... a biological database covering protein domains Pfam: database of protein domains Protein Protein structure Protein structure ... Protein domains, connected by intrinsically disordered flexible linker domains, induce long-range allostery via protein domain ... multi-domain proteins. Many domains in eukaryotic multidomain proteins can be found as independent proteins in prokaryotes, ... Protein Engineering. 15 (11): 871-9. doi:10.1093/protein/15.11.871. PMID 12538906. "Protein Domains, Domain Assignment, ...
This protein domain, often found in bacterial species, is actually of viral origin. The protein forms an oligomer and functions ... The function of this protein domain is to digest DNA. Most viruses, inject their host with linear DNA, and this gets ... YqaJ is one of three protein subunits that form a toroid with a tapered channel passing through the middle. The channel changes ... In molecular biology, the YqaJ refers to the YqaJ/K domain from the skin prophage of the bacterium, Bacillus subtilis. ...
Conserved Protein Domain Family rfc, The Reduced Folate Carrier (RFC) Family (TC 2 ... Proteins of the RFC family are so-far restricted to animals. RFC proteins possess 12 putative transmembrane a-helical spanners ... "The conserved domain database in 2023.", Nucleic Acids Res. 51(D1):D384-D388.. ...
Conserved Protein Domain Family dxs, DXP synthase is a thiamine diphosphate-dependent enzyme related to transketolase and the ... "CDD/SPARCLE: the conserved domain database in 2020.", Nucleic Acids Res. 48(D1):D265-D268.. ...
Human DND1-RRM2 forms a non-canonical domain swapped dimer.. Kumari, P., Bhavesh, N.S.. (2021) Protein Sci 30: 1184-1195 ... Structure of RRM2 domain of DND1 protein. *PDB DOI: https://doi.org/10.2210/pdb6LE1/pdb ... We have determined the 2.3 Å crystal structure of the human DND1-RRM2 domain. The structure revealed an interesting non- ... have delineated the structural basis of the stable domain swapped dimer formation using the residue level dynamics of protein ...
A scientific resource for the HEAT protein domain containing information on structure, function, and domain binding. ... Domain Binding and Function. The protein domain HEAT. (Huntington, Elongation Factor 3, PR65/A, TOR) is found in the four ... containing proteins include the Ran-GTP binding importin and exportin cargo transport proteins. A substantial number of HEAT. ... domain consists of repeats of two anti-parallel α-helices and two turns arranged about a common axis. These repeats are linked ...
9 is a nonredundant adapter protein that functions in the innate immune system in the assembly of multifunctional signaling ... Caspase recruitment domain-containing protein (Card)9 is a nonredundant adapter protein that functions in the innate immune ... Caspase recruitment domain-containing protein 9 signaling in innate immunity and inflammation Trends Immunol. 2013 Jun;34(6): ... Together with B cell lymphoma (Bcl)10 and the paracaspase, mucosa-associated lymphoid tissue lymphoma translocation protein ( ...
Monomeric Protein L B1 Domain with a G15A Mutation ... Monomeric Protein L B1 Domain with a G15A Mutation. *PDB DOI: ... Single-site mutations induce 3D domain swapping in the B1 domain of protein L from Peptostreptococcus magnus.. ONeill, J.W., ... Thermodynamic and kinetic studies of the Protein L B1 domain (Ppl) suggest a folding pathway in which, during the folding ... Thermodynamic and kinetic studies of the Protein L B1 domain (Ppl) suggest a folding pathway in which, during the folding ...
YAP1 redox domain. Timeline for Protein YAP1 redox domain from g.78.1.1: YAP1 redox domain: *Protein YAP1 redox domain from g. ... Domain for 1sse: *. Domain d1sse.1: 1sse A:,B: [105981]. More info for Protein YAP1 redox domain from g.78.1.1: ... 78.1.1: YAP1 redox domain first appeared in SCOP 1.69. *Protein YAP1 redox domain from g.78.1.1: YAP1 redox domain appears in ... Lineage for Protein: YAP1 redox domain. *Root: SCOPe 2.08 *. Class g: Small proteins [56992] (100 folds). ...
protein coding gene. Chr1:128171635-128207115 (+). 129S1/SvImJ MGP_129S1SvImJ_G0016427. protein coding gene. Chr1:131480322- ... protein coding gene. Chr1:141014907-141054009 (+). DBA/2J MGP_DBA2J_G0016275. protein coding gene. Chr1:125613950-125649944 (+) ... protein coding gene. Chr1:130323536-130361573 (+). BALB/cJ MGP_BALBcJ_G0016370. protein coding gene. Chr1:126949973-126988597 ... protein coding gene. Chr1:130485973-130525735 (+). C57BL/6NJ MGP_C57BL6NJ_G0016831. protein coding gene. Chr1:136420500- ...
