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*  Depsipeptide in Treating Patients With Solid Tumors - Full Text View - ClinicalTrials.gov
Depsipeptide in Treating Patients With Solid Tumors. The safety and scientific validity of this study is the responsibility of ... Patients receive depsipeptide IV over 4 hours on days 1 and 5. Treatment continues every 21 days in the absences of disease ... Phase I Trial of a Four Hour Infusion of Depsipeptide (NSC630176) Given on Days 1 and 5 of a 21 Day Cycle in Patients With ... PURPOSE: Phase I trial to study the effectiveness of depsipeptide in treating patients who have solid tumors for which no ...
https://clinicaltrials.gov/ct2/show/NCT00019318
*  Depsipeptide - Wikipedia
A depsipeptide is a peptide in which one or more of its amide, -C(O)NHR-, groups are replaced by the corresponding ester, -C(O) ... Depsipeptides have also been used in research to probe the importance of hydrogen bond networks in protein folding kinetics and ... Mirabamides A-D. Depsipeptides from the sponge Siliquariaspongia mirabilis that inhibit HIV-1 fusion. J. Nat. Prod. 2007;70(11 ... Several depsipeptides natural products from Streptomyces have been studied for their antimicrobial activity. These form a new, ...
https://en.wikipedia.org/wiki/Depsipeptide
*  Aspergillicins A-E: five novel depsipeptides from the marine-derived fungus Aspergillus carneus - Organic & Biomolecular...
This study also yielded a series of new depsipeptides, aspergillic ... Aspergillicins A-E: five novel depsipeptides from the marine-derived fungus Aspergillus carneus R. J. Capon, C. Skene, M. ... This study also yielded a series of new depsipeptides, aspergillicins A-E (2-6) and the known terrestrial fungal metabolite ... Aspergillicins A-E: five novel depsipeptides from the marine-derived fungus Aspergillus carneus ...
http://pubs.rsc.org/en/Content/ArticleLanding/2003/OB/B302306K
*  Influence of surfactants on depsipeptide submicron particle formation
Surfactants are required for the formation and stabilization of hydrophobic polymeric particles in aqueous environment. In order to form submicron particles of varying sizes from oligo[3-(S)-sec-butylmorpholine-2,5-dione]diols ((OBMD)-diol), different surfactants were investigated. As new surfactants, four-armed star-shaped oligo(ethylene glycol)s of molecular weights of 5-20 kDa functionalized with desamino-tyrosine (sOEG-DAT) resulted in smaller particles with lower PDI than with desaminotyrosyl tyrosine (sOEG-DATT) in an emulsion/solvent evaporation method. In a second set of experiments, sOEG-DAT of Mn = 10 kDa was compared with the commonly employed emulsifiers polyvinylalcohol (PVA), polyoxyethylene (20) sorbitan monolaurate (Tween 20), and D-α-tocopherol polyethylene glycol succinate (VIT E-TPGS) for OBMD particle preparation. sOEG-DAT allowed to systematically change sizes in a range of 300 up to 900 nm with narrow polydispersity, while in the other cases, a lower size range (250-400 ...
https://insights.ovid.com/ejopab/201707000/00009275-201707000-00008
*  Marine Drugs | Free Full-Text | Biochemical Studies of the Lagunamides, Potent Cytotoxic Cyclic Depsipeptides from the Marine...
... are potent cytotoxic cyclic depsipeptides isolated from the filamentous marine cyanobacterium, Lyngbya majuscula, from Pulau ...
http://www.mdpi.com/1660-3397/10/5/1126/notes
*  Marine Drugs | Free Full-Text | Inhibition of Virulence Gene Expression in Staphylococcus aureus by Novel Depsipeptides from a...
Inhibition of Virulence Gene Expression in Staphylococcus aureus by Novel Depsipeptides from a Marine Photobacterium. Maria ... Inhibition of Virulence Gene Expression in Staphylococcus aureus by Novel Depsipeptides from a Marine Photobacterium. Marine ... "Inhibition of Virulence Gene Expression in Staphylococcus aureus by Novel Depsipeptides from a Marine Photobacterium." Mar. ... Inhibition of Virulence Gene Expression in Staphylococcus aureus by Novel Depsipeptides from a Marine Photobacterium. Mar. ...
http://www.mdpi.com/1660-3397/9/12/2537/xml
*  Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma - Full Text View -...
Experimental: Treatment (single-agent depsipeptide) Patients receive depsipeptide (romidepsin) intravenously (IV) over 4 hours ... Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma. This study has been ... Patients receive depsipeptide (romidepsin) intravenously (IV) over 4 hours on days 1, 8, and 15. Courses repeat every 28 days ... Drugs used in chemotherapy, such as depsipeptide, work in different ways to stop the growth of tumor cells, either by killing ...
https://clinicaltrials.gov/ct2/show/NCT00112463?cond=%22Epithelioid+sarcoma%22&rank=6
*  A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates. - PubMed - NCBI
A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates.. Taliani M1, ... We have used the same principle to synthesize internally quenched depsipeptide fluorogenic substrates based on resonance energy ... To overcome these difficulties, we have recently developed depsipeptide substrates incorporating an ester bond between residues ...
https://www.ncbi.nlm.nih.gov/pubmed/8811880?dopt=Abstract
*  Impact of Core-Forming Segment Structure on Drug Loading in Biodegradable Polymeric Micelles Using PEG-b-Poly(lactide-co...
