RCSB PDB - 2E73: Solution structure of the phorbol esters/diacylglycerol binding domain of protein kinase C gamma
Solution structure of the phorbol esters/diacylglycerol binding domain of protein kinase C gamma ... Solution structure of the phorbol esters/diacylglycerol binding domain of protein kinase C gamma. Tanabe, W., Suzuki, S., Muto ... Solution structure of the phorbol esters/diacylglycerol binding domain of protein kinase C gamma. *PDB DOI: https://doi.org/ ...
Dual phospholipase C/diacylglycerol requirement for protein kinase D1 activation in lymphocytes.
Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons - France Génomique
Signaling Pathways Activated by B-Cell Receptor in CLL
BCR: B-cell receptor; BLNK: B-cell linker protein; BTK: Brutons tyrosine kinase; DAG: Diacylglycerol; GSK: Glycogen synthase ... BCR: B-cell receptor; BLNK: B-cell linker protein; BTK: Brutons tyrosine kinase; DAG: Diacylglycerol; GSK: Glycogen synthase ... The phosphorylated ITAMs recruit the spleen tyrosine kinase (SYK) to the receptor, where it becomes activated by ... phosphorylation of tyrosines in its kinase domain, and propagates the signal activation to downstream signaling proteins.[10] ...
PA-03-112: DEVELOPMENT AND APPLICATION OF PET AND SPECT LIGANDS FOR BRAIN IMAGING STUDIES (PHASED INNOVATION AWARD)
o Intracellular targets: abnormal protein aggregates including amyloid or tau deposition; diacylglycerol; gene expression ... protein kinases; stem cells. The following objectives would make appropriate topics for proposed R21/R33 projects. This list is ... and disease related proteins) that are of broad interest to the scientific community. The widespread availability and use of ... disease-related proteins) that are of broad interest to the neuroscience research community, and 2) new technologies for ...
Bisphenol A Exposure and Cardiac Electrical Conduction in Excised Rat Hearts | Environmental Health Perspectives | Vol. 122, No...
... phosphoinositide 3-kinase; PKA, protein kinase A; PKC, protein kinase C; PKG, protein kinase G; PLC, phospholipase C. BPA ... diacylglycerol; ER, estrogen receptor; K+, potassium; maxi-K+ channels, Ca2+-activated K+ channels; Na+, sodium; NO, nitric ... Abbreviations: AC, adenylate cyclase; AKT, protein kinase B; Ca2+, calcium; cAMP, cyclic adenosine monophosphate; cGMP, cyclic ...
PA-03-112: DEVELOPMENT AND APPLICATION OF PET AND SPECT LIGANDS FOR BRAIN IMAGING STUDIES (PHASED INNOVATION AWARD)
o Intracellular targets: abnormal protein aggregates including amyloid or tau deposition; diacylglycerol; gene expression ... protein kinases; stem cells. The following objectives would make appropriate topics for proposed R21/R33 projects. This list is ... and disease related proteins) that are of broad interest to the scientific community. The widespread availability and use of ... disease-related proteins) that are of broad interest to the neuroscience research community, and 2) new technologies for ...
Notch Signaling in the Astroglial Phenotype: Relevance to Glutamatergic Transmission | IntechOpen
5.Glial differentiation and the Ca2+/diacylglycerol-dependent protein kinase (PKC). *6.Another Notch in the belt: PKC/Notch ... Protein expression of the Α, Γ, Δ and Ε subspecies of protein kinase C changes as C6 Glioma cells become contact inhibited and ... 5. Glial differentiation and the Ca2+/diacylglycerol-dependent protein kinase (PKC). As already mentioned, glial ... Protein kinase Cdelta negatively regulates Notch1-dependent transcription via a kinase-independent mechanism in vitro. ...
Mezerein - Wikipedia
... which share the capacity of mimicking diacylglycerol (DAG) and thus activating different isoforms of protein kinase C. Mezerein ... Mezerein and other phorbol esters interact with protein kinase C (PKC). Protein kinase C controls the cell cycle, so chemicals ... Black A, Black J (2013). "Protein kinase C signaling and cell cycle regulation. Review". Front Immunol. 3 (423): 423. doi: ... 2004). "Reactive oxygen species amplify protein kinase C signaling in high glucose-induced fibronectin expression by human ...
Frontiers | The Succinate Receptor as a Novel Therapeutic Target for Oxidative and Metabolic Stress-Related Conditions
... is a G protein-coupled receptor that is closely related to the family of P2Y purinoreceptors. It is expressed in a variety of ... is a G protein-coupled receptor that is closely related to the family of P2Y purinoreceptors. It is expressed in a variety of ... protein kinase C; pERK1/2, phosphorylated extracellularly regulated kinase 1/2; COX, cyclo-oxogenase, eNOS, endothelial nitric ... Abbreviations: PIP2, Phosphatidylinositol 4,5-bisphosphate; PLC, phospholipase C; DAG, diacylglycerol; IP3, inositol 1,4,5- ...