Protein target information for POU domain protein (chicken). Find diseases associated with this biological target and compounds ...
Timeline for Protein Cytochrome f, large domain from b.2.6.1: Cytochrome f, large domain: *Protein Cytochrome f, large domain ... 1 protein). *. Protein Cytochrome f, large domain [49443] (5 species). this domain is interrupted by a small domain which is ... Protein Cytochrome f, large domain from b.2.6.1: Cytochrome f, large domain appears in SCOP 1.73. *Protein Cytochrome f, large ... Other proteins in same PDB: d1e2wa2, d1e2wb2. complexed with hec; mutant. *Domains for 1e2z: *. Domain d1e2za1: 1e2z A:1-168,A: ...
Our analysis of this data reveals an absolute protein-to-RNA ratio of 102-104 for bacterial populations and 103-105 for an ... Here we report the temporal measurements of absolute RNA and protein levels per gene within a mixed bacterial-archaeal ... cellulose-degrading and methane-producing consortium at the strain level and estimate protein-to-RNA ratios and RNA-protein ... RNA/protein levels) to highlight phenotypical complementarity. Our findings show that upgrading multi-omic toolkits with ...
... which may help to protect non-repaired DNA ends from separating until they can be rejoined by DNA repair proteins. It has been ... Clustering of double strand break-containing chromosome domains is not inhibited by inactivation of major repair proteins ... This work demonstrates that neither inactivation of the major repair proteins XRCC3 and the DNA-dependent protein kinase (DNA- ... which may help to protect non-repaired DNA ends from separating until they can be rejoined by DNA repair proteins. It has been ...
ARH/RhoGEF and pleckstrin domain protein 2 (pig). Find diseases associated with this biological target and compounds tested ...
Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the ... Synonyms: Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76, SLP-76 tyrosine ... Structural basis for recognition of the T cell adaptor protein SLP-76 by the SH3 domain of phospholipase Cgamma1. Deng, L., ... Distinct role of ZAP-70 and Src homology 2 domain-containing leukocyte protein of 76 kDa in the prolonged activation of ...
De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens. Download Prime PubMed App ... GeneticProtein DomainsProtein Processing, Post-TranslationalRNA, Guide, KinetoplastidaSMARCB1 ProteinSoftware ... De Novo Identification of Essential Protein Domains From CRISPR-Cas9 tiling-sgRNA Knockout Screens. Nat Commun. 2019 10 4;10(1 ... De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens.. Nat Commun. 2019 10 04; 10 ...
Crystallographic analysis of the N-terminal domain of Middle East respiratory syndrome coronavirus nucleocapsid protein ... The N-terminal domain of the nucleocapsid protein from Middle East respiratory syndrome coronavirus (MERS-CoV NP-NTD) contains ... Keywords: Middle East respiratory syndrome coronavirus; nucleocapsid protein; N-terminal domain; RNA binding. ... Crystallographic analysis of the N-terminal domain of Middle East respiratory syndrome coronavirus nucleocapsid protein. ...
PR domain-containing protein 9 (PRDM9) is a major regulator of the localization of meiotic recombination hotspots in the human ... related domain that is predicted to be a potential protein interaction domain. Here, we show that truncation of the KRAB domain ... the sequences of the KRAB domains of PRDM9 and SSX proteins are quite divergent from those of canonical KRAB domain proteins, ... Protein sequence alignment of the KRAB domains from human PRDM9 (Q9NQV7), mouse PRDM9 (Q96EQ9), proteins of the human SSX ...
Rhombotin-1, Cysteine-rich protein TTG-1, LIM domain only protein 1, T-cell translocation protein 1, RBTN1, RHOM1, TTG1, LMO-1 ... LIM domains might play a part in protein interactions; hence the protein may regulate transcription by competitively binding to ... LIM domain only 1 (LMO1) is a protein-coding gene. LMO1 encodes a transcriptional regulator which contains two cysteine-rich ... LMO1protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol. ...
Title: Deep mutational scanning of entire human protein interaction domain families Host: Fran Supek, PhD Abstract: ... This interaction domain family, composed of 54 members in humans, has served as a model system for the study of protein ... This dataset of ~2M quantitative protein-protein interaction measurements will enable training a deep neural network that ... To adress the sequence-function relationship`in protein-protein interactions, we conducted a deep mutational scanning of the ...
