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*  Biotin deficiency - Wikipedia
DNA mutational analysis revealed that the child was homozygous for a novel E64K mutation and that his mother and father were ... "Real time PCR assays to detect common mutations in the biotinidase gene and application of mutational analysis to newborn ...
https://en.wikipedia.org/wiki/Biotin_deficiency
*  Aryl hydrocarbon receptor - Wikipedia
Shen ES, Whitlock JP (1992). "Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding ... Lusska A, Shen E, Whitlock JP (1993). "Protein-DNA interactions at a dioxin-responsive enhancer. Analysis of six bona fide DNA- ... Dolwick KM, Swanson HI, Bradfield CA (1993). "In vitro analysis of Ah receptor domains involved in ligand-activated DNA ... The first is the basic-region (b), which is involved in the binding of the transcription factor to DNA. The second is the helix ...
https://en.wikipedia.org/wiki/Aryl_hydrocarbon_receptor
*  MEF2C - Wikipedia
Molkentin JD, Black BL, Martin JF, Olson EN (Jun 1996). "Mutational analysis of the DNA binding, dimerization, and ... Molkentin JD, Li L, Olson EN (Jul 1996). "Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding ...
https://en.wikipedia.org/wiki/MEF2C
*  Oncogenomics - Wikipedia
Nucleotide sequence context influences mutation probability and analysis of mutational (mutable) DNA motifs can be essential ... If DNA repair is deficient, DNA damage tends to accumulate. Such excess DNA damage can increase mutational errors during DNA ... Mutational analysis of entire gene families revealed that genes of the same family have similar functions, as predicted by ... 2008). "Quantitative analysis of mitochondrial DNA 4977-bp deletion in sporadic breast cancer and benign breast diseases". ...
https://en.wikipedia.org/wiki/Oncogenomics
*  James Champoux - Wikipedia
49-57 Mutational analysis of the preferential binding of human topoisomerase I to supercoiled DNA. Yang Z, Carey JF, Champoux ... Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1. Interthal H, Champoux JJ The ... DNA Topoisomerases: Structure, Function, and Mechanism, Vol. 70:369-413 (Volume publication date July 2001). Annual review of ... 2009 Nov; 284 47: 32225-38 Assays for the preferential binding of human topoisomerase I to supercoiled DNA. Yang Z, Champoux JJ ...
https://en.wikipedia.org/wiki/James_Champoux
*  Nick (DNA) - Wikipedia
Sriskanda V, Shuman S (January 1998). "Chlorella virus DNA ligase: nick recognition and mutational analysis". Nucleic Acids Res ... With human DNA ligase, this forms a crystallized complex. The complex, which has a DNA-adenlyate intermediate, allows DNA ... At the end of the segment that DNA polymerase acts on, DNA ligase must repair the final segment of DNA backbone in order to ... By creating nicks, the DNA forms a circular shape. Nicked DNA can be the result of DNA damage or purposeful and carefully ...
https://en.wikipedia.org/wiki/Nick_(DNA)
*  Sleeping Beauty transposon system - Wikipedia
"Mutational analysis of the N-terminal DNA-binding domain of sleeping beauty transposase: critical residues for DNA binding and ... DNA transposons translocate from one DNA site to another in a simple, cut-and-paste manner (Fig. 1). Transposition is a precise ... DNA transposons precisely insert defined DNA sequences (Fig. 1) almost randomly into host genomes thereby increasing the ... The insertion site can be elsewhere in the same DNA molecule, or in another DNA molecule (or chromosome). In mammalian genomes ...
https://en.wikipedia.org/wiki/Sleeping_Beauty_transposon_system
*  DNA glycosylase - Wikipedia
"Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase". Nucleic Acids Res. 32 ( ... Uracil-DNA glycosylases are DNA repair enzymes that excise uracil residues from DNA by cleaving the N-glycosydic bond, ... Lindahl, T. (1986). "DNA Glycosylases in DNA Repair". Mechanisms of DNA Damage and Repair: 335-340. doi:10.1007/978-1-4615-9462 ... This was the most frequent DNA repair abnormality found among the 8 DNA repair genes tested. NEIL1 was also one of six DNA ...
https://en.wikipedia.org/wiki/DNA_glycosylase
*  11β-Hydroxysteroid dehydrogenase type 1 - Wikipedia
Sriskanda V, Schwer B, Ho CK, Shuman S (October 1999). "Mutational analysis of Escherichia coli DNA ligase identifies amino ...
