... *Formula: C11H18N2O2 ...https://webbook.nist.gov/cgi/inchi/InChI%3D1S/C11H18N2O2/c1-3-7
Patent US6071497 - Microparticles for lung delivery comprising diketopiperazine - Google Patents
In a preferred embodiment, the drug delivery system is based on the formation of diketopiperazine microparticles which are ... The monoprotected diketopiperazine is reacted to produce a diketopiperazine with one sidechain and protecting group. Removal of ... Catalysis of diketopiperazine synthesis. US8778403. Sep 3, 2013. Jul 15, 2014. Mannkind Corporation. Diketopiperazine ... Synthesis of Symmetrical Diketopiperazine Derivatives. The diketopiperazine derivatives are symmetrical when both side chains ...http://www.google.com/patents/US6071497?dq=4,923,986
Useful Chemistry: Diketopiperazine in pocket
Diketopiperazine in pocket Just got this image from Keith Davies of Find-A-Drug of one of the potential anti-malarial ... diketopiperazines we are trying to make sitting in a pocket of enoyl reductase. With both phenolic groups binding, it is clear ...http://usefulchem.blogspot.com/2006/04/diketopiperazine-in-pocket.html
Diketopiperazine - Wikipedia
2,5-Diketopiperazines are cyclodipeptides often obtainable via condensation of two α-amino acids. 2,6-Diketopiperazines may be ... A diketopiperazine (DKP), also known as a dioxopiperazine or piperazinedione, is a class of organic molecules in which the two ... Of these three isomeric diketopiperazines, the 2,5-derivatives have attracted the greatest interest. DPKs can be visualized as ... The 2,3-diketopiperazines may be viewed as oxamides obtained from ethylenediamine. ...https://en.wikipedia.org/wiki/Diketopiperazine
Synthesis of monoalkylidene diketopiperazines and application to the synthesis of barettin - Organic & Biomolecular Chemistry ...
The synthesis starts with the diketopiperazine nucleus intact and the side chains are installed using iterative aldol ... Synthesis of monoalkylidene diketopiperazines and application to the synthesis of barettin E. W. Kelley, S. G. Norman and J. R ... The route represents a general strategy for synthesis of a wide array of mono-alkylidene diketopiperazine structures, including ... The synthesis starts with the diketopiperazine nucleus intact and the side chains are installed using iterative aldol ...https://pubs.rsc.org/en/Content/ArticleLanding/2017/OB/C7OB02297B
2,5-Diketopiperazine - Wikipedia
The diketopiperazine skeleton protects both the N and O termini of the glycine. For this application, the diketopiperazine is O ... The most studied of all the simple 2,5-diketopiperazines is the histidyl-proline 2,5-diketopiperazine cyclo(L-His-L-Pro) which ... 2,5-Diketopiperazines (2,5-DKPs) which include mono- and disubstituted 2,5-diketopiperazines, their annulated, spiro-annulated ... Formation of the 2,5-diketopiperazine ring by enolate acylation was used in the construction of the 2,5-diketopiperazine ring ...https://en.wikipedia.org/wiki/2,5-Diketopiperazine
Separation of Cyclic Dipeptides (Diketopiperazines) from Their Corresponding Linear Dipeptides by RP-HPLC and Method Validation
Diketopiperazines (DKPs) are the smallest possible cyclic peptides composed of two -amino acids. They are abundant natural ... A. Lin, Y. Fang, T. Zhu, Q. Gu, and W. Zhu, "A new diketopiperazine alkaloid isolated from an algicolous Aspergillus flavus ... K. Saito, M. Horie, Y. Hoshino, N. Nose, H. Nakazawa, and M. Fujita, "Determination of diketopiperazine in soft drinks by high ... F. Fdhila, V. Vázquez, J. L. Sánchez, and R. Riguera, "DD-Diketopiperazines: antibiotics active against Vibrio anguillarum ...https://www.hindawi.com/journals/cri/2013/310269/
Marine Drugs | Free Full-Text | Diketopiperazine Derivatives from the Marine-Derived Actinomycete Streptomyces sp. FXJ7.328
Five new diketopiperazine derivatives, (3Z,6E)-1-N-methyl-3-benzy lidene-6-(2S-methyl-3-hydroxypropylidene)piperazine-2,5-dione ... Keywords: Streptomyces; diketopiperazine derivatives; antivirus activity; H1N1 Streptomyces; diketopiperazine derivatives; ... Five new diketopiperazine derivatives, (3Z,6E)-1-N-methyl-3-benzy lidene-6-(2S-methyl-3-hydroxypropylidene)piperazine-2,5-dione ... Diketopiperazine Derivatives from the Marine-Derived Actinomycete Streptomyces sp. FXJ7.328. Pei Wang 1. ...http://www.mdpi.com/1660-3397/11/4/1035
Synthesis of Diketopiperazine Based Bioactive Compounds via Palladium Catalyzed Cascade Alkynylation Reactions | Projects | FP7...
