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*  NIOSHTIC-2 Publications Search - 20020791 - O6-methylguanine DNA adducts associated with occupational nitrosamine exposure.
... curing operation were compared with the peripheral blood lymphocyte concentrations of two nitrosamine-related DNA adducts. N7- ... methylguanine (N7mdG) and 06-methylguanine (O6mdG), and with the activity of the enzyme that repairs 06mdG adducts, 06- ... alkylguanine-DNA alkyltransferase (AGT). The occupational personal breathing zone (PB ... The 06mdG adduct concentrations were much lower than those of N7mdG, ranging from non-detectable to 12.7 06mdG adducts/lO' ...
https://www.cdc.gov/niosh/nioshtic-2/20020791.html
*  Bulky DNA Adducts and Risk of Cancer | Cancer Epidemiology, Biomarkers & Prevention
Popp W., Schell C., Kraus R., Vahrenholz C., Wolf R., Radtke J., Bierwirth K., Norpoth K. DNA strand breakage and DNA adducts ... PAH-DNA adduct levels explained tumor outcome. For example, Nesnow et al. (10) found a correlation between the formation of DNA ... Bulky DNA adducts were measured by 32P-postlabelling (in the majority of studies) or ELISA. Six studies measured adducts in ... DNA adducts, according to smoking status. An overall 83% excess of adduct levels was found in cases compared with controls in ...
https://cebp.aacrjournals.org/content/12/2/157
*  New Method Pairs Artificial Nucleotide, Mutant Polymerase to Detect DNA Adducts | GenomeWeb
New Method Pairs Artificial Nucleotide, Mutant Polymerase to Detect DNA Adducts. Jan 21, 2015 ... Home » New Method Pairs Artificial Nucleotide, Mutant Polymerase to Detect DNA Adducts ... Alkylating substances such as tobacco smoke and environmental toxins can create mutagenic alkylguanine DNA adducts. This type ... DNA Quantification and Normalization with Promega QuantiFluor Dyes on the Fluent Laboratory Automation Solution ...
https://www.genomeweb.com/pcr/new-method-pairs-artificial-nucleotide-mutant-polymerase-detect-dna-adducts
*  Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer | PNAS
This aflatoxin-DNA adduct excretion product serves as a biomarker of the biologically effective dose of aflatoxin, and elevated ... Loeb has predicted that a 2-fold reduction in mutation rates, as might be anticipated from this decline in DNA adduct burden, ... Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer. Patricia A. Egner, Jin- ... 1, this aflatoxin-DNA adduct excretion product serves as a biomarker of the biologically effective dose of aflatoxin and ...
https://www.pnas.org/content/98/25/14601
*  NIOSHTIC-2 Publications Search - 00227652 - DNA adducts and related biomarkers in assessing the risk of complex mixtures.
The findings of recent studies which assessed macromolecular adducts formed by carcinogens were used to illustrate the ... DNA adducts and related biomarkers in assessing the risk of complex mixtures.. ... NIOSH-Author; Biological-monitoring; Bioassays; Carcinogenesis; Risk-analysis; Laboratory-animals; DNA-adducts; Molecular- ... The findings of recent studies which assessed macromolecular adducts formed by carcinogens were used to illustrate the ...
https://www.cdc.gov/niosh/nioshtic-2/00227652.html
*  Tobacco-specific carcinogens induce hypermethylation, DNA adducts and DNA damage in Bladder Cancer.
DNA adducts and DNA damage. DNA methyltransferase 1 (DNMT1) expression was significantly higher in smokers than non-smokers ... Tobacco-specific carcinogens induce hypermethylation, DNA adducts and DNA damage in Bladder Cancer. September 13, 2017 Smoking ... DNA adducts, and extensive DNA damage in BLCA cells. Co-treatment of BLCA cells with these carcinogens and the methylation ... DNA adducts, DNA damage. These findings were confirmed through the isotopic labeled metabolic flux analysis. Screens using ...
https://www.urotoday.com/recent-abstracts/urologic-oncology/bladder-cancer/98317-tobacco-specific-carcinogens-induce-hypermethylation-dna-adducts-and-dna-damage-in-bladder-cancer.html
*  MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts | JCB
... which increases the stability of Top2-DNA adducts (Pommier et al., 2010). These unprocessed Top2-DNA adducts block DNA ... To quantify Top2-DNA adducts in Xenopus genomic DNA in the presence and absence of DNA repair factors, we adapted a protocol ... Top2-DNA adducts are thought to be excised throughout the cell cycle. Indeed, we observe resection defects from Top2-DNA adduct ... To ascertain the requirements for CtIP and MRN in replication of DNA bearing Top2-DNA adducts, we examined DNA replication in ...
http://jcb.rupress.org/content/212/4/399?cct=1418
*  IJMS | Free Full-Text | Detection of Riddelliine-Derived DNA Adducts in Blood of Rats Fed Riddelliine
... derived DNA adducts. In this study we report the formation of these DHP-derived DNA adducts in blood DNA of rats fed ... leucocyte DNA can bind with DHP to form a set of DHP-derived DNA adducts generated in liver; (ii) DHP-derived DNA adducts in ... the levels of DHP-derived DNA adduct in blood and liver were determined by 32P-postlabeling/HPLC. Maximum DNA adduct formation ... The levels of the DHP-derived DNA adducts in blood of rats receiving 0.1 and 1.0 mg/kg doses were 12.9 and 51.8 adducts/107 ...
http://www.mdpi.com/1422-0067/3/9/1019
*  Relationship of Nitropyrene-Derived DNA Adducts to Carcinogenesis | Research Project Database | Grantee Research Project...