Avhandling: An albumin-binding domain as a scaffold for bispecific affinity proteins . ... bispecific protein domains with ability to recognize several different target proteins were generated. In paper I, a bispecific ... An albumin-binding domain as a scaffold for bispecific affinity proteins Detta är en avhandling från Stockholm : KTH Royal ... Small bispecific binding proteins based on the albumin-binding domain could potentially contribute to this field. The new ...
B domain; Linker, sequence connecting SH3 and GK domains, C domain; GK, guanylate kinase, D domain; AID, Ca2+ channel α1 ... The β4a A domain is involved in protein-protein interactions. Results thus far suggest that the β4a-A is highly conserved and ... as a binding site in protein-protein interactions with synaptotagmin I and the LC2 domain of microtubule-associated protein 1A ... This indicates that the target proteins were not interacting with the expressed pGBKT7-binding domain. Four proteins were ...
Nacrein, which is composed of a carbonic anhydrase domain and a Gly-X-Asn repeat domain, is one of the organic matrix proteins ... The Carbonic Anhydrase Domain Protein Nacrein is Expressed in the Epithelial Cells of the Mantle and Acts as a Negative ... Hiroshi Miyamoto, Fumiko Miyoshi, and Jun Kohno "The Carbonic Anhydrase Domain Protein Nacrein is Expressed in the Epithelial ... Hiroshi Miyamoto, Fumiko Miyoshi, Jun Kohno "The Carbonic Anhydrase Domain Protein Nacrein is Expressed in the Epithelial Cells ...
In this study, we investigated the retinal CLOCK homolog protein neuronal PAS-domain protein 2 (NPAS2) and found it localized ... Circadian Rhythm of Contrast Sensitivity Is Regulated by a Dopamine-Neuronal PAS-Domain Protein 2-Adenylyl Cyclase 1 Signaling ... Circadian Rhythm of Contrast Sensitivity Is Regulated by a Dopamine-Neuronal PAS-Domain Protein 2-Adenylyl Cyclase 1 Signaling ... Circadian Rhythm of Contrast Sensitivity Is Regulated by a Dopamine-Neuronal PAS-Domain Protein 2-Adenylyl Cyclase 1 Signaling ...
The bHLH domain is thought to be responsible for heterodimerization with other bHLH proteins such as E12 protein or SEF2 ... The aim of my work is to characterize functional domains in TWIST protein, and to determine the interacting partner for TWIST ... Identification and functional characterization of protein domains in the transcription factor TWIST Saethre-Chotzen syndrome is ... I wanted to determine if the TWIST protein or its conserved motifs interact with other regulatory proteins to help to regulate ...
They share the ability to domain swap by exchanging a beta-strand, beta4. Here we use NMR spectroscopy and molecular dynamics ... We propose that the dynamic properties of the beta-sheet and its modification upon ligand binding underlie the domain swapping ... Strikingly the region of greatest conformational variability was the beta4-strand that domain swaps to form the dimer. Binding ... suggesting an early intermediate structurefor unfolding and/or domain swapping. ...
... domain. Based on this domain structure GKs are anticipated to link G-protein and phospholipid signal pathways; however, their ... GK4, a G-protein-coupled receptor with a phosphatidylinositol phosphate kinase domain in Phytophthora infestans, is involved in ... Oomycetes possess a family of novel proteins called GPCR-PIPKs (GKs) that are composed of a seven-transmembrane spanning (7-TM ... PiGK1 and PiGK4 were fused to monomeric red fluorescent protein (mRFP) and ectopically expressed in P.¿infestans. In growing ...
For example, one injected effector protein is a regulatory enzyme called a protein kinase; it has a key domain structure that ... Legionella effector proteins contain functional "domains" (segments) that are not found among other bacteria but rather among ... Other investigators have noticed that some of effector protein eukaryotic domains can be found in the large DNA viruses that ... The presence of eukaryotic domains in these effector proteins indicates that Legionella acquired them from eukaryotic hosts, ...
Cross Domain Bacteria (CDB) Protein : The Fallout Emerges Sep 24, 2023 * Cross Domain Bacteria (CDB) Protein : Exotic Crystal ... The water-soluble protein that has been isolated from the Cross-Domain Bacteria (CDB) is anything but a single or simple ... Cross-Domain Bacteria (CDB) Protein : The Fallout Emerges. Crystal Biology, Synthetic Blood & Clotting, and Polymer Formation ... Items 1 and 2 have largely been addressed, or at least previewed, with the recent paper, Cross Domain Bacteria (CDB) Protein : ...