Thus, we propose the synthesis of a series of diketopiperazine derivatives, based on the structure of known diketopiperazine ... Synthesis of Diketopiperazine Based Bioactive Compounds via Palladium Catalyzed Cascade Alkynylation Reactions. From 2013-04-01 ... Synthesis of Diketopiperazine Based Bioactive Compounds via Palladium Catalyzed Cascade Alkynylation Reactions ... Final Report Summary - CASDKP (Synthesis of Diketopiperazine Based Bioactive Compounds via Palladium Catalyzed Cascade ...https://cordis.europa.eu/project/rcn/107177_en.html
Sequential Ugi reaction/base-induced ring closing/IAAC protocol toward triazolobenzodiazepine-fused diketopiperazines and...
Sequential Ugi reaction/base-induced ring closing/IAAC protocol toward triazolobenzodiazepine-fused diketopiperazines and ... Sequential Ugi reaction/base-induced ring closing/IAAC protocol toward triazolobenzodiazepine-fused diketopiperazines and ... diketopiperazine-fused triazolobenzodiazepines 7 and hydantoin-fused triazolobenzodiazepines 10, and X-ray crystal structure ...https://www.beilstein-journals.org/bjoc/articles/14/49/downloads
Marine Drugs | Free Full-Text | A New Diketopiperazine, Cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian...
Demospongiae), a new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine) (1), was isolated together with the known ... The isolation and structure elucidation of the diketopiperazine (1), together with the activity of 1-8 against a panel of human ...http://www.mdpi.com/1660-3397/9/11/2469/notes
US Patent # 9,968,125. Nicotine--diketopiperazine microparticle formulations and methods of making the same - Patents.com
... in particular fumaryl diketopiperazine (FDKP). The invention relates to the various t ... This invention relates to nicotine microparticles formulations made with the help of a diketopiperazine compound, ... 1. A particulate formulation comprising nicotine and a diketopiperazine, wherein the diketopiperazine is fumaryl ... Nicotine--diketopiperazine microparticle formulations and methods of making the same Abstract. This invention relates to ...http://patents.com/us-9968125.html
Indian Patents. 242919:'A SUBSTITUTED DIKETOPIPERAZINE COMPOUND OF FORMULA (1)'
SUBSTITUTED DIKETOPIPERAZINES AND THEIR USE AS OXYTOCYN ANTAGONISTS. This invention relates to novel diketopiperazine ... A SUBSTITUTED DIKETOPIPERAZINE COMPOUND OF FORMULA (1)'. Abstract. The present invention relates to a substituted ... 1. A substituted diketopiperazine compound of formula (1):. (Formula Removed). wherein R1 is 2-indanyl, R2 is 1-methylpropyl, ... International patent application PCT/EP02/14823 describes a class of diketopiperazine derivatives which exhibit a particularly ...http://www.allindianpatents.com/patents/242919-a-substituted-diketopiperazine-compound-of-formula-1
CH O Hydrogen Bonds in Clicked Diketopiperazine-Based Amide Rotaxanes • Sonderforschungsbereich 765
CH···O Hydrogen Bonds in Clicked Diketopiperazine-Based Amide Rotaxanes. E.V. Dzyuba, L. Kaufmann, N.L. Löw, A.K. Meyer, H.D.F ... Two amide rotaxanes were synthesized in high yields using a novel N,N′-dipropargyl diketopiperazine axle centerpiece as the ...http://www.sfb765.de/publikationen/a01013/index.html
Formation of N-Protected bis-3,6-(4-aminoalkyl)-2,5,diketopiperazine - Patent application
