Marine Drugs | Free Full-Text | Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening...Marine Drugs | Free Full-Text | Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening...

All of these Topo I inhibitors demonstrated activities against Topo I-mediated relaxation of supercoiled DNA at the ... DNA topoisomerase I (Topo I) inhibitors constitute a family of antitumor agents with demonstrated clinical effects on human ... Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening from Natural Products. Lan-Ting ... "Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening from Natural Products." Mar. Drugs ...
more infohttp://www.mdpi.com/1660-3397/15/7/217

Synthesis and biological activity evaluation of 1H-benzimidazoles via mammalian DNA topoisomerase I and cytostaticity assays |...Synthesis and biological activity evaluation of 1H-benzimidazoles via mammalian DNA topoisomerase I and cytostaticity assays |...

Synthesis and biological activity evaluation of 1H-benzimidazoles via mammalian DNA topoisomerase I and cytostaticity assays. ... The characterized compounds were screened to identify if they interfere with mammalian type I DNA topoisomerase activity via in ... Synthesis and biological activity evaluation of 1H-benzimidazoles via mammalian DNA topoisomerase I and cytostaticity assays ... Some benzimidazole derivatives also interfere with the reactions of DNA topoisomerases, the enzymes functioning at almost all ...
more infohttp://clincancerres.aacrjournals.org/content/14/19_Supplement/A16

Alterations in the DNA topoisomerase IV grlA gene responsible...Alterations in the DNA topoisomerase IV grlA gene responsible...

A 4.2-kb DNA fragment conferring quinolone res ... Alterations in the DNA topoisomerase IV grlA gene responsible ... These results suggest that both DNA gyrase and DNA topoisomerase IV may be targets of quinolones and that the quinolone ... Alterations in the DNA topoisomerase IV grlA gene responsible for quinolone resistance in Staphylococcus aureus.. Authors * J ... A 4.2-kb DNA fragment conferring quinolone resistance was cloned from a quinolone-resistant clinical isolate of Staphylococcus ...
more infohttps://www.mysciencework.com/publication/show/alterations-in-the-dna-topoisomerase-iv-grla-gene-responsible-for-quinolone-resistance-in-staphylococcus-aureus

Selective Targeting of Topoisomerase IV and DNA Gyrase in Staphylococcus aureus: Different Patterns of Quinolone- Induced...Selective Targeting of Topoisomerase IV and DNA Gyrase in Staphylococcus aureus: Different Patterns of Quinolone- Induced...

1996) DNA gyrase and topoisomerase IV on the bacterial chromosome: quinolone-induced DNA cleavage. J. Mol. Biol. 258:627-637. ... 1996) DNA strand cleavage is required for replication fork arrest by a frozen topoisomerase-quinolone-DNA ternary complex. J. ... It appears that for S. aureus topoisomerase IV-DNA-drug complexes, as is the case with E. coligyrase-DNA-drug complexes (35), a ... Chromosomal distribution of topoisomerase IV-DNA-quinolone complexes.To measure the size of DNA fragments generated by ...
more infohttps://aac.asm.org/content/44/8/2160?ijkey=b7a6578d5ad770ac4ae2fd1c9ab01b77bb671382&keytype2=tf_ipsecsha

PROSITEPROSITE

TOPOISOMERASE_I_PROK, PS00396; Prokaryotic DNA topoisomerase I active site (PATTERN). * Consensus pattern:. [EQ]-x-L-Y-[DEQSTLM ... When a prokaryotic type I topoisomerase breaks a DNA backbone bond, it simultaneously forms a protein-DNA link where the ... interconversion of topological DNA isomers. Type I topoisomerases act by catalyzing the transient breakage of DNA, one strand ... DNA topoisomerase I (EC 5.99.1.2) [1,2,3,4] is one of the two types of enzyme that catalyze the ...
more infohttp://prosite.expasy.org/PDOC00333

Topoisomerase IIα controls the decatenation checkpoint<...Topoisomerase IIα controls the decatenation checkpoint<...

