Phospholipid:diacylglycerol acyltransferase - Wikipedia
In enzymology, a phospholipid:diacylglycerol acyltransferase (EC 2.3.1.158) is an enzyme that catalyzes the chemical reaction ... diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and ... The systematic name of this enzyme class is phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase. This enzyme is also called ... An important human protein from this family is lecithin-cholesterol acyltransferase. Dahlqvist A, Stahl U, Lenman M, Banas A, ...
Characterization of type-2 diacylglycerol acyltransferases in Haematococcus lacustris reveals their functions and engineering...
Diacylglycerol acyltransferases (DGATs) catalyze the last step of acyl-CoA-dependent TAG biosynthesis... ... diacylglycerol acyltransferase and phospholipid:diacylglycerol acyltransferase from terrestrial plants and microalgae. Lipids. ... Identification and characterization of PtDGAT2B, an acyltransferase of the DGAT2 acyl-coenzyme A:diacylglycerol acyltransferase ... Diacylglycerol acyltransferases (DGATs) catalyze the final acylation of sn-1, 2-diacylglycerol (DAG) to form TAG, which is the ...
Diacylglycerol O-acyltransferase 1 (Q08650) - Yeast Metabolome Database
Diacylglycerol O-acyltransferase 1 (Q08650) - Yeast Metabolome Database
MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism
PDB 6VYI | Chain CRYO-EM STRUCTURE OF HUMAN DIACYLGLYCEROL O-ACYLTRANSFERASE 1 | 6VYI A | 3D Structure | canSARS
HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD | Journal of...
... diacylglycerol o-acyltransferase 1; FASN, fatty acid synthase; GPAM, mitochondrial glycerol-3-phosphate acyltransferase; LPIN, ... diacylglycerol o-acyltransferase 1; FAS/FASN, fatty acid synthase; FA, fatty acid; GPAM, mitochondrial glycerol-3-phosphate ... acyltransferase; GPX1, glutathione peroxidase 1; HMGCS/HMGCR, hydroxymethylglutaryl-CoA synthase/reductase; LDLR, low-density ...
A distinct DGAT with sn-3 acetyltransferase activity that synthesizes unusual, reduced-viscosity oils in Euonymus and...
... possessed acetyl-CoA diacylglycerol acetyltransferase activity but lacked long-chain acyl-CoA diacylglycerol acyltransferase ... An uncharacterized membrane-bound O-acyltransferase (MBOAT) family member was the most abundant acyltransferase in the ... Euonymus alatus diacylglycerol acetyltransferase). Yeast microsomes expressing EaDAcT ...
Polymorphisms of diacylglycerol acyltransferase 2 gene and their relationship with growth traits in goats. | Mol Biol Rep;39(2...
Polymorphisms of diacylglycerol acyltransferase 2 gene and their relationship with growth Polymorphisms of diacylglycerol ... Diacylglycerol acyltransferase (DGAT) plays a critical role in the synthesis of triacylglycerol. In this study, PCR-SSCP and ... acyltransferase 2 gene and their relationship with growth traits in goats. Fang, Xingtang; Zhang, Jingmin; Xu, Haixia; Zhang, ...
Defective in Cuticular Ridges (DCR) of Arabidopsis thaliana, a Gene Associated with Surface Cutin Formation, Encodes a Soluble...
Encodes a Soluble Diacylglycerol Acyltransferase. In: Journal of Biological Chemistry, 285 (49). pp. 38337-38347. ... Taken together, these data suggest that a broad specific DAG acyltransferase may be involved in the cutin as well as in the TAG ... A key step in the triacylglycerol (TAG) biosynthetic pathway is the final acylation of diacylglycerol (DAG) by DAG ... Overexpression of At5g23940 in a Saccharomyces cerevisiae quadruple mutant deficient in DAG acyltransferases resulted in TAG ...
Publication : USDA ARS
Title: MOLECULAR CHARACTERIZATION OF THE ACYL-COA-DEPENDENT DIACYLGLYCEROL ACYLTRANSFERASE IN PLANTS Author. He, Xiaohua ... Molecular characterization of the acyl-coa-dependent diacylglycerol acyltransferase in plants. Research Signpost: Recent ... Technical Abstract: The Acyl CoA:diacylglycerol (DGAT) is a membrane enzyme that catalyses the final step in TAG biosynthesis. ...
metabolic pathway pertinent to the brain - Ontology Report - Rat Genome Database
diacylglycerol O-acyltransferase 1. IEA. ISO. KEGG. SMPDB. SMP:00074 rno:00830. NCBI chr 7:108,223,860...108,235,413 Ensembl ... lecithin retinol acyltransferase. TAS. ISO. IEA. SMPDB. KEGG. RGD. PMID:21718801. SMP:00074 rno:00830, RGD:6484679. NCBI chr 2: ... lecithin retinol acyltransferase. ISO. RGD. PMID:20212494. RGD:8547536. NCBI chr 2:168,264,093...168,273,155 Ensembl chr 2: ... lecithin retinol acyltransferase. ISO. RGD. PMID:21621639. RGD:6484672. NCBI chr 2:168,264,093...168,273,155 Ensembl chr 2: ...
Immune cell - IFRD1 - The Human Protein Atlas
Diacylglycerol O-acyltransferase 2. 1.0000. 21. Contact *NEWS ARTICLES. *PRESS ROOM. *[email protected] ...
