The enzyme DNA-(apurinic or apyrimidinic site) lyase, also referred to as DNA-(apurinic or apyrimidinic site) 5- ... or DNA AP lyase (EC 4.2.99.18) catalyzes the cleavage of the C-O-P bond 3 from the apurinic or apyrimidinic site in DNA via β- ... Other names for DNA AP lyase include: AP lyase; AP endonuclease class I; endodeoxyribonuclease (apurinic or apyrimidinic); ... DNA-(apurinic or apyrimidinic site) lyase activity". HumanCyc. SRI International. Retrieved March 9, 2015. Müller TA, Andrzejak ...

DNA-(apurinic or apyrimidinic site) lyase. A. 285. Homo sapiens. Mutation(s): 2 Gene Names: APEX1, APE, APE1, APEX, APX, HAP1, ... High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.. He, H. ... Apurinic/apyrimidinic endonuclease I (APE1) is an essential base excision repair enzyme that catalyzes a Mg²⁺-dependent ... Our website will not work properly. Please update to a newer version or download a new web browser, such as Chrome or Firefox. ...

XRCC1 participates in DNA single strand break and base excision repair (BER) to preserve genetic stability in mammalian cells. ... DNA-(Apurinic or Apyrimidinic Site) Lyase / metabolism * DNA-Binding Proteins / physiology* * Glutathione Transferase / ... Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1 J Biol ... XRCC1 participates in DNA single strand break and base excision repair (BER) to preserve genetic stability in mammalian cells. ...

The investigation reported in Chapter Three characterized the repair of uracil mismatches and apurinic/apyrimidinic (AP) sites ... This activity was unique, as there is no other report of a DNA glycosylase/AP lyase that acts on single stranded DNA. ... The investigation showed that the lysate was capable of removing uracil from DNA, generating AP sites. The lysate then ... After the removal of adenine, the DNA was then cleaved, possibly by an associated lyase activity. ...

ec 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase. pdb deposition date 2000-01-24. ... Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. pubmed doi rcsb ... Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal). 1ebmA02. 3.30.310.40. Alpha Beta. 2-Layer Sandwich. TATA- ... DNA (5-D(*GP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)- ... HhH-GPD superfamily base excision DNA repair protein. A. ...

DNA glycosylase/DNA-(apurinic or apyrimidinic site) lyase. 7e-10. 63.9. NC_011757:577611:592856. 592856. 593557. 702. ... endonuclease III; DNA-(apurinic or apyrimidinic site) lyase. 1e-19. 96.3. NC_008148:2231045:2238225. 2238225. 2238920. 696. ... DNA-(apurinic or apyrimidinic site) lyase, endonuclease III. 5e-14. 77.8. NC_014958:2614399:2630678. 2630678. 2631352. 675. ... endonuclease III / DNA-(apurinic or apyrimidinic site) lyase. 4e-13. 75.1. NC_016885:417661:421107. 421107. 421496. 390. ...

AlzheimerNet is an open web server that could be used for netting or predicting the binding of multiple targets of Alzheimer ... DNA-(apurinic or apyrimidinic site) lyase. View. P27986. Phosphatidylinositol 3-kinase regulatory subunit alpha. View. ...

DNA-(apurinic or apyrimidinic site) lyase activity. GO:0008311. double-stranded DNA 3-5 exodeoxyribonuclease activity. ...

DNA-(Apurinic or Apyrimidinic Site) Lyase 19% * DNA Damage 19% * DNA Repair Enzymes 18% ...

DNA-(Apurinic or Apyrimidinic Site) Lyase 100% * Urinary Bladder Neoplasms 64% * Muscles 40% ... Association between Biliary Pathogens, Surgical Site Infection, and Pancreatic Fistula: Results of a Randomized Trial of ... Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and ...

DNA-(apurinic or apyrimidinic site) lyase activity. F. IDA. Dme. FBgn0002622. Hsa. RPS3. ... Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for ... oxidized purine base lesion DNA N-glycosylase activity. F. IDA. Dme. FBgn0002622. ...