https://en.wikipedia.org/wiki/11%CE%B2-Hydroxysteroid_dehydrogenase_type_1
*  DNA-PKcs - Wikipedia
"Mutational analysis of thirty-two double-strand DNA break repair genes in breast and pancreatic cancers". Cancer Res. 68 (4): ... On its own, DNA-PKcs is inactive and relies on Ku to direct it to DNA ends and trigger its kinase activity. DNA-PKcs is ... MicroRNA-101 targets DNA-PKcs via binding to the 3'- UTR of DNA-PKcs mRNA and efficiently reduces protein levels of DNA-PKcs. ... DNA-PK also cooperates with ATR and ATM to phosphorylate proteins involved in the DNA damage checkpoint. DNA damage appears to ...
https://en.wikipedia.org/wiki/DNA-PKcs
*  Φ29 DNA polymerase - Wikipedia
de Vega M, Lázaro JM, Salas M, Blanco L (1998). "Mutational analysis of phi29 DNA polymerase residues acting as ssDNA ligands ... "Whole genome amplification with Phi29 DNA polymerase to enable genetic or genomic analysis of samples of low DNA yield". ... motif of phi29 DNA polymerase as a metal ligand during both TP-primed and DNA-primed DNA synthesis". J Mol Biol. 283 (3): 633- ... "Highly efficient DNA synthesis by the phage Φ29 DNA polymerase. Symmetrical mode of DNA replication". J. Biol. Chem. 264 (15): ...
https://en.wikipedia.org/wiki/%CE%A629_DNA_polymerase
*  Uracil-DNA glycosylase - Wikipedia
"Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis". ... "Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis". ... Haug T, Skorpen F, Lund H, Krokan HE (Oct 1994). "Structure of the gene for human uracil-DNA glycosylase and analysis of the ... DNA sequences from bacteria in permafrost were amplified using PCR. One series of runs amplified the DNA sequences as-is (to ...
https://en.wikipedia.org/wiki/Uracil-DNA_glycosylase
*  FLP-FRT recombination - Wikipedia
A mutational analysis of the FLP binding site". Journal of Molecular Biology. 201 (2): 405-421. doi:10.1016/0022-2836(88)90147- ... Golic, M M; Rong, Y S; Petersen, R B; Lindquist, S L; Golic, K G (1997-09-15). "FLP-mediated DNA mobilization to specific ... The nucleophilic properties of the tyrosine attack and bind to the 3'-phosphate at the point of DNA cleavage. The resulting 5'- ... hydroxyl group of the cleaved DNA acts as the nucleophile and attacks the 3'-phosphate on the complementarily cleaved DNA ...
https://en.wikipedia.org/wiki/FLP-FRT_recombination
*  XPA - Wikipedia
Miyamoto I, Miura N, Niwa H, Miyazaki J, Tanaka K (Jun 1992). "Mutational analysis of the structure and function of the ... "Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain". ... "Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein". Biochemical and ... "Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein". Biochemical and ...
https://en.wikipedia.org/wiki/XPA
*  List of MeSH codes (E05) - Wikipedia
... sequence analysis, dna MeSH E05.393.760.700.300 --- dna mutational analysis MeSH E05.393.760.705 --- sequence analysis, protein ... actuarial analysis MeSH E05.318.740.150 --- analysis of variance MeSH E05.318.740.150.500 --- multivariate analysis MeSH ... discriminant analysis MeSH E05.318.740.400 --- factor analysis, statistical MeSH E05.318.740.475 --- matched-pair analysis MeSH ... protein array analysis MeSH E05.393.525.700 --- random amplified polymorphic dna technique MeSH E05.393.525.870 --- two-hybrid ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(E05)
*  LIG1 - Wikipedia
"Chlorella virus DNA ligase: nick recognition and mutational analysis". Nucleic Acids Res. 26 (2): 525-31. doi:10.1093/nar/26.2. ... DNA ligase 1 is an enzyme that in humans is encoded by the LIG1 gene. DNA ligases are important tools for DNA replication and ... LIG1 encodes DNA ligase I, which functions in DNA replication and the base excision repair process. Eukaryotic DNA ligase 1 ... Of the known eukaryotic DNA ligases, DNA ligase I is the only ligase involved in DNA replication making it the most studied of ...
https://en.wikipedia.org/wiki/LIG1
*  DNAJC5 - Wikipedia
1999). "Mutational analysis of cysteine-string protein function in insulin exocytosis". J. Cell Sci. 112 (9): 1345-51. PMID ... 2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865-71. doi:10.1038/414865a. ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... 2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357-66. doi:10.1093/dnares/7.6.357. PMID ...