Y. Ohya, H. Matsunami, E. Yamabe, and T. Ouchi, "Cell attachment and growth on films prepared from poly(depsipeptide-co-lactide ... T. Ouchi, T. Nozaki, A. Ishikawa, I. Fujimoto, and Y. Ohya, "Synthesis and enzymatic hydrolysis of lactic acid-depsipeptide ... co-depsipeptide) Block Copolymers. Akihiro Takahashi,1 Yuta Ozaki,2 Akinori Kuzuya,1,2 and Yuichi Ohya1,2 ...
https://www.hindawi.com/journals/bmri/2014/579212/ref/
*  Synthesis, 68Ga-Radiolabeling, and Preliminary In Vivo Assessment of a Depsipeptide-Derived Compound as a Potential PET/CT...
J. S. Davies, "The cyclization of peptides and depsipeptides," Journal of Peptide Science, vol. 9, no. 8, pp. 471-501, 2003. ... Synthesis, 68Ga-Radiolabeling, and Preliminary In Vivo Assessment of a Depsipeptide-Derived Compound as a Potential PET/CT ... conformational and membrane ion transport studies of proline-adamantane hybrid cyclic depsipeptides," Biopolymers, vol. 89, no ...
https://www.hindawi.com/journals/bmri/2015/284354/ref/
*  Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide...
Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide ... Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide ... Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide ... Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide ...
https://jb.asm.org/content/175/1/117?ijkey=30074f619b9c2b6f811091d913c3a52ce3b5adc4&keytype2=tf_ipsecsha
*  A macrolactonization approach to the total synthesis of the antimicrobial cyclic depsipeptide LI-F04a and diastereoisomeric...
A macrolactonization approach to the total synthesis of the antimicrobial cyclic depsipeptide LI-F04a and diastereoisomeric ... A macrolactonization approach to the total synthesis of the antimicrobial cyclic depsipeptide LI-F04a and diastereoisomeric ... The LI-F or fusaricidin class of cyclic depsipeptides are produced by a number of strains of Bacillus (Paenebacillus) and ... There has been recent interest in the synthesis of the LI-F family of cyclic depsipeptides due to their antifungal activity. ...
https://www.beilstein-journals.org/bjoc/articles/8/154
*  Plus it
Efflux of Depsipeptide FK228 (FR091228, NSC-630176) is Mediated by Both P-glycoprotein and MRP1. Jim J. Xiao, Amy B. Foraker, ... Efflux of Depsipeptide FK228 (FR091228, NSC-630176) is Mediated by Both P-glycoprotein and MRP1. Jim J. Xiao, Amy B. Foraker, ... Efflux of Depsipeptide FK228 (FR091228, NSC-630176) is Mediated by Both P-glycoprotein and MRP1. Jim J. Xiao, Amy B. Foraker, ... Efflux of Depsipeptide FK228 (FR091228, NSC-630176) is Mediated by Both P-glycoprotein and MRP1 ...
http://jpet.aspetjournals.org/content/early/2005/01/05/jpet.104.072033
*  US Patent # 5,663,140. Use of cyclic depsipeptides having 12 ring atoms for combating endoparasites, new cyclic...
The present invention relates to the use of cyclic depsipeptides having 12 ring atoms of the general formula (I) ##STR1## in ... to new cyclic depsipeptides having 12 ring atoms, and to processes for their preparation. Certain cyclic depsipeptides having ... A cyclic depsipeptide of the formula (I): ##STR82## in which R.sup.1 represents hydrogen or represents C.sub.1-9 -alkyl, C.sub. ... 2. New cyclic depsipeptides having 12 ring atoms of the formula (I) ##STR3## in which R.sup.1 represents hydrogen, C.sub.1-9 - ...
http://patents.com/us-5663140.html
*  Biochemical studies of the lagunamides, potent cytotoxic cyclic depsipeptides from the marine cyanobacterium Lyngbya majuscula ...
Lagunamides A (1) and B (2) are potent cytotoxic cyclic depsipeptides isolated from the filamentous marine cyanobacterium, ... Biochemical studies of the lagunamides, potent cytotoxic cyclic depsipeptides from the marine cyanobacterium Lyngbya majuscula ... potent cytotoxic cyclic depsipeptides from the marine cyanobacterium Lyngbya majuscula. Marine Drugs 10 (5) : 1126-1137. ...
https://scholarbank.nus.edu.sg/handle/10635/63533
*  Enniatin synthetase, a novel type of multifunctional enzyme catalyzing depsipeptide synthesis in Fusarium oxysporum. -...
