Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in...Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in...

Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in ... Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in ... Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in ... Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in ...
more infohttp://www.genetics.org/content/209/1/115

ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma.  - PubMed - NCBIATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma. - PubMed - NCBI

ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma.. Koschmann C1, Calinescu AA2, Nunez ... ATRX Loss Promotes Tumor Growth and Impairs Non-Homologous End Joining DNA Repair in Glioma ... ATRX Loss Promotes Tumor Growth and Impairs Non-Homologous End Joining DNA Repair in Glioma ... ATRX Loss Promotes Tumor Growth and Impairs Non-Homologous End Joining DNA Repair in Glioma ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/26936505

PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining.  - PubMed - NCBIPARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining. - PubMed - NCBI

PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining.. Luijsterburg MS ... PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining ... PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining ... PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/26895424?dopt=Abstract

Synthesis-Dependent Microhomology-Mediated End Joining: A Unifying Model For Multiple DNA Double Strand Break Repair Outcomes. ...Synthesis-Dependent Microhomology-Mediated End Joining: A Unifying Model For Multiple DNA Double Strand Break Repair Outcomes. ...

Abstract: DNA double-strand breaks (DSBs) are repaired by homology-directed repair or non-homologous end joining. End-joining ... repair can be classified as classical non-homologous end joining, which requires DNA ligase 4, or "alternative" end joining ( ... Synthesis-Dependent Microhomology-Mediated End Joining: A Unifying Model For Multiple DNA Double Strand Break Repair Outcomes. ... A meta-analysis of end-joining repair junctions produced in the course of previous studies in Drosophila showed that ...
more infohttps://dl.tufts.edu/catalog/tufts:21061

XRCC4 | Cancer Genetics WebXRCC4 | Cancer Genetics Web

Blood-based DNA methylation of DNA repair genes in the non-homologous end-joining (NEHJ) pathway in patient with glioma.. Int J ... DNA binding - DNA ligase IV complex - DNA ligation involved in DNA repair - DNA repair - DNA-dependent protein kinase-DNA ... Here, we show that TMPRSS2-ERG blocks nonhomologous end-joining (NHEJ) DNA repair by inhibiting DNA-PKcs. VCaP cells, which ... The X-ray complementing group 4 (XRCC4, OMIM: 194363) plays a key role in non-homologous end-joining DNA repair pathway in ...
more infohttp://www.cancerindex.org/geneweb/XRCC4.htm

LIG4 | Cancer Genetics WebLIG4 | Cancer Genetics Web

Blood-based DNA methylation of DNA repair genes in the non-homologous end-joining (NEHJ) pathway in patient with glioma.. Int J ... DNA ligation - DNA ligation involved in DNA recombination - DNA ligation involved in DNA repair - DNA repair - DNA-dependent ... nonhomologous end joining complex - nucleolus - nucleoplasm - nucleotide-excision repair, DNA gap filling - nucleus - plasma ... BACKGROUND: Nonhomologous end joining (NHEJ) is a pathway that repairs DNA double-strand breaks (DSBs) to maintain genomic ...
more infohttp://www.cancerindex.org/geneweb/LIG4.htm

Absence of TERT in ctc1 mutant plants leads to telomere | Open-iAbsence of TERT in ctc1 mutant plants leads to telomere | Open-i

DNA End-Joining Repair*. *Recombination, Genetic*. *Telomerase/genetics/physiology*. *Telomere Homeostasis*. *Telomere-Binding ... revealing a competition between telomerase and end-joining recombination proteins for access to deprotected telomeres. ... revealing a competition between telomerase and end-joining recombination proteins for access to deprotected telomeres. ... D) TRF analysis of bulk telomere length in DNA from flower buds of CTC1 TERT, CTC1 tert, ctc1 TERT and ctc1 tert mutants using ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC4231758_gku897fig6&req=4

DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining |...DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining |...