https://en.wikipedia.org/wiki/DNAJC5
*  DNA damage theory of aging - Wikipedia
Although both mitochondrial and nuclear DNA damage can contribute to aging, nuclear DNA is the main subject of this analysis. ... compiled a lengthy list of mouse mutational models with pathologic features of premature aging, all caused by different DNA ... DNA polymerase gamma is the enzyme that replicates mitochondrial DNA. A mouse mutant with a defect in this DNA polymerase is ... If a DNA repair protein is deficient, unrepaired DNA damages tend to accumulate. Such accumulated DNA damages appear to cause ...
https://en.wikipedia.org/wiki/DNA_damage_theory_of_aging
*  KIF1B - Wikipedia
2001). "Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at ... The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31-9. doi ... 2004). "Genomic structure and mutational analysis of the human KIF1Balpha gene located at 1p36.2 in neuroblastoma". Int. J. ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143-50. doi: ...
https://en.wikipedia.org/wiki/KIF1B
*  GRE Biochemistry, Cell and Molecular Biology Test - Wikipedia
... transduction and conjugation Recombination and complementation Mutational analysis Genetic mapping and linkage analysis B. ... Genome Maintenance DNA replication DNA damage and repair DNA modification DNA recombination and gene conversion E. Gene ... maps and PCR Nucleic acid blotting and hybridization DNA cloning in prokaryotes and eukaryotes Sequencing and analysis Protein- ... Genomics Genome structure Physical mapping Repeated DNA and gene families Gene identification Transposable elements ...
https://en.wikipedia.org/wiki/GRE_Biochemistry,_Cell_and_Molecular_Biology_Test
*  MYLK2 - Wikipedia
Soung YH, Lee JW, Kim SY (2006). "Mutational analysis of the kinase domain of MYLK2 gene in common human cancers". Pathol. Res ... Deloukas P, Matthews LH, Ashurst J (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 ( ... Strausberg RL, Feingold EA, Grouse LH (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse ... Jeronimo C, Forget D, Bouchard A (2007). "Systematic analysis of the protein interaction network for the human transcription ...
https://en.wikipedia.org/wiki/MYLK2
*  Hepatitis delta virus ribozyme - Wikipedia
... mutational analysis introduces single/double mutations outside the ribozyme to ensure the observed ribozyme activity is ... Second, a series of DNA oligomer complementary to different regions of AS1/2 were used to rescue the ribozyme activity; the ... Sklená\r̆, Vladmír; Felgon, Juli (28 June 1990). "Formation of a stable triplex from a single DNA strand". Nature. 345 (6278): ... Rajagopal, Ponni; Feigon, Juli (22 June 1989). "Triple-strand formation in the homopurine:homopyrimidine DNA oligonucleotides d ...
https://en.wikipedia.org/wiki/Hepatitis_delta_virus_ribozyme
*  Models of DNA evolution - Wikipedia
Tavaré S (1986). "Some Probabilistic and Statistical Problems in the Analysis of DNA Sequences" (PDF). Lectures on Mathematics ... For example, mutational biases and purifying selection favoring conservative changes are probably both responsible for the ... In DNA evolution, under the assumption of a common process for each site, the stationary frequencies, π A , π G , π C , π T {\ ... Consider a DNA sequence of fixed length m evolving in time by base replacement. Assume that the processes followed by the m ...
https://en.wikipedia.org/wiki/Models_of_DNA_evolution
*  HGSNAT - Wikipedia
2006). "DNA sequence and analysis of human chromosome 8". Nature. 439 (7074): 331-5. doi:10.1038/nature04406. PMID 16421571. ... 2007). "Mutational analysis of the HGSNAT gene in Italian patients with mucopolysaccharidosis IIIC (Sanfilippo C syndrome). ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743. Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). " ...
https://en.wikipedia.org/wiki/HGSNAT
*  Cancer genome sequencing - Wikipedia
... and Genome Data Analysis Centers. Each cancer type will undergo comprehensive genomic characterization and analysis. The data ... COSMIC also includes mutational data published in scientific literature. The TCGA is multi-institutional effort to understand ... It is a biochemical laboratory method for the characterization and identification of the DNA or RNA sequences of cancer cell(s ... This analysis can be used to make pharmacological treatment recommendations. As of February 2012, this has only been done for ...
https://en.wikipedia.org/wiki/Cancer_genome_sequencing