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*  Multicellular signalling model for DNA double-strand break repair kinetics after low-dose radiation on Environmental XPRT
This paper introduces the Multicellular Signalling (MULTISIG1) model in which DNA double-strand break (DSB) repair initiation ... Article Multicellular signalling model for DNA double-strand break repair kinetics after low-dose radiation. ... Multicellular signalling model for DNA double-strand break .... Multicellular signalling model for DNA double-strand break ... is estimated to be about 0.4 break repairs/h on different DNA molecules.. Keywords: DNA molecules, double-strand breaks, low ...
https://www.environmental-expert.com/articles/multicellular-signalling-model-for-dna-double-strand-break-repair-kinetics-after-low-dose-radiation-211924
*  Download A Histone H3K36 Chromatin Switch Coordinates Dna Double Strand Break Repair Pathway Choice 2014
However so as it is, in iterative download A histone H3K36 chromatin switch coordinates DNA double strand break repair pathway ... in download A histone H3K36 chromatin switch coordinates DNA double strand break repair pathway may bring one of the happiest ... KIRRALIE SMITH: A download A histone H3K36 chromatin switch coordinates DNA double strand break repair pathway choice of the ... Some problems in our download A histone H3K36 chromatin switch coordinates DNA double strand break repair pathway do a ...
http://bobcatsworld.com/library/download-A-histone-H3K36-chromatin-switch-coordinates-DNA-double-strand-break-repair-pathway-choice-2014.php
*  BCR-ABL stimulates mutagenic homologous DNA double-strand break repair via the DNA-end-processing factor CtIP : Carcinogenesis ...
Through comparative analysis of different DNA double-strand break (DSB) repair mechanisms as a function of the BCR-ABL status ... Through comparative analysis of different DNA double-strand break (DSB) repair mechanisms as a function of the BCR-ABL status ... in human megakaryocytic and CML cell lines, we found that BCR-ABL upregulates error-prone DSB repair pathways [single-strand ...
http://oxfordindex.oup.com/view/10.1093/carcin/bgq216
*  Characterization of cellular DNA repair capacity by molecular and cytogenetic approaches: suitability as intermediate phenotype...
DNA breaks, double-stranded [MeSH]. DNA repair [MeSH]. Neoplasms [MeSH]. Sister chromatid exchange [MeSH] ... The purpose of this study was to elucidate if the cellular DNA repair capacity, genotypes of DNA repair genes and the ... The measured DNA repair end points are largely independent and can be used to characterize different aspects of the cellular ... DNA repair assays were performed in parallel on peripheral blood samples of the probands: the baseline and the radiation ...
https://oparu.uni-ulm.de/xmlui/handle/123456789/2284
*  The E3 Ubiquitin Ligase EDD Regulates S-Phase and G(2)/M DNA Damage Checkpoints
M arrest after double strand DNA breaks. Defective checkpoint activation in EDD-depleted cells led to radio-resistant DNA ... M arrest after double strand DNA breaks. Defective checkpoint activation in EDD-depleted cells led to radio-resistant DNA ... Here, we demonstrate that EDD is necessary for G(1)/S and intra S phase DNA damage checkpoint activation and for the ... Here, we demonstrate that EDD is necessary for G(1)/S and intra S phase DNA damage checkpoint activation and for the ...
https://www.garvan.org.au/research/publications/2251
*  DNA Double-strand Breaks After SPECT
Radiation-induced DNA double-strand breaks after myocardial scintigraphy.. Outcome Description:. DNA double-strand breaks will ... DNA Double-strand Breaks Following Myocardial Scintigraphy. Trial Phase:. N/A. Minimum Age:. 19 Years. Maximum Age:. N/A ... DNA Double-strand Breaks Following Myocardial Scintigraphy. Inclusion Criteria:. - myocardial SPECT clinically indicated. ...
http://www.knowcancer.com/cancer-trials/NCT01380821/
*  Targeting DNA Double-Strand Breaks with TAL Effector Nucleases | Genetics
When a double-strand DNA break occurs at the target site, it is repaired through single-strand annealing between the duplicated ... Targeting DNA Double-Strand Breaks with TAL Effector Nucleases Message Subject (Your Name) has forwarded a page to you from ... Targeting DNA Double-Strand Breaks with TAL Effector Nucleases. Michelle Christian, Tomas Cermak, Erin L. Doyle, Clarice ... Targeting DNA Double-Strand Breaks with TAL Effector Nucleases. Michelle Christian, Tomas Cermak, Erin L. Doyle, Clarice ...
http://www.genetics.org/content/186/2/757
*  DNA double-strand break repair Rad50 ATPase, putative (B0EMR2) | InterPro | EMBL-EBI
DNA double-strand break repair Rad50 ATPase, putative (B0EMR2) Accession. B0EMR2 (B0EMR2_ENTDS) ...