Non-homologous end joining often uses microhomology: implications for alternative end joining. DNA Repair (Amst) 17: 74-80. doi ... DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining Download PDF ... 2013) Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double ... DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining ...
more infohttps://www.prolekarniky.cz/casopisy/plos-genetics/2015-1/dna-damage-response-factors-from-diverse-pathways-including-dna-crosslink-repair-mediate-alternative-end-joining-55643

Isolation of a Schizosaccharomyces pombe rad21ts Mutant That Is Aberrant in Chromosome Segregation, Microtubule Function, DNA...Isolation of a Schizosaccharomyces pombe rad21ts Mutant That Is Aberrant in Chromosome Segregation, Microtubule Function, DNA...

1996 Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol. Cell. Biol. 16: ... is also important for DNA repair (Hartwell and Weinert 1989). These DNA repair and checkpoint control systems have been ... A DNA double-strand break repair system is important for cell proliferation because DNA is often damaged during mitosis by γ ... DNA repair, and DNA replication. Rad21 may be involved in these biological events as well as proper segregation of chromosomes ...
more infohttps://www.genetics.org/content/148/1/49?ijkey=6bbc5661e8a6332a6e7a731624529399bd5725c0&keytype2=tf_ipsecsha

Silencing of end-joining repair for efficient site-specific gene insertion after TALEN/CRISPR mutagenesis in Aedes aegypti |...Silencing of end-joining repair for efficient site-specific gene insertion after TALEN/CRISPR mutagenesis in Aedes aegypti |...

2010) The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 79:181-211 ... Silencing of end-joining repair for efficient site-specific gene insertion after TALEN/CRISPR mutagenesis in Aedes aegypti. ... Silencing of end-joining repair for efficient site-specific gene insertion after TALEN/CRISPR mutagenesis in Aedes aegypti ... depleting these components had opposing effects on end-joining-based repair, even though SSA, a form of HDR, increased in both ...
more infohttps://www.pnas.org/content/112/13/4038.full

Silencing of end-joining repair for efficient site-specific gene insertion after TALEN/CRISPR mutagenesis in Aedes aegypti |...Silencing of end-joining repair for efficient site-specific gene insertion after TALEN/CRISPR mutagenesis in Aedes aegypti |...

2010) The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 79:181-211 ... Silencing of end-joining repair for efficient site-specific gene insertion after TALEN/CRISPR mutagenesis in Aedes aegypti. ... Silencing of end-joining repair for efficient site-specific gene insertion after TALEN/CRISPR mutagenesis in Aedes aegypti ... depleting these components had opposing effects on end-joining-based repair, even though SSA, a form of HDR, increased in both ...
more infohttps://www.pnas.org/content/112/13/4038?ijkey=5faa4c4ea2fab969f369aee980f4c99a826d5f0e&keytype2=tf_ipsecsha

CtIP tetramer assembly is required for DNA-end resection and repair | Nature Structural & Molecular BiologyCtIP tetramer assembly is required for DNA-end resection and repair | Nature Structural & Molecular Biology

... repair. Although it is well established that CtIP promotes DNA-end resection in preparation for homology-dependent DSB repair, ... N terminus of human CtIP forms a tetrameric structure that is required for resection of broken DNA ends to permit their repair ... Notably, we establish that this mutation abrogates CtIP oligomer assembly in cells, thus leading to strong defects in DNA-end ... These findings indicate that the CtIP tetramer architecture described here is essential for effective DSB repair by homologous ...
more infohttps://www.nature.com/articles/nsmb.2937?error=cookies_not_supported&code=fb92404f-64e4-490d-a7b8-3e00abe21a17

Targeted Inactivation of Mouse RAD52Reduces Homologous Recombination but Not Resistance to Ionizing Radiation | Molecular and...Targeted Inactivation of Mouse RAD52Reduces Homologous Recombination but Not Resistance to Ionizing Radiation | Molecular and...

