DNA adducts levels were significantly lower in pipe or cigar smokers than in cigarette smokers. In multivariate analysis, ... Nitrosamine and benzo[a]pyrene DNA adducts were measured in lymphocytes. CYP1A2 activity was greater (p,0.0001) in cigarette ...
Dataset Parameters for Benthic Surveillance DNA Xenobiotic Adducts data * bsfac_h * Dataset Parameters for Benthic Surveillance ...
N-nitrosodimethylamine and 7-methylguanine DNA adducts in tissues of rats fed Chinese salted fish. ... Epstein Barr virus DNA analysis in blood predicts disease progression in a rare case of plasmablastic lymphoma with effusion. ... Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a ...
DNA adducts as link between in vitro and in vivo carcinogenicity - A case study with benzo[a]pyrene. Curr. Res. Toxicol. 4 , ...
Investigating DNA Adduct Formation by Flavor Chemicals and Tobacco Byproducts in E-cigarettes Using In Silico Approaches. The ... One mechanism of interest is DNA adduct formation, which may lead to carcinogenesis. Scientists at the FDA Center for Tobacco ... Good concordance was observed between DNA adduct formation and models predicting mammalian mutagenicity and skin sensitization ... both of which are known to form DNA adducts. Using in silico toxicology approaches, they conducted a structural similarity ...
Dietary components modify the ability of garlic to suppress 7,12-dimethylbenz(a)anthracene-induced mammary DNA adducts. J Nutr ... Suppression in carcinogen bioactivation, as indicated by a reduction in DNA adducts, might account in part for this combined ... When ROS attack DNA, oxidized bases are generated and the unrepaired oxidative DNA damage can induce mutations. Formation of ... DNA methylation, cancer susceptibility, and nutrient interactions. Exp Biol Med (Maywood). 2004;229:988-995. [PubMed] [DOI] [ ...
Accurate characterization of carcinogenic DNA adducts using MALDI tandem time-of-flight mass.... 2009. Chiu, Norman H.. Faculty ... Comparison of Accuracy on DNA Quantitation Determined by MALDI-TOF Mass Spectrometry and UV .... 2010. Chiu, Norman H.. Faculty ... Comparison of Accuracy on DNA Quantitation Determined by MALDI-TOF Mass Spectrometry and UV .... 2010. Boyko, Alison Lisa. ...
Genotoxicity describes structural DNA damage, for example, strand breaks, adducts, deletions and rearrangements. If host DNA ... Integration of microbial DNA into the host genome is a virulence mechanism for multiple viruses that are causally associated ... CDT is produced by Escherichia coli and Campylobacter jejuni (among others) and induces double-strand DNA breaks via its DNAse ... This conceptual framework can also be applied to well-established microbial carcinogens which induce DNA damage either directly ...
Nucleotide excision repair is a DNA repair pathway that repairs any damage that distorts the DNA helix or bulky adducts on the ... as measured by the unscheduled DNA synthesis assay when compared to early-stage (stages I and II). In addition, our lab ... DNA. Our lab has previously shown that late-stage (stages III and IV) treatment-resistant breast cancer cell lines have ...
In the software, additional adducts (Na+, NH4+, CH3COO−, HCOO−) and transformations (glucuronidation, di-glucuronidation, ... Aflatoxin-8,9-epoxide (AFBO), the epoxidation product, is the most reactive species and binds either to DNA (generating guanine ... The albumin-AFBO complex could not be retrieved here because albumin/lysine adducts were precipitated during the sample ... adducts) or proteins. AFB1-8,9-epoxide can also be hydrolyzed in vitro to the dihydrodiol-form. Next to these phase I ...
... found that those women with high levels of PAH-DNA adducts had a 50 percent greater risk of breast cancer.[4] The formation of ... Exposure and DNA Adduct Semi-Quantitation in Archived Human Tissues. International Journal of Environmental Research and Public ... PAH-DNA adducts, an indicator of PAH exposure, is linked to cancer development. [5] ...
... and formation of hemoglobin and DNA adducts after inhalation of C2 -C8 1-alkenes [olefins] in the rat. Carcinogenesis. 16, 1603 ...
Kato, S., Bowman, E. D., Harrington, A. M., Blomeke, B., and Shields, P. G. Human lung carcinogen-DNA adduct levels mediated by ... Rimbach, G., Guo, Q., Akiyama, T., Matsugo, S., Moini, H., Virgili, F., and Packer, L. Ferric nitrilotriacetate induced DNA and ... effect of a fermented papaya preparation on redox status and DNA damage in healthy elderly individuals and relationship with ...
Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust ... Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthene tetraols in a ... disruption of Nrf2 enhances susceptibility to airway inflammatory responses and DNA damage induced by diesel exhaust particles ...