http://www.ebi.ac.uk/interpro/protein/B0EMR2
*  Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration | PNAS
... linear double-stranded DNA; ss, single-stranded DNA. The ratios of relaxed circular and linear double-strand DNA (rc/lin) were ... b) A double-strand break formed by I-SceI endonuclease activity. (c) Product formed by NHEJ of a double-strand break. Precise ... Double-strand breaks can be repaired by homology- and nonhomology-dependent mechanisms, although repair of double-strand breaks ... often through conversion of single-strand lesions into double-strand breaks during DNA replication in growing cells. Double- ...
https://www.pnas.org/content/101/30/11135?ijkey=597c945ab8bd4d9e832d4bb60d8546610a5c4529&keytype2=tf_ipsecsha
*  Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis | PNAS
Here we show that in Arabidopsis, endoreduplication is induced by DNA double-strand breaks (DSBs), but not directly by DNA ... Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis. Sumiko Adachi, Kazunori Minamisawa, Yoko ... Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis. Sumiko Adachi, Kazunori Minamisawa, Yoko ... Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis Message Subject (Your Name) has sent you a ...
http://www.pnas.org/content/108/24/10004?ijkey=f49e92cea4ff68c009727d50ebcb1be6c7d33b15&keytype2=tf_ipsecsha
*  Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing | Nature Methods
Biotinylated tags bind double-strand breaks in genomic DNA; after enrichment and sequencing, this allows precise, genome-wide ... Mapping of meiotic single-stranded DNA reveals double-stranded-break hotspots near centromeres and telomeres. . Curr. Biol. 17 ... Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing. *Nicola Crosetto1, 2. n11, n12*, Abhishek ... High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome. . EMBO J. 29, 1446-1457 (2010). ...
https://www.nature.com/articles/nmeth.2408?error=cookies_not_supported&code=7cb81b1e-2c06-417e-9dd3-08256b692688
*  Intrinsic radiosensitivity and DNA double-strand breaks in human cells
Among the large spectrum of DNA damage induced by radiation, DNA double-strand breaks (DSBs) are considered, to date, as the ... Intrinsic radiosensitivity and DNA double-strand breaks in human cells Bibliographie. Journal title : Cancer Radiothérapie. ... Keywords > DNA double-strand breaks, DNA repair, radiosensitivity Research Unit > IRSN Authors > FORAY Nicolas, JOUBERT Aurélie ...
https://www.irsn.fr/EN/Research/publications-documentation/Publications/IRSN/Pages/Intrinsic-radiosensitivity-and-DNA-double-strand-breaks-in-human-cells-3644.aspx
*  Kinetic analysis of DNA double-strand break repair pathways in Arabidopsis. - PubMed - NCBI
DNA Repair (Amst). 2011 Jun 10;10(6):611-9. doi: 10.1016/j.dnarep.2011.04.002. Epub 2011 Apr 29. Research Support, Non-U.S. ... Kinetic analysis of DNA double-strand break repair pathways in Arabidopsis.. Charbonnel C1, Allain E, Gallego ME, White CI. ... Double-strand breaks in genomic DNA (DSB) are potentially lethal lesions which separate parts of chromosome arms from their ... DNA Repair (Amst). 2011 Jun 10;10(6):611-9. doi: 10.1016/j.dnarep.2011.04.002. Epub 2011 Apr 29. ...
https://www.ncbi.nlm.nih.gov/pubmed/21530420?dopt=Abstract
*  Roles of Post-translational Modifications in DNA Double-Strand Break Repair | SpringerLink
A particularly hazardous type of DNA lesion is the double-strand break (DSB),... ... Genomic integrity is constantly challenged by DNA lesions, several thousands of which occur in each human cell every day. ... A particularly hazardous type of DNA lesion is the double-strand break (DSB), which can lead to large genetic alterations if ... Sarangi P., Zhao X. (2014) Roles of Post-translational Modifications in DNA Double-Strand Break Repair. In: Bell E. (eds) ...
https://link.springer.com/referenceworkentry/10.1007/978-1-4614-6436-5_79-2
*  Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. - PubMed - NCBI
DNA ends exposed after introduction of double-strand breaks (DSBs) undergo 5'-3' nucleolytic degradation to generate single- ... Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing.. Mimitou EP1, Symington LS. ... Processing of the HO-induced break renders the DNA single-stranded and resistant to digestion with restriction enzymes, giving ... Second, Exo1 and/or Sgs1 rapidly process this intermediate to generate extensive tracts of single-stranded DNA that serve as ...
https://www.ncbi.nlm.nih.gov/pubmed/18806779?dopt=Abstract
*  Processing of Damaged DNA Ends for Double-Strand Break Repair in Mammalian Cells
"Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks," ... DNA double-strand breaks are extremely toxic DNA lesions that arise from a variety of sources, including ionizing radiation [1 ... phosphoglycolate-terminated DNA double-strand breaks," DNA Repair, vol. 8, no. 8, pp. 901-911, 2009. View at Publisher · View ... overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1," Journal of Biological Chemistry, vol. ...