PA-03-112: DEVELOPMENT AND APPLICATION OF PET AND SPECT LIGANDS FOR BRAIN IMAGING STUDIES (PHASED INNOVATION AWARD)
o Intracellular targets: abnormal protein aggregates including amyloid or tau deposition; diacylglycerol; gene expression ... protein kinases; stem cells. The following objectives would make appropriate topics for proposed R21/R33 projects. This list is ... and disease related proteins) that are of broad interest to the scientific community. The widespread availability and use of ... disease-related proteins) that are of broad interest to the neuroscience research community, and 2) new technologies for ...
Complement mutations in diacylglycerol kinase-ε-associated atypical hemolytic uremic syndrome - PubMed
... the basis of plasma infusions and complement inhibition are potentially useful in patients with combined diacylglycerol kinase- ... Data suggest that complement dysregulation influences the onset and disease severity in carriers of diacylglycerol kinase-ε ... A diagram of the diacylglycerol kinase-ε protein depicting the different protein domains is shown. Arrows identify the ... Pedigrees of patients with atypical hemolytic uremic syndrome carrying diacylglycerol kinase-ε (DGKE) mutations. For each ...
PA-06-018: Development of PET and SPECT Ligands for Brain Imaging (STTR [R41/R42])
... protein kinases; stem cells *Development of selective hormone receptor radioligands (e.g., for estrogen receptor ß, ... Intracellular targets: amyloid deposition; diacylglycerol; gene expression markers; lipid metabolism; neuroinflammatory markers ... and disease related proteins) that are of broad interest to the scientific community. These radiotracers will be used for ... and disease related proteins) that are of broad interest to the scientific community. The widespread availability and use of ...
Platelet Disorders: Overview of Platelet Disorders, Pathophysiology of Platelet Disorders, Autoimmune Thrombocytopenias
... protein kinase C; TGF = transforming growth factor; VWF= von Willebrand factor View Media Gallery ... diacylglycerol; GP = glycoprotein; IP3 = inositol trisphosphate; ITAM = immunoreceptor tyrosine-based activation motif; P2Y = ... protein kinase C; TGF = transforming growth factor; VWF= von Willebrand factor ... increased affinity for von Willebrand protein in the resting stage leads to the deletion of plasma von Willebrand protein. This ...
Platelet Disorders: Overview of Platelet Disorders, Pathophysiology of Platelet Disorders, Autoimmune Thrombocytopenias
... protein kinase C; TGF = transforming growth factor; VWF= von Willebrand factor View Media Gallery ... diacylglycerol; GP = glycoprotein; IP3 = inositol trisphosphate; ITAM = immunoreceptor tyrosine-based activation motif; P2Y = ... protein kinase C; TGF = transforming growth factor; VWF= von Willebrand factor ... increased affinity for von Willebrand protein in the resting stage leads to the deletion of plasma von Willebrand protein. This ...
Long non‑coding RNAs, lipid metabolism and cancer (Review)
i] AMPK, AMP-activated protein kinase; ATGL, adipose tissue triglyceride lipase; CCAT1, colon cancer-associated transcript 1; ... lncRNA NEAT1 maintains the high expression of ATGL and its catalytic products free FA (FFA) and diacylglycerol (DAG) and PPARα ... Long intergenic non-protein coding RNA 00514 (LINC00514) is a novel lncRNA. Overexpression of LINC00514 promotes the ... Knocking down LUCAT1 induced p53 expression at the protein level but not at the mRNA level, suggesting that LUCAT1 may affect ...
Creating new fluorescent probes for cell biology | Nature Reviews Molecular Cell Biology
Genetically-encoded reporter constructs that are derived from fluorescent proteins are leading a revolution in the real-time ... Oancea, E. & Meyer, T. Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals. Cell 95, 307- ... Cyclic AMP-dependent protein kinase binding to A-kinase anchoring proteins in living cells by fluorescence resonance energy ... Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two- ...
Structure of membrane diacylglycerol kinase in lipid bilayers - PubMed
... is a small integral membrane protein, responsible for the ATP-dependent phosphorylation of diacylglycerol to phosphatidic acid ... Membrane protein structural validation by oriented sample solid-state NMR: diacylglycerol kinase. Murray DT, Li C, Gao FP, Qin ... Diacylglycerol kinase (DgkA) is a small integral membrane protein, responsible for the ATP-dependent phosphorylation of ... Structure of membrane diacylglycerol kinase in lipid bilayers Jianping Li 1 , Yang Shen 2 , Yanke Chen 3 , Zhengfeng Zhang 1 , ...