Although Topo IIα-MDC1 interaction is not required for checkpoint activation induced by DNA damage, it is required for ... title = "Topoisomerase IIα controls the decatenation checkpoint",. abstract = "Topoisomerase II (Topo II) is required to ... Luo, K., Yuan, J., Chen, J., & Lou, Z. (2009). Topoisomerase IIα controls the decatenation checkpoint. Nature Cell Biology, 11( ... Luo, K, Yuan, J, Chen, J & Lou, Z 2009, Topoisomerase IIα controls the decatenation checkpoint, Nature Cell Biology, vol. 11 ...
more infohttps://mayoclinic.pure.elsevier.com/en/publications/topoisomerase-ii%CE%B1-controls-the-decatenation-checkpoint

Eukaryotic topoisomerase II preferentially cleaves alternating purine-pyrimidine repeats<...Eukaryotic topoisomerase II preferentially cleaves alternating purine-pyrimidine repeats<...

Analysis of this DNA on sequencing gels showed that the enzyme cleaved a number of sites, all within the 54 base pair RY repeat ... Analysis of this DNA on sequencing gels showed that the enzyme cleaved a number of sites, all within the 54 base pair RY repeat ... Analysis of this DNA on sequencing gels showed that the enzyme cleaved a number of sites, all within the 54 base pair RY repeat ... Analysis of this DNA on sequencing gels showed that the enzyme cleaved a number of sites, all within the 54 base pair RY repeat ...
more infohttps://yonsei.pure.elsevier.com/en/publications/eukaryotic-topoisomerase-ii-preferentially-cleaves-alternating-pu

Optical-Tweezers Study of Topoisomerase InhibitionOptical-Tweezers Study of Topoisomerase Inhibition

Topoisomerase V relaxes supercoiled DNA by a constrained swiveling mechanism.. Taneja B, Schnurr B, Slesarev A, Marko JF, ... Effect of pH on the overstretching transition of double-stranded DNA: evidence of force-induced DNA melting.. Williams MC, ... Optical-Tweezers Study of Topoisomerase Inhibition. Pla D, Sischka A, Albericio F, Alvarez M, Fernandez-Busquets X, Anselmetti ... Salt dependence of the elasticity and overstretching transition of single DNA molecules.. Wenner JR, Williams MC, Rouzina I, ...
more infohttps://pub.uni-bielefeld.de/publication/1633270

Research Highlight - Programmed activation of cancer cell apoptosis: A tumor-targeted phototherapeutic topoisomerase I inhibitorResearch Highlight - Programmed activation of cancer cell apoptosis: A tumor-targeted phototherapeutic topoisomerase I inhibitor

Topoisomerase I is a vital enzyme that controls DNA topology during replication, transcription, and recombination. An elevated ... PT-1 interferes with DNA re-ligation, diminishes the expression of topoisomerase I, and enhances the expression of inter alia ... Programmed activation of cancer cell apoptosis: A tumor-targeted phototherapeutic topoisomerase I inhibitor. ... This system contains SN-38-a prodrug of the topoisomerase I inhibitor irinotecan. ...
more infohttp://chem.korea.ac.kr/index.php?mid=Research_Highlight&page=2&document_srl=2470

Topoisomerase II Alpha  - Product: Leica BiosystemsTopoisomerase II Alpha - Product: Leica Biosystems

Topoisomerase II alpha is an essential nuclear enzyme involved in DNA replication and is a target for many anti-cancer drugs ... Topoisomerase II alpha expression and activity is linked to the cell cycle and is associated with the proliferation status of ... Decreased expression of topoisomerase II alpha is the predominant mechanism of resistance to several chemotherapeutic agents. A ... Reports of the analysis of primary breast tumors have indicated that topoisomerase II beta is more widely expressed than ...
more infohttps://www.leicabiosystems.com/ihc-ish-fish/immunohistochemistry-ihc-antibodies-novocastra-reagents/primary-antibodies/products/topoisomerase-ii-alpha/

Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I...Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I...

T1 - Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I ... Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I ... Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I ... Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I ...
more infohttps://moh-it.pure.elsevier.com/en/publications/tumor-regression-and-curability-of-preclinical-neuroblastoma-mode

Metal complexes as DNA intercalators  - WRAP: Warwick Research Archive PortalMetal complexes as DNA intercalators - WRAP: Warwick Research Archive Portal

Fit in the Intercalation of a Derivative of the Mixed Topoisomerase I/II Poison N-(2-(Dimethylamino)ethyl)acridine-4- ... 58) Liu, H. K.; Parkinson, J. A.; Bella, J.; Wang, F. Y.; Sadler, P. J. DNA Penetrative DNA Intercalation and G-base ... Conformation of DNA Modified by Monofunctional Ru(II) Arene Complexes: Recognition by DNA Binding Proteins and Repair. ... Effect of Bulky Lesions on DNA - Solution Structure of A DNA Duplex Containing A Cholesterol Adduct. J. Bio. Chem. 2004, 279, ...
more infohttp://wrap.warwick.ac.uk/40311/

