... double-strand break (DSB) repair and full-size genome formation. Only recently, cellular FEN1 has been identified as a key ... LCSH]: DNA replication , Phosphorylation , Viruses Reproduction , Transfection , Genomics , Small interfering RNA , DNA repair ... is a member of the family of structure-specific endonucleases implicated in regulation of DNA damage response and DNA ... Depletion of FEN1 and inhibition of its enzymatic activity during HCMV infection significantly reduced nascent viral DNA ...