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*  Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. - Nuffield Department...
... a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and ... In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2 ... To identify common PrCa susceptibility alleles, we previously conducted ... Chromosomes, Human, Disease Susceptibility, Genome, Human, Genome-Wide Association Study, Genotype, Humans, Male, Polymorphism ...
https://www.nds.ox.ac.uk/publications/108255
*  Hitchhiker's Guide to the Galaxy on Linkage disequilibrium
Mittal, KK (1976). "The HLA polymorphism and susceptibility to disease". Vox Sang. 31?-73 (3): 161-73. PMID 969389.. ... The presence of linkage disequilibrium between an HLA locus and a presumed major gene of disease susceptibility corresponds to ... Table 4. Association of HLA alleles with rheumatic and autoimmune diseases among white populations[11] Disease. HLA allele. ... Putting aside 2 diseases with high relative risks both of which are also with high δ. {\displaystyle \delta }. values, among ...
http://hitchhikersgui.de/Linkage_disequilibrium
*  Gene Variant Identified for Kawasaki Disease Susceptibility
They have identified plausible gene variants that predispose some children to developing the disease. ... have conducted novel whole genome sequencing of a family in which two of four children were affected by Kawasaki disease. ... Gene Variant Identified for Kawasaki Disease Susceptibility Researchers use novel whole genome sequencing of affected African ... Kawasaki disease (KD) is the most common acquired heart disease in children. Untreated, roughly one-quarter of children with KD ...
https://health.ucsd.edu/news/releases/pages/2017-02-09-gene-variant-identified-for-kawasaki-disease-susceptibility.aspx
*  New method for finding disease-susceptibility genes
This accounts for all individual differences, including susceptibility for disease and diverse phenotypes. Such genetic ... This algorithm has also been considered as a new promising approach for the identification of candidate disease genes, as it ... With this algorithm, we can easily identify new drug targets, thereby deepening our understanding of diseases and unlock new ... Through the statistical analysis of GWAS summary data, it is possible to identify the disease-associated SNPs. ...
http://www.iran-daily.com/News/215767.html
*  ApoE4, a-beta, and Alzheimer's disease susceptibility :: DNA Learning Center
Alzheimer's disease. An overview of Alzheimer's disease-related content on Genes to Cognition Online.. SOURCE: G2C. ... Late-onset Alzheimer's disease. Professor Donna Wilcock discusses late-onset Alzheimer's disease, which involves the clearance ... Late-onset genes for Alzheimer's disease. Professor Donna Wilcock discusses the late-onset gene for Alzheimer's disease, ApoE4 ... disease]. But, importantly, that tendency to Alzheimer's [disease] won't really show itself until you are in your sixties or ...
https://www.dnalc.org/view/2138-ApoE4-a-beta-and-Alzheimer-s-disease-susceptibility.html
*  Genetic variation in Toll-like receptors and disease susceptibility. - PubMed - NCBI
Genetic variation in Toll-like receptors and disease susceptibility.. Netea MG1, Wijmenga C, O'Neill LA. ... Much has been learned about the role of TLRs in human immunity from studies linking TLR genetic variation with disease. First, ... interaction explains the differences in the effect of TLR polymorphisms on susceptibility to infection and autoimmune disease ... in genes encoding several TLRs and associated genes have been associated with both infectious and autoimmune diseases. The ...
https://www.ncbi.nlm.nih.gov/pubmed/22610250?dopt=Abstract
*  CD2-Associated Protein Haploinsufficiency Is Linked to Glomerular Disease Susceptibility | Science
CD2-Associated Protein Haploinsufficiency Is Linked to Glomerular Disease Susceptibility. By Jeong M. Kim, Hui Wu, Gopa Green, ... CD2-Associated Protein Haploinsufficiency Is Linked to Glomerular Disease Susceptibility. By Jeong M. Kim, Hui Wu, Gopa Green, ... Mutations in several podocyte genes have recently been implicated in susceptibility to glomerular disease (21, 22). Here we ... CD2-Associated Protein Haploinsufficiency Is Linked to Glomerular Disease Susceptibility Message Subject. (Your Name) has ...
http://science.sciencemag.org/content/300/5623/1298?ijkey=f67a7a5869b35770699be1aa9bc5bcdac3ced245&keytype2=tf_ipsecsha
*  JCI - Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. ... Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. ... Further, mice lacking Atg5 in podocytes exhibited strongly increased susceptibility to models of glomerular disease. These ... Injury and loss of podocytes are leading factors of glomerular disease and renal failure. The postmitotic podocyte is the ...