DNA TopoisomeraseDNA Topoisomerase

... there is DNA topoisomerase III and DNA topoisomerase IV. DNA Topoisomerase. DNA Topoisomerase: DNA Topoisomerase is an enzyme ... As well as DNA topoisomerase I and DNA topoisomerase II, there is DNA topoisomerase III and DNA topoisomerase IV. DNA ... DNA Topoisomerase cuts the DNA. DNA Topoisomerase type I cuts one strand and DNA topoisomerase type II cuts both strands. DNA ... DNA Topoisomerase aids the transcription and replication of DNA. As well as DNA topoisomerase I and DNA topoisomerase II, ...
more infohttps://www.highveld.com/molecular-biology/dna-topoisomerase.html

Cytometry, Antitumour Drugs and DNA Topoisomerases | SpringerLinkCytometry, Antitumour Drugs and DNA Topoisomerases | SpringerLink

Danks MK, Schmidt CA, Ciitain MC, Suttle DP, Beck WT (1988) Altered catalytic activity of and DNA cleavage by DNA topoisomerase ... Smith PJ, Morgan SA, Fox ME, Watson JV (1990) Mitoxantrone-DNA binding and the induction of topoisomerase II associated DNA ... Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors. Cancer Res 46: 3075- ... Smith PJ (1990) DNA topoisomerase dysfunction: a new goal for antitumor chemotherapy. Bio Essays 12: 167-172Google Scholar ...
more infohttps://link.springer.com/chapter/10.1007/978-3-642-84616-8_23

DNA topoisomerase III (IPR005738) | InterPro | EMBL-EBIDNA topoisomerase III (IPR005738) | InterPro | EMBL-EBI

DNA topoisomerase III (IPR005738). Short name: TopoIII Overlapping homologous superfamilies *DNA topoisomerase, type IA, ... DNA topoisomerase, type IA, central region, subdomain 2 (IPR013825). *DNA topoisomerase, type IA, central region, subdomain 3 ( ... The type IB family of DNA topoisomerases includes eukaryotic nuclear topoisomerase I, topoisomerases of poxviruses, and ... DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical ...
more infohttps://www.ebi.ac.uk/interpro/entry/IPR005738

DNA topoisomerase, type IIA (IPR001241) | InterPro | EMBL-EBIDNA topoisomerase, type IIA (IPR001241) | InterPro | EMBL-EBI

DNA topoisomerase, type IIA (IPR001241) *DNA topoisomerase II, eukaryotic-type (IPR001154). *DNA topoisomerase IV, subunit B, ... DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical ... GO:0006265 DNA topological change Molecular Function. GO:0005524 ATP binding GO:0003677 DNA binding GO:0003918 DNA ... Topoisomerase II (called gyrase in bacteria) primarily introduces negative supercoils into DNA. In bacteria, topoisomerase II ...
more infohttp://www.ebi.ac.uk/interpro/entry/IPR001241

DNA topoisomerase 2-beta - DrugBankDNA topoisomerase 2-beta - DrugBank

DNA topoisomerase 2-beta. Q02880. Details. Drug Relations. Drug Relations. DrugBank ID. Name. Drug group. Pharmacological ... DNA topoisomerase 2-beta. Kind. protein. Organism. Humans. Protein. Name. UniProt ID. ...
more infohttps://www.drugbank.ca/bio_entities/BE0002425

DNA topoisomerase 2-beta - DrugBankDNA topoisomerase 2-beta - DrugBank

DNA topoisomerase 2-beta. Details. Name. DNA topoisomerase 2-beta. Kind. protein. Organism. Human. Polypeptides. Name. UniProt ... DNA topoisomerase 2-beta. Q02880. Details. Drug Relations. Drug Relations. DrugBank ID. Name. Drug group. Pharmacological ...
more infohttps://www.drugbank.ca/biodb/bio_entities/BE0002425

DNA Topoisomerase IV - Semantic ScholarDNA Topoisomerase IV - Semantic Scholar

Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating ... A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands ... enzyme that resolves interlinked daughter chromosomes following DNA replication. ... DNA Topoisomerase IV. Known as: Topoisomerase IV, DNA, Topo IV, DNA Topoisomerase IV [Chemical/Ingredient] (More). ...
more infohttps://www.semanticscholar.org/topic/DNA-Topoisomerase-IV/508540