https://www.hindawi.com/journals/isrn/2012/345805/
*  Processing of Damaged DNA Ends for Double-Strand Break Repair in Mammalian Cells
"Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks," ... phosphoglycolate-terminated DNA double-strand breaks," DNA Repair, vol. 8, no. 8, pp. 901-911, 2009. View at Publisher · View ... overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1," Journal of Biological Chemistry, vol. ... "DNA double-strand breaks and ATM activation by transcription-blocking DNA lesions," Cell Cycle, vol. 9, no. 2, pp. 274-278, ...
https://www.hindawi.com/journals/isrn/2012/345805/ref/
*  DNA Double-Strand Break Rejoining in Complex Normal Tissues (Journal Article) | SciTech Connect
Double-strand breaks (DSBs) are the most deleterious form of DNA damage induced by ionizing radiation, and the cells' capacity ... 63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BRAIN; DNA; DNA ... Journal Article: DNA Double-Strand Break Rejoining in Complex Normal Tissues. *Citation Details ...
https://www.osti.gov/scitech/biblio/21172473
*  Modulation of Saccharomyces cerevisiae DNA double-strand break repair by SRS2 and RAD51. | Genetics
Modulation of Saccharomyces cerevisiae DNA double-strand break repair by SRS2 and RAD51.. G T Milne, T Ho and D T Weaver ... Modulation of Saccharomyces cerevisiae DNA double-strand break repair by SRS2 and RAD51.. G T Milne, T Ho and D T Weaver ... Modulation of Saccharomyces cerevisiae DNA double-strand break repair by SRS2 and RAD51.. G T Milne, T Ho and D T Weaver ... RAD52 function is required for virtually all DNA double-strand break repair and recombination events in Saccharomyces ...
http://www.genetics.org/content/139/3/1189
*  Examining the Role of HDACs in DNA Double-Strand Break Repair in Neurons | SpringerLink
Upon DNA double-strand breaks (DSBs), deacetylation of H3K56 and H4K16 by HDACs occurs immediately... ... Genome stability DNA damage Histone deacetylation Histone deacetylases (HDACs) DNA repair DNA double-strand breaks (DSBs) ... Upon DNA double-strand breaks (DSBs), deacetylation of H3K56 and H4K16 by HDACs occurs immediately at break sites, and is ... Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ (2001) ATM phosphorylates histone H2AX in response to DNA double-strand breaks ...
https://link.springer.com/protocol/10.1007%2F978-1-4939-9434-2_13
*  Chromatin Response During DNA Double Strand Break Repair | JILA Science
Chromatin Response During DNA Double Strand Break Repair. Event Details. Event Dates: Wednesday, March 18, 2015 - 3:30pm ...
https://jila.colorado.edu/events/2014/tba-37
*  Genes | Free Full-Text | RNF20-SNF2H Pathway of Chromatin Relaxation in DNA Double-Strand Break Repair
In DNA double-strand break (DSB) repair, the well-known mark of histones is the phosphorylation of the H2A variant, H2AX, which ... The ubiquitylation of histone H2B by RNF20 E3 ligase was recently found to be a DNA damage-induced histone modification. This ... of histone modifications with chromatin remodeling factors has broadened our understanding of chromatin dynamics in DNA ... DNA double-strand break repair; ubiquitylation of histone H2B; RNF20; chromatin relaxation; SNF2H; KAP-1; CHD3.1 DNA double- ...
http://www.mdpi.com/2073-4425/6/3/592
*  Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks | JCB
Abbreviations used in this paper: DNA-PK, DNA-dependent protein kinase; DNA-PKCS, DNA-PK catalytic subunit; DSB, double-strand ... DNA-PKCS) plays an important role during the repair of DNA double-strand breaks (DSBs). It is recruited to DNA ends in the ... Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair. Mutat. Res. 362:9-19. ... Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. Naoya Uematsu, Eric Weterings, Ken-ichi ...
http://jcb.rupress.org/content/177/2/219?ijkey=8d8e081b41de49a199156eeaeef1a9332e7b0f94&keytype2=tf_ipsecsha
*  FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress | Nature...
... through the generation of MUS81-induced DNA double-strand brea… ... is required to eliminate cells with excessive DNA replication ... DNA replication stress promotes genome instability and cell death. Here Fugger et al. describe how FBH1, via its helicase ... How to cite this article: Fugger et al. FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death ... a poorly understood process where the replication machinery dissociates from the DNA and DNA double-strand breaks (DSBs) are ...
https://www.nature.com/articles/ncomms2395?error=cookies_not_supported&code=ab29cd46-27c4-48df-b0e4-b7bdcb53dc91
*  Frontiers | Pathologic Replication-Independent Endogenous DNA Double-Strand Breaks Repair Defect in Chronological Aging Yeast |...
Especially in the mutant, some unknown sequence was found inserted at the breaks. In addition, % difference of cell viability ... Especially in the mutant, some unknown sequence was found inserted at the breaks. In addition, % difference of cell viability ... an alternative pathway might be employed or an end modification process might occur as inserted sequences at the breaks were ... an alternative pathway might be employed or an end modification process might occur as inserted sequences at the breaks were ...
https://www.frontiersin.org/articles/10.3389/fgene.2018.00501/full