https://www.jci.org/articles/view/39492/figure/1
*  JCI - Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. Björn Hartleben,1 ... Further, mice lacking Atg5 in podocytes exhibited strongly increased susceptibility to models of glomerular disease. These ... a major risk factor for glomerular disease and end-stage kidney disease (5). It is very reasonable to assume that autophagy ... ultimately culminating in end-stage renal disease (ESRD). Podocyte injury is therefore a key determinant of glomerular diseases ...
https://www.jci.org/articles/view/39492
*  New GTEx findings show how DNA differences influence gene activity, disease susceptibility | EurekAlert! Science News
... resource to help establish how differences in individual genomic make-up can affect gene activity and contribute to disease. It ... including genes related to neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. They also found more ... IMAGE: GTEx findings reveal new insights into how DNA differences influence gene activity, disease susceptibility. view more ... New GTEx findings show how DNA differences influence gene activity, disease susceptibility NIH-funded pilot study provides a ...
https://www.eurekalert.org/pub_releases/2015-05/nhgr-ngf050715.php
*  Researchers study genetic clues underlying disease susceptibility among minorities - Healthcanal.com : Healthcanal.com
Heart disease. 06/15/2019 Heart disease Higher coronary artery calcium levels in middle-age may indicate higher risk for future ... as well as common diseases such as cancer and heart disease.. "The goal of the PAGE program is to investigate ancestrally ... 06/15/2019 Heart disease Higher coronary artery calcium levels in middle-age may indicate higher risk for future heart problems ... diverse populations to gain a better understanding of how genetic factors influence susceptibility to disease," said ...
https://www.healthcanal.com/genetics-birth-defects/42847-researchers-study-genetic-clues-underlying-disease-susceptibility-among-minorities.html
*  Study Finds Protein Link to Sexually Transmitted Disease Susceptibility - TheBodyPRO.com
Researchers in Australia's Centre for Innate Immunity and Infectious Diseases at the Monash Institute of Medical Research have ... The information provided through TheBodyPRO.com should not be used for diagnosing or treating a health problem or a disease. It ... Researchers in Australia's Centre for Innate Immunity and Infectious Diseases at the Monash Institute of Medical Research have ... It may also be possible to apply IFNe research to endometriosis, pelvic inflammatory disease, and other reproductive system ...
http://www.thebodypro.com/content/70699/study-finds-protein-link-to-sexually-transmitted-d.html
*  Comprehensive Search for Alzheimer Disease Susceptibility Loci in the APOE Region
... Gyungah Jun, PhD, Badri N. Vardarajan, PhD, ... SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. Am J Hum Genet. ... National Cell Repository for Alzheimer's Disease, U24 AG021886; NIA Late-Onset Alzheimer's Disease Study, U24 AG026395 and U24 ... National Institute on Aging Alzheimer's Disease Centers (C and D), and Alzheimer's Disease Neuroimaging Initiative Study (E and ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3579659/?lang=en-ca
*  Fruit flies 'push the limit' to help us understand age-related disease susceptibilities | EurekAlert! Science News
Fruit flies 'push the limit' to help us understand age-related disease susceptibilities. Florida Atlantic University ... Fruit flies 'push the limit' to help us understand age-related disease susceptibilities ... to try and understand mechanisms of age-related disease susceptibilities and how to protect against them at the cellular level ... Fruit Flies 'Push the Limit' to Help Us Understand Disease Suseptibilities (IMAGE) view more ...
https://www.eurekalert.org/pub_releases/2015-06/fau-ff061515.php
*  Why Sex Matters: How the X-chromosome influences disease susceptibility Tickets, Wed, Oct 18, 2017 at 6:00 PM | Eventbrite
How the X-chromosome influences disease susceptibility - Wednesday, October 18, 2017 at Landmark Americana Tap & Grill, ... Why Sex Matters: How the X-chromosome influences disease susceptibility. by Science on the Hill ... Why Sex Matters: How the X-chromosome influences disease susceptibility at Landmark Americana Tap & Grill 2481 North 54th ... providing insight into the mechanisms behind sex-biased diseases. Ladies and gents are all welcome to join us for the free ...
https://www.eventbrite.com/e/why-sex-matters-how-the-x-chromosome-influences-disease-susceptibility-tickets-38555667038
*  Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility | SpringerLink
... on the basis of HLA-conferred disease susceptibility. We monitored 74 ... Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility. ... on the basis of HLA-conferred disease susceptibility. ... distinct genetic variants in type 1 diabetes and celiac disease ... Smyth DJ, Cooper JD, Howson JM et al (2011) FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to ...
https://link.springer.com/article/10.1007/s00125-017-4258-7
*  The role of MAPT sequence variation in mechanisms of disease susceptibility | Biochemical Society Transactions
The role of MAPT sequence variation in mechanisms of disease susceptibility. Tara M. Caffrey, Richard Wade-Martins ... The role of MAPT sequence variation in mechanisms of disease susceptibility Message Subject (Your Name) has forwarded a page to ... genetic variation at a gene locus affects gene expression and leads to susceptibility to disease is a high priority in disease ... genetic models are required to understand the role of MAPT sequence variation in mechanisms of disease susceptibility. ...
http://www.biochemsoctrans.org/content/40/4/687
*  Predictive Characteristics of Diabetes-Associated Autoantibodies Among Children With HLA-Conferred Disease Susceptibility in...