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703 * DNA-(apurinic or apyrimidinic site) lyase ... Label: double-stranded DNA 3\-5\ exodeoxyribonuclease activity Synonyms: double-stranded DNA 3\-5\ ...

DNA-(apurinic or apyrimidinic site) lyase MutM. 97%. PM0084000. 111. A0A6M2Y1J5. Adenylosuccinate lyase. 97.01%. PM0084011. ... DNA gyrase subunit A (EC 5.6.2.2). 96.56%. PM0083998. 93. A0A6M2Y3K7. Phosphopantetheine adenylyltransferase. 96.56%. PM0083671 ... Home » HOMOLOGY MODELLING AND ANALYSIS OF PROTEIN DRUG TARGETS FOR ERYSIPELOTHRIX RHUSIOPATHIAE A BACTERIAL PATHOGEN CAUSING ... NCBI Database: This website was looked upon to derive the known data regarding the organism of interest. A detailed search on ...

DNA-(apurinic or apyrimidinic site) lyase activity. Details: Catalysis of the cleavage of the C-O-P bond 3 to the apurinic or ... apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3-terminal unsaturated sugar and a product with a terminal ... DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported ... Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; This... cl00490 327.587 3.40E-108 245 ...

DNA-(apurinic or apyrimidinic site) lyase activity GO:0003906 Molecular Function 0.0. - ... DNA N-glycosylase activity GO:0019104 Molecular Function 0.0. - Sma3. 4 iron, 4 sulfur cluster binding GO:0051539 Molecular ... DNA methylation GO:0006306 Biological Process 0.0. - Sma3. regulation of gene expression by genetic imprinting GO:0006349 ... maintenance of DNA methylation GO:0010216 Biological Process 0.0. - Sma3. negative regulation of chromatin silencing GO:0031936 ...

DNA-(apurinic or apyrimidinic site) lyase activity GO:0003906 * 2-hydroxyisoflavanone dehydratase activity ...

DNA glycosylase/AP lyase Nei;. EC=3.2.2.-;. EC=4.2.99.18;. AltName: Full=DNA-(apurinic or apyrimidinic site) lyase Nei;. ... Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta ... GO:0003906; Molecular function:DNA-(apurinic or apyrimidinic site) endonuclease activity. GO:0000703; Molecular function: ... Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes ...

A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase (RefSeq). 37, 314. ... recombination and DNA strand exchange inhibitor protein (RefSeq). 211, 314. BSU28590. yshC. hypothetical protein (RefSeq). 211 ... DNA-remodelling primosomal protein (RefSeq). 67, 293. BSU22830. gpsA. NAD(P)H-dependent glycerol-3-phosphate dehydrogenase ( ... You can browse the history, make updates, raise questions and share these activities with social web. ...

DNA-(Apurinic or Apyrimidinic Site) Lyase Medicine & Life Sciences 20% * Deamination Medicine & Life Sciences 18% ... In human cells, the enzymatic activities initiating DNA base excision repair (BER) of 8-oxoG, U and AP sites are the 8-oxoG DNA ... In human cells, the enzymatic activities initiating DNA base excision repair (BER) of 8-oxoG, U and AP sites are the 8-oxoG DNA ... In human cells, the enzymatic activities initiating DNA base excision repair (BER) of 8-oxoG, U and AP sites are the 8-oxoG DNA ...

DNA-(apurinic or apyrimidinic site) lyase 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=apn2 PE=1 SV=1. 21. 587. ... DNA-(apurinic or apyrimidinic site) lyase 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=apn2 PE=1 SV=1. 21. 587. ... DNA-(apurinic or apyrimidinic site) lyase OS=Gorilla gorilla gorilla GN=APEX1 PE=3 SV=1. 66. 351. 6.0E-20. ... DNA-(apurinic or apyrimidinic site) lyase, chloroplastic OS=Arabidopsis thaliana GN=ARP PE=1 SV=2. 13. 350. 3.0E-18. ...