JCI - Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration...
... phlorizin treatment did not improve insulin receptor autophosphorylation nor did the treatment lower liver diacylglycerol. We ... Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not ... Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not ... We tested the hypothesis that liver protein kinase C (PKC) is increased in non-insulin-dependent diabetes mellitus (NIDDM). To ...
Involvement of Protein Kinase C-ε in Activity-Dependent Potentiation of Large Dense-Core Vesicle Exocytosis in Chromaffin Cells...
2002) Move over protein kinase C, youve got company: alternative cellular effectors of diacylglycerol and phorbol esters. J ... such as mitogen-activated protein kinases, cyclin-dependent kinases, PKA, Rho kinase, as well as PKC (Arbuzova et al., 2002; ... 1998) Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for ... 2001) Protein kinase C isoforms as therapeutic targets in nervous system disease states. Pharmacol Res 44:353-361. ...
CDD Conserved Protein Domain Family: C1 DGKtheta typeV rpt3
Conserved Protein Domain Family C1_DGKtheta_typeV_rpt3, Diacylglycerol (DAG) kinase (EC 2 ... third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar ... proteins. Diacylglycerol (DAG) kinase (EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic ... It may regulate the activity of protein kinase C by controlling the balance between the two signaling lipids, diacylglycerol ...
IJMS | Free Full-Text | Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids
... protein kinase C; SN, substantia nigra; VGCC, voltage-gate Ca2+ channel; VTA, ventral tegmental area; ↑- activation and/or ... Abbreviations: AC, adenylyl cyclase; AD, Alzheimers disease; DAG, diacylglycerol; EPSP, excitatory postsynaptic potential; ... Alternatively, by binding to the membrane proteins and modulating the activity of these proteins they execute their non-genomic ... The ApoEε4 allele is associated with a high risk for AD as it promotes Aβ deposition and τ-protein hyperphosphorylation. ...
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Biomarkers Search
Enhanced stimulation of diacylglycerol and lipid synthesis by insulin in denervated muscle. Altered protein kinase C activity ... Effects of insulin on diacylglycerol-protein kinase C signaling in rat diaphragm and soleus muscles and relationship to glucose ... Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin- ... 9. Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3 ...
cerebellum | Journal of Neuroscience
IJMS | Free Full-Text | Resveratrol as a Multifunctional Topical Hypopigmenting Agent
Ca2+/calmodulin-dependent protein kinase; DG = diacylglycerol; ERK = extracellular signal-regulated kinase; ET = endothelin; ... The cyclic AMP-dependent protein kinase (PKA), protein kinase C (PKC), and mitogen-activated protein kinase (MAPK) signaling ... The cyclic AMP-dependent protein kinase (PKA), protein kinase C (PKC), and mitogen-activated protein kinase (MAPK) signaling ... Ca2+/calmodulin-dependent protein kinase; DG = diacylglycerol; ERK = extracellular signal-regulated kinase; ET = endothelin; ...
Cover Glass »
Overexpression of Diacylglycerol Kinase η Enhances Gαq-Coupled G Protein-Coupled Receptor Signaling April 15, 2014 ... Multiple genome-wide association studies have linked diacylglycerol kinase η(DGKη) to bipolar disorder (BPD). ... Acetate supplementation increases brain acetyl-CoA metabolism, alters histone and non-histone protein acetylation, increases ...
Minutes of the 132nd Meeting of the NATIONAL ADVISORY COUNCIL ON ALCOHOL ABUSE AND ALCOHOLISM | National Institute on Alcohol...
... transduction pathways repeatedly appear in INIA-Wests work-a novel G-protein-linked receptor and a diacylglycerol zeta kinase ... The processes and targets on which INIA-West focuses include the toll-like receptor (TLR4), proteins in the regulation of NF- ... Investigators found reduced messenger RNA for BDMF, as well as reduced protein in the PFC. Investigators injected BDNF into ... Representing a major change in the consortiums direction, investigators have identified small molecules to target proteins ...
WikiGenes - KST-1A0004 - (2S)-2,5,7,8-tetramethyl-2-[(4R,8S)-4,8,12...
Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth ... Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues. Kunisaki, M ... Because immunoblotting studies did not exhibit any difference in the protein levels of DAG kinase alpha and gamma, the effect ... In contrast, treatment with D-alpha-tocopherol and protein kinase-C beta-isoform inhibition (LY333531) prevented the increases ...