1996) Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol. Cell. Biol. 16: ... 1996) Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in ... types of breaks that occur during these processes are normally repaired via the end-to-end rejoining pathway involving the DNA- ... Two main pathways are known to be involved in the repair of DSBs in eukaryotes: end-to-end rejoining, a homology-independent ...
more infohttps://mcb.asm.org/content/18/11/6423?ijkey=5d30c8274b7e83144545a3436d02a63412687221&keytype2=tf_ipsecsha

Ways of improving precise knock-in by genome-editing technologies | SpringerLinkWays of improving precise knock-in by genome-editing technologies | SpringerLink

Lieber MR (2010) The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem ... Microhomology-mediated end joining and homologous recombination share the initial end resection step to repair DNA double- ... Chan SH, Yu AM, McVey M (2010) Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in ... Chen L, Trujillo K, Sung P, Tomkinson AE (2000) Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA- ...
more infohttps://link.springer.com/article/10.1007%2Fs00439-018-1953-5

Andrea E Wahner Hendrickson, MD - Research Output
     - Mayo ClinicAndrea E Wahner Hendrickson, MD - Research Output - Mayo Clinic

DNA End-Joining Repair Neoplasms Gene Deletion 1 Citation (Scopus) Can Poly (ADP-Ribose) Polymerase Inhibitors Palliate ...
more infohttps://mayoclinic.pure.elsevier.com/en/persons/andrea-e-wahner-hendrickson/publications/

Health Sciences Research - Research Output
     - Mayo ClinicHealth Sciences Research - Research Output - Mayo Clinic

DNA End-Joining Repair Neoplasms Gene Deletion 1 Citation (Scopus) 5-year overall survival in patients with lung cancer ... A 25 year experience of perineal hernia repair. McKenna, N. P., Habermann, E. B., Larson, D., Kelley, S. R. & Mathis, K. L., ... Adherence of cell-free DNA noninvasive prenatal screens to ACMG recommendations. Skotko, B. G., Allyse, M., Bajaj, K., Best, R ...
more infohttps://mayoclinic.pure.elsevier.com/en/organisations/health-sciences-research-3/publications/

Nonhomologous | definition of nonhomologous by Medical dictionaryNonhomologous | definition of nonhomologous by Medical dictionary

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.. New Resveratrol and NAD+ ... After DNA damage, cells can be repaired through two mechanisms: nonhomologous end joining (NHEJ) and homologous recombination ( ... Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway," PLOS Biology, 2017; ... The dsDNA breaks can be repaired via homology-directed repair (HDR) or nonhomologous end-joining (NHEJ).. CRISPR-Cas9 System: ...
more infohttps://medical-dictionary.thefreedictionary.com/nonhomologous

ASMscience | Genome Editing of Food-GASMscience | Genome Editing of Food-G

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 79 : 181-211.[ ... Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat Methods 6 : 343-345.[CrossRef] [PubMed] ... DNA fusion product of phage P2 with plasmid pBR322: a new phasmid. Mol Gen Genet 189 : 343-347.[CrossRef] ... The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature 468 : 67-71.[CrossRef] [PubMed] ...
more infohttp://www.asmscience.org/content/book/10.1128/9781555819705.chap17

Practical Recommendations for Improving Efficiency and Accuracy of the CRISPR/Cas9 Genome Editing System | SpringerLinkPractical Recommendations for Improving Efficiency and Accuracy of the CRISPR/Cas9 Genome Editing System | SpringerLink

... and efficient tool for modifying genomic DNA. Despite obvious advantages, it is not devoid of certain drawbacks, such as ... Lieber, M. R. (2010) The mechanism of double-strand DNA break repair by the nonhomologous DNA end-join-ing pathway, Annu. Rev. ... Comparison of nonhomologous end joining and homologous recombination in human cells, DNA Repair (Amst)., 7, 1765-1771.CrossRef ... Verma, P., and Greenberg, R. A. (2016) Noncanonical views of homology-directed DNA repair, Genes Devel., 30, 1138-1154.CrossRef ...
more infohttps://link.springer.com/article/10.1134/S0006297918060020

Cells  | Free Full-Text | Bring It to an End: Does Telomeres Size Matter? | HTMLCells | Free Full-Text | Bring It to an End: Does Telomeres Size Matter? | HTML

... their main purpose is to mask DNA ends from the DNA-repair machinery by formation of protective loops. Through life and cell ... the very tip of our DNA has been shown to impact transcription by position effect. TPE and a long-reach counterpart, TPE-OLD, ... Free DNA extremities are exposed to exonuclease and at risk for non-homologous ends joining between DNA molecules [20]. These ... Found at the edge of each chromosome, their main purpose is to mask DNA ends from the DNA-repair machinery by formation of ...
more infohttps://www.mdpi.com/2073-4409/8/1/30/htm

Differential responses of MET activations to MET kinase inhibitor and neutralizing antibody | Journal of Translational Medicine...Differential responses of MET activations to MET kinase inhibitor and neutralizing antibody | Journal of Translational Medicine...