DNA damage was evaluated by staining the cells with γH2AX antibody, and the DNA damage foci were observed with a fluorescent ... Our studies revealed that the synergistic lethality of HDAC and PARP inhibitors resulted from promoting DNA damage and ... and synergistically induced cell apoptosis and DNA damage, while had no detectable toxicity to normal prostate epithelial cells ... inhibiting HR DNA damage repair pathways, in particular targeting the UHRF1/BRCA1 protein complex. The synergistic lethality of ...

In contrast, no apurinic/apyrimidinic sites were detected in any of our DNA preparations as revealed by digestion with Endo IV ... 4. The NER and SP lyase DNA repair systems are important for repair of DNA damage caused mainly by the UV-B portion of sunlight ... To detect apurinic/apyrimidinic (AP) sites, DNA was first digested with Endonuclease IV (Endo IV) (Epicentre Technologies) ( ... but not apurinic/apyrimidinic (AP) sites.. (ii) Spore DNA damage correction during spore germination is dependent upon ...

... to the abasic site. Despite extensive study, there is no structure of a bacterial AP endonuclease bound to substrate DNA. ... Whereas several enzymes are required to complete the multistep repair process of damaged bases, apurinic-apyrimidic (AP) ... Our data reveal subtle differences in AP-site recognition and kinetics between the human and bacterial enzymes that may reflect ... Furthermore, the structural mechanism for AP-site cleavage is incomplete. Here we report a detailed structural and biochemical ...

Keywords: Apex1 Protein, Human, Cell Nucleus Antigen, Dna (apurinic Or Apyrimidinic Site) Lyase, Dna Binding Protein, Dna ... Dna Glycosylases, Dna-(apurinic Or Apyrimidinic Site) Lyase, Dna-Binding Proteins, Methyl Methanesulfonate, Molecular Sequence ... Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional protein contributing to genome stability via repair of DNA ... Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules ...

DNA-(apurinic or apyrimidinic site) lyase activity ferrous iron binding chemoattractant activity methylcytosine dioxygenase ... DNA 6mA demethylase; DNA lyase ABH1; DNA N6-methyl adenine demethylase; DNA N6-methyl adenine demethylase ALKBH1; DNA oxidative ... Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double- ... stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. ...

DNA Damage. DNA Repair. DNA-(Apurinic or Apyrimidinic Site) Lyase Publication Types: Lecture. Webcast ... The DNA Repair Interest Group is concerned with all forms of DNA damage and repair. As a major defense against environmental ... The members of the DNA Repair Interest Group perform research in areas including DNA repair enzymology and fine structure, ... History of DNA Repair: Chinese Hamster Cells and DNA Repair - a Long-Lasting Affair ...

DNA Ligases. *DNA-(Apurinic or Apyrimidinic Site) Lyase. *MutS DNA Mismatch-Binding Protein ... "DNA Repair Enzymes" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "DNA Repair Enzymes" by people in UAMS Profiles by year, and ... Below are the most recent publications written about "DNA Repair Enzymes" by people in Profiles over the past ten years. ...

Despite the elaborate proofreading system employed during DNA synthesis, errors (including incorrect base-pairing or insertion ... This leaves an apyrimidinic site (or apurinic, if a purine was removed), both referred to as AP sites.. ... A deoxyribose phosphate lyase removes the single, base-free, sugar phosphate residue. DNA polymerase and DNA ligase complete ... DNA Repair. , Home , , Biochemistry , Chapter: Biochemistry : DNA Structure, Replication, and Repair. Despite the elaborate ...

DNA Ligases. *DNA-(Apurinic or Apyrimidinic Site) Lyase. *MutS DNA Mismatch-Binding Protein ... This graph shows the total number of publications written about "DNA Ligases" by people in this website by year, and whether " ... "DNA Ligases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by ...

Carbon-Oxygen Lyases. *DNA-(Apurinic or Apyrimidinic Site) Lyase. *Hydro-Lyases. *Polysaccharide-Lyases ... This graph shows the total number of publications written about "Carbon-Oxygen Lyases" by people in this website by year, and ... "Carbon-Oxygen Lyases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Carbon-Oxygen Lyases" by people in Profiles. ...