WikiGenes - TOP2 - DNA topoisomerase 2WikiGenes - TOP2 - DNA topoisomerase 2

Yeast DNA topoisomerase II is encoded by a single-copy, essential gene. Goto, T., Wang, J.C. Cell (1984) [Pubmed] ... Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II. ... Human DNA topoisomerases II alpha and II beta can functionally substitute for yeast TOP2 in chromosome segregation and ... Complementation of a yeast top2ts mutation by a cDNA encoding rat DNA topoisomerase II alpha. Yoon, J.H., Park, S.H., Cho, H.A ...
more infohttps://www.wikigenes.org/e/gene/e/855636.html

DNA topoisomerase-targeting antitumor drugs can be studied in yeast | PNASDNA topoisomerase-targeting antitumor drugs can be studied in yeast | PNAS

... disappear if the TOP1 gene encoding DNA topoisomerase I is disrupted. This shows that DNA topoisomerase I is the sole target of ... DNA topoisomerase-targeting antitumor drugs can be studied in yeast Message Subject (Your Name) has sent you a message from ... DNA topoisomerase-targeting antitumor drugs can be studied in yeast. J Nitiss and J C Wang ... An analog of mAMSA), which is ineffective as an inhibitor of DNA topoisomerase II in mammalian cells, is also ineffective in ...
more infohttps://www.pnas.org/content/85/20/7501?ijkey=347786ad7e184249bebf4e8773bfa45aaf05963e&keytype2=tf_ipsecsha

DNA topoisomerase-targeting antitumor drugs can be studied in yeast | PNASDNA topoisomerase-targeting antitumor drugs can be studied in yeast | PNAS

... disappear if the TOP1 gene encoding DNA topoisomerase I is disrupted. This shows that DNA topoisomerase I is the sole target of ... DNA topoisomerase-targeting antitumor drugs can be studied in yeast Message Subject (Your Name) has sent you a message from ... DNA topoisomerase-targeting antitumor drugs can be studied in yeast. J Nitiss and J C Wang ... An analog of mAMSA), which is ineffective as an inhibitor of DNA topoisomerase II in mammalian cells, is also ineffective in ...
more infohttps://www.pnas.org/content/85/20/7501?ijkey=d58ddbb662648d9b1ff6522bd0693f2d17cb6613&keytype2=tf_ipsecsha

DNA topoisomerase type II (ATP-hydrolyzing) activity | SGDDNA topoisomerase type II (ATP-hydrolyzing) activity | SGD

DNA topoisomerase II, DNA topoisomerase IV activity, DNA topoisomerase type II activity, topoisomerase, topoisomerase II, type ... deoxyribonucleate topoisomerase, deoxyribonucleic topoisomerase activity, DNA topoisomerase (ATP-hydrolysing), ... Gene Ontology Term: DNA topoisomerase type II (ATP-hydrolyzing) activity. GO ID. GO:0003918 Aspect. Molecular Function. ... Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate ...
more infohttps://www.yeastgenome.org/go/GO:0003918

RCSB PDB - Protein Feature View 









 - DNA topoisomerase 1 - P11387 (TOP1 HUMAN)RCSB PDB - Protein Feature View - DNA topoisomerase 1 - P11387 (TOP1 HUMAN)

OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in ... Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently ... The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3- ... ATP-independent breakage of single-stranded DNA, followed by passage and rejoining. UniProt ...
more infohttp://www.rcsb.org/pdb/protein/P11387

DNA topoisomerase - WikipediaDNA topoisomerase - Wikipedia

Only mammalian DNA topoisomerase II can break up two intertwined DNA strands. The unique ability of DNA unlinking is necessary ... Through this reaction DNA topoisomerase is able to break and rejoin the phosphate backbone of DNA. Topoisomerase probably ... DNA topoisomerase (EC 5.99.1.2, type I DNA topoisomerase, untwisting enzyme, relaxing enzyme, nicking-closing enzyme, swivelase ... doi:10.1146/annurev.biochem.58.1.351 Topoisomerase DNA topoisomerase at the US National Library of Medicine Medical Subject ...
more infohttps://en.wikipedia.org/wiki/DNA_topoisomerase