... by inhibiting the activation of an important inflammatory agent called NF-kappaB and by decreasing levels of DNA adducts (a ... marker of DNA damage). In addition to genistein, another isoflavone found in soybeans called daidzen has also demonstrated ...
The DNA repair enzyme AlkB was identified in E. coli more than three decades ago. Since then, nine mammalian homologs, all ... Substrates recognized by the different AlkB homologs comprise erroneous methyl- and etheno adducts in DNA, unique wobble ... coli AlkB serves as a DNA repair enzyme, only two mammalian homologs have been confirmed to repair DNA in vivo. The other ... The DNA repair enzyme AlkB was identified in E. coli more than three decades ago. Since then, nine mammalian homologs, all ...
Damage detection by the UvrABC pathway: Crystal structure of UvrB bound to fluorescein-adducted DNA. ... Structural Basis of DNA Damage Recognition and Processing by UvrB: crystal structure of a UvrB/DNA complex. ... Structure of RecG bound to three-way DNA junction. 1hv8. CRYSTAL STRUCTURE OF A DEAD BOX PROTEIN FROM THE HYPERTHERMOPHILE ... Crystal structure of the DNA repair protein UvrB point mutant Y96A revealing a novel fold for domain 2. ...
Potentiation of DNA-adduct formation and cytotoxicity of platinum-containing drugs by low pH. Int J Cancer. 1993 Apr 22; 54(1): ...
Mechanism of replication blocking and bypass of Y-family polymerase Eta by bulky acetylaminofluorene DNA adducts ... A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair. The Integrin Ligand c(RGDf(NMe)Nal) Reduces Neointimal ... Entrapment of DNA in an intersubunit tunnel system of a single-stranded DNA-binding protein. ... Bypass of DNA Lesions Generated During Anticancer Treatment with Cisplatin by DNA Polymerase Eta. ...
DNA owes its remarkable photostability to the ability of its building blocks - the nucleosides - to efficiently dissipate the ... Giussani, A., Conti, I., Nenov, A. & Garavelli, M. Photoinduced formation mechanism of the thymine-thymine (6-4) adduct in DNA ... Middleton, C. T. et al. DNA Excited-State Dynamics: From Single Bases to the Double Helix. Annu. Rev. Phys. Chem. 60, 217-239 ( ... Haiser, K. et al. Mechanism of UV-Induced Formation of Dewar Lesions in DNA. Angew. Chemie Int. Ed. 51, 408-411 (2012). ...
Characterization and quantitation of busulfan DNA adducts in the blood of patients receiving busulfan therapy. Guidolin, V., Li ... Liquid Chromatography-Mass Spectrometry Screening of Cyclophosphamide DNA Damage In Vitro and in Patients Undergoing ...
Effects of berberine on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adduct formation in human leukemia cells ...
Polyaromatic hydrocarbons and nicotine-derived nitrosamine ketone (NNK) are known to cause DNA damage by forming DNA adducts in ... This difference may be due to differences in DNA repair mechanisms. Although still considered controversial, it is well known ...
... and causes formation of DNA adducts. ... reacts with DNA in the absence of metabolizing enzymes, ...
An assessment of the genotoxic impact of the Sea Empress oil spill by the measurement of DNA adduct levels in selected ...
... pyrene Induced DNA Adducts in the Presence of Arsenic" Manuscript in preparation. ... My main projects are in the development of novel biosensors that use synthetic DNA fragments as probes for the detection of ... Simultaneous Detection of Ultraviolet B-Induced DNA Damage Using Capillary Electrophoresis with Laser-Induced Fluorescence, ... environmental contaminants in aquatic systems and the study of cellular DNA damage from environmental agents such as ...
2005) Induction of Cyp1a1 and Cyp1b1 and formation of DNA adducts in C57BL/6, Balb/c, and F1 mice following in utero exposure ... to electrophilic DNA-binding derivatives (Cheng and Morgan, 2001; Flint et al., 2010; Harkitis et al., 2015; Kawajiri, 1999; ... to DNA-binding metabolites (Cheng and Morgan, 2001; Kawajiri, 1999; Mulder et al., 2001; Pasanen and Pelkonen, 1994). In ...
... to the more stable DNA adducts and less to the water adducts via transition-states of similar heights. Non-carcinogenic ... in 2022) as a pivotal tool providing insights into the likelihood of reactive ion formation and subsequent DNA alkylation for a ... Despite the re-emergence of combinatorial approaches to explore considerably larger chemical spaces, notably with DNA encoded ... 1. Kunig, V., Potowski, M., Gohla, A. & Brunschweiger, A. DNA-encoded libraries - an efficient small molecule discovery ...
Multiple DNA adducts accept been identified for the three might electrophilic metabolites of BD, numberless of which win ... Also, since N N N N O H N H HDNA N N O NH H DNA N N N N O CH3 N H HDNA N N C H 3 O H O DNA guanine cytosine guanine thymidine a ...