RCSB PDB - 1WP5: Crystal structure of the C-terminal domain of DNA topoisomerase IV
Crystal structure of the C-terminal domain of DNA topoisomerase IV ... Bacteria possess two closely related yet functionally distinct essential type IIA topoisomerases (Topos). DNA gyrase supports ... Structure of the topoisomerase IV C-terminal domain: a broken beta-propeller implies a role as geometry facilitator in ... Crystal structure of the C-terminal domain of DNA topoisomerase IV. *PDB DOI: https://doi.org/10.2210/pdb1WP5/pdb ...
RCSB PDB - 1CYY: CRYSTAL STRUCTURE OF THE 30 KDA FRAGMENT OF E. COLI DNA TOPOISOMERASE I. HEXAGONAL FORM
It has been proposed that both type IA and type II enzymes change conformation dramatically during the reaction cycle in order ... In order to change the topology of DNA, topoisomerases pass one or two DNA strands through transient single or double strand ... In order to change the topology of DNA, topoisomerases pass one or two DNA strands through transient single or double strand ... DNA topoisomerases are the enzymes responsible for maintaining the topological states of DNA. ...
data 1Z5A
Type II DNA topoisomerase VI subunit B 53510.363 2 5.99.1.3 ? ? ? 2 non-polymer syn MAGNESIUM ION 24.305 2 ? ? ? ? 3 non- ... type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _ ... type.id metalc _struct_conn_type.criteria ? _struct_conn_type.reference ? # loop_ _struct_sheet.id _struct_sheet.type _struct_ ... type PDB 1MU5 Topoisomerase VI-B, apo monomer form unspecified PDB 1MX0 Topoisomerase VI-B, AMPPNP-bound dimer form ...
data 3L4J
A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. _citation.journal_abbrev Nature _ ... Isomerase/DNA _struct_keywords.text ;TOPOISOMERASE, PROTEIN-DNA COMPLEX, COVALENTLY LINKED COMPLEX, DNA SUPERCOILING, DNA ... DNA topoisomerase II # loop_ _entity_poly.entity_id _entity_poly.type _entity_poly.nstd_linkage _entity_poly.nstd_monomer _ ... Topoisomerase II-DNA cleavage complex, apo _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_ ...
RCSB PDB - 5J3S: Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 in complex with a small...
Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 in complex with a small molecule inhibitor ... activity of topoisomerase II (TOP2). TDP2 facilitates therapeutic resistance to topoisomerase poisons, which are widely used in ... which are widely used in the treatment of a range of cancer types. Consequently, TDP2 is an interesting target for the ... activity of topoisomerase II (TOP2). TDP2 facilitates therapeutic resistance to topoisomerase poisons, ...