A linear dependence of rate of enniatin synthesis on enzyme concentration was observed, indicating that depsipeptide formation ... Enniatin synthetase, a novel type of multifunctional enzyme catalyzing depsipeptide synthesis in Fusarium oxysporum.. ... Enniatin synthetase, a multifunctional enzyme catalyzing depsipeptide formation in Fusarium oxysporum was purified to 98% ...
https://www.scienceopen.com/document?vid=4c3db99c-931a-48cf-8ecd-18bfb3095762
*  Low Dose Histone Deacetylase Inhibitor, Depsipeptide FR901228, Promotes Adenoviral Transduction in Human Rhabdomyosarcoma Cell...
Depsipeptide FR901228, Promotes Adenoviral Transduction in Human Rhabdomyosarcoma Cell Lines. . Biblioteca virtual para leer y ... Depsipeptide FR901228 can be used as a vehicle to enhance adenoviral transduction in a majority of RMScells. The mechanism of ... Pretreatment of five of six RMS cell lines with 0.5 ng-ml of depsipeptide FR901228 for 72 h resulted in increasedviral uptake ... Changes in CAR and αv integrin expression RMS in response topretreatment with depsipeptide FR901128 was determined using RT-PCR ...
http://libros.duhnnae.com/2017/jul7/150087609943-Low-Dose-Histone-Deacetylase-Inhibitor-Depsipeptide-FR901228-Promotes-Adenoviral-Transduction-in-Human-Rhabdomyosarcoma-Cell-Lines.php
*  Surveying the sequence diversity of model prebiotic peptides by mass spectrometry | PNAS
... and L depsipeptides, and (F) d, G, A, and L depsipeptides. As shown in the yellow region, many new glycolic acid depsipeptides ... L depsipeptide compositions detected, and (C) d+G+A+L depsipeptide compositions detected. Depsipeptides containing glycolic- ... Three-dimensional maps (m/z, Rt, dt) of confirmed depsipeptide compositions are shown in Fig. 2 A-C. All depsipeptides ... Malic-acid depsipeptides contained more leucine than glycine or alanine after one cycle, and very few malic-acid depsipeptides ...
http://www.pnas.org/content/114/37/E7652
*  Current Protein & Peptide Science, Volume 18 - Number 5
Chemical Classification of Cyclic Depsipeptides. , 18(5): 425 - 452. Lien Taevernier, Evelien Wynendaele, Bert Gevaert and Bart ...
https://benthamscience.com/journals/current-protein-and-peptide-science/volume/18/issue/5/
*  Ghent University Academic Bibliography
Chemical classification of cyclic depsipeptides Lien Taevernier (UGent) , Evelien Wynendaele (UGent) , Bert Gevaert (UGent) and ...
https://biblio.ugent.be/publication?q=keyword+exact+%22CONFORMATIONAL-ANALYSIS%22
*  Published Research | Page 9 | BIO5
Fungal Cyclooligomer Depsipeptides: From Classical Biochemistry To Combinatorial Biosynthesis.. This review surveys the ... Fungal cyclooligomer depsipeptides such as beauvericin, bassianolide, and enniatins display antibiotic, antifungal, ... Precursor-directed biosynthesis was used to produce analogues of the cyclic depsipeptide mycotoxin beauvericin (1) using the ... Biosynthesis Of The Cyclooligomer Depsipeptide Beauvericin, A Virulence Factor Of The Entomopathogenic Fungus Beauveria ...
http://www.bio5.org/research/published-research?page=8
*  Ghent University Library Search Results
Adsorption of cyclic depsipeptide mycotoxins to glass Lien Taevernier, Stijn Vansteelandt, Bart De Spiegeleer Published in 2014 ...
https://lib.ugent.be/en/catalog?q=%22Bart+De+Spiegeleer%22&search_field=author&sort=title
*  Inhibitors of protein translocation across membranes of the secretory pathway: novel antimicrobial and anticancer agents |...
They are also produced by a non-ribosomal peptide synthetase [43]. The cyclic depsipeptide apratoxin A (Fig. 2) was discovered ...
https://link.springer.com/article/10.1007/s00018-017-2743-2
*  Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula.
... bis-thiazoline-containing cyclic depsipeptides with a rare β-amino acid, extensive N-methylation, and a large number of d-amino ... Next Document: Cyclic depsipeptides, grassypeptolides D and E and Ibu-epidemethoxylyngbyastatin 3, from a Red Sea L.... ... Depsipeptides / chemistry, isolation & purification*, pharmacology. Humans. Inhibitory Concentration 50. Mice. Molecular ... Grassypeptolides F (1) and G (2), bis-thiazoline-containing cyclic depsipeptides with a rare β-amino acid, extensive N- ...
http://www.biomedsearch.com/nih/Grassypeptolides-F-G-Cyanobacterial-Peptides/21806011.html