In METamp cells, INC280 induced a DNA damage response with activation of repair through the p53BP1/ATM signaling pathway. ... The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem. 2010;79:181-211 ... By contrast, nonhomologous end-joining (NHEJ) provides flexibility in repair by re-joining the broken ends together without ... and promotes DNA repair through the NHEJ mechanism. NHEJ offers efficient rejoining of DSB ends but is an error-prone repair ...
more infohttps://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1628-y

Jawaharlal Nehru Centre for Advanced Scientific ResearchJawaharlal Nehru Centre for Advanced Scientific Research

Human Transcriptional coactivator PC4 stimulates DNA end joining and activates DSB repair activity. JMB, J Mol Biol 385, 788 - ... Kolthur-Seetharam U, Pradeepa MM, Gupta N, Narayanaswamy R and Rao MR., Spatiotemporal organization of AT- and GC-rich DNA and ... R. Lakshmi, V. Baskar and U. Ranga, Extraction of Superior Quality Plasmid DNA by a Combination of Modified Alkaline Lysis and ... Sunil K. Noothi, Mamata Kombrabail, Kundu T.K., G. Krishnamoorthy and Basuthkar J. Rao, Enhanced DNA dynamics due to cationic ...
more infohttp://www.jncasr.ac.in/cpmupub.php?dept_id=MBGU&yeartype=All&empid=&pubtype=year

Mutant IDH1 cooperates with ATRX loss to drive the alternative lengthening of telomere phenotype in glioma<...Mutant IDH1 cooperates with ATRX loss to drive the alternative lengthening of telomere phenotype in glioma<...

The telomere capping complex component RAP1 and the nonhomologous DNA end joining repair factor XRCC1 were each downregulated ... The telomere capping complex component RAP1 and the nonhomologous DNA end joining repair factor XRCC1 were each downregulated ... The telomere capping complex component RAP1 and the nonhomologous DNA end joining repair factor XRCC1 were each downregulated ... The telomere capping complex component RAP1 and the nonhomologous DNA end joining repair factor XRCC1 were each downregulated ...
more infohttps://pure.fujita-hu.ac.jp/en/publications/mutant-idh1-cooperates-with-atrx-loss-to-drive-the-alternative-le

Find Research Outputs
             - Scholars @ UT Health San AntonioFind Research Outputs - Scholars @ UT Health San Antonio

Microhomology selection for Microhomology mediated end joining in Saccharomyces Cerevisiae. Lee, K., Ji, J. H., Yoon, K., Che, ... mTOR Signaling Upregulates CDC6 via Suppressing miR-3178 and Promotes the Loading of DNA Replication Helicase. Wu, X., Li, S., ... Mitophagy activation repairs Lebers hereditary optic neuropathy-associated mitochondrial dysfunction and improves cell ...
more infohttps://scholars.uthscsa.edu/en/publications/?format=&page=9

53BP1 is degraded except when bound to a damage site.A. | Open-i53BP1 is degraded except when bound to a damage site.A. | Open-i

DNA Breaks, Double-Stranded. *DNA End-Joining Repair. *HeLa Cells. *Humans. *Protein Stability ... 53BP1 regulates DNA double-strand break (DSB) repair. In functional assays for specific DSB repair pathways, we found that ... 53BP1 regulates DNA double-strand break (DSB) repair. In functional assays for specific DSB repair pathways, we found that ... Regulation of 53BP1 protein stability by RNF8 and RNF168 is important for efficient DNA double-strand break repair. ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC4206297_pone.0110522.g006&req=4