Such combinations of chemicals with DNA are called DNA adducts. Because adducts interfere with normal DNA replication, their ... between the location of DNA adducts and mutation, the investigators compared the regions in DNA where adducts formed to those ... analyzed the chemical structure of the adducts, and (3) determined in which region of the DNA the adducts formed. When the ... Relationship of Nitropyrene-Derived DNA Adducts to Carcinogenesis. EPA Grant Number: R828112C055. Subproject: this is ...
https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2318
*  DNA adduct - Wikipedia
DNA adducts are a type of DNA damage. DNA damage is considered to be the primary cause of carcinogenesis. Adduct Adductomics ... "DMBA-DNA adduct" in a scientific journal refers to a piece of DNA that has DMBA attached to it. The presence of such an adduct ... of a specific type of DNA adduct called M1dG. When a chemical binds to DNA, the DNA becomes damaged, and proper and complete ... a naturally occurring product of lipid peroxidation DNA adducts include: etheno-DNA adducts: 1,N(6)-etheno-2'-deoxyadenosine ( ...
https://en.wikipedia.org/wiki/DNA_adduct
*  Bulky DNA adducts and lung cancer risk: a prospective study in EPIC investigation | Cancer Research
Leukocyte DNA adducts were analysed blindly using the 32P DNA postlabelling technique. The intensity of adduct patterns was ... Objectives were to investigate prospectively the ability of DNA adducts to predict cancer, and to study the determinants of DNA ... Bulky DNA adducts and lung cancer risk: a prospective study in EPIC investigation. Marco Peluso, Armelle Munnia, Domenico Palli ... Our large prospective study suggests that the presence of bulky 32P-postlabelling DNA adducts in the WBC of non-smokers may ...
http://cancerres.aacrjournals.org/content/65/9_Supplement/512.2
*  Tamoxifen-DNA Adduct Formation in Rat Liver Determined by Immunoassay and 32P-Postlabeling | Cancer Research
The TAM-DNA CIA, which is specific for TAM-DNA adducts and detects 2.6 adducts per 109 nucleotides, may become the method of ... Although linearity in adduct formation would be expected, the predicted adduct level, 2 TAM-DNA adducts per 108 nucleotides, ... The probability that a DNA adduct can cause a mutation is related to the extent of DNA adduct formation and persistence as well ... The persistence of TAM-DNA adducts in rat liver DNA was determined by measuring adduct concentrations in rats given 45 mg TAM/ ...
http://cancerres.aacrjournals.org/content/59/19/4829
*  IJERPH | Free Full-Text | Ultrasensitive UPLC-MS-MS Method for the Quantitation of Etheno-DNA Adducts in Human Urine
Etheno-DNA adducts are generated from the metabolism of exogenous carcinogens and endogenous lipid peroxidation. We and others ... Etheno-DNA adducts are generated from the metabolism of exogenous carcinogens and endogenous lipid peroxidation. We and others ... Ultrasensitive UPLC-MS-MS Method for the Quantitation of Etheno-DNA Adducts in Human Urine. Shiwei Cui 1,2,3. ... "Ultrasensitive UPLC-MS-MS Method for the Quantitation of Etheno-DNA Adducts in Human Urine." Int. J. Environ. Res. Public ...
http://www.mdpi.com/1660-4601/11/10/10902
*  Investigation of benzo(a)pyrene and aflatoxin B1-DNA adducts by indirect immunofluorescence - Request PDF
... pyrene and aflatoxin B1-DNA adducts by indirect immunofluorescence ... A comparative investigation of DNA adducts, DNA strand breaks and gene mutations induced by benzo(a)pyrene and (racemic)-anti- ... A comparative investigation of DNA adducts, DNA strand breaks and gene mutations induced by benzo pyrene and -anti-benzo pyrene ... A comparative investigation of DNA adducts, DNA strand breaks and gene mutations induced by benzo[a]pyrene and (+/-)-anti-benzo ...
https://eurekamag.com/research/001/869/001869605.php
*  Serum Level of Antibody against Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA Adducts in People Dermally Exposed to PAHs
... Lenka ... 10-epoxide-DNA Adducts in People Dermally Exposed to PAHs," Journal of Immunology Research, vol. 2014, Article ID 834389, 6 ...
https://www.hindawi.com/journals/jir/2014/834389/cta/
*  HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision...