5-diketopiperazine. An example of a method for the synthesis of 3,6-bis-4-(N-trifluoroacetyl)aminobutyl-2,5-diketopiperazine ... 5-diketopiperazines that provides the N-protected diketopiperazines in good yield while preserving the protecting groups and ... 1 is a scheme showing the cyclocondensation of an N-protected amino acid into a diketopiperazine.  FIG. 2 is a scheme ... TABLE-US-00001 TABLE 1 Catalysts for diketopiperazine synthesis. Catalyst Amount Reaction yield P2O5 0.76 g (0.15 eq.) 55% P2O5 ...http://www.patentsencyclopedia.com/app/20130012710
Econazole nitrate Assay Standard- CAS Number 24169-02-6
Enalapril diketopiperazine. 20 mg. BP 743. Add to basket Enalapril maleate. 100 mg. BP 741. Add to basket ...https://www.lgcstandards.com/DE/en/Econazole-nitrate-Assay-Standard/p/BP%20139
Lidocaine (Lignocaine) hydrochloride- CAS Number 6108-05-0
Lisinopril diketopiperazine. 25 mg. BP 696. Add to basket Lithium lactate Assay Standard. 100 mg. BP 433. Add to basket ...https://www.lgcstandards.com/IT/en/Lidocaine-Lignocaine-hydrochloride/p/BP%20214
Development and evaluatio… - Göteborgs universitet
2,5-diketopiperazine, antifungal agents, antimicrobial, Candida krusei, MRSA, structure-activity, blood-stream infections, ... In this study, a series of novel 2,5-diketopiperazines were designed, synthesized, and evaluated for their antimicrobial ... Development and evaluation of cationic amphiphilic antimicrobial 2,5-diketopiperazines. Artikel i vetenskaplig tidskrift ...https://www.gu.se/forskning/publikation/?languageId=100000&disableRedirect=true&returnUrl=http%3A%2F%2Fwww.gu.se%2Fenglish%2Fresearch%2Fpublication%2F%3FpublicationId%3D271952&publicationId=271952
The Chemistry of Mycotoxins | SpringerLink
Thio)diketopiperazines Stefan Bräse, Franziska Gläser, Carsten S. Kramer, Stephanie Lindner, Anna M. Linsenmeier, Kye-Simeon ... diketopiperazines) activity. Nowadays, many laboratories around the world are specialized in the detection of mycotoxins in ... diketopiperazines). The biology of mycotoxins is also described. ...https://link.springer.com/book/10.1007/978-3-7091-1312-7
Assessment of Docetaxel + Plinabulin Compared to Docetaxel + Placebo in Patients With Advanced NSCLC With at Least One...
Diketopiperazines. Antineoplastic Agents. Tubulin Modulators. Antimitotic Agents. Mitosis Modulators. Molecular Mechanisms of ...https://clinicaltrials.gov/ct2/show/NCT02504489
Aspartame | European Food Safety Authority
Is Di-ketopiperazine (DKP) from aspartame a safety concern?. Moisture, pH, temperature and storage time can all affect the ... Di-ketopiperazine' or DKP). Conversion of aspartame to DKP results in the loss of the sweet taste for which aspartame is used. ...http://www.efsa.europa.eu/en/topics/topic/aspartame
Journal of the Brazilian Chemical Society
Diketopiperazines Produced by an Aspergillus fumigatus Brazilian Strain. Niege A. J. C. Furtado; M nica T. Pupo; Ivone Carvalho ... Diketopiperazines Produced by an Aspergillus fumigatus Brazilian Strain. J. Braz. Chem. Soc. 2005;16(6b):1448-1453. ...http://jbcs.sbq.org.br/default.asp?ed=87
Journal of the Brazilian Chemical Society
Antibacterial Modified Diketopiperazines from two Ascidians of the Genus Didemnum. Miriam H. Kossuga; Simone P. Lira; Shayna ... Antibacterial Modified Diketopiperazines from two Ascidians of the Genus Didemnum. J. Braz. Chem. Soc. 2009;20(4):704-711. ...http://jbcs.sbq.org.br/default.asp?ed=49
cyclic peptide; Glycine, N-glycyl-, cyclic peptide; Glycylglycine lactam; 2,5-Diketopiperazine; 2,5-Dioxopiperazine; Piperazine ...https://webbook.nist.gov/cgi/inchi/InChI%3D1S/C4H6N2O2/c7-3-1-5-4