction of the complex does not eliminate dosage compensation of most X-linked genes. However, one ... In this way, the twofold inverse-dosage effect of the X is used to achieve a proper level of dosage compensation, but the ... Sequence-specific targeting of dosage compensation in Drosophila favors an active chromatin context. The Drosophila MSL complex ... In the dosage compensation system of the X chromosome in Drosophila, a unique opportunity is presented to address this question ...
http://www.sdbonline.org/sites/fly/gene/sexlthl4.htm
*  Early Evolution of MHC Polymorphism by Donald Forsdyke
... the hypothesis provides a possible insight into the evolution of X chromosome dosage compensation, genetic dominance and the ... 17] Forsdyke D. R., Relationship of X chromosome dosage compensation to intracellular self/not-self discrimination: a ... temperature-sensitive mutations and even X chromosome dosage compensation [16-19]. Three basic postulates are that: ... 18] Forsdyke D. R., The heat-shock response and the molecular basis of genetic dominance, J. Theor. Biol. 167 (1994) pp. 1-5. ...
http://qspace.library.queensu.ca/bitstream/handle/1974/136/mhc001.htm
*  X chromosome dosage compensation via enhanced transcriptional elongation in Drosophila. - PubMed - NCBI
Dosage Compensation, Genetic/genetics*. *Drosophila Proteins/genetics. *Drosophila Proteins/metabolism. *Drosophila ... X chromosome dosage compensation via enhanced transcriptional elongation in Drosophila.. Larschan E1, Bishop EP, Kharchenko PV ... The biochemical mechanisms used for dosage compensation must function over a wide dynamic range of transcription levels and ... It has been proposed that the MSL complex regulates transcriptional elongation to control dosage compensation, a model ...
https://www.ncbi.nlm.nih.gov/pubmed/21368835
*  Adaptation across the genome: multivariate decomposition indicates different roles for the X and autosomes
Dosage compensation does not appear to double the male X-linked genetic variance, but this effect may be complex to detect. ... 1. The genetic architecture of sexual dimorphism. Open this publication in new window or tab ,,The genetic architecture of ... though the amount of variance was small suggesting adaptive potential from standing genetic variance is limited. Genetic ... The intersexual genetic correlation is negatively associated with sex-bias in expression in D. melanogaster, and the rate of ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:842931
*  Free Medical Flashcards about biochem test 2 2011
This phenomenon makes females genetic mosaics, and maybe the reason they sometimes act crazy. Also called Dosage Compensation. ... it is the genetic component of multifactoral traits. When one gene supresses the phonotype of a totally different gene it is ... 2. no mutation 3. no genetic drift 4. no migration 5. no natural selection. ...
https://www.studystack.com/flashcard-674385
*  Familial imbalance in 16p13.11 leads to a dosage compensation rearrangement in an unaffected carrier | BMC Medical Genetics |...
... a dualistic strategy is essential for the full characterization of genomic rearrangements as well as for appropriate genetic ... Further dosage and haplotype familial studies revealed that both the maternal grandfather and uncle had also the same 16p ... Genomic compensation observed in the mother probably occurred as a consequence of interchromosomal postzygotic nonallelic ... Alkalay AA, Guo T, Montagna C, Digilio MC, Dallapiccola B, Marino B, Morrow B: Genetic dosage compensation in a family with ...
https://0-bmcmedgenet-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s12881-014-0116-3