The DNA Damage Response Kinases DNA-dependent Protein Kinase (DNA-PK) and Ataxia Telangiectasia Mutated (ATM) Are Stimulated by ... The most frequent DNA adduct made by the anticancer drug cisplatin, the 1,2-intrastrand d(GpG) cross-link, as well as the minor ... HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision ... HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision ...
https://www.pnas.org/content/91/22/10394?ijkey=0574f531f0fba5b43c963ef8d0391f27afae1b18&keytype2=tf_ipsecsha
*  Cytochrome b5 imp acts on cytochrome P450-medi ated met a bolism of benzo[ a]pyrene and its DNA adduct form ation: studies in...
BaP-DNA adduct formation in vivo. The BaP-DNA adduct pattern obtained from in vivo treatments consisted of one major adduct ... BaP-DNA adduct formation in the livers of HRN mice was ~ sevenfold higher than in WT mice. BaP-DNA adduct formation in HBRN ... DNA adduct levels were calculated as described (Phillips and Arlt 2014). Results were expressed as DNA adducts/108 nucleotides. ... adduct 2 was the predominant DNA adduct formed with the formation of dG-N 2 -BPDE (adduct 1) being much lower (Supplementary ...
https://link.springer.com/article/10.1007/s00204-018-2162-7
*  Quantification of DNA adducts formed in liver, lungs, and isolated lung cells of rats and mice exposed to 14C-styrene by nose...
Reactive metabolites may form specific DNA adducts and induce the tumors observed in mice. ... Reactive metabolites may form specific DNA adducts and induce the tumors observed in mice. To determine DNA adducts in specific ... HPEG was the major adduct and was about three times higher in Type II cells than in total lung. For mice, DNA adduct levels in ... Quantification of DNA adducts formed in liver, lungs, and isolated lung cells of rats and mice exposed to 14C-styrene by nose- ...
https://www.rti.org/publication/quantification-dna-adducts-formed-liver-lungs-and-isolated-lung-cells-rats-and-mice-0
*  Repair of mitomycin C mono- and interstrand cross-linked DNA adducts by UvrABC: a new model
A) Chemical structures of MC, MC-mono-dG, and ICL dG-MC-dG DNA adducts. (B) The DNA sequence of the 61-bp DNA fragment ... In order to obtain definitive UvrABC-DNA adduct interactions 61-bp DNA fragments containing a site-specific MC-mono-dG adduct ( ... kink in the DNA helix (17). Similar to the ICL dG-MC-dG adduct, it has been shown that an MC-mono-dG adduct does not induce DNA ... If an ICL dG-MC-dG adduct does not cause DNA bending then what are the signals for UvrABC to recognize this adduct as a DNA ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2978355/
*  Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate...
The effects of p-XSC on the BPDE-DNA adduct formation. (A) BPDE-DNA isolated from Squamous cell carcinomas SCC1483 cells. (B) ... Levels of BPDE-DNA adducts were quantitated from three independent experiments. Results are the means ± S.D. of three separate ... In addition, we showed that dietary p-XSC inhibits B[a]P-DNA adduct formation, cell proliferation and cyclin D1 protein ... Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate ...
https://www.ncbi.nlm.nih.gov/pubmed/19344691?dopt=Abstract
*  DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis - ccceh.org
You are here: Home / Scientific Papers / DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta- ... DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis. Carcinogenesis. May 2008;29(5):932- ... Bulky DNA adducts are biomarkers of exposure to aromatic compounds and of the ability of the individual to metabolically ... DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis. .meta-data{ width:250px; float:right ...
https://ccceh.org/scientific-papers/dna-adducts-and-cancer-risk-in-prospective-studies-a-pooled-analysis-and-a-meta-analysis
*  Methods Development Toward the Measurement of Polyaromatic Hydrocarbon-DNA Adducts by Mass Spectrometry | Health Effects...
DNA adducts, a class of DNA adducts associated with exposure to constituents of diesel emissions and other combustion products ... Methods Development Toward the Measurement of Polyaromatic Hydrocarbon-DNA Adducts by Mass Spectrometry. Roger W GiesePaul ... Mass spectrometry (MS) is used in this study to measure DNA adducts and linked to a chromatographic system, such as gas ... In this study, the investigators set out to develop derivatives of PAH-DNA adducts that are better than those that currently ...
https://www.healtheffects.org/publication/methods-development-toward-measurement-polyaromatic-hydrocarbon-dna-adducts-mass
*  Hyperthermia enhances the cytotoxicity and plantinum-DNA adduct formation of lobaplatin and oxaliplatin in cultured SW 1573 ...
Hyperthermia enhances the cytotoxicity and plantinum-DNA adduct formation of lobaplatin and oxaliplatin in cultured SW 1573 ...
http://dare.uva.nl/search?metis.record.id=138028
*  Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity | Science
Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity ... Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity ... Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity ... Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity ...
http://science.sciencemag.org/content/226/4676/843