Predictive Characteristics of Diabetes-Associated Autoantibodies Among Children With HLA-Conferred Disease Susceptibility in ... Predictive Characteristics of Diabetes-Associated Autoantibodies Among Children With HLA-Conferred Disease Susceptibility in ... Predictive Characteristics of Diabetes-Associated Autoantibodies Among Children With HLA-Conferred Disease Susceptibility in ... Predictive Characteristics of Diabetes-Associated Autoantibodies Among Children With HLA-Conferred Disease Susceptibility in ...
http://diabetes.diabetesjournals.org/content/58/12/2835
*  Clinical Implication of the C Allele of the ITPKC Gene SNP rs28493229 in Kawasaki Disease: Association With Disease...
Association With Disease Susceptibility and BCG Scar Reactivation.. Lin MT1, Wang JK, Yeh JI, Sun LC, Chen PL, Wu JF, Chang CC ... gene has been linked to the susceptibility to Kawasaki disease (KD). The implication remains unclear. ... Clinical Implication of the C Allele of the ITPKC Gene SNP rs28493229 in Kawasaki Disease: ... we demonstrated that the C-allele of ITPKC SNP rs28493229 is associated with KD susceptibility and BCG scar reactivation during ...
https://www.ncbi.nlm.nih.gov/pubmed/20805785?dopt=Abstract
*  Study of Association of CD40-CD154 Gene Polymorphisms with Disease Susceptibility and Cardiovascular Risk in Spanish Rheumatoid...
... we aimed to replicate previous findings related to disease susceptibility in Spanish RA population. Furthermore, as the major ... Conclusion Data from our pilot study indicate a potential association of rs1883832 CD40 gene polymorphism with susceptibility ... complication in RA disease patients is the development of CV events due to accelerated atherosclerosis, and elevated levels of ... is a chronic inflammatory disease associated with increased cardiovascular (CV) mortality. Since CD40-CD154 binding has direct ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049214
*  Misdiagnosis of Coronary heart disease, susceptibility to, 2 - RightDiagnosis.com
... susceptibility to, 2 including hidden diseases, diagnosis mistakes, alternative diagnoses, differential diagnoses, and ... Next: Videos for Coronary heart disease, susceptibility to, 2 Diseases » Coronary heart disease, susceptibility to, 2 » ... Home Diagnostic Testing for Coronary heart disease, susceptibility to, 2. *Signs of Coronary heart disease, susceptibility to, ... Thyroid Disease -- Rare Types *more ...» *Senior Health: rare types of diseases: *Alzheimer Disease -- Rare Types *Diabetes -- ...
https://www.rightdiagnosis.com/c/coronary_heart_disease_susceptibility_to_2/misdiag.htm
*  Genetic Polymorphisms in the Growth Hormone Receptor: Impact on Growth Response and Disease Susceptibility | BenthamScience
Genetic Polymorphisms in the Growth Hormone Receptor: Impact on Growth Response and Disease Susceptibility. Author(s): K. Ihara ... Title: Genetic Polymorphisms in the Growth Hormone Receptor: Impact on Growth Response and Disease Susceptibility ... and synthesis of the emerging findings on the GHR polymorphisms in relation to GH responsiveness or disease susceptibilities, ... and synthesis of the emerging findings on the GHR polymorphisms in relation to GH responsiveness or disease susceptibilities, ...
http://www.eurekaselect.com/95166
*  Dietary Administration of Banana (Musa acuminata) Peel Flour Affects the Growth, Antioxidant Status, Cytokine Responses, and...
... and Disease Susceptibility of Rohu, Labeo rohita. Sib Sankar Giri,1 Jin Woo Jun,1 Venkatachalam Sukumaran,2 and Se Chang Park1 ... B. Austin and D. A. Austin, Bacterial Fish Pathogens: Diseases of Farmed and Wild Fish, Springer-Praxis, Chichester, UK, 4th ... W.-Q. Cai, S.-F. Li, and J.-Y. Ma, "Diseases resistance of Nile tilapia (Oreochromis niloticus), blue tilapia (Oreochromis ... B. A. Freeman and J. D. Crapo, "Biology of disease: free radicals and tissue injury," Laboratory Investigation, vol. 47, no. 5 ...
https://www.hindawi.com/journals/jir/2016/4086591/ref/