Decanoyl coenzyme A = 90 1264-57-9
Decanoyl coenzyme A is a substrate for acyltransferase; ... and in the human diacylglycerol acyltransferase 1 and 2 assays. ... A Novel Acyl-CoA: Diacylglycerol Acyltransferase 1 (DGAT1) inhibitor, GSK2973980A, Inhibits Postprandial Triglycerides and ... Decanoyl coenzyme A is a substrate for acyltransferase.. It is a substrate for human liver glycine-N-acylase. ... Effect of membrane environment on the activity and inhibitability by malonyl-CoA of the carnitine acyltransferase of hepatic ...
Hypertriglyceridemia Medication: Fibric Acid Agents, Omega-3 Acids, Lipid-Lowering Agents, Other, Lipid-Lowering Agents, Statins
Omega 3 acids are thought to inhibit acyl CoA:1,2-diacylglycerol acyltransferase. Increased mitochondrial and peroxisomal beta- ... Potential mechanisms of action include acyl CoA:1,2-diacylglycerol acyltransferase inhibition, increased hepatic mitochondrial ... 2-diacylglycerol acyltransferase (DGAT), decreases lipogenesis in liver, and increases plasma lipoprotein lipase activity. ...
Frontiers | Qushi Huayu decoction ameliorates non-alcoholic fatty liver disease in rats by modulating gut microbiota and serum...
Lipid subclasses, including diacylglycerol (DG), triglycerides (TG), phosphatidylethanolamine (PE), phosphatidylcholine (PC), ... Lipid subclasses, including diacylglycerol (DG), triglycerides (TG), phosphatidylethanolamine (PE), phosphatidylcholine (PC), ... Diacylglycerol acyltransferase catalyzes DG acylation, the last step in TG synthesis. The newly synthesized TG can be directed ... PA can be converted into cytidine diphosphate-diacylglycerol, a substrate for the synthesis of PI, PG, and cardiolipins, or can ...
Browse ORF cDNA clones by species Cryptosporidium muris RN66, letter c, page 1
Human Metabolome Database: HMDB0294604 (DG(20:3(6,8,11)-OH(5)/0:0/10:0)) Protein Associations
Diacylglycerol O-acyltransferase 1. O75907 DGAT1. 8q24.3. Enzyme. Not Available. HMDBP00244. 1-phosphatidylinositol 4,5- ... Diacylglycerol kinase alpha. P23743 DGKA. 12q13.3. Unknown. Not Available. HMDBP00234. Diacylglycerol kinase delta. Q16760 DGKD ... Diacylglycerol kinase iota. O75912 DGKI. 7q32.3-q33. Unknown. Not Available. HMDBP00241. Bile salt-activated lipase. P19835 CEL ... Diacylglycerol kinase beta. Q9Y6T7 DGKB. 7p21.2. Unknown. Not Available. HMDBP00239. Endothelial lipase. Q9Y5X9 LIPG. 18q21.1. ...
T 1589/10 (Improved milk production/GEORGES) 18-09-2015 | Epo.org
BindingDB PrimarySearch ki
Assessing Sub-saharian Erythrina for Efficacy: Traditional uses, Biological Activities and Phytochemistry
Amidepsine A - ALX-380-262 - Enzo Life Sciences
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and ... Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of ... Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC50=10.2µM) and Raji ...
JCI - Cannabinoid receptor 1 signaling in hepatocytes and stellate cells does not contribute to NAFLD
Hepatocyte deletion of triglyceride-synthesis enzyme acyl CoA: diacylglycerol acyltransferase 2 reduces steatosis without ... or diacylglycerol acyltransferase 2 (the enzyme that catalyzes the final step in TG synthesis), markedly reduces hepatic ... Lecithin retinol acyltransferase (Lrat) was highly expressed in quiescent HSCs, whereas Col1a1 enrichment represented a more ...
DGAT | DGAT pathway | DGAT inhibitors
AZD3988 is a diacylglycerol acyl transferase-1 (DGAT-1) inhibitor with IC50s of 6, 5, 11 nM for human, rat, mouse, respectively ... A 922500 is a diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50 values are 7 and 24 nM at human and mouse DGAT-1 ... GSK2973980A is a potent and selective Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC50 of 3 nM. ... T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with ...
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WikiGenes - Expressed Sequence Tags
Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity
2001Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family membersJ Biol Chem. 276:38870-38876 ... 2002Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1J Clin Invest. 109:1049- ... 1998Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesisProc ... B) Diacylglycerol and mono alkyl-diacylglycerol were decreased in iWAT of ADGAT DKO mice (n=6). ...
Lovaza (omega 3 fatty acids) dosing, indications, interactions, adverse effects, and more
Possibly inhibits acyl CoA: 1,2-diacylglycerol acyltransferase, increases peroxisomal beta-oxidation in liver; may decrease ...
BNL | Staff | Changcheng Xu, Biology Department
Fan J, Yan C, Zhang X, Xu C (2013) Dual Role for Phospholipid:Diacylglycerol Acyltransferase: Enhancing Fatty Acid Synthesis ... Fan J, Yan C, Xu C (2013) Phospholipid:diacylglycerol acyltransferase-mediated triacylglycerol biosynthesis is crucial for ... Fan J, Yan C, Roston R, Shanklin J, Xu C (2014) Arabidopsis Lipins, PDAT1 Acyltransferase, and SDP1 Triacylglycerol Lipase ...
Cell Signaling & Oncology - Research Areas - Products